Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas

doi:10.1083/jcb.102.5.1558

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Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas

DG Bole, LM Hendershot and JF Kearney

A rat monoclonal antibody specific for immunoglobulin (Ig) heavy chain binding protein (BiP) has allowed the examination of the association of BiP with assembling Ig precursors in mouse B lymphocyte-derived cell lines. The anti-BiP monoclonal antibody immunoprecipitates BiP along with noncovalently associated Ig heavy chains. BiP is a component of the endoplasmic reticulum and binds free intracellular heavy chains in nonsecreting pre-B (mu+, L-) cell lines or incompletely assembled Ig precursors in (H+, L+) secreting hybridomas and myelomas. In the absence of light chain synthesis, heavy chains remain associated with BiP and are not secreted. The association of BiP with assembling Ig molecules in secreting hybridomas is transient and is restricted to the incompletely assembled molecules which are found in the endoplasmic reticulum. BiP loses affinity and disassociates with Ig molecules when polymerization with light chain is complete. We propose that the association of BiP with Ig heavy chain precursors is a novel posttranslational processing event occurring in the endoplasmic reticulum. The Ig heavy chains associated with BiP are not efficiently transported from the endoplasmic reticulum to the Golgi apparatus. Therefore, BiP may prevent the premature escape and eventual secretion of incompletely assembled Ig molecules.
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Cho, S., Park, S. M., Kim, T. D., Kim, J. H., Kim, K.-T., Jang, S. K. (2007). BiP Internal Ribosomal Entry Site Activity Is Controlled by Heat-Induced Interaction of NSAP1. Mol. Cell. Biol. 27: 368-383 [Abstract] [Full Text]
Marciniak, S. J., Ron, D. (2006). Endoplasmic reticulum stress signaling in disease.. Physiol. Rev. 86: 1133-1149 [Abstract] [Full Text]
Obeng, E. A., Carlson, L. M., Gutman, D. M., Harrington, W. J. Jr, Lee, K. P., Boise, L. H. (2006). Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells. Blood 107: 4907-4916 [Abstract] [Full Text]
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Powell, K. (2005). A big BiP on the radar screen. JCB 171: 759-759 [Full Text]
Gray, M. D., Mann, M., Nitiss, J. L., Hendershot, L. M. (2005). Activation of the Unfolded Protein Response Is Necessary and Sufficient for Reducing Topoisomerase II{alpha} Protein Levels and Decreasing Sensitivity to Topoisomerase-Targeted Drugs. Mol. Pharmacol. 68: 1699-1707 [Abstract] [Full Text]
Elkabetz, Y., Argon, Y., Bar-Nun, S. (2005). Cysteines in CH1 Underlie Retention of Unassembled Ig Heavy Chains. J. Biol. Chem. 280: 14402-14412 [Abstract] [Full Text]
Shen, J., Snapp, E. L., Lippincott-Schwartz, J., Prywes, R. (2005). Stable Binding of ATF6 to BiP in the Endoplasmic Reticulum Stress Response. Mol. Cell. Biol. 25: 921-932 [Abstract] [Full Text]
Lombrana, M., Moralejo, F. J., Pinto, R., Martin, J. F. (2004). Modulation of Aspergillus awamori Thaumatin Secretion by Modification of bipA Gene Expression. Appl. Environ. Microbiol. 70: 5145-5152 [Abstract] [Full Text]
