ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18)

doi:10.1083/jcb.111.6.3129

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ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18)

MS Diamond, DE Staunton, AR de Fougerolles, SA Stacker, J Garcia-Aguilar, ML Hibbs and TA Springer
Committee on Cell and Developmental Biology, Harvard Medical School, Boston, Massachusetts 02115.

While the leukocyte integrin lymphocyte function-associated antigen (LFA)-1 has been demonstrated to bind intercellular adhesion molecule (ICAM)-1, results with the related Mac-1 molecule have been controversial. We have used multiple cell binding assays, purified Mac- 1 and ICAM-1, and cell lines transfected with Mac-1 and ICAM-1 cDNAs to examine the interaction of ICAM-1 with Mac-1. Stimulated human umbilical vein endothelial cells (HUVECs), which express a high surface density of ICAM-1, bind to immunoaffinity-purified Mac-1 adsorbed to artificial substrates in a manner that is inhibited by mAbs to Mac-1 and ICAM-1. Transfected murine L cells or monkey COS cells expressing human ICAM-1 bind to purified Mac-1 in a specific and dose-dependent manner; the attachment to Mac-1 is more temperature sensitive, lower in avidity, and blocked by a different series of ICAM-1 mAbs when compared to LFA-1. In a reciprocal assay, COS cells cotransfected with the alpha and beta chain cDNAs of Mac-1 or LFA-1 attach to immunoaffinity- purified ICAM-1 substrates; this adhesion is blocked by mAbs to ICAM-1 and Mac-1 or LFA-1. Two color fluorescence cell conjugate experiments show that neutrophils stimulated with fMLP bind to HUVEC stimulated with lipopolysaccharide for 24 h in an ICAM-1-, Mac-1-, and LFA-1- dependent fashion. Because cellular and purified Mac-1 interact with cellular and purified ICAM-1, we conclude that ICAM-1 is a counter receptor for Mac-1 and that this receptor pair is responsible, in part, for the adhesion between stimulated neutrophils and stimulated endothelial cells.
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Woolhouse, I. S., Bayley, D. L., Lalor, P., Adams, D. H., Stockley, R. A. (2005). Endothelial interactions of neutrophils under flow in chronic obstructive pulmonary disease. Eur Respir J 25: 612-617 [Abstract] [Full Text]
Ehirchiou, D., Xiong, Y.-M., Li, Y., Brew, S., Zhang, L. (2005). Dual Function for a Unique Site within the {beta}2I Domain of Integrin {alpha}M{beta}2. J. Biol. Chem. 280: 8324-8331 [Abstract] [Full Text]
Muro, S., Gajewski, C., Koval, M., Muzykantov, V. R. (2005). ICAM-1 recycling in endothelial cells: a novel pathway for sustained intracellular delivery and prolonged effects of drugs. Blood 105: 650-658 [Abstract] [Full Text]
Solovjov, D. A., Pluskota, E., Plow, E. F. (2005). Distinct Roles for the {alpha} and {beta} Subunits in the Functions of Integrin {alpha}M{beta}2. J. Biol. Chem. 280: 1336-1345 [Abstract] [Full Text]
Chavakis, E., Aicher, A., Heeschen, C., Sasaki, K.-i., Kaiser, R., El Makhfi, N., Urbich, C., Peters, T., Scharffetter-Kochanek, K., Zeiher, A. M., Chavakis, T., Dimmeler, S. (2005). Role of {beta}2-integrins for homing and neovascularization capacity of endothelial progenitor cells. JEM 201: 63-72 [Abstract] [Full Text]
Parry, C., Bell, S., Minson, T., Browne, H. (2005). Herpes simplex virus type 1 glycoprotein H binds to {alpha}v{beta}3 integrins. J. Gen. Virol. 86: 7-10 [Abstract] [Full Text]
Flick, M. J., Du, X., Degen, J. L. (2004). Fibrin(ogen)-{alpha}M{beta}2 Interactions Regulate Leukocyte Function and Innate Immunity In Vivo. Exp. Biol. Med. 229: 1105-1110 [Abstract] [Full Text]
