The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex

doi:10.1083/jcb.107.4.1575

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The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex

B Gumbiner, B Stevenson and A Grimaldi
Department of Pharmacology and Cell Biology Program, University of California, San Francisco 94143.

The role of the epithelial adhesion molecule uvomorulin in the formation of the epithelial junctional complex in the Madin-Darby canine kidney (MDCK) cell line was investigated. Experiments were carried out to determine whether specific inhibition of uvomorulin function would interfere selectively with the formation, stability, or function of the apical zonula adherens (ZA) and zonula occludens (ZO), or whether it would interfere with all forms of intercellular contact including the desmosomes. The effects of blocking antibodies and Fab fragments to uvomorulin on the formation of the junctional complex was examined with a Ca2+ switch assay for de novo junction assembly. The formation of the ZO, the ZA, and the desmosomes was assayed by fluorescence staining with an antibody to the tight junction-specific protein ZO-1, with rhodamine-phalloidin for ZA-associated actin filaments, and with an anti-desmoplakin antibody, respectively. Under different conditions and times of antibody treatment the extent of inhibition of the formation of each of the junctional elements was very similar. The ability of the cells to eventually overcome the inhibitory effect of the antibodies and form junctions correlated with the reappearance of uvomorulin at the regions of cell-cell contact. Therefore uvomorulin seems to mediate an early adhesion event between epithelial cells that is a prerequisite for the assembly of all elements of the junctional complex. In contrast, the transepithelial electrical resistance of confluent, well-established monolayers of MDCK cells grown on filters was not greatly affected by treatment with the various antibodies or Fab fragments. A small transient decrease in resistance observed with the polyclonal alpha-uvomorulin IgG may be due to a more subtle modulation of the junctional complex.
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Humlicek, A. L., Manzel, L. J., Chin, C. L., Shi, L., Excoffon, K. J. D. A., Winter, M. C., Shasby, D. M., Look, D. C. (2007). Paracellular Permeability Restricts Airway Epithelial Responses to Selectively Allow Activation by Mediators at the Basolateral Surface. J. Immunol. 178: 6395-6403 [Abstract] [Full Text]
Ozaki, M., Ogita, H., Takai, Y. (2007). Involvement of integrin-induced activation of protein kinase C in the formation of adherens junctions. GENES CELLS 12: 651-662 [Abstract] [Full Text]
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Achache, H., Revel, A. (2006). Endometrial receptivity markers, the journey to successful embryo implantation. Hum Reprod Update 12: 731-746 [Abstract] [Full Text]
Ducharme, N. A., Hales, C. M., Lapierre, L. A., Ham, A.-J. L., Oztan, A., Apodaca, G., Goldenring, J. R. (2006). MARK2/EMK1/Par-1B{alpha} Phosphorylation of Rab11-Family Interacting Protein 2 Is Necessary for the Timely Establishment of Polarity in Madin-Darby Canine Kidney Cells. Mol. Biol. Cell 17: 3625-3637 [Abstract] [Full Text]
Sobolik-Delmaire, T., Katafiasz, D., Wahl, J. K. III (2006). Carboxyl Terminus of Plakophilin-1 Recruits It to Plasma Membrane, whereas Amino Terminus Recruits Desmoplakin and Promotes Desmosome Assembly. J. Biol. Chem. 281: 16962-16970 [Abstract] [Full Text]
