The Journal of Cell Biology, Vol 111, 1089-1105, Copyright © 1990 by The Rockefeller University Press

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Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring

JB Gorlin, R Yamin, S Egan, M Stewart, TP Stossel, DJ Kwiatkowski and JH Hartwig
Department of Medicine, Massachusetts General Hospital, Charlestown.

Actin-binding protein (ABP-280, nonmuscle filamin) is a ubiquitous dimeric actin cross-linking phosphoprotein of peripheral cytoplasm, where it promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. The complete nucleotide sequence of human endothelial cell ABP cDNA predicts a polypeptide subunit chain of 2,647 amino acids, corresponding to 280 kD, also the mass derived from physical measurements of the native protein. The actin-binding domain is near the amino-terminus of the subunit where the amino acid sequence is similar to other actin filament binding proteins, including alpha-actinin, beta-spectrin, dystrophin, and Dictyostelium abp-120. The remaining 90% of the sequence comprises 24 repeats, each approximately 96 residues long, predicted to have stretches of beta-sheet secondary structure interspersed with turns. The first 15 repeats may have substantial intrachain hydrophobic interactions and overlap in a staggered fashion to yield a backbone with mechanical resilience. Sequence insertions immediately before repeats 16 and 24 predict two hinges in the molecule near points where rotary-shadowed molecules appear to swivel in electron micrographs. Both putative hinge regions are susceptible to cleavage by proteases and the second also contains the site that binds the platelet glycoprotein Ib/IX complex. Phosphorylation consensus sequences are also located in the hinges or near them. Degeneracy within every even- numbered repeat between 16 and 24 and the insertion before repeat 24 may convert interactions within chains to interactions between chains to account for dimer formation within a domain of 7 kD at the carboxy- terminus. The structure of ABP dimers resembles a leaf spring. Interchain interactions hold the leaves firmly together at one end, whereas intrachain hydrophobic bonds reinforce the arms of the spring where the leaves diverge, making it sufficiently stiff to promote high- angle branching of actin filaments. The large size of the leaves, their interruption by two hinges and flexible actin-binding site, facilitate cross-linking of widely dispersed actin filaments.
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• Nakamura, F., Osborn, T. M., Hartemink, C. A., Hartwig, J. H., Stossel, T. P. (2007). Structural basis of filamin A functions. JCB 179: 1011-1025 [Abstract] [Full Text]  
• Mammoto, A., Huang, S., Ingber, D. E. (2007). Filamin links cell shape and cytoskeletal structure to Rho regulation by controlling accumulation of p190RhoGAP in lipid rafts. J. Cell Sci. 120: 456-467 [Abstract] [Full Text]  
• Khaire, N., Muller, R., Blau-Wasser, R., Eichinger, L., Schleicher, M., Rief, M., Holak, T. A., Noegel, A. A. (2007). Filamin-regulated F-actin Assembly Is Essential for Morphogenesis and Controls Phototaxis in Dictyostelium. J. Biol. Chem. 282: 1948-1955 [Abstract] [Full Text]  
• Carugo, O. (2007). Statistical validation of the root-mean-square-distance, a measure of protein structural proximity. Protein Eng Des Sel 0: gzl051v2-5 [Abstract] [Full Text]  
• Kyndt, F., Gueffet, J.-P., Probst, V., Jaafar, P., Legendre, A., Le Bouffant, F., Toquet, C., Roy, E., McGregor, L., Lynch, S. A., Newbury-Ecob, R., Tran, V., Young, I., Trochu, J.-N., Le Marec, H., Schott, J.-J. (2007). Mutations in the Gene Encoding Filamin A as a Cause for Familial Cardiac Valvular Dystrophy. Circulation 115: 40-49 [Abstract] [Full Text]  
