biobytes

biobytes: November 16, 2009

16 Nov 2009 10:50:00 EST

In the November 16th edition of biobytes, Cathleen Carlin (Case Western Reserve University, Cleveland, OH) explains how an adenoviral protein regulates cholesterol trafficking... (more)

biobytes: October 19, 2009

19 Oct 2009 10:50:00 EST

In the October 19th edition of biobytes, Preethi Vijayaraj (University of Bonn, Germany) explains how keratins regulate protein biosynthesis (<a href="http://jcb.rupress.org/cgi/content/abstract/187/2/175">Vijayaraj et al.</a>, JCB - 05:50); Soman Abraham (Duke University, Durham, NC) reveals that mast cells release insoluble packages of TNF that signal to remote lymph nodes... (more)

biobytes: September 21, 2009

21 Sep 2009 10:50:00 EST

In the September 21st edition of biobytes, Veila Fowler (The Scripps Research Institute, La Jolla, CA) describes the cytoskeletal structures that underlie hexagonal packing in lens epithelial cells... (more)

biobytes: August 24, 2009

24 Aug 2009 09:50:00 EST

In the August 24th edition of biobytes, Julie Hollien (University of Utah, Salt Lake City, UT) describes how stress activates an ER-membrane nuclease to degrade mRNAs (Hollien et al., JCB - 00:45); Arne Akbar (University College London, UK) provides one explanation for why immunity diminishes with age (Agius et al., JEM - 08:15); and Valter Longo (University of Southern California, Los Angeles, CA) reveals how an oncogene homolog promotes mutations in aging yeast (Madia et al., JCB - 16:15). Plus a round-up of other highlights from the JCB (08:15)and JEM (13:35). The show was written and produced by Eun Choi, Amy Maxmen and Ben Short. Presented by Ben Short.

biobytes: July 27, 2009

27 Jul 2009 09:50:00 EST

In the July 27th edition of biobytes, Primal de Lanerolle (University of Illinois Medical School, Chicago, IL) explains how SUMOylation guides actin into the nucleus (Hofmann et al., JCB - 00:45); Victor Nizet (UC San Diego, CA) discovers that Streptococcus bacteria use a cell wall protein to evade engulfment by host immune cells (Carlin et al., JEM - 07:40); and Jonathan Cooper (Fred Hutchinson Cancer Research Center, Seattle, WA) reveals that an endocytic adaptor protein recycles integrins to the leading edge to promote cell migration (Teckchandani et al., JCB - 14:35). Plus a round-up of other highlights from the JCB (05:35) and JEM (14:35). The show was written and produced by Eun Choi, Amy Maxmen, and Ben Short. Presented by Ben Short.

biobytes: June 29, 2009

29 Jun 2009 09:50:00 EST

In the June 29th edition of biobytes, Matthew Tyska (Vanderbilt University, Nashville, TN) reveals how the intestinal brush border sends out packages of enzymes to combat gut pathogens (McConnell et al., JCB); Alwin Kraemer (German Cancer Research Center, Heidelberg) explains how two centrosomal proteins mutated in neurodevelopmental disorders regulate mitotic entry (Tibelius et al., JCB); and JEM news editor Amy Maxmen describes how an immune pathway helps tumors grow (Wang et al., JEM). The show was written and produced by Amy Maxmen, Ben Short and Ruth Williams. Presented by Ruth Williams.

biobytes: June 1, 2009

1 Jun 2009 11:50:00 EST

In the June 1st edition of biobytes, Kristen Nowak and Nigel Laing (Centre for Medical Research, University of Western Australia) reveal that a heart muscle protein can replace its skeletal muscle counterpart to correct serious myopathy (Nowak et al., JCB), Manuela Sironi explains how parasites have driven interleukin gene evolution (Fumagalli et al., JEM), and Renato Iozzo tells of the anti-tumor effects of decorin protein (Goldoni et al., JCB). The show was written and produced by Amy Maxmen, Ben Short, and Ruth Williams. Presented by Ruth Williams.

