Newest Articles
Role of SUMOylation in human septin functionYeast septins were among the first proteins reported to be SUMOylated, but the impact of this modification on septin function is unclear. Ribet et al. show that septins are SUMOylated in humans and that SUMOylation is critical for septin bundle formation and septin function in cell division.
RAB7/8 require modification by ICMT to regulate NOTCHSome prenylated proteins such as RAS require carboxyl methylation by ICMT for proper association with cellular membranes. Court et al. show that RAB7 and RAB8 are among these proteins and that by affecting vesicular transport, these GTPases regulate NOTCH signaling in an ICMT-dependent fashion.
Sgs1/BLM suppresses R-loop formationChang et al. link the RECQ-like helicase BLM and its yeast orthologue Sgs1 to preventing DNA damage caused by the accumulation of DNA:RNA hybrid structures called R-loops. This adds to a growing family of helicases implicated in R-loop resolution.
RSG1 promotes primary cilia initiationPrimary cilia are essential for normal development and tissue homeostasis, but the mechanisms that remodel the centriole to promote cilia initiation are not well understood. Agbu et al. report that mouse RSG1, a small GTPase, regulates a late step in cilia initiation, downstream of TTBK2 and the CPLANE protein INTU.
mTORC activation by PtdIns3P and lysosome movementmTORC1 is activated by lysosome positioning and by amino acid–induced phosphatidylinositol 3-phosphate (PtdIns3P). Hong et al. show that amino acids stimulate recruitment of the PtdIns3P-binding protein FYCO1 to lysosomes and promote contacts between FYCO1 lysosomes and ER that contains the PtdIns3P effector Protrudin, mediating lysosome translocation and facilitating mTORC1 activation.
FANCI/D2 regulate the dynamics of splicing factorsMoriel-Carretero et al. show that the Fanconi anemia proteins FANCI and FANCD2 associate with the splicing factor SF3B1 and that DNA replication stress induces the FANCI-dependent release of SF3B1 from nuclear speckles. FANCI and FANCD2 prevent accumulation of postcatalytic intron lariats, suggesting that they help coordinate DNA replication and transcription.
Pax4 induces δ-to-ß–like cell conversionDiabetes can result from the loss or dysfunction of insulin-producing δ cells. Druelle et al. find that ectopic expression of the pancreatic beta cell master gene Pax4 in somatostatin-expressing δ cells triggers an endocrine cell neogenesis process. Importantly, the beta-like cells thereby generated are functional and can partly reverse the consequences of chemically induced diabetes.
Current Issue
October 2, 2017
Volume 216, No. 10
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Reviews & Opinions
- Protein sequestration at the nuclear periphery as a potential regulatory mechanism in premature aging
Serebryannyy and Misteli provide a perspective on how protein sequestration at the inner nuclear membrane and nuclear lamina might influence aging.
- A three-alarm signal for endocytosis?
A combination of high membrane curvature and two phosphoinositides initiates an actin polymerization pathway that could help cells complete endocytosis when vesicle scission is delayed.
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Machesky and Braga preview work from the Gottardi laboratory exploring the role of a new interaction between α-catenin homodimers and PIP3 in cell adhesion.