Decourt, C., Galea, H. R., Sirac, C., Cogne, M. (2004). Immunologic basis for the rare occurrence of true nonsecretory plasma cell dyscrasias. J. Leukoc. Biol. 76: 528-536 [Abstract] [Full Text]
Gala, F. A., Morrison, S. L. (2004). V Region Carbohydrate and Antibody Expression. J. Immunol. 172: 5489-5494 [Abstract] [Full Text]
Longshaw, V. M., Chapple, J. P., Balda, M. S., Cheetham, M. E., Blatch, G. L. (2004). Nuclear translocation of the Hsp70/Hsp90 organizing protein mSTI1 is regulated by cell cycle kinases. J. Cell Sci. 117: 701-710 [Abstract] [Full Text]
Schamel, W. W. A., Kuppig, S., Becker, B., Gimborn, K., Hauri, H.-P., Reth, M. (2003). A high-molecular-weight complex of membrane proteins BAP29/BAP31 is involved in the retention of membrane-bound IgD in the endoplasmic reticulum. Proc. Natl. Acad. Sci. USA 100: 9861-9866 [Abstract] [Full Text]
Elkabetz, Y., Kerem, A., Tencer, L., Winitz, D., Kopito, R. R., Bar-Nun, S. (2003). Immunoglobulin Light Chains Dictate Vesicular Transport-dependent and -independent Routes for IgM Degradation by the Ubiquitin-Proteasome Pathway. J. Biol. Chem. 278: 18922-18929 [Abstract] [Full Text]
Zou, X., Piper, T. A., Smith, J. A., Allen, N. D., Xian, J., Bruggemann, M. (2003). Block in Development at the Pre-B-II to Immature B Cell Stage in Mice Without Ig{kappa} and Ig{lambda} Light Chain. J. Immunol. 170: 1354-1361 [Abstract] [Full Text]
Meunier, L., Usherwood, Y.-K., Chung, K. T., Hendershot, L. M. (2002). A Subset of Chaperones and Folding Enzymes Form Multiprotein Complexes in Endoplasmic Reticulum to Bind Nascent Proteins. Mol. Biol. Cell 13: 4456-4469 [Abstract] [Full Text]
Cui, Y., Wang, W., Fan, Z. (2002). Cytoplasmic Vestibule of the Weak Inward Rectifier Kir6.2 Potassium Channel. J. Biol. Chem. 277: 10523-10530 [Abstract] [Full Text]
Wiens, G. D., Lekkerkerker, A., Veltman, I., Rittenberg, M. B. (2001). Mutation of a Single Conserved Residue in VH Complementarity-Determining Region 2 Results in a Severe Ig Secretion Defect. J. Immunol. 167: 2179-2186 [Abstract] [Full Text]
Dul, J. L., Davis, D. P., Williamson, E. K., Stevens, F. J., Argon, Y. (2001). Hsp70 and Antifibrillogenic Peptides Promote Degradation and Inhibit Intracellular Aggregation of Amyloidogenic Light Chains. JCB 152: 705-716 [Abstract] [Full Text]
Sagt, C. M. J., Kleizen, B., Verwaal, R., de Jong, M. D. M., Müller, W. H., Smits, A., Visser, C., Boonstra, J., Verkleij, A. J., Verrips, C. T. (2000). Introduction of an N-Glycosylation Site Increases Secretion of Heterologous Proteins in Yeasts. Appl. Environ. Microbiol. 66: 4940-4944 [Abstract] [Full Text]
Hashim, S., Mukherjee, K., Raje, M., Basu, S. K., Mukhopadhyay, A. (2000). Live Salmonella Modulate Expression of Rab Proteins to Persist in a Specialized Compartment and Escape Transport to Lysosomes. J. Biol. Chem. 275: 16281-16288 [Abstract] [Full Text]
Mukherjee, K., Siddiqi, S. A., Hashim, S., Raje, M., Basu, S. K., Mukhopadhyay, A. (2000). Live Salmonella Recruits N-Ethylmaleimide-Sensitive Fusion Protein on Phagosomal Membrane and Promotes Fusion with Early Endosome. JCB 148: 741-754 [Abstract] [Full Text]
Knarr, G., Modrow, S., Todd, A., Gething, M.-J., Buchner, J. (1999). BiP-binding Sequences in HIV gp160. IMPLICATIONS FOR THE BINDING SPECIFICITY OF BiP. J. Biol. Chem. 274: 29850-29857 [Abstract] [Full Text]
