Centrosome movement in the early divisions of Caenorhabditis elegans: a cortical site determining centrosome position

doi:10.1083/jcb.109.3.1185

This Article

	Full Text (PDF, 3299K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JCB
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Hyman, A. A.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Hyman, A. A.


Social Bookmarking

	What's this?

ARTICLES

Centrosome movement in the early divisions of Caenorhabditis elegans: a cortical site determining centrosome position

AA Hyman
Laboratory of Molecular Biology, Medical Research Council, Cambridge, England.

In Caenorhabditis elegans embryos, early blastomeres of the P cell lineage divide successively on the same axis. This axis is a consequence of the specific rotational movement of the pair of centrosomes and nucleus (Hyman, A. A., and J. G. White. 1987. J. Cell Biol. 105:2123-2135). A laser has been used to perturb the centrosome movements that determine the pattern of early embryonic divisions. The results support a previously proposed model in which a centrosome rotates towards its correct position by shortening of connections, possibly microtubules, between a centrosome and a defined site on the cortex of the embryo.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Zhang, H., Skop, A. R., White, J. G. (2008). Src and Wnt signaling regulate dynactin accumulation to the P2-EMS cell border in C. elegans embryos. J. Cell Sci. 121: 155-161 [Abstract] [Full Text]
Patalano, S., Pruliere, G., Prodon, F., Paix, A., Dru, P., Sardet, C., Chenevert, J. (2006). The aPKC-PAR-6-PAR-3 cell polarity complex localizes to the centrosome attracting body, a macroscopic cortical structure responsible for asymmetric divisions in the early ascidian embryo. J. Cell Sci. 119: 1592-1603 [Abstract] [Full Text]
Leslie, M. (2006). Centrosome choreography. JCB 172: 328-328 [Full Text]
Zhang, S. O., Weisblat, D. A. (2005). Applications of mRNA injections for analyzing cell lineage and asymmetric cell divisions during segmentation in the leech Helobdella robusta. Development 132: 2103-2113 [Abstract] [Full Text]
Schmidt, D. J., Rose, D. J., Saxton, W. M., Strome, S. (2005). Functional Analysis of Cytoplasmic Dynein Heavy Chain in Caenorhabditis elegans with Fast-acting Temperature-sensitive Mutations. Mol. Biol. Cell 16: 1200-1212 [Abstract] [Full Text]
Labbe, J.-C., McCarthy, E. K., Goldstein, B. (2004). The forces that position a mitotic spindle asymmetrically are tethered until after the time of spindle assembly. JCB 167: 245-256 [Abstract] [Full Text]
Skop, A. R., Liu, H., Yates, J. III, Meyer, B. J., Heald, R. (2004). Dissection of the Mammalian Midbody Proteome Reveals Conserved Cytokinesis Mechanisms. Science 305: 61-66 [Abstract] [Full Text]
Ogawa, S., Matsubayashi, Y., Nishida, E. (2004). An evolutionarily conserved gene required for proper microtubule architecture in Caenorhabditis elegans. GENES CELLS 9: 83-93 [Abstract] [Full Text]
Bergmann, D. C., Lee, M., Robertson, B., Tsou, M.-F. B., Rose, L. S., Wood, W. B. (2003). Embryonic handedness choice in C. elegans involves the G{alpha} protein GPA-16. Development 130: 5731-5740 [Abstract] [Full Text]
Wright, A. J., Hunter, C. P. (2003). Mutations in a {beta}-Tubulin Disrupt Spindle Orientation and Microtubule Dynamics in the Early Caenorhabditis elegans Embryo. Mol. Biol. Cell 14: 4512-4525 [Abstract] [Full Text]
Tsou, M.-F. B., Ku, W., Hayashi, A., Rose, L. S. (2003). PAR-dependent and geometry-dependent mechanisms of spindle positioning. JCB 160: 845-855 [Abstract] [Full Text]
Haydar, T. F., Ang, E. Jr., Rakic, P. (2003). Mitotic spindle rotation and mode of cell division in the developing telencephalon. Proc. Natl. Acad. Sci. USA 100: 2890-2895 [Abstract] [Full Text]
Nagasato, C., Motomura, T. (2002). Influence of the centrosome in cytokinesis of brown algae: polyspermic zygotes of Scytosiphon lomentaria (Scytosiphonales, Phaeophyceae). J. Cell Sci. 115: 2541-2548 [Abstract] [Full Text]
