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Meet our Community: Focus on Sue Biggins and cell division

Special Collection: Mitochondria and Autophagy, curated by JCB Board member Richard Youle

  • Mitochondria and Autophagy
    A special collection of recent exciting articles selected by JCB Board member Richard Youle
  • Submit and receive an initial decision within a week.
  • Meet our Authors, Readers, and Reviewers
    Meet Sue Biggins and rediscover her and related work about cell division
  • Review: Visualizing transcription factor dynamics in living cells, by Liu and Tjian
  • Metabolism
    Tsuchiya…Kohno assess the role of the IRE1α–XBP1 pathway in pancreatic β cells
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Newest Articles

  • Dynamics of sister chromatid resolution during cell cycle progression
    Dynamics of sister chromatid resolution

    Stanyte et al. use dCas9-mEGFP labelling to image endogenous genomic loci and show that sister loci separate shortly after their replication and rapidly equilibrate their relative position, thereby establishing a sister chromatid resolution topology in G2 that largely reflects the DNA replication program. The data suggest that cohesin enrichment sites are not persistent cohesive sites in human cells.

    Rugile Stanyte ... Daniel W. Gerlich
    Article | April 25, 2018
  • Characterization of LAMP1-labeled nondegradative lysosomal and endocytic compartments in neurons
    Revisiting LAMP1 as a marker for neuronal lysosome

    Cheng et al. combine quantitative immunoelectron microscopy and light imaging microscopy to comprehensively analyze LAMP1 subcellular distribution in neurons. The data show that a significant portion of LAMP1-positive organelles are not degradative, illustrating the need for additional lysosomal and endocytic markers to define endolysosomal compartments in the nervous system.

    Xiu-Tang Cheng ... Zu-Hang Sheng
    Article | April 25, 2018
  • Hierarchical recruitment of ribosomal proteins and assembly factors remodels nucleolar pre-60S ribosomes
    Nucleolar 60S ribosomal subunit remodeling events

    Ribosome biogenesis involves numerous pre-rRNA processing events to remove internal and external transcribed spacer sequences, ultimately yielding three mature rRNAs. Biedka et al. show that ribosomal proteins and assembly factors remodel several neighborhoods, including two 60S ribosomal subunit functional centers, during removal of the ITS2 spacer RNA.

    Stephanie Biedka ... John L. Woolford
    Article | April 24, 2018
  • PI(4,5)P2 determines the threshold of mechanical force–induced B cell activation
    PI(4,5)P2 enrichment regulates the mechanical force–induced B cell activation

    Antigens deliver mechanical forces to B cell receptors (BCRs) to initiate B cell activation. Using mechanical force biosensors, Wan et al. show that the enrichment of PI(4,5)P2 within the IgG-BCR membrane microdomain determines the threshold of mechanical force–induced B cell activation.

    Zhengpeng Wan ... Wanli Liu
    Article | April 23, 2018
  • Microtubule end tethering of a processive kinesin-8 motor Kif18b is required for spindle positioning
    Kif18b walks to microtubule ends and shortens them

    Kinesin-8 Kif18b shortens astral microtubules in mitosis. Combining cell biology and biochemical reconstitution, McHugh et al. show that Kif18b walks and accumulates to microtubule plus ends in a phosphospecific manner to regulate astral microtubule dynamics and center the mitotic spindle.

    Toni McHugh ... Julie P.I. Welburn
    Article | April 16, 2018
  • Hsp40/70/110 chaperones adapt nuclear protein quality control to serve cytosolic clients
    Chaperones manage misfolded proteins in the nucleus

    Quality control (QC) pathways for misfolded proteins depend on E3 ubiquitin ligases and associated chaperones. Prasad et al. show that Hsp40/70/110 chaperones traffic and manage misfolded proteins in the nucleus, extending the nuclear protein QC pathway to include cytosolic clients.

    Rupali Prasad ... Davis T.W. Ng
    Article | April 13, 2018
  • Lymphatic exosomes promote dendritic cell migration along guidance cues
    Lymphatic exosomes enhance directional migration

    Inflammation stimulates lymphatic endothelial cells to release exosomes, which accumulate in the perivascular stroma. Brown et al. show that these exosomes promote the directional migration of dendritic cells along guidance cues in complex environments by enhancing dynamic cellular protrusions in a CX3CL1-dependent manner.

    Markus Brown ... Dontscho Kerjaschki
    Article | April 12, 2018
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The Journal of Cell Biology: 217 (4)

Current Issue

April 2, 2018
Volume 217, No. 4

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Reviews & Opinions

  • Posttranscriptional regulation of T helper cell fate decisions

    Hoefig and Heissmeyer review how microRNAs, long noncoding RNAs, RNA-binding proteins, and ubiquitin-modifying enzymes regulate T helper cell differentiation downstream of transcription.

    Kai P. Hoefig ... Vigo Heissmeyer Review | April 23, 2018
  • Modulation of the secretory pathway by amino-acid starvation

    van Leeuwen et al. discuss how the cellular secretory pathway adapts and contributes to stress-induced pathways during nutrient starvation.

    Wessel van Leeuwen ... Catherine Rabouille Review | April 18, 2018
  • Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling

    Wang et al. review the dual role of superoxide dismutases in controlling reactive oxygen species (ROS) damage and regulating ROS signaling across model systems as well as their involvement in human diseases.

    Ying Wang ... Siegfried Hekimi Review | April 18, 2018

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The Year in Cell Biology: 2017


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