van Deventer, S J H, Tami, J A, Wedel, M K, European Colitis Study Group, (2004). A randomised, controlled, double blind, escalating dose study of alicaforsen enema in active ulcerative colitis. Gut 53: 1646-1651 [Abstract] [Full Text]
Bode, L., Rudloff, S., Kunz, C., Strobel, S., Klein, N. (2004). Human milk oligosaccharides reduce platelet-neutrophil complex formation leading to a decrease in neutrophil {beta} 2 integrin expression. J. Leukoc. Biol. 76: 820-826 [Abstract] [Full Text]
Otto, V. I., Schurpf, T., Folkers, G., Cummings, R. D. (2004). Sialylated Complex-type N-Glycans Enhance the Signaling Activity of Soluble Intercellular Adhesion Molecule-1 in Mouse Astrocytes. J. Biol. Chem. 279: 35201-35209 [Abstract] [Full Text]
Hidalgo, A., Peired, A. J., Weiss, L. A., Katayama, Y., Frenette, P. S. (2004). The integrin {alpha}M{beta}2 anchors hematopoietic progenitors in the bone marrow during enforced mobilization. Blood 104: 993-1001 [Abstract] [Full Text]
Zen, K., Babbin, B. A., Liu, Y., Whelan, J. B., Nusrat, A., Parkos, C. A. (2004). JAM-C Is a Component of Desmosomes and a Ligand for CD11b/CD18-mediated Neutrophil Transepithelial Migration. Mol. Biol. Cell 15: 3926-3937 [Abstract] [Full Text]
Hoefer, I. E., van Royen, N., Rectenwald, J. E., Deindl, E., Hua, J., Jost, M., Grundmann, S., Voskuil, M., Ozaki, C. K., Piek, J. J., Buschmann, I. R. (2004). Arteriogenesis Proceeds via ICAM-1/Mac-1- Mediated Mechanisms. Circ. Res. 94: 1179-1185 [Abstract] [Full Text]
Wetzel, A., Chavakis, T., Preissner, K. T., Sticherling, M., Haustein, U.-F., Anderegg, U., Saalbach, A. (2004). Human Thy-1 (CD90) on Activated Endothelial Cells Is a Counterreceptor for the Leukocyte Integrin Mac-1 (CD11b/CD18). J. Immunol. 172: 3850-3859 [Abstract] [Full Text]
Mankelow, T. J., Spring, F. A., Parsons, S. F., Brady, R. L., Mohandas, N., Chasis, J. A., Anstee, D. J. (2004). Identification of critical amino-acid residues on the erythroid intercellular adhesion molecule-4 (ICAM-4) mediating adhesion to {alpha}V integrins. Blood 103: 1503-1508 [Abstract] [Full Text]
Hagi-Pavli, E., Farthing, P. M., Kapas, S. (2004). Stimulation of adhesion molecule expression in human endothelial cells (HUVEC) by adrenomedullin and corticotrophin. Am. J. Physiol. Cell Physiol. 286: C239-C246 [Abstract] [Full Text]
Dunne, J. L., Collins, R. G., Beaudet, A. L., Ballantyne, C. M., Ley, K. (2003). Mac-1, but Not LFA-1, Uses Intercellular Adhesion Molecule-1 to Mediate Slow Leukocyte Rolling in TNF-{alpha}-Induced Inflammation. J. Immunol. 171: 6105-6111 [Abstract] [Full Text]
Nishi, N., Shoji, H., Seki, M., Itoh, A., Miyanaka, H., Yuube, K., Hirashima, M., Nakamura, T. (2003). Galectin-8 modulates neutrophil function via interaction with integrin {alpha}M. Glycobiology 13: 755-763 [Abstract] [Full Text]
Hatoum, O. A., Miura, H., Binion, D. G. (2003). The vascular contribution in the pathogenesis of inflammatory bowel disease. Am. J. Physiol. Heart Circ. Physiol. 285: H1791-H1796 [Full Text]
Kiefmann, R., Heckel, K., Dorger, M., Schenkat, S., Stoeckelhuber, M., Wesierska-Gadek, J., Goetz, A. E. (2003). Role of poly(ADP-ribose) synthetase in pulmonary leukocyte recruitment. Am. J. Physiol. Lung Cell. Mol. Physiol. 285: L996-L1005 [Abstract] [Full Text]
Muro, S., Cui, X., Gajewski, C., Murciano, J.-C., Muzykantov, V. R., Koval, M. (2003). Slow intracellular trafficking of catalase nanoparticles targeted to ICAM-1 protects endothelial cells from oxidative stress. Am. J. Physiol. Cell Physiol. 285: C1339-C1347 [Abstract] [Full Text]
