Newest Articles
Rab GTPase phosphorylation by LRRK2Parkinson’s disease–associated LRRK2 kinase is activated on the Golgi by Rab29 but phosphorylates Rab10 there and on other compartments. This study shows that phosphorylation is restricted to membrane surfaces but need not take place on the Golgi.
Rab7 regulates cilia disassemblyWang et al. identify Rab7 as a novel regulator of primary cilia disassembly. Their findings demonstrate that Rab7 localization to primary cilia is required for intraciliary F-actin polymerization, which is indispensable for the regulation of cilia ectocytosis and disassembly.
Role and regulation of ETAA1 in genome stabilityAchuthankutty et al. show that the recently identified ATR kinase activator ETAA1 has an important role in protecting against chromosomal instability arising from incompletely replicated DNA, driven by cell cycle– and replication stress–regulated, phosphorylation-dependent control of its ATR-activating domain.
Insulin controls triglyceride release from liverKumar et al. describe a detailed pathway for channeling fat from the liver into blood across fed/fasted cycles. Insulin, phosphatidic acid, and kinesin collaborate in hepatocytes to deliver lipid droplets to the smooth ER, where they are catabolized to supply fat for lipoprotein production and secretion.
Lysosomal cholesterol regulates calcium signalingTiscione et al. report a molecular mechanism that links lysosomal cholesterol export with the regulation of key intracellular Ca2+ signaling pathways to influence synaptic architecture in health and neurodegenerative NPC1 disease.
Two septation phases discriminated by Bgs1 with LatARamos et al. establish that fission yeast septation proceeds in two phases. Initially, the septum is immature and, upon F-actin depolymerization, loses the Bgs1 glucan synthase and fails to ingress. During a second phase, the mature septum can maintain Bgs1 and ingression without F-actin, and ingression becomes Cdc42 and exocyst dependent.
Phosphoregulation of tropomyosin in actin functionPalani et al. reveal a new mechanism by which the F-actin binding protein tropomyosin is regulated. They find that phosphorylation of tropomyosin reduces its affinity for F-actin, allowing the competing Adf1 to bind and sever actin filaments.
Current Issue
October 7, 2019
Volume 218, No. 10
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Reviews & Opinions
- Kindlin-3 stokes the life span of podosomes
Hongquan Zhang highlights new work from Klapproth et al. that identifies a kindlin-3–leupaxin–paxillin signaling pathway that regulates podosome stability.
- Protein quality control in the secretory pathway
One third of the eukaryotic proteome matures in the secretory pathway. Sun and Brodsky describe the machinery that maintains protein fidelity and how its actions are coordinated.
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Brown and Koslover highlight recent work from Maza and colleagues that examines the mechanisms underlying compartmentalization of membrane proteins.