• Feng, Y., Chen, M. H., Moskowitz, I. P., Mendonza, A. M., Vidali, L., Nakamura, F., Kwiatkowski, D. J., Walsh, C. A. (2006). Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis. Proc. Natl. Acad. Sci. USA 103: 19836-19841 [Abstract] [Full Text]  
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• Bicknell, L S, Morgan, T, Bonafe, L, Wessels, M W, Bialer, M G, Willems, P J, Cohn, D H, Krakow, D, Robertson, S P (2005). Mutations in FLNB cause boomerang dysplasia. J. Med. Genet. 42: e43-e43 [Abstract] [Full Text]  
• Rybakova, I. N., Ervasti, J. M. (2005). Identification of Spectrin-like Repeats Required for High Affinity Utrophin-Actin Interaction. J. Biol. Chem. 280: 23018-23023 [Abstract] [Full Text]  
• Berry, F. B., O'Neill, M. A., Coca-Prados, M., Walter, M. A. (2005). FOXC1 Transcriptional Regulatory Activity Is Impaired by PBX1 in a Filamin A-Mediated Manner. Mol. Cell. Biol. 25: 1415-1424 [Abstract] [Full Text]  
• Knuth, M., Khaire, N., Kuspa, A., Lu, S. J., Schleicher, M., Noegel,, A. A. (2004). A novel partner for Dictyostelium filamin is an {alpha}-helical developmentally regulated protein. J. Cell Sci. 117: 5013-5022 [Abstract] [Full Text]  
• Guerrini, R., Mei, D., Sisodiya, S., Sicca, F., Harding, B., Takahashi, Y., Dorn, T., Yoshida, A., Campistol, J., Kramer, G., Moro, F., Dobyns, W. B., Parrini, E. (2004). Germline and mosaic mutations of FLN1 in men with periventricular heterotopia. Neurology 63: 51-56 [Abstract] [Full Text]  
• Zimmerman, A. W., Nelissen, J. M. D. T., van Emst-de Vries, S. E., Willems, P. H. G. M., de Lange, F., Collard, J. G., van Leeuwen, F. N., Figdor, C. G. (2004). Cytoskeletal restraints regulate homotypic ALCAM-mediated adhesion through PKC{alpha} independently of Rho-like GTPases. J. Cell Sci. 117: 2841-2852 [Abstract] [Full Text]  
• Onoprishvili, I., Andria, M. L., Kramer, H. K., Ancevska-Taneva, N., Hiller, J. M., Simon, E. J. (2003). Interaction Between the {micro} Opioid Receptor and Filamin A Is Involved in Receptor Regulation and Trafficking. Mol. Pharmacol. 64: 1092-1100 [Abstract] [Full Text]  
• Sampson, L. J., Leyland, M. L., Dart, C. (2003). Direct Interaction between the Actin-binding Protein Filamin-A and the Inwardly Rectifying Potassium Channel, Kir2.1. J. Biol. Chem. 278: 41988-41997 [Abstract] [Full Text]  
• Loy, C. J., Sim, K. S., Yong, E. L. (2003). Filamin-A fragment localizes to the nucleus to regulate androgen receptor and coactivator functions. Proc. Natl. Acad. Sci. USA 100: 4562-4567 [Abstract] [Full Text]  
• Seck, T., Baron, R., Horne, W. C. (2003). Binding of Filamin to the C-terminal Tail of the Calcitonin Receptor Controls Recycling. J. Biol. Chem. 278: 10408-10416 [Abstract] [Full Text]  
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• Nikki, M., Merilainen, J., Lehto, V.-P. (2002). FAP52 Regulates Actin Organization via Binding to Filamin. J. Biol. Chem. 277: 11432-11440 [Abstract] [Full Text]  
• van der Flier, A., Kuikman, I., Kramer, D., Geerts, D., Kreft, M., Takafuta, T., Shapiro, S. S., Sonnenberg, A. (2002). Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin {beta} subunits. JCB 156: 361-376 [Abstract] [Full Text]  
• Yuan, Y., Shen, Z. (2001). Interaction with BRCA2 Suggests a Role for Filamin-1 (hsFLNa) in DNA Damage Response. J. Biol. Chem. 276: 48318-48324 [Abstract] [Full Text]  
• Dyson, J. M., O'Malley, C. J., Becanovic, J., Munday, A. D., Berndt, M. C., Coghill, I. D., Nandurkar, H. H., Ooms, L. M., Mitchell, C. A. (2001). The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin. JCB 155: 1065-1080 [Abstract] [Full Text]  
