Unique distribution of the extracellular matrix component thrombospondin in the developing mouse embryo

doi:10.1083/jcb.107.6.2737

This Article

	Full Text (PDF, 6977K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JCB
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by O'Shea, K. S.
	Articles by Dixit, V. M.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by O'Shea, K. S.
	Articles by Dixit, V. M.


Social Bookmarking

	What's this?

ARTICLES

Unique distribution of the extracellular matrix component thrombospondin in the developing mouse embryo

KS O'Shea and VM Dixit
Department of Anatomy, University of Michigan Medical School, Ann Arbor 48109.

Immunocytochemical localization of thrombospondin (TSP), a trimeric glycoprotein constituent of extracellular matrices, produced striking regional and temporal patterns of distribution in the developing mouse embryo. TSP was present in many basement membranes, surrounded epithelial cells, and was associated with peripheral nerve outgrowth. During organogenesis, TSP was also found on the surface of myoblasts and chondroblasts, and TSP was differentially deposited in cortical layers. With differentiation of chondrocytes and myotubes immunoreactivity was decreased, and differential cortical staining was lost. Presence of TSP was associated with morphogenetic processes of proliferation, migration, and intercellular adhesion.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Grado-Ahuir, J. A., Aad, P. Y., Ranzenigo, G., Caloni, F., Cremonesi, F., Spicer, L. J. (2009). Microarray analysis of insulin-like growth factor-I-induced changes in messenger ribonucleic acid expression in cultured porcine granulosa cells: Possible role of insulin-like growth factor-I in angiogenesis. J ANIM SCI 87: 1921-1933 [Abstract] [Full Text]
Liu, A., Garg, P., Yang, S., Gong, P., Pallero, M. A., Annis, D. S., Liu, Y., Passaniti, A., Mann, D., Mosher, D. F., Murphy-Ullrich, J. E., Goldblum, S. E. (2009). Epidermal Growth Factor-like Repeats of Thrombospondins Activate Phospholipase C{gamma} and Increase Epithelial Cell Migration through Indirect Epidermal Growth Factor Receptor Activation. J. Biol. Chem. 284: 6389-6402 [Abstract] [Full Text]
Pallero, M. A., Elzie, C. A., Chen, J., Mosher, D. F., Murphy-Ullrich, J. E. (2008). Thrombospondin 1 binding to calreticulin-LRP1 signals resistance to anoikis. FASEB J. 22: 3968-3979 [Abstract] [Full Text]
Sozo, F., Hooper, S. B., Wallace, M. J. (2007). Thrombospondin-1 expression and localization in the developing ovine lung. J. Physiol. 584: 625-635 [Abstract] [Full Text]
Sutton, C. D., O'Byrne, K., Goddard, J. C., Marshall, L.-J., Jones, L., Garcea, G., Dennison, A. R., Poston, G., Lloyd, D. M., Berry, D. P. (2005). Expression of Thrombospondin-1 in Resected Colorectal Liver Metastases Predicts Poor Prognosis. Clin. Cancer Res. 11: 6567-6573 [Abstract] [Full Text]
Sottile, J., Hocking, D. C. (2002). Fibronectin Polymerization Regulates the Composition and Stability of Extracellular Matrix Fibrils and Cell-Matrix Adhesions. Mol. Biol. Cell 13: 3546-3559 [Abstract] [Full Text]
Lymn, J. S., Rao, S. J., Clunn, G. F., Gallagher, K. L., O'Neil, C., Thompson, N. T., Hughes, A. D. (1999). Phosphatidylinositol 3-Kinase and Focal Adhesion Kinase Are Early Signals in the Growth Factor�Like Responses to Thrombospondin-1 Seen in Human Vascular Smooth Muscle. Arterioscler. Thromb. Vasc. Bio. 19: 2133-2140 [Abstract] [Full Text]