biobytes: May 4, 2009

4 May 2009 11:50:00 EST

In the May 4th edition of biobytes we hear from Tatiana Petrova (University of Lausanne, Switzerland) about lymph vessel development (Norrmén et al., JCB), Makkuni Jayaram (University of Texas, Austin, TX) talks parasite persistence (Cui et al., JCB), and Thomas Jung (Novartis, Basel, Switzerland) tells us about a new drug to combat the autoinflammatory syndrome, CAPS (Lachmann et al., JEM; Nakamura et al., JEM). The show was written, presented and produced by Ruth Williams, with additional reporting by Justin Paul.

biobytes: April 6, 2009

6 Apr 2009 10:30:00 EST

In the April 6th edition of biobytes, we learn from Sergei Sokol (Mount Sinai School of Medicine, New York) about a polarity protein's role in brain development (Lake and Sokol, JCB), we find out from Paul Anderson (Harvard University, Boston, MA) and Roy Parker (University of Arizona, Tucson) how stressed cells act on their destructive urges by chopping up tRNAs (Yamasaki et al., JCB; Thompson and Parker, JCB); and Jonathan Sprent (Garvan Institute of Medical Research, Darlinghurst, Australia) tells us about a new cytokine/antibody combination that protects transplanted cells in recipient animals without the need for long-term immunosuppression (Webster et al., JEM). The show was written presented and produced by Ruth Williams, with additional reporting by Justin Paul.

biobytes: March 9, 2009

9 Mar 2009 12:00:00 EST

In the March 9th edition of biobytes, we hear from Marc Freeman (University of Massachusetts) and Michael Coleman (Babraham Institute, Cambridge, UK) about a mutant superhero protein that protects neurons from degeneration (Avery et al. and Conforti et al., JCB). Also, Alan Rapraeger (University of Wisconsin) tells us about a synthetic peptide called synstatin that blocks cancer's blood supply (Beauvais et al., JEM). The show was written, presented, and produced by Ruth Williams, with additional reporting by Justin Paul.

biobytes: February 9, 2009

9 Feb 2009 12:00:00 EST

In the February 9th edition of biobytes, we learn from Scott Coonrod (Cornell University, Ithaca, NY) how neutrophils modify their chromatin to make effective bug-trapping nets (Wang et al., JCB). Patrick Wilson (University of Chicago) explains why having some self-reactive immune cells might not be a bad thing (Duty et al., JEM). And Tilmann Achsel (University of Leuven, Belgium) describes how, in neurons, mRNAs make the journey from nucleus to dendrites (di Penta et al., JCB). The show was written, presented, and produced by Ruth Williams, with additional reporting by Justin Paul.

biobytes: January 19, 2009 - ASCB Meeting

19 Jan 2009 12:00:00 EST

The January 19th issue of biobytes brings you highlights of the 2008 annual meeting of the American Society for Cell Biology. We learn how bone marrow transplants might stall neurodegeneration (Craig Montell, Johns Hopkins University Medical School, Baltimore, MD). JCB News Editor, Ben Short, tells us about David Boettiger's (University of Pennsylvania, PA) work on the extracellular matrix and cell signaling. We hear how cancer cells find their way into the brain (Joan Massagué, Memorial Sloan-Kettering Cancer Center, New York, NY). And lastly, we learn that fly phagocytes get the midnight munchies for certain bugs (Mimi Shirasu-Hiza, Stanford University, CA) and that breast cancer cells can have very intimate living arrangements (Michael Overholtzer, Memorial Sloan-Kettering Cancer Center, New York, NY). The show was written, presented and produced by Ruth Williams, with additional writing by Ben Short.

biobytes: December 15, 2008

15 Dec 2008 12:00:00 EST

In the December 15th edition of biobytes we hear from Eline Luning Prak (University of Pennsylvania) about antibody gene editing and autoimmunity (Panigrahi et al., JEM), Richard Youle (National Institutes of Health, Bethesda) tells us how a Parkinson's-associated protein prompts mitophagy (Narendra et al., JCB), and Christina Mitchell and Megan McGrath (Monash University, Melbourne, Australia) explain how a protein called FHL1 makes muscle cells mighty (Cowling et al., JCB). The show was written, presented, and produced by Ruth Williams, with additional reporting by Justin Paul.