• Flanagan, L. A., Chou, J., Falet, H., Neujahr, R., Hartwig, J. H., Stossel, T. P. (2001). Filamin A, the Arp2/3 complex, and the morphology and function of cortical actin filaments in human melanoma cells. JCB 155: 511-518 [Abstract] [Full Text]  
• Sheen, V. L., Dixon, P. H., Fox, J. W., Hong, S. E., Kinton, L., Sisodiya, S. M., Duncan, J. S., Dubeau, F., Scheffer, I. E., Schachter, S. C., Wilner, A., Henchy, R., Crino, P., Kamuro, K., DiMario, F., Berg, M., Kuzniecky, R., Cole, A. J., Bromfield, E., Biber, M., Schomer, D., Wheless, J., Silver, K., Mochida, G. H., Berkovic, S. F., Andermann, F., Andermann, E., Dobyns, W. B., Wood, N. W., Walsh, C. A. (2001). Mutations in the X-linked filamin 1 gene cause periventricular nodular heterotopia in males as well as in females. Hum Mol Genet 10: 1775-1783 [Abstract] [Full Text]  
• Borbiev, T., Verin, A. D., Shi, S., Liu, F., Garcia, J. G. N. (2001). Regulation of endothelial cell barrier function by calcium/calmodulin-dependent protein kinase II. Am. J. Physiol. Lung Cell. Mol. Physiol. 280: L983-L990 [Abstract] [Full Text]  
• Lin, R., Karpa, K., Kabbani, N., Goldman-Rakic, P., Levenson, R. (2001). Dopamine D2 and D3 receptors are linked to the actin cytoskeleton via interaction with filamin A. Proc. Natl. Acad. Sci. USA 98: 5258-5263 [Abstract] [Full Text]  
• van der Ven, P. F.M., Wiesner, S., Salmikangas, P., Auerbach, D., Himmel, M., Kempa, S., Hayess, K., Pacholsky, D., Taivainen, A., Schroder, R., Carpen, O., Furst, D. O. (2000). Indications for a Novel Muscular Dystrophy Pathway: {gamma}-Filamin, the Muscle-Specific Filamin Isoform, Interacts with Myotilin. JCB 151: 235-248 [Abstract] [Full Text]  
• Ozanne, D. M., Brady, M. E., Cook, S., Gaughan, L., Neal, D. E., Robson, C. N. (2000). Androgen Receptor Nuclear Translocation Is Facilitated by the f-Actin Cross-Linking Protein Filamin. Mol. Endocrinol. 14: 1618-1626 [Abstract] [Full Text]  
• Li, M., Bermak, J. C., Wang, Z. W., Zhou, Q. Y. (2000). Modulation of Dopamine D2 Receptor Signaling by Actin-Binding Protein (ABP-280). Mol. Pharmacol. 57: 446-452 [Abstract] [Full Text]  
• Guo, Y, Zhang, S., Sokol, N, Cooley, L, Boulianne, G. (2000). Physical and genetic interaction of filamin with presenilin in Drosophila. J. Cell Sci. 113: 3499-3508 [Abstract]  
• Leonardi, A., Ellinger-Ziegelbauer, H., Franzoso, G., Brown, K., Siebenlist, U. (2000). Physical and Functional Interaction of Filamin (Actin-binding Protein-280) and Tumor Necrosis Factor Receptor-associated Factor 2. J. Biol. Chem. 275: 271-278 [Abstract] [Full Text]  
• Stahlhut, M., van Deurs, B. (2000). Identification of Filamin as a Novel Ligand for Caveolin-1: Evidence for the Organization of Caveolin-1-associated Membrane Domains by the Actin Cytoskeleton. Mol. Biol. Cell 11: 325-337 [Abstract] [Full Text]  
• Krief, S., Faivre, J.-F., Robert, P., Le Douarin, B., Brument-Larignon, N., Lefrere, I., Bouzyk, M. M., Anderson, K. M., Greller, L. D., Tobin, F. L., Souchet, M., Bril, A. (1999). Identification and Characterization of cvHsp. A NOVEL HUMAN SMALL STRESS PROTEIN SELECTIVELY EXPRESSED IN CARDIOVASCULAR AND INSULIN-SENSITIVE TISSUES. J. Biol. Chem. 274: 36592-36600 [Abstract] [Full Text]  
• Li, M.-g., Serr, M., Edwards, K., Ludmann, S., Yamamoto, D., Tilney, L. G., Field, C. M., Hays, T. S. (1999). Filamin Is Required for Ring Canal Assembly and Actin Organization during Drosophila Oogenesis. JCB 146: 1061-1074 [Abstract] [Full Text]  