Davis, D. P., Khurana, R., Meredith, S., Stevens, F. J., Argon, Y. (1999). Mapping the Major Interaction Between Binding Protein and Ig Light Chains to Sites Within the Variable Domain. J. Immunol. 163: 3842-3850 [Abstract] [Full Text]
Outinen, P. A., Sood, S. K., Pfeifer, S. I., Pamidi, S., Podor, T. J., Li, J., Weitz, J. I., Austin, R. C. (1999). Homocysteine-Induced Endoplasmic Reticulum Stress and Growth Arrest Leads to Specific Changes in Gene Expression in Human Vascular Endothelial Cells. Blood 94: 959-967 [Abstract] [Full Text]
Lee, Y.-K., Brewer, J. W., Hellman, R., Hendershot, L. M. (1999). BiP and Immunoglobulin Light Chain Cooperate to Control the Folding of Heavy Chain and Ensure the Fidelity of Immunoglobulin Assembly. Mol. Biol. Cell 10: 2209-2219 [Abstract] [Full Text]
Wang, J.-F., Bown, C., Young, L. T. (1999). Differential Display PCR Reveals Novel Targets for the Mood-Stabilizing Drug Valproate Including the Molecular Chaperone GRP78. Mol. Pharmacol. 55: 521-527 [Abstract] [Full Text]
Gardiol, A., Racca, C., Triller, A. (1999). Dendritic and Postsynaptic Protein Synthetic Machinery. J. Neurosci. 19: 168-179 [Abstract] [Full Text]
George, C. H., Kendall, J. M., Campbell, A. K., Evans, W. H. (1998). Connexin-Aequorin Chimerae Report Cytoplasmic Calcium Environments along Trafficking Pathways Leading to Gap Junction Biogenesis in Living COS-7 Cells. J. Biol. Chem. 273: 29822-29829 [Abstract] [Full Text]
Zimmer, K.-p., Naim, H., Weber, P., Ellis, H. J., Ciclitira, P. J. (1998). Targeting of gliadin peptides, CD8, {alpha}/�-TCR, and {gamma}/{delta}-TCR to Golgi complexes and vacuoles within celiac disease enterocytes. FASEB J. 12: 1349-1357 [Abstract] [Full Text]
Mardassi, H., Gonin, P., Gagnon, C. A., Massie, B., Dea, S. (1998). A Subset of Porcine Reproductive and Respiratory Syndrome Virus GP3 Glycoprotein Is Released into the Culture Medium of Cells as a Non-Virion-Associated and Membrane-Free (Soluble) Form. J. Virol. 72: 6298-6306 [Abstract] [Full Text]
Zhu, Z.-B., Atkinson, T. P., Volanakis, J. E. (1998). A Novel Type II Complement C2 Deficiency Allele in an African-American Family. J. Immunol. 161: 578-584 [Abstract] [Full Text]
Holloway, M. P., Bram, R. J. (1998). Co-localization of Calcium-modulating Cyclophilin Ligand with Intracellular Calcium Pools. J. Biol. Chem. 273: 16346-16350 [Abstract] [Full Text]
Yu, G., Chen, F., Levesque, G., Nishimura, M., Zhang, D.-M., Levesque, L., Rogaeva, E., Xu, D., Liang, Y., Duthie, M., George-Hyslop, P. H.�S., Fraser, P. E. (1998). The Presenilin 1�Protein Is a Component of a High Molecular Weight Intracellular Complex That Contains beta -Catenin. J. Biol. Chem. 273: 16470-16475 [Abstract] [Full Text]
Martin, T. M., Wiens, G. D., Rittenberg, M. B. (1998). Inefficient Assembly and Intracellular Accumulation of Antibodies with Mutations in VH CDR2. J. Immunol. 160: 5963-5970 [Abstract] [Full Text]
Kim, P. S., Arvan, P. (1998). Endocrinopathies in the Family of Endoplasmic Reticulum (ER) Storage Diseases: Disorders of Protein Trafficking and the Role of ER Molecular Chaperones. Endocr. Rev. 19: 173-202 [Abstract] [Full Text]
Muresan, Z., Arvan, P. (1998). Enhanced Binding to the Molecular Chaperone BiP Slows Thyroglobulin Export from the Endoplasmic Reticulum. Mol. Endocrinol. 12: 458-467 [Abstract] [Full Text]
