Newest Articles
Complexin and Bruchpilot are tethering partnersBy performing an in vivo screen in Drosophila melanogaster, Scholz, Ehmann, et al. identify Complexin as a functional interaction partner of Bruchpilot. The two proteins mediate a physical attachment of synaptic vesicles to the active zone cytomatrix and promote rapid, sustained synaptic transmission.
A quenching tool to measure cell wall porosityCell wall porosity of fungi and plants could not be determined in vivo previously. Application of a novel method links dynamic changes in wall porosity to stress-induced cell elongation in plant roots and uptake of antifungal drugs in yeast cells.
Regulation of kinesin-1 by MAP7 family proteinsHooikaas et al. show that mammalian MAP7 family proteins act redundantly to activate the kinesin-1 motor protein. Using experiments in cells and in vitro reconstitution assays, they demonstrate that MAP7 proteins promote microtubule recruitment and processivity of kinesin-1 by transiently associating with the stalk region of the motor.
Cyclin B3 is indispensable for oocyte meiosis IProper chromosome segregation during meiosis requires cyclins associated with cyclin-dependent kinases. Li et al. generate Ccnb3 mutant mice via CRISPR/Cas9 and identify a requirement for cyclin B3 in female meiosis I.
Snx14 regulates ER–droplet contactsFree fatty acids are toxic, but are stored in lipid droplets (LDs) that bud from the ER. Datta et al. show that cerebellar ataxia–linked protein Snx14 localizes to ER–droplet contacts and promotes LD growth. This implicates Snx14 in LD homeostasis which, when perturbed, contributes to disease.
Mitotic H2B S6 phosphorylationSeibert et al. identify a new phosphorylation event of histone H2B at serine 6 during mitosis with CDK1 and PP1 as writers and erasers of this modification. This phosphorylation contributes to chromatin dislocation of the histone chaperone SET during mitosis and is required for mitotic chromosome segregation.
ETAA1 activates ATR to regulate mitosisBass and Cortez use comparative quantitative mass spectrometry analyses of cells lacking either ATR activator, ETAA1 or TOPBP1. They identify a role for ETAA1 and ATR activation in the regulation of chromosome alignment and segregation in mitosis through Aurora B activity.
Current Issue
February 4, 2019
Volume 218, No. 2
Submit your Research
Reviews & Opinions
- Resistance is futile: Centering forces yield for asymmetric cell division
Alper and Zanic highlight new findings from Sallé et al. about the forces that can control asymmetric cell division.
- Immune checkpoint inhibitors
Hui details the cell biology underlying the action of immune checkpoint inhibitors.
Most Read
Advertisement
Katharina Schlacher previews work from Chow et al. that links ATM activation in cerebellar Purkinje cells with mitochondrial function and ATP production during periods of high energy demand.