Newest Articles
Cell-cycle control of cell polarityIn Saccharomyces cerevisiae, polarization of Cdc42 is regulated by the cell cycle, but the regulatory mechanisms are not well understood. Moran et al. show that G1 cyclin–dependent kinase activity enables localization of a subset of Cdc42 effectors to sites enriched for Cdc42.
Checkpoint control of late cytokinesisEvents of cytokinesis occur in a precise sequence. Brace et al. describe a checkpoint mechanism in budding yeast that enforces this order by blocking a final secretion event until early division processes are complete.
Dynamic nanoscale ER morphologySchroeder et al. quantitatively evaluate ER architecture in live cells at a ∼50-nm resolution through stimulated emission depletion (STED) microscopy. The ER is not limited to uniform sheets and tubules; they observe dynamic, nanoscale-size holes in ER sheets termed “nanoholes,” and they characterize the effects of perturbations of reticulons, Climp63, and the microtubule cytoskeleton on ER membrane nanostructures.
Regulators of JMY’s actin nucleation activityThe actin regulator JMY creates filament networks that move membranes during autophagy. Hu and Mullins find that JMY is normally inhibited by interaction with the STRAP protein, but upon starvation, JMY is recruited away from STRAP and activated by LC3.
Cytohesin-1 regulates HGF-dependent cell migrationSplice variants of the Arf6 guanine exchange factor cytohesin-1 display differential affinity for PI(4,5)P2 and PI(3,4,5)P3. Ratcliffe et al. show that the specific lipid binding of the diglycine variant of cytohesin-1 is needed for HGF-dependent cell migration and establishment of the leading edge, thereby regulating cancer cell migration following activation of the proto-oncogenic receptor tyrosine kinase Met.
Regulation of mitochondrial ultrastructure by FAM92A1Wang et al. demonstrate that the novel Bin-Amphiphysin-Rvs (BAR) domain protein FAM92A1 possesses membrane-remodeling activity essential for mitochondrial ultrastructure. The findings uncover a role for BAR domain protein as a critical organizer of the mitochondrial inner membrane that is indispensable for mitochondrial function.
Axonal transport of actinChakrabarty et al. propose a model in which slow axonal transport of actin can occur by a biased polymerization of actin filaments along the axon shaft without the involvement of microtubules (MTs) or MT-based motors. These dynamics are distinct from polymer sliding—the canonical mechanism thought to convey cytoskeletal cargoes in slow transport.
Current Issue
November 5, 2018
Volume 217, No. 11
Submit your Research
Reviews & Opinions
- The interdependence of gene-regulatory elements and the 3D genome
Vermunt et al. discuss the relationship between gene-regulatory elements and nuclear architectural features in transcription.
- Wrapping up the fats—a structure of the lipid droplet biogenesis protein seipin
Maria Bohnert discusses the potential functional insight into lipid droplet formation provided by Sui et al.’s new cryo-EM structure of Drosophila seipin.
Most Read
Advertisement
Nilsson reviews the essential role of phosphoprotein phosphatases in the regulation of controlled dephosphorylation during cell division.