• El-Husseini, A. E.-d., Vincent, S. R. (1999). Cloning and Characterization of a Novel RING Finger Protein That Interacts with Class V Myosins. J. Biol. Chem. 274: 19771-19777 [Abstract] [Full Text]  
• Svitkina, T. M., Borisy, G. G. (1999). Arp2/3 Complex and Actin Depolymerizing Factor/Cofilin in Dendritic Organization and Treadmilling of Actin Filament Array in Lamellipodia. JCB 145: 1009-1026 [Abstract] [Full Text]  
• Ohta, Y., Suzuki, N., Nakamura, S., Hartwig, J. H., Stossel, T. P. (1999). The small GTPase RalA targets filamin to induce filopodia. Proc. Natl. Acad. Sci. USA 96: 2122-2128 [Abstract] [Full Text]  
• Loo, D. T., Kanner, S. B., Aruffo, A. (1998). Filamin Binds to the Cytoplasmic Domain of the beta 1-Integrin. IDENTIFICATION OF AMINO ACIDS RESPONSIBLE FOR THIS INTERACTION. J. Biol. Chem. 273: 23304-23312 [Abstract] [Full Text]  
• Xu, W.-f., Xie, Z.-w., Chung, D. W., Davie, E. W. (1998). A Novel Human Actin-Binding Protein Homologue That Binds to Platelet Glycoprotein Ibalpha. Blood 92: 1268-1276 [Abstract] [Full Text]  
• Takafuta, T., Wu, G., Murphy, G. F., Shapiro, S. S. (1998). Human beta -Filamin Is a New Protein That Interacts with the Cytoplasmic Tail of Glycoprotein Ibalpha. J. Biol. Chem. 273: 17531-17538 [Abstract] [Full Text]  
• Aplin, A. E., Howe, A., Alahari, S. K., Juliano, R. L. (1998). Signal Transduction and Signal Modulation by Cell Adhesion Receptors: The Role of Integrins, Cadherins, Immunoglobulin-Cell Adhesion Molecules, and Selectins. Pharmacol. Rev. 50: 197-264 [Abstract] [Full Text]  
• Xu, J., Wirtz, D., Pollard, T. D. (1998). Dynamic Cross-linking by alpha -Actinin Determines the Mechanical Properties of Actin Filament Networks. J. Biol. Chem. 273: 9570-9576 [Abstract] [Full Text]  
• Pfaff, M., Liu, S., Erle, D. J., Ginsberg, M. H. (1998). Integrin beta  Cytoplasmic Domains Differentially Bind to Cytoskeletal Proteins. J. Biol. Chem. 273: 6104-6109 [Abstract] [Full Text]  
• Ott, I., Fischer, E. G., Miyagi, Y., Mueller, B. M., Ruf, W. (1998). A Role for Tissue Factor in Cell Adhesion and Migration Mediated by Interaction with Actin-binding Protein 280. JCB 140: 1241-1253 [Abstract] [Full Text]  
• Meyer, S. C., Sanan, D. A., Fox, J. E. B. (1998). Role of Actin-binding Protein in Insertion of Adhesion Receptors into the Membrane. J. Biol. Chem. 273: 3013-3020 [Abstract] [Full Text]  
• Glogauer, M., Arora, P., Chou, D., Janmey, P. A., Downey, G. P., McCulloch, C. A. G. (1998). The Role of Actin-binding Protein 280 in Integrin-dependent Mechanoprotection. J. Biol. Chem. 273: 1689-1698 [Abstract] [Full Text]  
• Katanaev, V., Wymann, M. (1998). GTPgammaS-induced actin polymerisation in vitro: ATP- and phosphoinositide-independent signalling via Rho-family proteins and a plasma membrane-associated guanine nucleotide exchange factor. J. Cell Sci. 111: 1583-1594 [Abstract]  
• Liu, G., Thomas, L., Warren, R. A., Enns, C. A., Cunningham, C. C., Hartwig, J. H., Thomas, G. (1997). Cytoskeletal Protein ABP-280 Directs the Intracellular Trafficking of Furin and Modulates Proprotein Processing in the Endocytic Pathway. JCB 139: 1719-1733 [Abstract] [Full Text]  
• Fukata, M., Kuroda, S., Fujii, K., Nakamura, T., Shoji, I., Matsuura, Y., Okawa, K., Iwamatsu, A., Kikuchi, A., Kaibuchi, K. (1997). Regulation of Cross-linking of Actin Filament by IQGAP1, a Target for Cdc42. J. Biol. Chem. 272: 29579-29583 [Abstract] [Full Text]  
• Svitkina, T. M., Verkhovsky, A. B., McQuade, K. M., Borisy, G. G. (1997). Analysis of the Actin-Myosin II System in Fish Epidermal Keratocytes: Mechanism of Cell Body Translocation. JCB 139: 397-415 [Abstract] [Full Text]  
