In vitro and in vivo association of transforming growth factor-beta 1 with hepatic fibrosis

doi:10.1083/jcb.108.6.2477

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In vitro and in vivo association of transforming growth factor-beta 1 with hepatic fibrosis

MJ Czaja, FR Weiner, KC Flanders, MA Giambrone, R Wind, L Biempica and MA Zern
Albert Einstein College of Medicine, Marion Bessin Liver Research Center, Bronx, New York 10461.

Despite extensive efforts, little progress has been made in identifying the factors that induce hepatic fibrosis. Transforming growth factor- beta (TGF-beta) has been shown to enhance collagen production, therefore its role in hepatic fibrosis was investigated. Treatment of cultured hepatic cells with TGF-beta 1 increased type I procollagen mRNA levels 13-fold due to post-transcriptional gene regulation. When two animal models of hepatic fibrosis, murine schistosomiasis and CCl4- treated rats, were examined, they both exhibited increased levels of TGF-beta 1 gene expression at times that somewhat preceded the increase in collagen synthesis. In contrast, in murine schistosomiasis, mRNA levels of tumor necrosis factor and interleukin-1 peaked early in the fibrogenic process. Immunohistochemical analysis showed TGF-beta 1 to be present in normal mouse liver and to be markedly increased in mice infected with schistosomiasis. TGF-beta 1 appeared in the hepatic parenchyma, primarily in hepatocytes. These findings strongly suggest a role for TGF-beta 1 in a pathophysiological state.
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