Coquelle, F. M., Caspi, M., Cordelieres, F. P., Dompierre, J. P., Dujardin, D. L., Koifman, C., Martin, P., Hoogenraad, C. C., Akhmanova, A., Galjart, N., De Mey, J. R., Reiner, O. (2002). LIS1, CLIP-170's Key to the Dynein/Dynactin Pathway. Mol. Cell. Biol. 22: 3089-3102 [Abstract] [Full Text]
Bulgheresi, S., Kleiner, E., Knoblich, J. A. (2002). Inscuteable-dependent apical localization of the microtubule-binding protein Cornetto suggests a role in asymmetric cell division. J. Cell Sci. 114: 3655-3662 [Abstract] [Full Text]
Tsou, M.-F. B., Hayashi, A., DeBella, L. R., McGrath, G., Rose, L. S. (2002). LET-99 determines spindle position and is asymmetrically enriched in response to PAR polarity cues in C. elegans embryos. Development 129: 4469-4481 [Abstract] [Full Text]
Kaltschmidt, J. A., Brand, A. H. (2002). Asymmetric cell division: microtubule dynamics and spindle asymmetry. J. Cell Sci. 115: 2257-2264 [Abstract] [Full Text]
Yamamoto, A., Tsutsumi, C., Kojima, H., Oiwa, K., Hiraoka, Y. (2001). Dynamic Behavior of Microtubules during Dynein-dependent Nuclear Migrations of Meiotic Prophase in Fission Yeast. Mol. Biol. Cell 12: 3933-3946 [Abstract] [Full Text]
Gomes, J.-E., Encalada, S. E., Swan, K. A., Shelton, C. A., Carter, J. C., Bowerman, B. (2001). The maternal gene spn-4 encodes a predicted RRM protein required for mitotic spindle orientation and cell fate patterning in early C. elegans embryos. Development 128: 4301-4314 [Abstract] [Full Text]
Caron, J. M., Vega, L. R., Fleming, J., Bishop, R., Solomon, F. (2001). Single Site alpha -Tubulin Mutation Affects Astral Microtubules and Nuclear Positioning during Anaphase in Saccharomyces cerevisiae: Possible Role for Palmitoylation of alpha -Tubulin. Mol. Biol. Cell 12: 2672-2687 [Abstract] [Full Text]
Giansanti, M., Gatti, M, Bonaccorsi, S (2001). The role of centrosomes and astral microtubules during asymmetric division of Drosophila neuroblasts. Development 128: 1137-1145 [Abstract]
Schuyler, S., Pellman, D (2001). Search, capture and signal: games microtubules and centrosomes play. J. Cell Sci. 114: 247-255 [Abstract]
Miller, K. G., Rand, J. B. (2000). A Role for RIC-8 (Synembryn) and GOA-1 (Go{alpha}) in Regulating a Subset of Centrosome Movements During Early Embryogenesis in Caenorhabditis elegans. Genetics 156: 1649-1660 [Abstract] [Full Text]
Brody, S. L., Yan, X. H., Wuerffel, M. K., Song, S.-K., Shapiro, S. D. (2000). Ciliogenesis and Left-Right Axis Defects in Forkhead Factor HFH-4-Null Mice. Am. J. Respir. Cell Mol. Bio. 23: 45-51 [Abstract] [Full Text]
Pichler, S., Gonczy, P., Schnabel, H., Pozniakowski, A., Ashford, A., Schnabel, R., Hyman, A. A. (2000). OOC-3, a novel putative transmembrane protein required for establishment of cortical domains and spindle orientation in the P(1) blastomere of C. elegans embryos. Development 127: 2063-2073 [Abstract]
Lee, L., Tirnauer, J. S., Li, J., Schuyler, S. C., Liu, J. Y., Pellman, D. (2000). Positioning of the Mitotic Spindle by a Cortical-Microtubule Capture Mechanism. Science 287: 2260-2262 [Abstract] [Full Text]
Heil-Chapdelaine, R. A., Tran, N. K., Cooper, J. A. (2000). Dynein-dependent Movements of the Mitotic Spindle in Saccharomyces cerevisiae Do Not Require Filamentous Actin. Mol. Biol. Cell 11: 863-872 [Abstract] [Full Text]
Bobinnec, Y, Fukuda, M, Nishida, E (2000). Identification and characterization of Caenorhabditis elegans gamma-tubulin in dividing cells and differentiated tissues. J. Cell Sci. 113: 3747-3759 [Abstract]
Schaerer-Brodbeck, C, Riezman, H (2000). Saccharomyces cerevisiae Arc35p works through two genetically separable calmodulin functions to regulate the actin and tubulin cytoskeletons. J. Cell Sci. 113: 521-532 [Abstract]
Gonczy, P., Pichler, S., Kirkham, M., Hyman, A. A. (1999). Cytoplasmic Dynein Is Required for Distinct Aspects of Mtoc Positioning, Including Centrosome Separation, in the One Cell Stage Caenorhabditis elegans Embryo. JCB 147: 135-150 [Abstract] [Full Text]
