Topography of N-CAM structural and functional determinants. II. Placement of monoclonal antibody epitopes

doi:10.1083/jcb.103.5.1729

This Article

	Full Text (PDF, 1387K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JCB
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Frelinger, A. L.
	Articles by Rutishauser, U.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Frelinger, A. L., 3d
	Articles by Rutishauser, U.


Social Bookmarking

	What's this?

ARTICLES

Topography of N-CAM structural and functional determinants. II. Placement of monoclonal antibody epitopes

AL Frelinger 3d and U Rutishauser

The accompanying report (Watanabe, M., A. L. Frelinger III, and U. Rutishauser, 1986, J. Cell Biol., 103:1721-1727) describes a set of monoclonal antibodies (mAbs) directed against N-CAM epitopes representing the known major structural and functional domains of the molecule. In this study, we have generated and separated a variety of peptide fragments from N-CAM, and then used their size and reactivity with each antibody to position the antigenic sites along the peptide chain. This epitope map, together with the biological properties of the antibodies and previous studies on N-CAM, have been used to construct a topographical model for the molecule in the cell membrane.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Tsai, H.-H., Tessier-Lavigne, M., Miller, R. H. (2003). Netrin 1 mediates spinal cord oligodendrocyte precursor dispersal. Development 130: 2095-2105 [Abstract] [Full Text]
Rafuse, V. F., Landmesser, L. T. (2000). The Pattern of Avian Intramuscular Nerve Branching Is Determined by the Innervating Motoneuron and Its Level of Polysialic Acid. J. Neurosci. 20: 1056-1065 [Abstract] [Full Text]
Takei, K., Chan, T. A., Wang, F.-S., Deng, H., Rutishauser, U., Jay, D. G. (1999). The Neural Cell Adhesion Molecules L1 and NCAM-180 Act in Different Steps of Neurite Outgrowth. J. Neurosci. 19: 9469-9479 [Abstract] [Full Text]
Storms, S. D., Rutishauser, U. (1998). A Role for Polysialic Acid in Neural Cell Adhesion Molecule Heterophilic Binding to Proteoglycans. J. Biol. Chem. 273: 27124-27129 [Abstract] [Full Text]
Kiselyov, V. V., Berezin, V., Maar, T. E., Soroka, V., Edvardsen, K., Schousboe, A., Bock, E. (1997). The First Immunoglobulin-like Neural Cell Adhesion Molecule (NCAM) Domain Is Involved in Double-reciprocal Interaction with the Second Immunoglobulin-like NCAM Domain and in Heparin Binding. J. Biol. Chem. 272: 10125-10134 [Abstract] [Full Text]
Rafuse, V. F., Milner, L. D., Landmesser, L. T. (1996). Selective Innervation of Fast and Slow Muscle Regions during Early Chick Neuromuscular Development. J. Neurosci. 16: 6864-6877 [Abstract] [Full Text]
Nelson, R. W., Bates, P. A., Rutishauser, U. (1995). Protein Determinants for Specific Polysialylation of the Neural Cell Adhesion Molecule. J. Biol. Chem. 270: 17171-17179 [Abstract] [Full Text]
Rutishauser, U, Acheson, A, Hall, A., Mann, D., Sunshine, J (1988). The neural cell adhesion molecule (NCAM) as a regulator of cell-cell interactions. Science 240: 53-57 [Abstract]
Fujimoto, I., Bruses, J. L., Rutishauser, U. (2001). Regulation of Cell Adhesion by Polysialic Acid. EFFECTS ON CADHERIN, IMMUNOGLOBULIN CELL ADHESION MOLECULE, AND INTEGRIN FUNCTION AND INDEPENDENCE FROM NEURAL CELL ADHESION MOLECULE BINDING OR SIGNALING ACTIVITY. J. Biol. Chem. 276: 31745-31751 [Abstract] [Full Text]