biobytes: November 17, 2008

17 Nov 2008 12:00:00 EST

In the November 17th edition of biobytes we learn that valproic acid improves the memory deficits of Alzheimer's model mice (Qing et al., JEM), Alan Hall (Memorial Sloan-Kettering Cancer Center, New York) explains how Cdc42 keeps gut cells facing the right way (Jaffe et al., JCB), and Rachelle Crosbie (UCLA, CA) tells us why the little protein, sarcospan, could solve the big problem of Duchenne muscular dystrophy (Peter et al., JCB).The show was written, presented, and produced by Ruth Williams, with additional reporting by Justin Paul.

biobytes: October 20, 2008

20 Oct 2008 12:00:00 EST

In the October 20th edition of biobytes, Emma Hill (Journal of Cell Biology) joins us in the studio to discuss synaptic plasticity (Bergami et al., JCB) and also Alzheimer's disease (Sakurai et al., JCB), Franz Heinz (University of Vienna, Austria) explains how his team identified an entry code that flaviviruses use to get into cells (Fritz et al., JCB), and Vanda Lennon (Mayo Clinic College of Medicine, Rochester, MN) describes the molecular details of Devic's disease (Hinson et al., JEM). The show was written, presented, and produced by Ruth Williams, with additional reporting by Justin Paul.

biobytes: September 22, 2008

22 Sep 2008 12:00:00 EST

In the September 22nd edition of biobytes Hema Bashyam (Journal of Experimental Medicine) joins us in the studio to discuss long term cardiovascular risk from short term sugar highs in diabetes (El-Osta et al., JEM) , Joshua Sanes (Harvard University, Cambridge, MA) describes how laminin plays match maker between nerves and muscle cells (Nishimune et al., JCB), and Habib Zaghouani (University of Missouri, Columbia, MO) describes the cellular events in newborns that might explain why babies are so susceptible to certain infections (Lee et al., JEM). The show was written, presented and produced by Ruth Williams, with additional reporting by Justin Paul.

biobytes: August 25, 2008

25 Aug 2008 12:00:00 EST

In the August 25th edition of biobytes Hema Bashyam (Journal of Experimental Medicine) joins us in the studio to explain how ticks fend off immune cells while they feed (Deruaz et al., JEM), James Allison (Sloan-Kettering Cancer Center, New York) talks about a combination immunotherapy for cancer (Quezada et al., JEM), and Alana O'Reilly (Fox Chase Cancer Center, Philadelphia) explains how follicle stem cells have a hand in building their own niche (O'Reilly et al., JCB). The show was written, presented and produced by Ruth Williams, with additional reporting by Justin Paul.

biobytes: July 28, 2008

28 Jul 2008 12:00:00 EST

In the July 28th edition of biobytes Hema Bashyam (Journal of Experimental Medicine) joins us in the studio to discuss platelet derivation from ES cells (Nishikii et al., JEM) and a decade-early signal for Huntington's disease (Bjorkqvist et al., JEM), Pradipta Ghosh (University of California, San Diego) talks about a molecular switch for cell migration (Ghosh et al., JCB), and biobytes new recruit Justin Paul (Rockefeller University) asks Tony Hyman (Max Planck Institute, Dresden, Germany) how dividing cells set the length of their spindles. The show was written and presented by Ruth Williams and produced by Ruth Williams and Justin Paul.

biobytes: June 30, 2008

30 Jun 2008 12:20:00 EST

In the second June edition of biobytes we talk to Ken Smith (Cambridge University, UK) about how one protein poses a risk for two different autoimmune diseases (Willcocks et al., JEM), Aimee deCathelineau (Journal of Cell Biology) joins us in the studio to chat about pancreatitis and autophagy (Hashimoto et al., JCB), and Eric Schon (Columbia University, NY) discusses mitochondrial nucleoids and disease (Gilkerson et al., JCB). The show was written, presented, and produced by Ruth Williams.

biobytes: June 2, 2008

2 Jun 2008 13:50:00 EST

In the June edition of biobytes Peter Cook (Oxford University, UK) talks about what makes genes go to certain transcription factories (Xu and Cook, JCB), Toby Lawrence (Barts and The London School of Medicine and Dentistry, UK) tells us how to re-educate tumor macrophages (Hagemann et al., JEM), we hear about sluggish synaptic vesicles and schizophrenia from Zhuan Zhou (Peking University, Beijing, China)(Chen et al., JCB), and Xiao-Jiang Li (Emory University School of Medicine, Atlanta, GA) tells us about targeting cytoplasmic huntingtin aggregates with intrabodies (Wang et al., JCB), with comment from Junying Yuan (Harvard Medical School, Boston). The show was written, presented, and produced by Ruth Williams.

