Newest Articles
Mechanical activation of cofilin and neuron growthSynergism between myosin II contractility and cofilin activity modulates serotonin-dependent axon growth. Normally, cofilin-dependent decreases in actin density are compensated by increases in point contact density and traction force; however, myosin hyperactivation leads to catastrophic decreases in actin network density and neurite retraction.
XLF and H2AX function during DNA replicationChen et al. show that XLF functions to limit fork reversal during DNA replication. H2AX prevents MRE11-dependent replication stress in XLF-deficient cells, suggesting that H2AX prevents the resection of regressed arms at reversed forks.
TORC2 affects endocytosis via membrane tensionUsing chemical genetics, we show that acute inhibition of otherwise rapamycin-insensitive TORC2 triggers a slow increase in plasma membrane tension that provokes snapping of the bonds between adaptor proteins and polymerizing actin filaments and ultimately the cessation of endocytosis in yeast.
A new PTEN pathway reduces PIP2 on endosomesThis work reveals that the tumor suppressor PTEN acts through a PLC to reduce levels of endosomal PtdIns(4,5)P2, its own enzymatic product. This pathway can be chemically activated to rescue OCRL1 depletion in several disease models of the Lowe syndrome, a rare multisystemic genetic disease.
Outer kinetochore plasticityDhatchinamoorthy et al. suggest the stoichiometry of outer submodules of the budding yeast kinetochore is strongly influenced by factors at the kinetochore–microtubule interface such as Fin1 and Dam1. Outer kinetochore stoichiometry is remarkably plastic and responsive to microtubule-proximal regulation.
Microtubule coordination in kinetochore fibersVertebrate cells assemble mitotic spindles through multiple pathways. It is shown that Augmin-dependent, noncentrosomal nucleation generates the vast majority of microtubules in metaphase spindles. This results in a strong directional bias of microtubule growth toward individual kinetochores.
Mitotic heritability of macroH2AHow macroH2A, a histone variant involved in silencing gene expression, is inherited from parent to daughter cells is unclear. Using a combination of imaging, biochemical, and genomic approaches, Sato et al. describe how newly synthesized macroH2A is incorporated predominantly in the G1 phase of human mitosis, targeting heterochromatic regions.
Current Issue
May 6, 2019
Volume 218, No. 5
Submit your Research
Reviews & Opinions
- Bayonets over bombs: RIPK3 and MLKL restrict Listeria without triggering necroptosis
Zhang and Balachandran preview new findings from Sai et al. revealing that necroptosis signaling mediators can directly inhibit Listeria replication in gut epithelium.
- A balancing act: PHLPP2 fine tunes AKT activity and MYC stability in prostate cancer
Toivanen and Furic preview work from the Trotman laboratory showing the phosphatase PHLPP2 controls Myc stability, suggesting a new way to target Myc in prostate cancer.
Most Read
Advertisement
Van Den Bosch highlights the discovery by Kalinski et al. of Miro1 as an HDAC6 substrate that regulates mitochondrial trafficking in neurons and axon regeneration.