Expression of transforming growth factor-beta 1 in specific cells and tissues of adult and neonatal mice

doi:10.1083/jcb.108.2.661

This Article

Full Text (PDF, 9817K)

Alert me when this article is cited

Citation Map

Services

Email this article

Similar articles in this journal

Similar articles in PubMed

Alert me to new content in the JCB

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via CrossRef

Citing Articles via Google Scholar

Google Scholar

Articles by Thompson, N. L.

Articles by Sporn, M. B.

Search for Related Content

PubMed

PubMed Citation

Articles by Thompson, N. L.

Articles by Sporn, M. B.

Pubmed/NCBI databases

Compound via MeSH
Substance via MeSH

Social Bookmarking

What's this?

ARTICLES

Expression of transforming growth factor-beta 1 in specific cells and tissues of adult and neonatal mice

NL Thompson, KC Flanders, JM Smith, LR Ellingsworth, AB Roberts and MB Sporn
Laboratory of Chemoprevention, National Cancer Institute, Bethesda, Maryland 20892.

We have used immunohistochemical techniques to detect transforming growth factor-beta 1 (TGF-beta 1) in many tissues of adult and neonatal mice. Each of two antibodies raised to the amino-terminal 30 amino acids of TGF-beta 1 selectively stained this molecule in either intracellular or extracellular locations. Strong intracellular staining was found in adrenal cortex, megakaryocytes and other cells of the bone marrow, cardiac myocytes, chondrocytes, renal distal tubules, ovarian glandular cells, and chorionic cells of the placenta. Marked staining of extracellular matrix was found in cartilage, heart, pancreas, placenta, skin, and uterus. Staining was often particularly intense in specialized cells of a given tissue, suggesting unique roles for TGF- beta within that tissue. Levels of expression of mRNA for TGF-beta 1 and its histochemical staining did not necessarily correlate in a given tissue, as in the spleen. The present data lend further support to the concept that TGF-beta has an important role in controlling interactions between epithelia and surrounding mesenchyme.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Kaplan, D. H., Li, M. O., Jenison, M. C., Shlomchik, W. D., Flavell, R. A., Shlomchik, M. J. (2007). Autocrine/paracrine TGF{beta}1 is required for the development of epidermal Langerhans cells. JEM 204: 2545-2552 [Abstract] [Full Text]
Bujak, M., Frangogiannis, N. G. (2007). The role of TGF-{beta} signaling in myocardial infarction and cardiac remodeling. Cardiovasc Res 74: 184-195 [Abstract] [Full Text]
Janssens, K, Vanhoenacker, F, Bonduelle, M, Verbruggen, L, Van Maldergem, L, Ralston, S, Guanabens, N, Migone, N, Wientroub, S, Divizia, M T, Bergmann, C, Bennett, C, Simsek, S, Melancon, S, Cundy, T, Van Hul, W (2006). Camurati-Engelmann disease: review of the clinical, radiological, and molecular data of 24 families and implications for diagnosis and treatment. J. Med. Genet. 43: 1-11 [Abstract] [Full Text]
Janssens, K., ten Dijke, P., Janssens, S., Van Hul, W. (2005). Transforming Growth Factor-{beta}1 to the Bone. Endocr. Rev. 26: 743-774 [Abstract] [Full Text]
Saika, S., Miyamoto, T., Yamanaka, O., Kato, T., Ohnishi, Y., Flanders, K. C., Ikeda, K., Nakajima, Y., Kao, W. W.-Y., Sato, M., Muragaki, Y., Ooshima, A. (2005). Therapeutic Effect of Topical Administration of SN50, an Inhibitor of Nuclear Factor-{kappa}B, in Treatment of Corneal Alkali Burns in Mice. Am. J. Pathol. 166: 1393-1403 [Abstract] [Full Text]
Inoue, K., Nakamura, K., Abe, K., Hirakawa, T., Tsuchiya, M., Oomori, Y., Matsuda, H., Miyamoto, K., Minegishi, T. (2003). Mechanisms of Action of Transforming Growth Factor {beta} on the Expression of Follicle-Stimulating Hormone Receptor Messenger Ribonucleic Acid Levels in Rat Granulosa Cells. Biol. Reprod. 69: 1238-1244 [Abstract] [Full Text]
Sterner-Kock, A., Thorey, I. S., Koli, K., Wempe, F., Otte, J., Bangsow, T., Kuhlmeier, K., Kirchner, T., Jin, S., Keski-Oja, J., von Melchner, H. (2002). Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer. Genes Dev. 16: 2264-2273 [Abstract] [Full Text]