Youn, Y.-H., Hong, J., Burke, J. M. (2006). Cell Phenotype in Normal Epithelial Cell Lines with High Endogenous N-Cadherin: Comparison of RPE to an MDCK Subclone.. IOVS 47: 2675-2685 [Abstract] [Full Text]
Battle, M. A., Konopka, G., Parviz, F., Gaggl, A. L., Yang, C., Sladek, F. M., Duncan, S. A. (2006). Hepatocyte nuclear factor 4{alpha} orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver. Proc. Natl. Acad. Sci. USA 103: 8419-8424 [Abstract] [Full Text]
Soini, Y, Kinnula, V, Kahlos, K, Paakko, P (2006). Claudins in differential diagnosis between mesothelioma and metastatic adenocarcinoma of the pleura.. J. Clin. Pathol. 59: 250-254 [Abstract] [Full Text]
Lee, D. B. N., Huang, E., Ward, H. J. (2006). Tight junction biology and kidney dysfunction. Am. J. Physiol. Renal Physiol. 290: F20-F34 [Abstract] [Full Text]
Osler, M. E., Chang, M. S., Bader, D. M. (2005). Bves modulates epithelial integrity through an interaction at the tight junction. J. Cell Sci. 118: 4667-4678 [Abstract] [Full Text]
Carrozzino, F., Soulie, P., Huber, D., Mensi, N., Orci, L., Cano, A., Feraille, E., Montesano, R. (2005). Inducible expression of Snail selectively increases paracellular ion permeability and differentially modulates tight junction proteins. Am. J. Physiol. Cell Physiol. 289: C1002-C1014 [Abstract] [Full Text]
Sanders, D S A (2005). Mucosal integrity and barrier function in the pathogenesis of early lesions in Crohn's disease. J. Clin. Pathol. 58: 568-572 [Abstract] [Full Text]
Ivanov, A. I., Hunt, D., Utech, M., Nusrat, A., Parkos, C. A. (2005). Differential Roles for Actin Polymerization and a Myosin II Motor in Assembly of the Epithelial Apical Junctional Complex. Mol. Biol. Cell 16: 2636-2650 [Abstract] [Full Text]
Muller, S. L., Portwich, M., Schmidt, A., Utepbergenov, D. I., Huber, O., Blasig, I. E., Krause, G. (2005). The Tight Junction Protein Occludin and the Adherens Junction Protein {alpha}-Catenin Share a Common Interaction Mechanism with ZO-1. J. Biol. Chem. 280: 3747-3756 [Abstract] [Full Text]
Harris, T. J.C., Peifer, M. (2004). Adherens junction-dependent and -independent steps in the establishment of epithelial cell polarity in Drosophila. JCB 167: 135-147 [Abstract] [Full Text]
Cereijido, M., Contreras, R. G., Shoshani, L. (2004). Cell Adhesion, Polarity, and Epithelia in the Dawn of Metazoans. Physiol. Rev. 84: 1229-1262 [Abstract] [Full Text]
Yamada, A., Irie, K., Fukuhara, A., Ooshio, T., Takai, Y. (2004). Requirement of the actin cytoskeleton for the association of nectins with other cell adhesion molecules at adherens and tight junctions in MDCK cells. GENES CELLS 9: 843-855 [Abstract] [Full Text]
Lehtonen, S., Lehtonen, E., Kudlicka, K., Holthofer, H., Farquhar, M. G. (2004). Nephrin Forms a Complex with Adherens Junction Proteins and CASK in Podocytes and in Madin-Darby Canine Kidney Cells Expressing Nephrin. Am. J. Pathol. 165: 923-936 [Abstract] [Full Text]
Lee, D. B. N., Jamgotchian, N., Allen, S. G., Kan, F. W. K., Hale, I. L. (2004). Annexin A2 heterotetramer: role in tight junction assembly. Am. J. Physiol. Renal Physiol. 287: F481-F491 [Abstract] [Full Text]
Tobey, N. A., Argote, C. M., Hosseini, S. S., Orlando, R. C. (2004). Calcium-switch technique and junctional permeability in native rabbit esophageal epithelium. Am. J. Physiol. Gastrointest. Liver Physiol. 286: G1042-G1049 [Abstract] [Full Text]
Ohkubo, T., Ozawa, M. (2004). The transcription factor Snail downregulates the tight junction components independently of E-cadherin downregulation. J. Cell Sci. 117: 1675-1685 [Abstract] [Full Text]
