Mineralocorticoid regulation of transcription of transfected mouse mammary tumor virus DNA in cultured kidney cells

doi:10.1083/jcb.106.6.2119

This Article

	Full Text (PDF, 960K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JCB
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Cato, A. C.
	Articles by Weinmann, J.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Cato, A. C.
	Articles by Weinmann, J.


Social Bookmarking

	What's this?

ARTICLES

Mineralocorticoid regulation of transcription of transfected mouse mammary tumor virus DNA in cultured kidney cells

AC Cato and J Weinmann
Kernforschungszentrum Karlsruhe, Institut fur Genetik und Toxikologie, Federal Republic of Germany.

Renal cells contain two corticosteroid-binding entities defined on the basis of hormone-binding selectivity as type I (mineralocorticoid) and type II (glucocorticoid). The mineralocorticoid, aldosterone can bind to both type I and type II receptors. This poses problems in defining the characteristics of a true mineralocorticoid regulated expression of specific genes. We have used chimaeric constructs bearing the mouse mammary tumor virus (MMTV) promoter to study aldosterone action in the feline renal cell line CRFK. We have shown that in these cells aldosterone induces MMTV transcription through its own receptor (type I). This induction of MMTV transcription by aldosterone is a primary response to the hormone. We have shown that the DNA sequences that mediate the aldosterone response overlap the hormone response element (HRE) required for the glucocorticoid, progestin, and androgen induction of transcription at the MMTV long terminal repeat region. Thus the aldosterone regulation of MMTV long terminal repeat transcription is identical to the mode of action of the other steroid hormones at this promoter.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Li, Q., Su, A., Chen, J., Lefebvre, Y. A., Hache, R. J. G. (2002). Attenuation of Glucocorticoid Signaling through Targeted Degradation of p300 via the 26S Proteasome Pathway. Mol. Endocrinol. 16: 2819-2827 [Abstract] [Full Text]
Falkenstein, E., Tillmann, H.-C., Christ, M., Feuring, M., Wehling, M. (2000). Multiple Actions of Steroid Hormones---A Focus on Rapid, Nongenomic Effects. Pharmacol. Rev. 52: 513-556 [Abstract] [Full Text]
Benitah, J.-P., Vassort, G. (1999). Aldosterone Upregulates Ca2+ Current in Adult Rat Cardiomyocytes. Circ. Res. 85: 1139-1145 [Abstract] [Full Text]
Prefontaine, G. G., Walther, R., Giffin, W., Lemieux, M. E., Pope, L., Hache, R. J. G. (1999). Selective Binding of Steroid Hormone Receptors to Octamer Transcription Factors Determines Transcriptional Synergism at the Mouse Mammary Tumor Virus Promoter. J. Biol. Chem. 274: 26713-26719 [Abstract] [Full Text]
Giffin, W., Gong, W., Schild-Poulter, C., Hache, R. J. G. (1999). Ku Antigen-DNA Conformation Determines the Activation of DNA-Dependent Protein Kinase and DNA Sequence-Directed Repression of Mouse Mammary Tumor Virus Transcription. Mol. Cell. Biol. 19: 4065-4078 [Abstract] [Full Text]
Hache, R. J.�G., Tse, R., Reich, T., Savory, J. G.�A., Lefebvre, Y. A. (1999). Nucleocytoplasmic Trafficking of Steroid-free Glucocorticoid Receptor. J. Biol. Chem. 274: 1432-1439 [Abstract] [Full Text]
Wehling, M., Spes, C. H., Win, N., Janson, C. P., Schmidt, B. M. W., Theisen, K., Christ, M. (1998). Rapid Cardiovascular Action of Aldosterone in Man. J. Clin. Endocrinol. Metab. 83: 3517-3522 [Abstract] [Full Text]