Newest Articles
Ykt6 in autophagosome fusionAutophagosome fusion with vacuoles requires a conserved fusion machinery, though the topology remained unclear. Two papers in this issue, Bas et al. and Gao et al., uncover Ykt6 as the required autophagosomal SNARE.
Ykt6 mediates autophagosome–vacuole fusionAutophagosome fusion with vacuoles requires a conserved fusion machinery, though the topology remained unclear. Two papers in this issue, Bas et al. and Gao et al., uncover Ykt6 as the required autophagosomal SNARE.
Cyclin B and oocyte meiosisCyclin B1 and its interaction with CDK1 are thought to be critical for meiosis I progression in oocytes. However, using oocyte-specific conditional knockouts, Li et al. show that Cyclin B2 activity can compensate for Cyclin B1 to trigger meiosis resumption.
VPS13 proteins transfer lipids at membrane contact sitesStructural and biochemical studies show that VPS13 family proteins are lipid transporters. VPS13A and VPS13C tether the ER to mitochondria and to endosomes/lysosomes, respectively, suggesting lipid dyshomeostasis as the cause of chorea acanthocytosis and Parkinson’s disease resulting from their mutations.
TMEM41B is required for autophagosome formationMorita et al. identify the endoplasmic reticulum multispanning membrane protein TMEM41B as a factor required for autophagosome formation. TMEM41B interacts physically and functionally with VMP1, a structurally related autophagy protein.
The stem cell niche is protected from apoptosisIrradiation temporarily arrests tissue regeneration. Volin et al. show that the ability of stem cells to regain regeneration relies on the resistance of their niche-supporting cells to apoptosis. This resistance is mediated by microRNAs that prevent apoptosis induction.
INPP5K and ER architectureEndoplasmic reticulum (ER) morphology is dynamic and key to its function during different cellular processes. Dong et al. now show in convergent studies in human cells and Caenorhabditis elegans neurons that a phosphoinositide phosphatase (INPP5K) is localized on the surface of the ER network and helps control the shape of the ER.
Current Issue
August 6, 2018
Volume 217, No. 8
Submit your Research
Reviews & Opinions
- Neuronal endosomes to lysosomes: A journey to the soma
Kulkarni and Maday preview studies from Cheng et al. and Yap et al. characterizing the organization of the endolysosomal system in neurons.
- Natural killers shed attachments to kill again
Felce and Dustin highlight work from Srpan et al. showing that shedding of the Fc receptor CD16 facilitates detachment of NK cells from targets, leading to increased mobility and serial engagement.
Most Read
Advertisement
Zaidel-Bar introduces work by Jones et al. demonstrating how adhesion is regulated during the cell cycle by CDK1.