Oh-Ishi, M., Omori, A., Kwon, J.-Y., Agui, T., Maeda, T., Furudate, S.-I. (1998). Detection and Identification of Proteins Related to the Hereditary Dwarfism of the rdw Rat. Endocrinology 139: 1288-1299 [Abstract] [Full Text]
Cole, N. B., Ellenberg, J., Song, J., DiEuliis, D., Lippincott-Schwartz, J. (1998). Retrograde Transport of Golgi-localized Proteins to the ER. JCB 140: 1-15 [Abstract] [Full Text]
Sagt, C. M.�J., Müller, W.�H., Boonstra, J., Verkleij, A. J., Verrips, C. T. (1998). Impaired Secretion of a Hydrophobic Cutinase by Saccharomyces cerevisiae Correlates with an Increased Association with Immunoglobulin Heavy-Chain Binding Protein (BiP). Appl. Environ. Microbiol. 64: 316-324 [Abstract] [Full Text]
Lievremont, J.-P., Rizzuto, R., Hendershot, L., Meldolesi, J. (1997). BiP, a Major Chaperone Protein of the Endoplasmic Reticulum Lumen, Plays a Direct and Important Role in the Storage of the Rapidly Exchanging Pool of Ca2+. J. Biol. Chem. 272: 30873-30879 [Abstract] [Full Text]
Muresan, Z., Arvan, P. (1997). Thyroglobulin Transport along the Secretory Pathway. INVESTIGATION OF THE ROLE OF MOLECULAR CHAPERONE, GRP94, IN PROTEIN EXPORT FROM THE ENDOPLASMIC RETICULUM. J. Biol. Chem. 272: 26095-26102 [Abstract] [Full Text]
Ault, B. H., Schmidt, B. Z., Fowler, N. L., Kashtan, C. E., Ahmed, A. E., Vogt, B. A., Colten, H. R. (1997). Human Factor H Deficiency. MUTATIONS IN FRAMEWORK CYSTEINE RESIDUES AND BLOCK IN H PROTEIN SECRETION AND INTRACELLULAR CATABOLISM. J. Biol. Chem. 272: 25168-25175 [Abstract] [Full Text]
Yabe, D., Nakamura, T., Kanazawa, N., Tashiro, K., Honjo, T. (1997). Calumenin, a Ca2+-binding Protein Retained in the Endoplasmic Reticulum with a Novel Carboxyl-terminal Sequence, HDEF. J. Biol. Chem. 272: 18232-18239 [Abstract] [Full Text]
Hsu, T.-A., Takahashi, N., Tsukamoto, Y., Kato, K., Shimada, I., Masuda, K., Whiteley, E. M., Fan, J.-Q., Lee, Y. C., Betenbaugh, M. J. (1997). Differential N-Glycan Patterns of Secreted and Intracellular IgG Produced in Trichoplusia ni Cells. J. Biol. Chem. 272: 9062-9070 [Abstract] [Full Text]
McCormick, T. S., McColl, K. S., Distelhorst, C. W. (1997). Mouse Lymphoma Cells Destined to Undergo Apoptosis in Response to Thapsigargin Treatment Fail to Generate a Calcium-mediated grp78/grp94 Stress Response. J. Biol. Chem. 272: 6087-6092 [Abstract] [Full Text]
Morris, J. A., Dorner, AndrewJ., Edwards, C. A., Hendershot, L. M., Kaufman, R. J. (1997). Immunoglobulin Binding Protein (BiP) Function Is Required to Protect Cells from Endoplasmic Reticulum Stress but Is Not Required for the Secretion of Selective Proteins. J. Biol. Chem. 272: 4327-4334 [Abstract] [Full Text]
Ruddon, R. W., Bedows, E. (1997). Assisted Protein Folding. J. Biol. Chem. 272: 3125-3128 [Full Text]
Berditchevski, F., Tolias, K. F., Wong, K., Carpenter, C. L., Hemler, M. E. (1997). A Novel Link between Integrins, Transmembrane-4 Superfamily Proteins (CD63 and CD81), and Phosphatidylinositol 4-Kinase. J. Biol. Chem. 272: 2595-2598 [Abstract] [Full Text]
Kuznetsov, G., Chen, L. B., Nigam, S. K. (1997). Multiple Molecular Chaperones Complex with Misfolded Large Oligomeric Glycoproteins in the Endoplasmic Reticulum. J. Biol. Chem. 272: 3057-3063 [Abstract] [Full Text]