Kanwar, Y. S., Wada, J., Lin, S., Danesh, F. R., Chugh, S. S., Yang, Q., Banerjee, T., Lomasney, J. W. (2004). Update of extracellular matrix, its receptors, and cell adhesion molecules in mammalian nephrogenesis. Am. J. Physiol. Renal Physiol. 286: F202-F215 [Abstract] [Full Text]
Faux, M. C., Ross, J. L., Meeker, C., Johns, T., Ji, H., Simpson, R. J., Layton, M. J., Burgess, A. W. (2004). Restoration of full-length adenomatous polyposis coli (APC) protein in a colon cancer cell line enhances cell adhesion. J. Cell Sci. 117: 427-439 [Abstract] [Full Text]
Fukuhara, A., Shimizu, K., Kawakatsu, T., Fukuhara, T., Takai, Y. (2003). Involvement of Nectin-activated Cdc42 Small G Protein in Organization of Adherens and Tight Junctions in Madin-Darby Canine Kidney Cells. J. Biol. Chem. 278: 51885-51893 [Abstract] [Full Text]
Shimizu, K., Takai, Y. (2003). Roles of the Intercellular Adhesion Molecule Nectin in Intracellular Signaling. J Biochem 134: 631-636 [Abstract] [Full Text]
Guo, X., Rao, J. N., Liu, L., Zou, T.-T., Turner, D. J., Bass, B. L., Wang, J.-Y. (2003). Regulation of adherens junctions and epithelial paracellular permeability: a novel function for polyamines. Am. J. Physiol. Cell Physiol. 285: C1174-C1187 [Abstract] [Full Text]
Li, L., Backer, J., Wong, A. S. K., Schwanke, E. L., Stewart, B. G., Pasdar, M. (2003). Bcl-2 expression decreases cadherin-mediated cell-cell adhesion. J. Cell Sci. 116: 3687-3700 [Abstract] [Full Text]
Rajasekaran, A. K., Rajasekaran, S. A. (2003). Role of Na-K-ATPase in the assembly of tight junctions. Am. J. Physiol. Renal Physiol. 285: F388-F396 [Abstract] [Full Text]
Lyu, J., Kim, J.-A, Chung, S. K., Kim, K.-S., Joo, C.-K. (2003). Alteration of Cadherin in Dexamethasone-Induced Cataract Organ-Cultured Rat Lens. IOVS 44: 2034-2040 [Abstract] [Full Text]
Wittchen, E. S., Haskins, J., Stevenson, B. R. (2003). NZO-3 Expression Causes Global Changes to Actin Cytoskeleton in Madin-Darby Canine Kidney Cells: Linking a Tight Junction Protein to Rho GTPases. Mol. Biol. Cell 14: 1757-1768 [Abstract] [Full Text]
Rubenstein, N. M., Guan, Y., Woo, P. L., Firestone, G. L. (2003). Glucocorticoid Down-regulation of RhoA Is Required for the Steroid-induced Organization of the Junctional Complex and Tight Junction Formation in Rat Mammary Epithelial Tumor Cells. J. Biol. Chem. 278: 10353-10360 [Abstract] [Full Text]
Huen, A. C., Park, J. K., Godsel, L. M., Chen, X., Bannon, L. J., Amargo, E. V., Hudson, T. Y., Mongiu, A. K., Leigh, I. M., Kelsell, D. P., Gumbiner, B. M., Green, K. J. (2002). Intermediate filament-membrane attachments function synergistically with actin-dependent contacts to regulate intercellular adhesive strength. JCB 159: 1005-1017 [Abstract] [Full Text]
Li, Q., Wang, J., Armant, D. R., Bagchi, M. K., Bagchi, I. C. (2002). Calcitonin Down-regulates E-cadherin Expression in Rodent Uterine Epithelium during Implantation. J. Biol. Chem. 277: 46447-46455 [Abstract] [Full Text]
Evans, S. M., Blyth, D. I., Wong, T., Sanjar, S., West, M. R. (2002). Decreased Distribution of Lung Epithelial Junction Proteins after Intratracheal Antigen or Lipopolysaccharide Challenge: Correlation with Neutrophil Influx and Levels of BALF sE-Cadherin. Am. J. Respir. Cell Mol. Bio. 27: 446-454 [Abstract] [Full Text]
Suzuki, A., Ishiyama, C., Hashiba, K., Shimizu, M., Ebnet, K., Ohno, S. (2002). aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization. J. Cell Sci. 115: 3565-3573 [Abstract] [Full Text]
Nunbhakdi-Craig, V., Machleidt, T., Ogris, E., Bellotto, D., White, C. L. III, Sontag, E. (2002). Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex. JCB 158: 967-978 [Abstract] [Full Text]
Kassab, F. Jr., Marques, R. P., Lacaz-Vieira, F. (2002). Modeling Tight Junction Dynamics and Oscillations. JGP 120: 237-247 [Abstract] [Full Text]
