Newest Articles
Regulation of NuMA by Importin-βNuMA has been suggested to function as a Ran-regulated spindle assembly factor that modulates spindle pole assembly. Chang et al. provide structural and biochemical evidence showing that NuMA contains an Importin-β–regulated microtubule-binding region, which allows Ran to regulate the NuMA functions required for the assembly of higher-order microtubule structures.
Control of cell growth and size in mitosisIn budding yeast, cell size is thought to be primarily controlled by a mechanism that delays cell cycle entry until sufficient growth has occurred in G1. Leitao and Kellogg show that nutrients modulate cell size by controlling the amount of growth that occurs during mitosis.
Structural plasticity of the living kinetochoreDhatchinamoorthy et al. use calibrated imaging, FRAP, and photoconversion to study the changes in kinetochore component copy numbers from G1 to anaphase and find that the Dam1 submodule is unchanged during anaphase, whereas MIND and Ndc80 submodules add copies, providing insight into the dynamics and plasticity of the kinetochore structure during chromosome segregation.
SNX-BARs in retromer-independent CI-MPR transportBy revisiting the classical role of retromer in endosomal sorting of the cation-independent mannose 6-phosphate receptor (CI-MPR), Simonetti et al. reveal that CI-MPR sorting actually occurs via SNX1/2–SNX5/6 membrane-tubulating complexes, thereby reappraising retromer’s role in this important transport process.
Cargo-selective SNX-BARS recycle CI-MPRKvainickas et al. show that the retromer cargo CI-MPR does not recycle from endosomes to the trans-Golgi network through interactions with the core retromer trimer. Instead, CI-MPR depends on cargo-selective SNX-BAR proteins, which function independently of the core retromer trimer.
Fibroblasts lead tumor invasion via fibronectinCancer-associated fibroblasts (CAFs) promote cancer cell invasion and dissemination by remodeling the extracellular matrix; however, the mechanism by which CAFs remodel the matrix is still unknown. Attieh et al. show that CAFs induce cancer cell invasion through fibronectin matrix assembly that is mainly mediated by integrin-αvβ3.
SecA mediates cotranslational protein targetingProteins are thought to be delivered to the bacterial plasma membrane cotranslationally by signal recognition particle or posttranslationally by SecA. Wang et al. identify a new membrane protein–targeting pathway in bacteria in which SecA cotranslationally recognizes and targets the inner membrane protein RodZ, which harbors an internal transmembrane domain.
Current Issue
September 4, 2017
Volume 216, No. 9
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Reviews & Opinions
- Catch and release: 14-3-3 controls Ncd in meiotic spindles
Dasso discusses work from Beaven et al. on the regulation of Ncd in the meiotic spindle by 14-3-3 proteins.
- How the vasculature delivers lung epithelia from an incorrect fate
Cross talk between pulmonary endothelia and epithelia prevents abnormal differentiation into liver cells.
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Casanova and Winckler discuss Liu et al.’s recent finding that WDR91 coordinates Rab and phosphoinositide conversion during endosome maturation in neurons.