Newest Articles
Rac3 promotes metastasis by regulating invadopodiaDonnelly et al. demonstrate that invasion and metastasis of breast cancer cells depend on Rac3-GTPase signaling at invadopodia. Using a novel FRET biosensor, they show that Rac3 activity is regulated by the spatial organization of two RhoGEFs. Rac3 balances the proteolytic and adhesive activities necessary for invasion by integrating extracellular matrix adhesion and MT1-MMP presentation at invadopodia.
IFN-I impairs antioxidative stress responsesType I interferon (IFN-I) triggers necroptosis in macrophages infected with S. Typhimurium by an unclear mechanism. Hos et al. now demonstrate that RIP3 enhances the interaction of Nrf2 with Pgam5 in response to IFN-I signaling in S. Typhimurium–infected macrophages, which abates Nrf2-dependent cytoprotective pathways and increases cell death.
UNC-45a folds myosin for stress fibersHow nonmuscle myosin II is recruited to contractile actomyosin bundles or stress fibers and assembled into functional bipolar filaments is unclear. Lehtimäki et al. show that UNC-45a functions as a myosin chaperone that contributes to the assembly of functional stress fibers.
Excitable subcellular contraction dynamicsA signaling network is revealed that combines positive and negative feedback to control the activity of the small GTPase Rho in adherent cells. This network generates spontaneous pulses of Rho activity and actomyosin contraction that are modulated by extracellular elasticity.
Role of SUMOylation in human septin functionYeast septins were among the first proteins reported to be SUMOylated, but the impact of this modification on septin function is unclear. Ribet et al. show that septins are SUMOylated in humans and that SUMOylation is critical for septin bundle formation and septin function in cell division.
RAB7/8 require modification by ICMT to regulate NOTCHSome prenylated proteins such as RAS require carboxyl methylation by ICMT for proper association with cellular membranes. Court et al. show that RAB7 and RAB8 are among these proteins and that by affecting vesicular transport, these GTPases regulate NOTCH signaling in an ICMT-dependent fashion.
Sgs1/BLM suppresses R-loop formationChang et al. link the RECQ-like helicase BLM and its yeast orthologue Sgs1 to preventing DNA damage caused by the accumulation of DNA:RNA hybrid structures called R-loops. This adds to a growing family of helicases implicated in R-loop resolution.
Current Issue
October 2, 2017
Volume 216, No. 10
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Reviews & Opinions
- So far, yet so close: α-Catenin dimers help migrating cells get together
Machesky and Braga preview work from the Gottardi laboratory exploring the role of a new interaction between α-catenin homodimers and PIP3 in cell adhesion.
- Protein sequestration at the nuclear periphery as a potential regulatory mechanism in premature aging
Serebryannyy and Misteli provide a perspective on how protein sequestration at the inner nuclear membrane and nuclear lamina might influence aging.
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Chamberland and Ritter discuss work from Kvainickas et al. and Simonetti et al. demonstrating a retromer-independent function of SNX-BAR proteins in endosomal recycling.