Sugerman, P.B., Savage, N.W., Walsh, L.J., Zhao, Z.Z., Zhou, X.J., Khan, A., Seymour, G.J., Bigby, M. (2002). THE PATHOGENESIS OF ORAL LICHEN PLANUS. CROBM 13: 350-365 [Abstract] [Full Text]
Schober, A., Hertel, R., Arumae, U., Farkas, L., Jaszai, J., Krieglstein, K., Saarma, M., Unsicker, K. (1999). Glial Cell Line-Derived Neurotrophic Factor Rescues Target-Deprived Sympathetic Spinal Cord Neurons But Requires Transforming Growth Factor-beta as Cofactor In Vivo. J. Neurosci. 19: 2008-2015 [Abstract] [Full Text]
Nicoletti, A., Michel, J.-B. (1999). Cardiac fibrosis and inflammation: interaction with hemodynamic and hormonal factors. Cardiovasc Res 41: 532-543 [Abstract] [Full Text]
Mizunuma, H., Liu, X., Andoh, K., Abe, Y., Kobayashi, J., Yamada, K., Yokota, H., Ibuki, Y., Hasegawa, Y. (1999). Activin from Secondary Follicles Causes Small Preantral Follicles to Remain Dormant at the Resting Stage. Endocrinology 140: 37-42 [Abstract] [Full Text]
Schober, A., Wolf, N., Huber, K., Hertel, R., Krieglstein, K., Minichiello, L., Kahane, N., Widenfalk, J., Kalcheim, C., Olson, L., Klein, R., Lewin, G. R., Unsicker, K. (1998). TrkB and Neurotrophin-4 Are Important for Development and Maintenance of Sympathetic Preganglionic Neurons Innervating the Adrenal Medulla. J. Neurosci. 18: 7272-7284 [Abstract] [Full Text]
Montuenga, L. M., Mariano, J. M., Prentice, M. A., Cuttitta, F., Jakowlew, S. B. (1998). Coordinate Expression of Transforming Growth Factor-{beta}1 and Adrenomedullin in Rodent Embryogenesis. Endocrinology 139: 3946-3957 [Abstract] [Full Text]
Yue, P., Massie, B. M., Simpson, P. C., Long, C. S. (1998). Cytokine expression increases in nonmyocytes from rats with postinfarction heart failure. Am. J. Physiol. Heart Circ. Physiol. 275: H250-H258 [Abstract] [Full Text]
Ehrhart-Bornstein, M., Hinson, J. P., Bornstein, S. R., Scherbaum, W. A., Vinson, G. P. (1998). Intraadrenal Interactions in the Regulation of Adrenocortical Steroidogenesis. Endocr. Rev. 19: 101-143 [Abstract] [Full Text]
Brand, C., Cherradi, N., Defaye, G., Chinn, A., Chambaz, E. M., Feige, J.-J., Bailly, S. (1998). Transforming Growth Factor beta 1 Decreases Cholesterol Supply to Mitochondria via Repression of Steroidogenic Acute Regulatory Protein Expression. J. Biol. Chem. 273: 6410-6416 [Abstract] [Full Text]
Ng, M.H.L., Chung, Y.F., Lo, K.W., Wickham, N.W.R., Lee, J.C.K., Huang, D.P. (1997). Frequent Hypermethylation of p16 and p15 Genes in Multiple Myeloma. Blood 89: 2500-2506 [Abstract] [Full Text]
Shi, Y., O'Brien, J. E., Fard, A., Zalewski, A. (1996). Transforming Growth Factor-�1 Expression and Myofibroblast Formation During Arterial Repair. Arterioscler. Thromb. Vasc. Bio. 16: 1298-1305 [Abstract] [Full Text]
Hiraki, Y., Inoue, H., Kondo, J., Kamizono, A., Yoshitake, Y., Shukunami, C., Suzuki, F. (1996). A Novel Growth-Promoting Factor Derived from Fetal Bovine Cartilage, Chondromodulin II. PURIFICATION AND AMINO ACID SEQUENCE. J. Biol. Chem. 271: 22657-22662 [Abstract] [Full Text]
Frank, S., Madlener, M., Werner, S. (1996). Transforming Growth Factors beta1, beta2, and beta3 and Their Receptors Are Differentially Regulated during Normal and Impaired Wound Healing. J. Biol. Chem. 271: 10188-10193 [Abstract] [Full Text]
Sheng, Z, Pennica, D, Wood, W., Chien, K. (1996). Cardiotrophin-1 displays early expression in the murine heart tube and promotes cardiac myocyte survival. Development 122: 419-428 [Abstract]
Cui, W, Fowlis, D J, Cousins, F M, Duffie, E, Bryson, S, Balmain, A, Akhurst, R J (1995). Concerted action of TGF-beta 1 and its type II receptor in control of epidermal homeostasis in transgenic mice.. Genes Dev. 9: 945-955 [Abstract]
Critchlow, M., Bland, Y., Ashhurst, D. (1994). The effects of age on the response of rabbit periosteal osteoprogenitor cells to exogenous transforming growth factor-beta 2. J. Cell Sci. 107: 499-516 [Abstract]
Lyons, K M, Pelton, R W, Hogan, B L (1989). Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development.. Genes Dev. 3: 1657-1668 [Abstract]
Papetti, M., Herman, I. M. (2002). Mechanisms of normal and tumor-derived angiogenesis. Am. J. Physiol. Cell Physiol. 282: C947-C970 [Abstract] [Full Text]