- Ferroptosis-like cell death in plants
Distéfano et al. show that an iron-dependent, oxidative cell death process with biochemical and morphological similarities to ferroptosis, as described in mammalian cells, has a physiological role in plants, regulating plant cell death in response to heat stress.
- A STRIPAK complex regulates axonal transport
The regulation of cargo transport within neurons is not well understood. Neisch et al. use Drosophila genetics to identify a multiprotein STRIPAK complex required for autophagosome and dense core vesicle transport in neurons. PP2A activity within the complex is necessary for transport.
- DGCR8 is required to exit pluripotency
DGCR8 is essential for mouse early development and microRNA biogenesis. Cirera-Salinas et al. report a new noncanonical function of DGCR8 essential for the exit from pluripotency of mouse embryonic stem cells.
- FKB-6 in meiotic chromosome pairing and synapsis
Dynein-mediated movement of microtubules is required for chromosome movement; its absence leads to aberrant segregation. Alleva et al. show that FKB-6, a cochaperone of Hsp-90, is required for proper chromosome movement through down-regulation of resting time between movements.
- Molecular basis of receptor-mediated transcytosis
Transcytosis plays an important role in establishing cell polarity and in mediating transport of large cargo across epithelial barriers, but its molecular basis is unclear. Nelms et al. present a new dataset of genes involved in receptor-mediated transcytosis and show that the apical and basolateral recycling and transcytotic pathways are genetically separable.
- Axonal autophagy promotes Wallerian degeneration
The pathophysiological function and induction mechanism of autophagy in neuronal axons have remained unclear. Wakatsuki et al. show that the GSK3B-mediated phosphorylation of MCL1 leads to its UPS-dependent degradation, which induces axonal autophagy and promotes axonal degeneration.
- Δψ-mediated mitochondrial translocation
Schendzielorz et al. report that mitochondrial precursors display different dependencies on the membrane potential (Δψ) for translocation. Two distinct Δψ-dependent steps promote precursor translocation, the first driving presequence translocation and the second acting on the mature portion of the polypeptide chain.