Schlesinger, A., Shelton, C. A., Maloof, J. N., Meneghini, M., Bowerman, B. (1999). Wnt pathway components orient a mitotic spindle in the early Caenorhabditis elegans embryo without requiring gene transcription in the responding cell. Genes Dev. 13: 2028-2038 [Abstract] [Full Text]
Gonczy, P., Schnabel, H., Kaletta, T., Amores, A. D., Hyman, T., Schnabel, R. (1999). Dissection of Cell Division Processes in the One Cell Stage Caenorhabditis elegans Embryo by Mutational Analysis. JCB 144: 927-946 [Abstract] [Full Text]
Lee, L., Klee, S. K., Evangelista, M., Boone, C., Pellman, D. (1999). Control of Mitotic Spindle Position by the Saccharomyces cerevisiae Formin Bni1p. JCB 144: 947-961 [Abstract] [Full Text]
Miller, R. K., Matheos, D., Rose, M. D. (1999). The Cortical Localization of the Microtubule Orientation Protein, Kar9p, Is Dependent upon Actin and Proteins Required for Polarization. JCB 144: 963-975 [Abstract] [Full Text]
Heil-Chapdelaine, R. A., Adames, N. R., Cooper, J. A. (1999). Formin' the Connection between Microtubules and the Cell Cortex. JCB 144: 809-811 [Full Text]
Gallagher, K, Smith, L. (1999). discordia mutations specifically misorient asymmetric cell divisions during development of the maize leaf epidermis. Development 126: 4623-4633 [Abstract]
Miller, R. K., Heller, K. K., Frisèn, L., Wallack, D. L., Loayza, D., Gammie, A. E., Rose, M. D. (1998). The Kinesin-related Proteins, Kip2p and Kip3p, Function Differently in Nuclear Migration in Yeast. Mol. Biol. Cell 9: 2051-2068 [Abstract] [Full Text]
O'Connell, K. F., Leys, C. M., White, J. G. (1998). A Genetic Screen for Temperature-Sensitive Cell-Division Mutants of Caenorhabditis elegans. Genetics 149: 1303-1321 [Abstract] [Full Text]
Giansanti, M. G., Bonaccorsi, S., Williams, B., Williams, E. V., Santolamazza, C., Goldberg, M. L., Gatti, M. (1998). Cooperative interactions between the central spindle and the contractile ring during Drosophila cytokinesis. Genes Dev. 12: 396-410 [Abstract] [Full Text]
Miller, R. K., Rose, M. D. (1998). Kar9p Is a Novel Cortical Protein Required for Cytoplasmic Microtubule Orientation in Yeast. JCB 140: 377-390 [Abstract] [Full Text]
Schumacher, J., Ashcroft, N, Donovan, P., Golden, A (1998). A highly conserved centrosomal kinase, AIR-1, is required for accurate cell cycle progression and segregation of developmental factors in Caenorhabditis elegans embryos. Development 125: 4391-4402 [Abstract]
Keating, H., White, J. (1998). Centrosome dynamics in early embryos of Caenorhabditis elegans. J. Cell Sci. 111: 3027-3033 [Abstract]
Reinsch, S, Gonczy, P (1998). Mechanisms of nuclear positioning. J. Cell Sci. 111: 2283-2295 [Abstract]
Inoue, S, Turgeon, B., Yoder, O., Aist, J. (1998). Role of fungal dynein in hyphal growth, microtubule organization, spindle pole body motility and nuclear migration. J. Cell Sci. 111: 1555-1566 [Abstract]
Neujahr, R, Albrecht, R, Kohler, J, Matzner, M, Schwartz, J., Westphal, M, Gerisch, G (1998). Microtubule-mediated centrosome motility and the positioning of cleavage furrows in multinucleate myosin II-null cells. J. Cell Sci. 111: 1227-1240 [Abstract]
Rose, L., Kemphues, K (1998). The let-99 gene is required for proper spindle orientation during cleavage of the C. elegans embryo. Development 125: 1337-1346 [Abstract]
Ding, D., Chikashige, Y, Haraguchi, T, Hiraoka, Y (1998). Oscillatory nuclear movement in fission yeast meiotic prophase is driven by astral microtubules, as revealed by continuous observation of chromosomes and microtubules in living cells. J. Cell Sci. 111: 701-712 [Abstract]
Shaw, S. L., Yeh, E., Maddox, P., Salmon, E.D., Bloom, K. (1997). Astral Microtubule Dynamics in Yeast: A Microtubule-based Searching Mechanism for Spindle Orientation and Nuclear Migration into the Bud. JCB 139: 985-994 [Abstract] [Full Text]
Manning, B. D., Padmanabha, R., Snyder, M. (1997). The Rho-GEF Rom2p Localizes to Sites of Polarized Cell Growth and Participates in Cytoskeletal Functions in Saccharomyces cerevisiae. Mol. Biol. Cell 8: 1829-1844 [Abstract] [Full Text]