Goldblum, S. E., Young, B. A., Wang, P., Murphy-Ullrich, J. E. (1999). Thrombospondin-1 Induces Tyrosine Phosphorylation of Adherens Junction Proteins and Regulates an Endothelial Paracellular Pathway. Mol. Biol. Cell 10: 1537-1551 [Abstract] [Full Text]
Barnes, J. L., Mitchell, R. J., Kanalas, J. J., Barnes, V. L. (1999). Differential Expression of Thrombospondin and Cellular Fibronectin During Remodeling in Proliferative Glomerulonephritis. J. Histochem. Cytochem. 47: 533-544 [Abstract] [Full Text]
Kyriakides, T. R., Zhu, Y.-H., Yang, Z., Bornstein, P. (1998). The Distribution of the Matricellular Protein Thrombospondin 2 in Tissues of Embryonic and Adult Mice. J. Histochem. Cytochem. 46: 1007-1016 [Abstract] [Full Text]
Bagavandoss, P., Sage, E. H., Vernon, R. B. (1998). Secreted Protein, Acidic and Rich in Cysteine (SPARC) and Thrombospondin in the Developing Follicle and Corpus Luteum of the Rat. J. Histochem. Cytochem. 46: 1043-1050 [Abstract] [Full Text]
Crombie, R., Silverstein, R. (1998). Lysosomal Integral Membrane Protein II Binds Thrombospondin-1. STRUCTURE-FUNCTION HOMOLOGY WITH THE CELL ADHESION MOLECULE CD36 DEFINES A CONSERVED RECOGNITION MOTIF. J. Biol. Chem. 273: 4855-4863 [Abstract] [Full Text]
Agius, E., Cochard, P. (1998). Comparison of Neurite Outgrowth Induced by Intact and Injured Sciatic Nerves: A Confocal and Functional Analysis. J. Neurosci. 18: 328-338 [Abstract] [Full Text]
Varela-Echavarria, A, Guthrie, S (1997). Molecules making waves in axon guidance.. Genes Dev. 11: 545-557
Thewke, D. P., Seeds, N. W. (1996). Expression of Hepatocyte Growth Factor/Scatter Factor, Its Receptor, c-met, and Tissue-Type Plasminogen Activator during Development of the Murine Olfactory System. J. Neurosci. 16: 6933-6944 [Abstract] [Full Text]
Gobron, S, Monnerie, H, Meiniel, R, Creveaux, I, Lehmann, W, Lamalle, D, Dastugue, B, Meiniel, A (1996). SCO-spondin: a new member of the thrombospondin family secreted by the subcommissural organ is a candidate in the modulation of neuronal aggregation. J. Cell Sci. 109: 1053-1061 [Abstract]
Canfield, A., Sutton, A., Hoyland, J., Schor, A. (1996). Association of thrombospondin-1 with osteogenic differentiation of retinal pericytes in vitro. J. Cell Sci. 109: 343-353 [Abstract]
Mikhailenko, I., Kounnas, M. Z., Strickland, D. K. (1995). Low Density Lipoprotein Receptor-related Protein/[IMAGE][IMAGE]-Macroglobulin Receptor Mediates the Cellular Internalization and Degradation of Thrombospondin. J. Biol. Chem. 270: 9543-9549 [Abstract] [Full Text]
Polverini, P.J. (1995). The Pathophysiology of Angiogenesis. CROBM 6: 230-247 [Abstract] [Full Text]
Adams, J., Lawler, J (1993). Diverse mechanisms for cell attachment to platelet thrombospondin. J. Cell Sci. 104: 1061-1071 [Abstract]
Tucker, R. P. (1993). The in situ localization of tenascin splice variants and thrombospondin 2 mRNA in the avian embryo. Development 117: 347-358 [Abstract]
Reichardt, L.F., Bossy, B., de Curtis, I., Neugebauer, K.M., Venstrom, K., Sretavan, D. (1992). Adhesive Interactions That Regulate Development of the Retina and Primary Visual Projection. Cold Spring Harb Symp Quant Biol 57: 419-429 [Abstract]
Stanford, C. M., Keller, J. C. (1991). The Concept of Osseointegration and Bone Matrix Expression. CROBM 2: 83-101 [Abstract] [Full Text]
Reichardt, L.F., Bossy, B., Carbonetto, S., de Curtis, I., Emmett, C., Hall, D.E., Ignatius, M.J., Lefcort, F., Napolitano, E., Large, T., Neugebauer, K.M., Tomaselli, K.J. (1990). Neuronal Receptors That Regulate Axon Growth. Cold Spring Harb Symp Quant Biol 55: 341-350 [Abstract]
Sauk, J. J. (1990). Stress Proteins in Development And Disease. CROBM 1: 235-245 [Full Text]