Newest Articles
ESCRT catalyzes autophagosome closureZhou et al. identify the mechanism of autophagosome (AP) closure. They show that Rab5 GTPase regulates an interaction between the ESCRT subunit Snf7 and Atg17 to bring ESCRT to APs where it catalyzes AP closure. These findings highlight the convergence of the endocytic and autophagic pathways at this step.
Talin F1–Rap1 binding in integrin activationThis work reveals that Rap1 GTPases bind directly to the talin1 F1 domain and by cooperating with a unique lipid-dependent amphipathic helix in the F1 domain effect talin1-mediated integrin activation.
Somatic autophagy of axonal mitochondriaHow mitochondria damaged in distal axons are cleared is not understood. Zheng et al. find that axonal mitochondria return to neuronal soma for mitophagy after ischemic insult. These spatial features of neuronal mitophagy provide insight into how neurons control mitochondrial quality under pathological conditions.
The RIPK3-MLKL pathway attacks cytosolic ListeriaThe RIPK3-MLKL pathway protects epithelial cells from Listeria monocytogenes invasion. Sai et al. find that Listeria infection activates MLKL but does not induce its oligomerization or necroptotic cell death. Instead, Listeria-activated MLKL directly targets intracellular bacteria and suppresses their replication.
Peroxisome import in Xenopus egg extractsPeroxisomes import proteins with a C-terminal SKL sequence by a poorly understood mechanism. Romano et al. use Xenopus egg extracts to study peroxisome import in vitro. The novel assay recapitulates import in vivo and provides mechanistic insights.
Lipid transport by ATG2Valverde et al. show that the autophagy protein ATG2 functions in autophagosome biogenesis by transferring lipids at ER–autophagosome contact sites.
DAPLE regulates G proteins in vivoThis work provides direct evidence that heterotrimeric G proteins can be activated in vivo by a cytoplasmic factor instead of by a GPCR. Specifically, DAPLE, a nonreceptor protein bearing an evolutionarily conserved Gα-binding and -activating (GBA) motif, triggers apical cell constriction during neurulation in Xenopus laevis embryos via G protein–dependent signaling.
Current Issue
April 1, 2019
Volume 218, No. 4
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Reviews & Opinions
- ATG9 raises the BAR for PI4P in autophagy
Shatz and Elazar discuss a recent study from Judith et al. demonstrating how ATG9A vesicles drive early autophagy.
- Post-translational regulation of ubiquitin signaling
Song and Luo review the roles of post-translational modifications in ubiquitin signaling.
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Sharma and Dwivedi highlight recent work from Wang et al. describing two GTPases that function directly as dynein adaptors for retrograde transport.