The Journal of Cell Biology, Vol 106, 2183-2190, Copyright © 1988 by The Rockefeller University Press

ARTICLES

Preferential expression of fibronectin receptors on immature thymocytes

PM Cardarelli, IN Crispe and MD Pierschbacher
Cancer Research Center, La Jolla Cancer Research Foundation, California 92037.

Fibronectin-adherent (FNR+) thymocytes are enriched for immature (CD4-8- ) and large (CD4+8+) cells, and depleted of mature (CD4-8+ and CD4+8-) and nonmature small (CD4+8+) cells. Among purified CD4-8- thymocytes, cells with the surface marker J11d and the IL-2 receptor, which can give rise to all other thymocyte subsets, showed selective attachment to fibronectin. Analysis of FNR+ thymocytes showed that such cells are greatly enriched for cells in cycle. Additionally, FNR+ cells expressed low levels of T cell receptor. These results suggest a role for the fibronectin receptor during the early, proliferative phase of thymocyte differentiation. The data suggest that loss of the fibronectin receptor is a hallmark of cells that have become committed either to functional maturation or to programmed cell death.
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