biobytes: May 2, 2008

2 May 2008 15:50:00 EST

In the May edition of biobytes we talk to Gerald Zamponi (University of Calgary, Canada) about what normal prion proteins get up to (Khosravani et al., JCB), Paul Goepfert (University of Alabama at Birmingham, AL) talks about HIV transmission (Goepfert et al., JEM, see also: Keipela et al., Nat Med), We learn that Rac1 has a role inside the nucleus (Michaelson et al., JCB), and Robert Schneider (New York University of Medicine, New York) reveals that translation control is more complex than we thought (Ramirez-Valle et al., JCB). The show was written, presented, and produced by Ruth Williams.

biobytes: April 7, 2008

7 Apr 2008 13:45:00 EST

In the April edition of biobytes Bart Lambrecht (Erasmus University Medical Centre, Rotterdam, Netherlands) reveals the secret of alum's success, Mario Colombo (Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy) talks about a tumor rejection by targeting T-regs, we hear about a new step in cancer cell movement from John Condeelis (Albert Einstein College of Medicine, New York), and we learn about the link between stem cells, lamin A, and aging. The show was written, presented, and produced by Ruth Williams.

biobytes: March 10, 2008

10 Mar 2008 12:00:00 EST

In the March edition of biobytes Craig Morrell (John Hopkins University School of Medicine, Baltimore) tells us about a brain factor that also promotes blood-clotting, we find out from Dennis Discher (University of Pennsylvania, Philadelphia) how macrophages stop short of swallowing 'self' cells, Norma Andrews (Yale University, New Haven) explains how membranes are repaired by endocytosis and exocytosis, and we learn about a downside of an innate antibacterial response. Written, presented, and produced by Ruth Williams.

biobytes: February 14, 2008 - ASCB

14 Feb 2008 13:00:00 EST

The February edition of biobytes is a special report on the recent annual meeting of the American Society for Cell Biology. We hear from Kasturi Mitra (National Institute of Health, Bathesda, MD) about a cell-wide mitochondrial fusion event that boosts ATP production; we learn how tumors build their own migration highways (work by Ning Yang, University of Wisconsin, Madison, WI); we hear from Karen Ridge (Northwestern University, Chicago, IL) about how lung cells deal with physical stress; and lastly, Nikki LeBrasseur finds out from Erika Holzbaur (University of Pennsylvania, Philadelphia, PA) how microtubule motorproteins deal with road bumps. The show was written, presented, and produced by Ruth Williams.

biobytes: December 18, 2007

18 Dec 2007 12:00:00 EST

In the December edition of biobytes we discuss how mature neurons avoid cell suicide, with Mohanish Deshmukh (University of North Carolina); the good and bad sides of a new angiogenesis factor, with Charles Lambert (University of Liege, Belgium); and lung cell overgrowth in asthma, with Patrick Berger (University of Bordeaux, France). We also learn what's behind a form of pyschosis that occurs in some lupus patients. The show was written, presented, and produced by Ruth Williams.

biobytes: November 19, 2007

19 Nov 2007 12:00:00 EST

In the November edition of Biobytes we discuss tumor cell migration with Aly Karsan (British Columbia Cancer Research Centre, Vancouver) and John Condeelis (Albert Einstein College of Medicine, New York), and we talk to Danielle Malo (McGill University, Canada) about typhoid and malaria. Also in the show: urinary tract infections and neurodegeneration. The show was written, presented, and produced by Ruth Williams.

biobytes: October 15, 2007

15 Oct 2007 12:00:00 EST

In the October edition of biobytes we discuss stressed out yeast with Mark Ashe (Manchester University, UK), sepsis drug engineering with Hartmut Weiler (Blood Research Institute, Milwaukee), and cell death by detachment with Lance Terada (University of Texas). Also in the show: autoantibodies in multiple sclerosis, and mRNA editing. The show was written, presented, and produced by Ruth Williams.