Rates of membrane-associated reactions: reduction of dimensionality revisited

doi:10.1083/jcb.102.1.88

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Rates of membrane-associated reactions: reduction of dimensionality revisited

MA McCloskey and MM Poo

The hypothesis that reactions associated with intracellular membranes enjoy a kinetic advantage from a reduced dimensionality for diffusion is inconsistent with available data on lateral diffusion rates, membrane-substrate affinities, and endogenous concentrations of enzymes and their aqueous substrates.
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