• Marti, A., Luo, Z., Cunningham, C., Ohta, Y., Hartwig, J., Stossel, T. P., Kyriakis, J. M., Avruch, J. (1997). Actin-biding Protein-280 Binds the Stress-activated Protein Kinase (SAPK) Activator SEK-1 and Is Required for Tumor Necrosis Factor-alpha Activation of SAPK in Melanoma Cells. J. Biol. Chem. 272: 2620-2628 [Abstract] [Full Text]  
• Meyer, S. C., Zuerbig, S., Cunningham, C. C., Hartwig, J. H., Bissell, T., Gardner, K., Fox, J. E.B. (1997). Identification of the Region in Actin-binding Protein that Binds to the Cytoplasmic Domain of Glycoprotein Ibalpha. J. Biol. Chem. 272: 2914-2919 [Abstract] [Full Text]  
• Edwards, D., Towb, P, Wasserman, S. (1997). An activity-dependent network of interactions links the Rel protein Dorsal with its cytoplasmic regulators. Development 124: 3855-3864 [Abstract]  
• Ikonen, E, de Almeid, J., Fath, K., Burgess, D., Ashman, K, Simons, K, Stow, J. (1997). Myosin II is associated with Golgi membranes: identification of p200 as nonmuscle myosin II on Golgi-derived vesicles. J. Cell Sci. 110: 2155-2164 [Abstract]  
• Li, X., Bennett, V. (1996). Identification of the Spectrin Subunit and Domains Required for Formation of Spectrin/Adducin/Actin Complexes. J. Biol. Chem. 271: 15695-15702 [Abstract] [Full Text]  
• Ohta, Y., Hartwig, J. H. (1996). Phosphorylation of Actin-binding Protein 280 by Growth Factors Is Mediated by p90 Ribosomal Protein S6 Kinase. J. Biol. Chem. 271: 11858-11864 [Abstract] [Full Text]  
• Stossel, T. (1993). On the crawling of animal cells. Science 260: 1086-1094 [Abstract]  
• Provance, D., McDowall, A, Marko, M, Luby-Phelps, K (1993). Cytoarchitecture of size-excluding compartments in living cells. J. Cell Sci. 106: 565-577 [Abstract]  
• Watt, F., Kubler, M., Hotchin, N., Nicholson, L., Adams, J. (1993). Regulation of keratinocyte terminal differentiation by integrin-extracellular matrix interactions. J. Cell Sci. 106: 175-182 [Abstract]  
• Luna, E., Hitt, A. (1992). Cytoskeleton--plasma membrane interactions. Science 258: 955-964 [Abstract]  
• Cunningham, C., Gorlin, J., Kwiatkowski, D., Hartwig, J., Janmey, P., Byers, H., Stossel, T. (1992). Actin-binding protein requirement for cortical stability and efficient locomotion. Science 255: 325-327 [Abstract]  
• Browne, K. A., Johnstone, R. W., Jans, D. A., Trapani, J. A. (2000). Filamin (280-kDa Actin-binding Protein) Is a Caspase Substrate and Is Also Cleaved Directly by the Cytotoxic T Lymphocyte Protease Granzyme B during Apoptosis. J. Biol. Chem. 275: 39262-39266 [Abstract] [Full Text]  
• Sasaki, A., Masuda, Y., Ohta, Y., Ikeda, K., Watanabe, K. (2001). Filamin Associates with Smads and Regulates Transforming Growth Factor-beta Signaling. J. Biol. Chem. 276: 17871-17877 [Abstract] [Full Text]  
• Hjalm, G., MacLeod, R. J., Kifor, O., Chattopadhyay, N., Brown, E. M. (2001). Filamin-A Binds to the Carboxyl-terminal Tail of the Calcium-sensing Receptor, an Interaction That Participates in CaR-mediated Activation of Mitogen-activated Protein Kinase. J. Biol. Chem. 276: 34880-34887 [Abstract] [Full Text]  
• D'Addario, M., Arora, P. D., Fan, J., Ganss, B., Ellen, R. P., McCulloch, C. A. G. (2001). Cytoprotection against Mechanical Forces Delivered through beta 1 Integrins Requires Induction of Filamin A. J. Biol. Chem. 276: 31969-31977 [Abstract] [Full Text]  
• van der Flier, A., Kuikman, I., Kramer, D., Geerts, D., Kreft, M., Takafuta, T., Shapiro, S. S., Sonnenberg, A. (2002). Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin {beta} subunits. JCB 156: 361-376 [Abstract] [Full Text]  

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