Gopalakrishnan, S., Dunn, K. W., Marrs, J. A. (2002). Rac1, but not RhoA, signaling protects epithelial adherens junction assembly during ATP depletion. Am. J. Physiol. Cell Physiol. 283: C261-C272 [Abstract] [Full Text]
Hirose, T., Izumi, Y., Nagashima, Y., Tamai-Nagai, Y., Kurihara, H., Sakai, T., Suzuki, Y., Yamanaka, T., Suzuki, A., Mizuno, K., Ohno, S. (2002). Involvement of ASIP/PAR-3 in the promotion of epithelial tight junction formation. J. Cell Sci. 115: 2485-2495 [Abstract] [Full Text]
Marzesco, A.-M., Dunia, I., Pandjaitan, R., Recouvreur, M., Dauzonne, D., Benedetti, E. L., Louvard, D., Zahraoui, A. (2002). The Small GTPase Rab13 Regulates Assembly of Functional Tight Junctions in Epithelial Cells. Mol. Biol. Cell 13: 1819-1831 [Abstract] [Full Text]
Boggon, T. J., Murray, J., Chappuis-Flament, S., Wong, E., Gumbiner, B. M., Shapiro, L. (2002). C-Cadherin Ectodomain Structure and Implications for Cell Adhesion Mechanisms. Science 296: 1308-1313 [Abstract] [Full Text]
Tian, Y. C., Phillips, A. O. (2002). Interaction between the Transforming Growth Factor-{beta} Type II Receptor/Smad Pathway and {beta}-Catenin during Transforming Growth Factor-{beta}1-Mediated Adherens Junction Disassembly. Am. J. Pathol. 160: 1619-1628 [Abstract] [Full Text]
Collins, J E (2002). Adhesion between dendritic cells and epithelial cells maintains the gut barrier during bacterial sampling. Gut 50: 449-450 [Full Text]
Wiggan, O'N., Fadel, M. P., Hamel, P. A. (2002). Pax3 induces cell aggregation and regulates phenotypic mesenchymal-epithelial interconversion. J. Cell Sci. 115: 517-529 [Abstract] [Full Text]
Schreider, C., Peignon, G., Thenet, S., Chambaz, J., Pincon-Raymond, M. (2002). Integrin-mediated functional polarization of Caco-2 cells through E-cadherin--actin complexes. J. Cell Sci. 115: 543-552 [Abstract] [Full Text]
Rajasekaran, S. A., Palmer, L. G., Moon, S. Y., Peralta Soler, A., Apodaca, G. L., Harper, J. F., Zheng, Y., Rajasekaran, A. K. (2001). Na,K-ATPase Activity Is Required for Formation of Tight Junctions, Desmosomes, and Induction of Polarity in Epithelial Cells. Mol. Biol. Cell 12: 3717-3732 [Abstract] [Full Text]
Gottardi, C. J., Wong, E., Gumbiner, B. M. (2001). E-Cadherin Suppresses Cellular Transformation by Inhibiting {beta}-Catenin Signaling in an Adhesion-Independent Manner. JCB 153: 1049-1060 [Abstract] [Full Text]
Sakisaka, T., Taniguchi, T., Nakanishi, H., Takahashi, K., Miyahara, M., Ikeda, W., Yokoyama, S., Peng, Y.-F., Yamanishi, K., Takai, Y. (2001). Requirement of Interaction of Nectin-1{alpha}/HveC with Afadin for Efficient Cell-Cell Spread of Herpes Simplex Virus Type 1. J. Virol. 75: 4734-4743 [Abstract] [Full Text]
Chung, N. P. Y., Cheng, C. Y. (2001). Is Cadmium Chloride-Induced Inter-Sertoli Tight Junction Permeability Barrier Disruption a Suitable in Vitro Model to Study the Events of Junction Disassembly during Spermatogenesis in the Rat Testis?. Endocrinology 142: 1878-1888 [Abstract] [Full Text]
Kawamoto, T., Shoda, J., Irimura, T., Miyahara, N., Furukawa, M., Ueda, T., Asano, T., Kano, M., Koike, N., Fukao, K., Tanaka, N., Todoroki, T. (2001). Expression of MUC1 Mucins in the Subserosal Layer Correlates with Postsurgical Prognosis of Pathological Tumor Stage 2 Carcinoma of the Gallbladder. Clin. Cancer Res. 7: 1333-1342 [Abstract] [Full Text]
Lum, H., Roebuck, K. A. (2001). Oxidant stress and endothelial cell dysfunction. Am. J. Physiol. Cell Physiol. 280: C719-C741 [Abstract] [Full Text]
