Newest Articles
Myosin anchors actin assembly to membranesActin assembly and type I myosins are both required for clathrin-mediated endocytosis. Here Pedersen and Drubin show that type I myosins anchor actin assembly factors to the plasma membrane at sites of clathrin-mediated endocytosis, facilitating force generation by actin assembly.
Septins sense curvature using an amphipathic helixThe basis of curvature sensing by the septin cytoskeleton is unknown. Cannon et al. now identify a conserved amphipathic helix that is necessary for recruitment of septins to sites of micrometer-scale curvature in vitro and in vivo.
FRET-based analysis of ER–TGN contact sitesVenditti et al. develop a novel FRET- and FLIM-based approach to monitor ER–trans Golgi network (TGN) contacts and identify VAP proteins, OSBP1, ORP9, and ORP10 as required to maintain contacts. OSBP1 and ORP9 play redundant structural roles, whereas ORP10’s requirement depends on its ability to transfer phosphatidylserine to the TGN.
FAPP1 controls SAC1 activity at ER–TGN contactsVenditti et al. identify FAPP1 as a new determinant of ER–trans-Golgi network contacts that interacts with the phosphoinositide phosphatase Sac1 and promotes its phosphatase activity. The results suggest that, by controlling PI4P levels, FAPP1 acts as a gatekeeper of cargo Golgi exit.
Myosin IIB assembly defines mechanoresponsivenessSchiffhauer et al. use mathematical modeling of Dictyostelium myosin II and experimental approaches in mammalian cells to demonstrate that multiple inputs modulate the ability of myosin II to assemble into filaments. These inputs integrate to govern the myosin II mechanoresponsiveness.
ATM regulates ATP levels through NRF1Oxidative stress, resulting from neuronal activity and depleted ATP levels, activates ATM, which phosphorylates NRF1, causing nuclear translocation and up regulation of mitochondrial gene expression. In ATM deficiency, ATP levels recover more slowly, particularly in active neurons with high energy demands.
Focal adhesions in heart valve developmentGunawan et al. analyze at single-cell resolution collective endocardial cell migration into the extracellular matrix and the cellular rearrangements forming leaflets during zebrafish heart valve formation. They show that focal adhesion activity driven by Integrin α5β1 and Talin1 are essential to drive cardiac valve morphogenesis in zebrafish.
Current Issue
January 7, 2019
Volume 218, No. 1
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Reviews & Opinions
- Dendritic cells mature to resist lamin degradation and herpes virus release
Florence Niedergang introduces work by Turan et al. demonstrating that herpes virus egress from dendritic cells is differentially regulated by kinesin-dependent positioning of lysosomes and autophagic degradation of nuclear lamins.
- Detaching the tether: Remodeling mitochondrial localization during meiosis
Soni Lacefield discusses new findings from Sawyer et al. revealing the developmental regulation of mitochondrial detachment from the cell cortex during meiosis.
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Leandro and Houten highlight new work from Zhou et al. exploring the disease relevance and toxicity of lysine metabolites in mitochondria.