Newest Articles
Cyclin B1 is a spindle checkpoint proteinCDK1-CCNB1 plays a well-established role in promoting mitosis. Alfonso-Pérez et al. now show that CDK1-CCNB1 forms a complex with the spindle checkpoint protein MAD1 at unattached kinetochores that directly promotes spindle checkpoint signaling.
MPS1 is a target of the B55-regulated exit pathwayHayward et al. show that CDK1-CCNB1 and PP2A-B55 limit spindle checkpoint signaling to a tightly defined window during mitosis. CDK1-CCNB1 promotes MPS1 localization to unattached kinetochores and thus creates a checkpoint-permissive state that is terminated by PP2A-B55 upon mitotic exit.
Dynein LIC1 and LIC2 in neocortical developmentThe retrograde microtubule motor cytoplasmic dynein is fundamental for mammalian brain development. Gonçalves et al. identify distinct roles for dynein cargo-binding subunits, the light intermediate chains, in neocortical development and uncover a novel function for dynein in terminal somal translocation of neurons.
Hook2 regulates cell divisionHook proteins are conserved dynein adaptors that promote the assembly of dynein–dynactin motor complexes. Dwivedi et al. show that Hook2 is a novel mitotic adaptor that mediates dynein–dynactin–dependent anchoring of the centrosome to the nuclear envelope and microtubule nucleation from mitotic centrosomes. In addition, Hook2 is needed for the dynactin-dependent targeting of the centralspindlin complex to the midzone for normal cytokinesis.
Mitochondrial CoQ domains at ER–mitochondria contactsCoQ lipids are built at the mitochondrial inner membrane by a multicomponent pathway. Subramanian et al. reveal that CoQ pathway components assemble via CoQ intermediates into domains at ER–mitochondria contacts, suggesting that CoQ domains function as metabolons that facilitate processive CoQ production and distribution.
DCAF12’s pleiotropic synaptic functionsPatrón et al. show that presynaptic Drosophila DCAF12 is required for neurotransmitter release and homeostatic synaptic plasticity at neuromuscular junctions. Postsynaptic nuclear DCAF12 controls the expression of glutamate receptor IIA subunits in cooperation with Cullin4 ubiquitin ligase.
Myosin anchors actin assembly to membranesActin assembly and type I myosins are both required for clathrin-mediated endocytosis. Here Pedersen and Drubin show that type I myosins anchor actin assembly factors to the plasma membrane at sites of clathrin-mediated endocytosis, facilitating force generation by actin assembly.
Current Issue
January 7, 2019
Volume 218, No. 1
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Reviews & Opinions
- Saccharopine, a lysine degradation intermediate, is a mitochondrial toxin
Leandro and Houten highlight new work from Zhou et al. exploring the disease relevance and toxicity of lysine metabolites in mitochondria.
- Dendritic cells mature to resist lamin degradation and herpes virus release
Florence Niedergang introduces work by Turan et al. demonstrating that herpes virus egress from dendritic cells is differentially regulated by kinesin-dependent positioning of lysosomes and autophagic degradation of nuclear lamins.
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Rickman and Smogorzewska discuss recent studies that detail the cellular mechanisms protecting genome stability at sites of stalled DNA replication.