Epithelial-mesenchymal interactions in the developing kidney lead to expression of tenascin in the mesenchyme

doi:10.1083/jcb.105.1.599

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Epithelial-mesenchymal interactions in the developing kidney lead to expression of tenascin in the mesenchyme

E Aufderheide, R Chiquet-Ehrismann and P Ekblom

Tenascin, a mesenchymal extracellular matrix glycoprotein, has been implicated in epithelial-mesenchymal interactions during fetal development (Chiquet-Ehrismann, R., E. J. Mackie, C. A. Pearson, T. Sakakura, 1986, Cell, 47:131-139). We have now investigated the expression of tenascin during embryonic development of the mouse kidney. In this system, mesenchymal cells convert into epithelial cells as a result of a tissue interaction. By immunofluorescence, tenascin could not be found in the mesenchyme until kidney tubule epithelial began to form. It then became detectable around condensates and s- shaped bodies, the early stages of tubulogenesis. In an in vitro culture system, tenascin expression by the mesenchyme is tightly coupled to the de novo formation of epithelial, and does not occur if tubulogenesis is suppressed. The results strongly suggest that the formation of the new epithelium stimulates the expression of tenascin in the nearby mesenchyme. During postnatal development, the expression of tenascin decreases and the spatial distribution changes. In kidneys from adult mice, no tenascin can be found in the cortex, but interspersed patches of staining are visible in the medullary stroma. The results strongly support the view that tenascin is involved in epithelial-mesenchymal interactions. It could therefore be crucial for embryonic development.
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BHATIA, S. N., BALIS, U. J., YARMUSH, M. L., TONER, M. (1999). Effect of cell-cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells. FASEB J. 13: 1883-1900 [Abstract] [Full Text]
Mackie, E., Tucker, R. (1999). The tenascin-C knockout revisited. J. Cell Sci. 112: 3847-3853 [Abstract]
Moore, A., McInnes, L, Kreidberg, J, Hastie, N., Schedl, A (1999). YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis. Development 126: 1845-1857 [Abstract]
Mendelsohn, C, Batourina, E, Fung, S, Gilbert, T, Dodd, J (1999). Stromal cells mediate retinoid-dependent functions essential for renal development. Development 126: 1139-1148 [Abstract]
Wallner, E. I., Yang, Q., Peterson, D. R., Wada, J., Kanwar, Y. S. (1998). Relevance of extracellular matrix, its receptors, and cell adhesion molecules in mammalian nephrogenesis. Am. J. Physiol. Renal Physiol. 275: F467-F477 [Abstract] [Full Text]
Denda, S., Reichardt, L. F., Müller, U. (1998). Identification of Osteopontin as a Novel Ligand for the Integrin alpha 8beta 1 and Potential Roles for This Integrin-Ligand Interaction in Kidney Morphogenesis. Mol. Biol. Cell 9: 1425-1435 [Abstract] [Full Text]
Hatini, V, Huh, S O, Herzlinger, D, Soares, V C, Lai, E (1996). Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2.. Genes Dev. 10: 1467-1478 [Abstract]
Deryugina, E. I., Bourdon, M. A. (1996). Tenascin mediates human glioma cell migration and modulates cell migration on fibronectin. J. Cell Sci. 109: 643-652 [Abstract]
Kispert, A, Vainio, S, Shen, L, Rowitch, D., McMahon, A. (1996). Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips. Development 122: 3627-3637 [Abstract]
Wirl, G, Hermann, M, Ekblom, P, Fassler, R (1995). Mammary epithelial cell differentiation in vitro is regulated by an interplay of EGF action and tenascin-C downregulation. J. Cell Sci. 108: 2445-2456 [Abstract]
Julian, J, Chiquet-Ehrismann, R, Erickson, H., Carson, D. (1994). Tenascin is induced at implantation sites in the mouse uterus and interferes with epithelial cell adhesion. Development 120: 661-671 [Abstract]
Rettig, W., Erickson, H., Albino, A., Garin-Chesa, P (1994). Induction of human tenascin (neuronectin) by growth factors and cytokines: cell type-specific signals and signalling pathways. J. Cell Sci. 107: 487-497 [Abstract]
Tucker, R., Hammarback, J., Jenrath, D., Mackie, E., Xu, Y (1993). Tenascin expression in the mouse: in situ localization and induction in vitro by bFGF. J. Cell Sci. 104: 69-76 [Abstract]
Saga, Y, Yagi, T, Ikawa, Y, Sakakura, T, Aizawa, S (1992). Mice develop normally without tenascin.. Genes Dev. 6: 1821-1831 [Abstract]
Umbhauer, M, Riou, J., Spring, J, Smith, J., Boucaut, J. (1992). Expression of tenascin mRNA in mesoderm during Xenopus laevis embryogenesis: the potential role of mesoderm patterning in tenascin regionalization. Development 116: 147-157 [Abstract]
Mina, M., Kollar, E. J., Bishop, J. A., Rohrbach, D. H. (1990). Interaction between The Neural Crest and Extracellular Matrix Proteins in Craniofacial Skeletogenesis. CROBM 1: 79-87 [Full Text]
Brandenberger, R., Schmidt, A., Linton, J., Wang, D., Backus, C., Denda, S., Muller, U., Reichardt, L. F. (2001). Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin {alpha}8{beta}1 in the embryonic kidney. JCB 154: 447-458 [Abstract] [Full Text]
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