Decaens, C., Cassio, D. (2001). Spatiotemporal expression of catenins, ZO-1, and occludin during early polarization of hepatic WIF-B9 cells. Am. J. Physiol. Cell Physiol. 280: C527-C539 [Abstract] [Full Text]
Bonvini, P., An, W. G., Rosolen, A., Nguyen, P., Trepel, J., Garcia de Herreros, A., Dunach, M., Neckers, L. M. (2001). Geldanamycin Abrogates ErbB2 Association with Proteasome-resistant {beta}-Catenin in Melanoma Cells, Increases {beta}-Catenin-E-Cadherin Association, and Decreases {beta}-Catenin-sensitive Transcription. Cancer Res. 61: 1671-1677 [Abstract] [Full Text]
Ojakian, G., Ratcliffe, D., Schwimmer, R (2001). Integrin regulation of cell-cell adhesion during epithelial tubule formation. J. Cell Sci. 114: 941-952 [Abstract]
Yanez-Mo, M, Tejedor, R, Rousselle, P, Sanchez -Madrid, F (2001). Tetraspanins in intercellular adhesion of polarized epithelial cells: spatial and functional relationship to integrins and cadherins. J. Cell Sci. 114: 577-587 [Abstract]
Rashid, M. G., Sanda, M. G., Vallorosi, C. J., Rios-Doria, J., Rubin, M. A., Day, M. L. (2001). Posttranslational Truncation and Inactivation of Human E-Cadherin Distinguishes Prostate Cancer from Matched Normal Prostate. Cancer Res. 61: 489-492 [Abstract] [Full Text]
Goto, Y., Uchida, Y., Nomura, A., Sakamoto, T., Ishii, Y., Morishima, Y., Masuyama, K., Sekizawa, K. (2000). Dislocation of E-Cadherin in the Airway Epithelium during an Antigen-Induced Asthmatic Response. Am. J. Respir. Cell Mol. Bio. 23: 712-718 [Abstract] [Full Text]
Mo, C., Schneeberger, E. E., Arvin, A. M. (2000). Glycoprotein E of Varicella-Zoster Virus Enhances Cell-Cell Contact in Polarized Epithelial Cells. J. Virol. 74: 11377-11387 [Abstract] [Full Text]
Liang, T. W., DeMarco, R. A., Mrsny, R. J., Gurney, A., Gray, A., Hooley, J., Aaron, H. L., Huang, A., Klassen, T., Tumas, D. B., Fong, S. (2000). Characterization of huJAM: evidence for involvement in cell-cell contact and tight junction regulation. Am. J. Physiol. Cell Physiol. 279: C1733-C1743 [Abstract] [Full Text]
Wittchen, E. S., Haskins, J., Stevenson, B. R. (2000). Exogenous Expression of the Amino-Terminal Half of the Tight Junction Protein Zo-3 Perturbs Junctional Complex Assembly. JCB 151: 825-836 [Abstract] [Full Text]
Man, Y., Hart, V. J., Ring, C. J. A., Sanjar, S., West, M. R. (2000). Loss of Epithelial Integrity Resulting from E-Cadherin Dysfunction Predisposes Airway Epithelial Cells to Adenoviral Infection. Am. J. Respir. Cell Mol. Bio. 23: 610-617 [Abstract] [Full Text]
Cereijido, M., Shoshani, L., Contreras, R. G. (2000). Molecular Physiology and Pathophysiology of Tight Junctions I. Biogenesis of tight junctions and epithelial polarity. Am. J. Physiol. Gastrointest. Liver Physiol. 279: G477-G482 [Abstract] [Full Text]
Toyofuku, T., Hong, Z., Kuzuya, T., Tada, M., Hori, M. (2000). WNT/Frizzled-2 Signaling Induces Aggregation and Adhesion among Cardiac Myocytes by Increased Cadherin-{beta}-Catenin Complex. JCB 150: 225-242 [Abstract] [Full Text]
Bush, K. T., Tsukamoto, T., Nigam, S. K. (2000). Selective degradation of E-cadherin and dissolution of E-cadherin-catenin complexes in epithelial ischemia. Am. J. Physiol. Renal Physiol. 278: F847-F852 [Abstract] [Full Text]
Charron, A. J., Nakamura, S., Bacallao, R., Wandinger-Ness, A. (2000). Compromised Cytoarchitecture and Polarized Trafficking in Autosomal Dominant Polycystic Kidney Disease Cells. JCB 149: 111-124 [Abstract] [Full Text]
Williams, E., Williams, G., Gour, B. J., Blaschuk, O. W., Doherty, P. (2000). A Novel Family of Cyclic Peptide Antagonists Suggests That N-cadherin Specificity Is Determined by Amino Acids That Flank the HAV Motif. J. Biol. Chem. 275: 4007-4012 [Abstract] [Full Text]