Newest Articles
PI(4,5)P2 enrichment regulates the mechanical force–induced B cell activationAntigens deliver mechanical forces to B cell receptors (BCRs) to initiate B cell activation. Using mechanical force biosensors, Wan et al. show that the enrichment of PI(4,5)P2 within the IgG-BCR membrane microdomain determines the threshold of mechanical force–induced B cell activation.
Kif18b walks to microtubule ends and shortens themKinesin-8 Kif18b shortens astral microtubules in mitosis. Combining cell biology and biochemical reconstitution, McHugh et al. show that Kif18b walks and accumulates to microtubule plus ends in a phosphospecific manner to regulate astral microtubule dynamics and center the mitotic spindle.
Chaperones manage misfolded proteins in the nucleusQuality control (QC) pathways for misfolded proteins depend on E3 ubiquitin ligases and associated chaperones. Prasad et al. show that Hsp40/70/110 chaperones traffic and manage misfolded proteins in the nucleus, extending the nuclear protein QC pathway to include cytosolic clients.
Lymphatic exosomes enhance directional migrationInflammation stimulates lymphatic endothelial cells to release exosomes, which accumulate in the perivascular stroma. Brown et al. show that these exosomes promote the directional migration of dendritic cells along guidance cues in complex environments by enhancing dynamic cellular protrusions in a CX3CL1-dependent manner.
LINC complex regulates DNA replication in muscle nucleiNuclear mechanotransduction has been implicated in the control of chromatin organization and gene expression. Wang et al. show that, in Drosophila myofibers, the LINC complex is required for the regulation of DNA replication and synchronized cell-cycle progression in myonuclei.
SFT-4/Surf4 family in soluble protein secretionSaegusa et al. report that the SFT-4/Surf4 cargo receptor homologs mediate export of soluble proteins such as lipoproteins from the ER. Efficient export of yolk proteins in C. elegans intestinal cells, or apoliprotein trafficking in human hepatocytes, requires SFT-4/Surf4 so that they may enhance secretion by maintaining ER exit site organization.
A quantitative 3D map of Condensins in mitosisWalther et al. systematically fluorescently tag endogenous Condensin subunits and map their abundance, physical spacing, and mitotic dynamics by fluorescence correlation spectroscopy–calibrated live-cell imaging and superresolution microscopy. They propose a three-step hierarchical loop model of mitotic chromosome compaction.
Current Issue
April 2, 2018
Volume 217, No. 4
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Reviews & Opinions
- Modulation of the secretory pathway by amino-acid starvation
van Leeuwen et al. discuss how the cellular secretory pathway adapts and contributes to stress-induced pathways during nutrient starvation.
- Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling
Wang et al. review the dual role of superoxide dismutases in controlling reactive oxygen species (ROS) damage and regulating ROS signaling across model systems as well as their involvement in human diseases.
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Hoefig and Heissmeyer review how microRNAs, long noncoding RNAs, RNA-binding proteins, and ubiquitin-modifying enzymes regulate T helper cell differentiation downstream of transcription.