Newest Articles
Draxin controls cranial neural crest EMTHutchins and Bronner show that a transient pulse of the secreted molecule Draxin regulates the timing and progression of cranial neural crest EMT along the anterior to posterior embryonic body axis by modulation of canonical Wnt signaling.
Ret augments p75-mediated programmed cell deathProgrammed cell death is a critical process in sculpting the developing nervous system, but the underlying signaling mechanisms remain poorly defined. Donnelly et al. demonstrate a non-canonical function for the neurotrophic factor receptor Ret in p75-mediated apoptosis in sympathetic neurons.
Endosomal microautophagy of autophagy receptorsMejlvang et al. show that amino acid starvation of human fibroblasts and a lung cancer cell line induces a rapid and selective degradation of a subset of proteins, including autophagy receptors p62/SQSTM1, NBR1, TAX1BP1, NDP52, and NCOA4, that is independent from mTOR and canonical macroautophagy but dependent on endosomal microautophagy.
Vps13 is recruited by competing adaptorsTargeting of Vps13 to membranes is highly dynamic. Bean et al. identify Ypt35 and Mcp1 as adaptors for Vps13 at endosomes and mitochondria, respectively, and show all known Vps13 adaptors use a related motif to compete for Vps13 membrane recruitment.
Ajuba regulates adhesion under tensionMechanical forces are generated during epithelial morphogenesis, but how cells maintain adhesion when exposed to these forces is poorly understood. Razzell et al. show that the LIM domain protein Ajuba localizes to adherens junctions under tension in the Drosophila embryo and is required to maintain cell adhesion during epithelial remodeling.
γ-Secretase stimulates membrane insertion of the HPV L2 protein during infectionAlthough human papillomaviruses (HPVs) cause many human cancers, the cellular basis of HPV infection remains mysterious. This manuscript reveals that the transmembrane protease γ-secretase harbors a novel chaperone activity, promoting insertion of the HPV L2 protein into endosomal membranes. L2 membrane insertion is required for further progression of infection.
Partial cohesin loss compromises mitotic fidelitySister chromatid cohesion is a prerequisite for faithful mitosis. Through artificial removal of precise amounts of cohesin from metaphase chromosomes, Carvalhal et al. show that sister chromatid cohesion is highly resistant to cohesin loss. Nevertheless, partial cohesin decay compromises mitotic fidelity by impairing chromosome attachments.
Current Issue
July 2, 2018
Volume 217, No. 7
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Reviews & Opinions
- A new look for the growing microtubule end?
Rice previews work from McIntosh et al. that reveals the structure of growing microtubule ends.
- An actin shell delays oocyte chromosome capture by microtubules
Verlhac discusses new work from Burdyniuk et al. demonstrating how F-actin coordinates the capture of chromosomes by microtubules in oocytes.
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Verlhac and Reggiori introduce work from Mostofa et al. that describes a role for the CLIP and cohibin complexes in repositioning ribosomal DNA during the process of nucleophagy.