Newest Articles
Disease-linked lamin mutation deregulates miR-335Mutations in A-type nuclear lamins cause laminopathies. Oldenburg et al. show that a lipodystrophy-causing lamin A mutation impairs adipogenic gene expression via upregulation of miR-335 through both epigenetic and conformational alterations of the MIR335 locus.
Mitotic functions of Nup2How nuclear pore complexes (NPCs) become segregated during mitosis is unclear. Suresh et al. reveal that Nup2 acts as a tether between NPCs and chromatin during mitosis. This effectively links DNA and NPC segregation and ensures accurate NPC inheritance to daughter nuclei.
Acidic cluster protein sorting machineryAcidic clusters act as sorting signals for packaging cargo into clathrin-coated vesicles. Navarro Negredo et al. show that the clathrin adaptor AP-1 subunit µ1 interacts with endogenous acidic cluster cargo as well as with the HIV-1 acidic cluster protein Nef, and they tease out the contribution of this interaction to acidic cluster protein trafficking.
MEIS triggers PARP1-mediated H1 evictionPARP1/ARTD1 induces chromatin opening by posttranslational modification of the linker histone H1, but how PARP1 is targeted to physiologically correct gene loci is poorly understood. Hau et al. show that in differentiating neurons, PARP1 is rapidly and specifically recruited to a neuron-specific promoter by the atypical homeodomain protein MEIS2.
Two dynein populations at the cortexDynein tethered to the cell cortex generates pulling forces that position the mitotic spindle. To understand the dynamics of this process, Schmidt et al. use fluorescently tagged endogenous dynein and show that two distinct cortical dynein populations together create a robust force-generating system in the polarized one-cell Caenorhabditis elegans embryo.
CENP-A and topo-II regulate chromosome sizeThe size of mitotic chromosomes is coordinated with cell size. Through an RNAi screen in Caenorhabditis elegans, Ladouceur et al. identify CENP-A and topo-II as factors affecting chromosome length. Quantitative analyses of protein dynamics suggest that CENP-A and topo-II localize and function independently to provide centromeric chromatin structure and determine the length of holocentric mitotic chromosomes.
TRIM37 ubiquitylates and stabilizes PEX5TRIM37 gene mutations cause muscle–liver–brain–eye (mulibrey) nanism: a rare autosomal recessive, prenatal onset growth disorder. Wang et al. find that TRIM37 ubiquitylates and stabilizes PEX5, the receptor for import of peroxisomal matrix proteins, suggesting that mulibrey nanism is a new peroxisomal biogenesis disorder.
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July 3, 2017
Volume 216, No. 7
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Victoria and Zurzolo discuss current evidence for the emerging role of lysosomal damage and tunneling nanotubes in the intercellular propagation of prion and prion-like proteins in neurodegenerative disease.