Newest Articles
GLP-1 signaling suppresses menin in β cellsMenin and glucagon-like peptide 1 (GLP-1) pathways play central yet opposing roles in regulating β cell function, with menin suppressing and GLP-1 promoting β cell function. Xing et al show that GLP-1 induces PKA-mediated phosphorylation of menin. Phosphorylation of menin triggers its interaction with nuclear actin to relieve menin’s transcriptional repression and increase insulin production.
LE/lysosome repositioning during ER stressBae et al. show that degradation of the mRNA encoding the adaptor Blos1 leads to the repositioning of late endosomes/lysosomes to the microtubule-organizing center in response to ER stress. This repositioning enhances cell survival during stress by promoting the clearance of protein aggregates.
COPII vesicles as a membrane source for autophagyThe membrane dynamics underlying the biogenesis of autophagosomes, including the origin of the autophagosomal membrane, are still elusive. Shima et al. use a recently developed COPII vesicle–labeling system to show that COPII vesicles are a membrane source in autophagosome formation.
A quenching tool to measure cell wall porosityCell wall porosity of fungi and plants could not be determined in vivo previously. Application of a novel method links dynamic changes in wall porosity to stress-induced cell elongation in plant roots and uptake of antifungal drugs in yeast cells.
Complexin and Bruchpilot are tethering partnersBy performing an in vivo screen in Drosophila melanogaster, Scholz, Ehmann, et al. identify Complexin as a functional interaction partner of Bruchpilot. The two proteins mediate a physical attachment of synaptic vesicles to the active zone cytomatrix and promote rapid, sustained synaptic transmission.
Regulation of kinesin-1 by MAP7 family proteinsHooikaas et al. show that mammalian MAP7 family proteins act redundantly to activate the kinesin-1 motor protein. Using experiments in cells and in vitro reconstitution assays, they demonstrate that MAP7 proteins promote microtubule recruitment and processivity of kinesin-1 by transiently associating with the stalk region of the motor.
Cyclin B3 is indispensable for oocyte meiosis IProper chromosome segregation during meiosis requires cyclins associated with cyclin-dependent kinases. Li et al. generate Ccnb3 mutant mice via CRISPR/Cas9 and identify a requirement for cyclin B3 in female meiosis I.
Current Issue
February 4, 2019
Volume 218, No. 2
Submit your Research
Reviews & Opinions
- Resistance is futile: Centering forces yield for asymmetric cell division
Alper and Zanic highlight new findings from Sallé et al. about the forces that can control asymmetric cell division.
- Immune checkpoint inhibitors
Hui details the cell biology underlying the action of immune checkpoint inhibitors.
Most Read
Advertisement
Katharina Schlacher previews work from Chow et al. that links ATM activation in cerebellar Purkinje cells with mitochondrial function and ATP production during periods of high energy demand.