Yang, M., Ellenberg, J., Bonifacino, J. S., Weissman, A. M. (1997). The Transmembrane Domain of a Carboxyl-terminal Anchored Protein Determines Localization to the Endoplasmic Reticulum. J. Biol. Chem. 272: 1970-1975 [Abstract] [Full Text]
Shtrom, S. S., Hall, Z. W. (1996). Formation of a Ligand-binding Site for the Acetylcholine Receptor in Vitro. J. Biol. Chem. 271: 25506-25514 [Abstract] [Full Text]
Bangs, J. D., Brouch, E. M., Ransom, D. M., Roggy, J. L. (1996). A Soluble Secretory Reporter System in Trypanosoma brucei. STUDIES ON ENDOPLASMIC RETICULUM TARGETING. J. Biol. Chem. 271: 18387-18393 [Abstract] [Full Text]
Robinson, A. S., Bockhaus, J. A., Voegler, A. C., Wittrup, K. D. (1996). Reduction of BiP Levels Decreases Heterologous Protein Secretion in Saccharomyces cerevisiae. J. Biol. Chem. 271: 10017-10022 [Abstract] [Full Text]
Knarr, G., Gething, M.-J., Modrow, S., Buchner, J. (1995). BiP Binding Sequences in Antibodies. J. Biol. Chem. 270: 27589-27594 [Abstract] [Full Text]
Wei, J., Hendershot, L. M. (1995). Characterization of the Nucleotide Binding Properties and ATPase Activity of Recombinant Hamster BiP Purified from Bacteria. J. Biol. Chem. 270: 26670-26676 [Abstract] [Full Text]
Russ, G., Esquivel, F., Yewdell, J. W., Cresswell, P., Spies, T., Bennink, J. R. (1995). Assembly, Intracellular Localization, and Nucleotide Binding Properties of the Human Peptide Transporters TAP1 and TAP2 Expressed by Recombinant Vaccinia Viruses. J. Biol. Chem. 270: 21312-21318 [Abstract] [Full Text]
Kirkpatrick, R. B., Ganguly, S., Angelichio, M., Griego, S., Shatzman, A., Silverman, C., Rosenberg, M. (1995). Heavy Chain Dimers as Well as Complete Antibodies Are Efficiently Formed and Secreted from Drosophila via a BiP-mediated Pathway. J. Biol. Chem. 270: 19800-19805 [Abstract] [Full Text]
Jacob, R., Bulleid, N. J., Naim, H. Y. (1995). Folding of Human Intestinal Lactase-phlorizin Hydrolase. J. Biol. Chem. 270: 18678-18684 [Abstract] [Full Text]
Gelman, M. S., Chang, W., Thomas, D. Y., Bergeron, J. J. M., Prives, J. M. (1995). Role of the Endoplasmic Reticulum Chaperone Calnexin in Subunit Folding and Assembly of Nicotinic Acetylcholine Receptors. J. Biol. Chem. 270: 15085-15092 [Abstract] [Full Text]
Marks, M. S., Germain, R. N., Bonifacino, J. S. (1995). Transient Aggregation of Major Histocompatibility Complex Class II Chains during Assembly in Normal Spleen Cells. J. Biol. Chem. 270: 10475-10481 [Abstract] [Full Text]
Lamand�, S. R., Chessler, S. D., Golub, S. B., Byers, P. H., Chan, D., Cole, W. G., Sillence, D. O., Bateman, J. F. (1995). Endoplasmic Reticulum-mediated Quality Control of Type I Collagen Production by Cells from Osteogenesis Imperfecta Patients with Mutations in the pro[IMAGE]1(I) Chain Carboxyl-terminal Propeptide which Impair Subunit Assembly. J. Biol. Chem. 270: 8642-8649 [Abstract] [Full Text]
Greene, L. E., Zinner, R., Naficy, S., Eisenberg, E. (1995). Effect of Nucleotide on the Binding of Peptides to 70-kDa Heat Shock Protein. J. Biol. Chem. 270: 2967-2973 [Abstract] [Full Text]
Cotner, T., Pious, D. (1995). HLA-DRbeta Chains Enter into an Aggregated Complex Containing GRP-78/BiP Prior to Their Degradation by the Pre-Golgi Degradative Pathway. J. Biol. Chem. 270: 2379-2386 [Abstract] [Full Text]