Stearns, T. (1997). Motoring to the Finish: Kinesin and Dynein Work Together to Orient the Yeast Mitotic Spindle. JCB 138: 957-960 [Full Text]
Cottingham, F. R., Hoyt, M. A. (1997). Mitotic Spindle Positioning in Saccharomyces cerevisiae Is Accomplished by Antagonistically Acting Microtubule Motor Proteins. JCB 138: 1041-1053 [Abstract] [Full Text]
Carminati, J. L., Stearns, T. (1997). Microtubules Orient the Mitotic Spindle in Yeast through Dynein-dependent Interactions with the Cell Cortex. JCB 138: 629-641 [Abstract] [Full Text]
Wheatley, S. P., Hinchcliffe, E. H., Glotzer, M., Hyman, A. A., Sluder, G., Wang, Y.-l. (1997). CDK1 Inactivation Regulates Anaphase Spindle Dynamics and Cytokinesis In Vivo. JCB 138: 385-393 [Abstract] [Full Text]
Morris, S. M., Anaya, P., Xiang, X., Morris, N. R., May, G. S., Yu-Lee, L.-y. (1997). A Prolactin-Inducible T Cell Gene Product Is Structurally Similar to the Aspergillus nidulans Nuclear Movement Protein NUDC. Mol. Endocrinol. 11: 229-236 [Abstract] [Full Text]
Bowerman, B, Ingram, M., Hunter, C. (1997). The maternal par genes and the segregation of cell fate specification activities in early Caenorhabditis elegans embryos. Development 124: 3815-3826 [Abstract]
Wang, S., Griffin, F., Clark, W. (1997). Cell-cell association directed mitotic spindle orientation in the early development of the marine shrimp Sicyonia ingentis. Development 124: 773-780 [Abstract]
Adams, R. J. (1996). Metaphase Spindles Rotate in the Neuroepithelium of Rat Cerebral Cortex. J. Neurosci. 16: 7610-7618 [Abstract] [Full Text]
Fishkind, D., Silverman, J., Wang, Y. (1996). Function of spindle microtubules in directing cortical movement and actin filament organization in dividing cultured cells. J. Cell Sci. 109: 2041-2051 [Abstract]
Hird, S., Paulsen, J., Strome, S (1996). Segregation of germ granules in living Caenorhabditis elegans embryos: cell-type-specific mechanisms for cytoplasmic localisation. Development 122: 1303-1312 [Abstract]
Bissen, S., Smith, C. (1996). Unequal cleavage in leech embryos: zygotic transcription is required for correct spindle orientation in subset of early blastomeres. Development 122: 599-606 [Abstract]
Esteban, M., Giovinazzo, G, Goday, C (1995). Chromatin diminution is strictly correlated to somatic cell behavior in early development of the nematode Parascaris univalens. J. Cell Sci. 108: 2393-2404 [Abstract]
Pringle, J.R., Bi, E., Harkins, H.A., Zahner, J.E., De Virgilio, C., Chant, J., Corrado, K., Fares, H. (1995). Establishment of Cell Polarity in Yeast. Cold Spring Harb Symp Quant Biol 60: 729-744 [Abstract]
Waddle, J., Cooper, J., Waterston, R. (1994). Transient localized accumulation of actin in Caenorhabditis elegans blastomeres with oriented asymmetric divisions. Development 120: 2317-2328 [Abstract]
Aist, J., Liang, H, Berns, M. (1993). Astral and spindle forces in PtK2 cells during anaphase B: a laser microbeam study. J. Cell Sci. 104: 1207-1216 [Abstract]
Hertzler, P., Clark, W. (1992). Cleavage and gastrulation in the shrimp Sicyonia ingentis: invagination is accompanied by oriented cell division. Development 116: 127-140 [Abstract]
Buendia, B., Clarke, P.R., Felix, M.A., Karsenti, E., Leiss, D., Verde, F. (1991). Regulation of Protein Kinases Associated with Cyclin A and Cyclin B and Their Effect on Microtubule Dynamics and Nucleation in Xenopus Egg Extracts. Cold Spring Harb Symp Quant Biol 56: 523-532 [Abstract]
Kellogg, D.R., Sullivan, W., Theurkauf, W., Oegema, K., Raff, J.W., Alberts, B.M. (1991). Studies on the Centrosome and Cytoplasmic Organization in the Early Drosophila Embryo. Cold Spring Harb Symp Quant Biol 56: 649-662 [Abstract]
Hoepfner, D., Schaerer, F., Brachat, A., Wach, A., Philippsen, P. (2002). Reorientation of Mispositioned Spindles in Short Astral Microtubule Mutant spc72Delta Is Dependent on Spindle Pole Body Outer Plaque and Kar3 Motor Protein. Mol. Biol. Cell 13: 1366-1380 [Abstract] [Full Text]