Newest Articles
Occluding junctions in tissue mechanics and repairSimple epithelial repair is mediated by the contraction of an actomyosin cable and cellular rearrangements at the wound edge. Carvalho et al. show that occluding junctions are required for epithelial repair by regulating these cellular rearrangements and tissue mechanical properties.
Cargo and clathrin light chains determine curvaturePhosphorylation of clathrin light chains (CLCs) regulates GPCR uptake but is dispensable for transferrin internalization. Maib et al. show that CLCb phosphorylation is required for efficient auxilin-mediated clathrin exchange to promote coated pit invagination in a cargo-specific manner.
Organization of ciliary tipsLouka et al. describe three conserved proteins that regulate the positions of microtubule ends near the tips of cilia. Mutations in two of these proteins cause a brain malformation, Joubert syndrome. Thus, microtubule ends in cilia may play a role in the pathology of Joubert syndrome.
Trypanosome KKT4 is a microtubule-tracking proteinThe evolutionarily divergent class of kinetoplastid organisms has a set of unconventional kinetochore proteins that drive chromosome segregation, but it is unclear which components interact with spindle microtubules. Llauró et al. now identify KKT4 as the first microtubule-binding kinetochore protein in Trypanosoma brucei, a major human pathogenic parasite.
Xrp1 mediates caz mutant phenotypesMallik et al. identify Xrp1 as a nuclear chromatin-binding protein involved in gene expression regulation that mediates phenotypes induced by loss of function of cabeza (caz), the Drosophila melanogaster orthologue of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) protein FUS. Knockdown of Xrp1 in motor neurons rescues phenotypes induced by ALS-mutant FUS.
Nuclear speckles function in intronless mRNA exportNuclear speckles (NSs) store splicing factors. Wang et al. show that many naturally intronless mRNAs associate with NSs and that speckle association enhances their export by facilitating TREX recruitment, suggesting that trafficking to NSs could be an important quality control step in intronless mRNA export.
CAST/ELKS coordinate retinal ribbon synapseThe retinal ribbon synapse is important for the processing of visual information. Hagiwara et al. show that the active zone proteins CAST and ELKS perform both redundant and unique functions in photoreceptors to promote the maturation, maintenance, and activity of ribbon synapses.
Current Issue
September 3, 2018
Volume 217, No. 9
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Reviews & Opinions
- Dendritic actin delivery service
Pai and Moore preview work from Nithianandam and Chien describing new actin structures called blobs that prefigure dendrite branching.
- Mechanical principles of nuclear shaping and positioning
Lele et al. review sources of cellular forces on the nucleus and the structural contributors to its mechanical response.
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Venkei and Yamashita summarize recent advances in our understanding of asymmetric stem cell division in tissue homeostasis.