Newest Articles
Endosomal TLRs differentially control neuronal morphologyHung et al. combine in vitro neuronal cultures, in utero electroporation, and transcriptomic profiling to show that the activation of TLR8, TLR7, or TLR3 results in dendritic shortening and that TLR7 and TLR3 but not TLR8 also control axonal growth. In-depth transcriptomic analyses show that TLRs use different downstream pathways to control neuronal morphology despite signaling through the same adapter, MYD88.
Xpo7 is a broad-spectrum exportin and a nuclear import receptorAksu et al. explore the vast cargo spectrum of exportin7/Xpo7 and present anti-Xpo7 nanobodies that acutely inhibit Xpo7’s transport cycles in living cells. Their expression selectively blocks nuclear enrichment of import cargoes as well as nuclear exclusion of export cargoes, establishing Xpo7 as a novel bidirectional nuclear transport receptor.
Nuclear transport adapts to varying heat stress in a multistep mechanismUsing a newly developed temperature shift assay, Ogawa and Imamoto find that nuclear transport pathways have different sensitivities to rising temperatures. The data suggest that the thermosensitivity of importin α1 enables a multistep shutdown of Ran-dependent transport according to the degree of heat stress.
Cyclin-dependent kinase regulation during return to growth and mitosisBy investigating how yeast cells coordinate polarity and division in a special type of cell division called return to growth, Gihana et al. discover that although checkpoints are normally beneficial, prolonged activation of the morphogenesis checkpoint is instead detrimental to the cell.
Wdr92/R2TP regulates dynein motor preassemblyWdr92 is associated with the multifunctional cochaperone, R2TP, but its function is unknown. In this study, the authors show that Drosophila Wdr92 is exclusively required for preassembly of ciliary dynein motor complexes, which are confined to sensory neuron ciliary dendrites and sperm flagella. Wdr92 is proposed to direct R2TP/HSP90 to dynein chain clients to chaperone cytoplasmic preassembly.
Centrosome amplification arises before neoplasiaLopes et al. examine centrosomes in human samples progressing from premalignant to metastatic lesions from patients with Barrett’s esophagus. They find that centrosome amplification can occur before transformation during human tumorigenesis, being repressed by p53, suggesting that centrosome amplification contributes to tumor initiation before p53 mutation.
Transcription factor control of chromosome condensationHow chromosomes compact into rod-shaped structures is a longstanding unresolved question of cell biology. Schiklenk et al. identify the transcription factor Zas1 as a central regulator of mitotic chromosome condensation in fission yeast and show that it uses a conserved transactivation domain–based mechanism to control gene expression.
Current Issue
May 7, 2018
Volume 217, No. 5
Submit your Research
Reviews & Opinions
- Protein kinase A activation: Something new under the sun?
Smith and Scott discuss work from Isensee et al. addressing the long-standing question of the regulation of protein kinase A–II activity by phosphorylation.
- Muscle tensions merge to cause a DNA replication crisis
Brayson et al. preview work from Wong et al. that provides evidence supporting the hypothesis that cell and tissue mechanics play a crucial role in the regulation of key nuclear functions.
Original Image Data
Most Read
Advertisement
Researchers reconstitute caveolae assembly in cell-free extracts to investigate how these membrane microdomains interact with signaling proteins.