Nde1 plays a role in recruitment of cytoplasmic dynein to cargo. This study finds that Cdk1 phosphorylation of Nde1 enhances its recruitment by CENP-F. This interaction controls Nde1 and, in turn, dynein levels at the G2 nuclear envelope and mitotic kinetochores from prophase through anaphase.

Adherent cells round up before dividing, but how this is linked to the cell cycle is unclear. Jones et al. demonstrate that CDK1 promotes adhesion complex formation and increases cell adhesion area from G1 to S phase. Subsequently, inhibitory phosphorylation of CDK1 by cyclin B1 triggers adhesion complex disassembly during G2 in preparation for mitosis.

Messenger et al. show that exosome secretion in cancer cells is Ca²⁺-stimulated and dependent on Ca²⁺-bound Munc13-4. Munc13-4, a late endosome priming factor, acts via a Rab11-dependent pathway to prepare multivesicular endosomes for exocytosis. These results indicate that Munc13-4 plays a central role in exosome release in cancer cells.