Redick, S., Schwarzbauer, J. (1995). Rapid intracellular assembly of tenascin hexabrachions suggests a novel cotranslational process. J. Cell Sci. 108: 1761-1769 [Abstract]
Gething, M.-J., Blond-Elguindi, S., Buchner, J., Fourie, A., Knarr, G., Modrow, S., Nanu, L., Segal, M., Sambrook, J. (1995). Binding Sites for Hsp70 Molecular Chaperones in Natural Proteins. Cold Spring Harb Symp Quant Biol 60: 417-428 [Abstract]
Jackson, M., Cohen-Doyle, M., Peterson, P., Williams, D. (1994). Regulation of MHC class I transport by the molecular chaperone, calnexin (p88, IP90). Science 263: 384-387 [Abstract]
Jayawickreme, S., Green, W., Claudio, T (1994). Cyclic AMP-regulated AChR assembly is independent of AChR subunit phosphorylation by PKA. J. Cell Sci. 107: 1641-1651 [Abstract]
Bangs, J., Uyetake, L, Brickman, M., Balber, A., Boothroyd, J. (1993). Molecular cloning and cellular localization of a BiP homologue in Trypanosoma brucei. Divergent ER retention signals in a lower eukaryote. J. Cell Sci. 105: 1101-1113 [Abstract]
Click, E.-M., Anderson, K.S., Androlewicz, M.J., Wei, M.L., Cresswell, P. (1992). Transport and Expression of Class I MHC Glycoproteins in an Antigen-processing Mutant Cell Line. Cold Spring Harb Symp Quant Biol 57: 571-577 [Abstract]
Beckmann, R., Mizzen, L., Welch, W. (1990). Interaction of Hsp 70 with newly synthesized proteins: implications for protein folding and assembly. Science 248: 850-854 [Abstract]
Hartl, F., Neupert, W (1990). Protein sorting to mitochondria: evolutionary conservations of folding and assembly. Science 247: 930-938 [Abstract]
Flynn, G., Chappell, T., Rothman, J. (1989). Peptide binding and release by proteins implicated as catalysts of protein assembly. Science 245: 385-390 [Abstract]
Straus, D B, Walter, W A, Gross, C A (1988). Escherichia coli heat shock gene mutants are defective in proteolysis.. Genes Dev. 2: 1851-1858 [Abstract]
Manganas, L. N., Trimmer, J. S. (2000). Subunit Composition Determines Kv1 Potassium Channel Surface Expression. J. Biol. Chem. 275: 29685-29693 [Abstract] [Full Text]
Augustine, J. G., de la Calle, A., Knarr, G., Buchner, J., Frederick, C. A. (2001). The Crystal Structure of the Fab Fragment of the Monoclonal Antibody MAK33. IMPLICATIONS FOR FOLDING AND INTERACTION WITH THE CHAPERONE BiP. J. Biol. Chem. 276: 3287-3294 [Abstract] [Full Text]
Chen, F., Yang, D.-S., Petanceska, S., Yang, A., Tandon, A., Yu, G., Rozmahel, R., Ghiso, J., Nishimura, M., Zhang, D. M., Kawarai, T., Levesque, G., Mills, J., Levesque, L., Song, Y.-Q., Rogaeva, E., Westaway, D., Mount, H., Gandy, S., St George-Hyslop, P., Fraser, P. E. (2000). Carboxyl-terminal Fragments of Alzheimer beta -Amyloid Precursor Protein Accumulate in Restricted and Unpredicted Intracellular Compartments in Presenilin 1-deficient Cells. J. Biol. Chem. 275: 36794-36802 [Abstract] [Full Text]
Fagioli, C., Sitia, R. (2001). Glycoprotein Quality Control in the Endoplasmic Reticulum. MANNOSE TRIMMING BY ENDOPLASMIC RETICULUM MANNOSIDASE I TIMES THE PROTEASOMAL DEGRADATION OF UNASSEMBLED IMMUNOGLOBULIN SUBUNITS. J. Biol. Chem. 276: 12885-12892 [Abstract] [Full Text]
Wiens, G. D., O'Hare, T., Rittenberg, M. B. (2001). Recovering Antibody Secretion Using a Hapten Ligand as a Chemical Chaperone. J. Biol. Chem. 276: 40933-40939 [Abstract] [Full Text]