El-Azami-El-Idrissi, M., Bauche, C., Loucka, J., Osicka, R., Sebo, P., Ladant, D., Leclerc, C. (2003). Interaction of Bordetella pertussis Adenylate Cyclase with CD11b/CD18: ROLE OF TOXIN ACYLATION AND IDENTIFICATION OF THE MAIN INTEGRIN INTERACTION DOMAIN. J. Biol. Chem. 278: 38514-38521 [Abstract] [Full Text]
Tada, H., Sugawara, S., Nemoto, E., Imamura, T., Potempa, J., Travis, J., Shimauchi, H., Takada, H. (2003). Proteolysis of ICAM-1 on Human Oral Epithelial Cells by Gingipains. JDR 82: 796-801 [Abstract] [Full Text]
Li, Y., Zhang, L. (2003). The Fourth Blade within the {beta}-Propeller Is Involved Specifically in C3bi Recognition by Integrin {alpha}M{beta}2. J. Biol. Chem. 278: 34395-34402 [Abstract] [Full Text]
Willeke, T., Schymeinsky, J., Prange, P., Zahler, S., Walzog, B. (2003). A role for Syk-kinase in the control of the binding cycle of the {beta}2 integrins (CD11/CD18) in human polymorphonuclear neutrophils. J. Leukoc. Biol. 74: 260-269 [Abstract] [Full Text]
Xiong, Y.-M., Chen, J., Zhang, L. (2003). Modulation of CD11b/CD18 Adhesive Activity by Its Extracellular, Membrane-Proximal Regions. J. Immunol. 171: 1042-1050 [Abstract] [Full Text]
Han, K. H., Chen, Y., Chang, M. K., Han, Y. C., Park, J.-H., Green, S. R., Boullier, A., Quehenberger, O. (2003). LDL activates signaling pathways leading to an increase in cytosolic free calcium and stimulation of CD11b expression in monocytes. J. Lipid Res. 44: 1332-1340 [Abstract] [Full Text]
Kevil, C. G., Chidlow, J. H., Bullard, D. C., Kucik, D. F. (2003). High-temporal-resolution analysis demonstrates that ICAM-1 stabilizes WEHI 274.1 monocytic cell rolling on endothelium. Am. J. Physiol. Cell Physiol. 285: C112-C118 [Abstract] [Full Text]
Murciano, J.-C., Muro, S., Koniaris, L., Christofidou-Solomidou, M., Harshaw, D. W., Albelda, S. M., Granger, D. N., Cines, D. B., Muzykantov, V. R. (2003). ICAM-directed vascular immunotargeting of antithrombotic agents to the endothelial luminal surface. Blood 101: 3977-3984 [Abstract] [Full Text]
Long, K. H., Gomez, F. J., Morris, R. E., Newman, S. L. (2003). Identification of Heat Shock Protein 60 as the Ligand on Histoplasma capsulatum That Mediates Binding to CD18 Receptors on Human Macrophages. J. Immunol. 170: 487-494 [Abstract] [Full Text]
Xiong, Y.-M., Haas, T. A., Zhang, L. (2002). Identification of Functional Segments within the beta 2I-domain of Integrin alpha Mbeta 2. J. Biol. Chem. 277: 46639-46644 [Abstract] [Full Text]
Luppi, P., Haluszczak, C., Betters, D., Richard, C. A. H., Trucco, M., DeLoia, J. A. (2002). Monocytes are progressively activated in the circulation of pregnant women. J. Leukoc. Biol. 72: 874-884 [Abstract] [Full Text]
Zen, K., Liu, Y., Cairo, D., Parkos, C. A. (2002). CD11b/CD18-Dependent Interactions of Neutrophils with Intestinal Epithelium Are Mediated by Fucosylated Proteoglycans. J. Immunol. 169: 5270-5278 [Abstract] [Full Text]
Takami, M., Terry, V., Petruzzelli, L. (2002). Signaling Pathways Involved in IL-8-Dependent Activation of Adhesion Through Mac-1. J. Immunol. 168: 4559-4566 [Abstract] [Full Text]
Welzenbach, K., Hommel, U., Weitz-Schmidt, G. (2002). Small Molecule Inhibitors Induce Conformational Changes in the I Domain and the I-like Domain of Lymphocyte Function-associated Antigen-1. MOLECULAR INSIGHTS INTO INTEGRIN INHIBITION. J. Biol. Chem. 277: 10590-10598 [Abstract] [Full Text]
Cherry, L. K., Weber, K. S. C., Klickstein, L. B. (2001). A Dominant Jurkat T Cell Mutation That Inhibits LFA-1-Mediated Cell Adhesion Is Associated with Increased Cell Growth. J. Immunol. 167: 6171-6179 [Abstract] [Full Text]
Akimov, S. S., Belkin, A. M. (2001). Cell surface tissue transglutaminase is involved in adhesion and migration of monocytic cells on fibronectin. Blood 98: 1567-1576 [Abstract] [Full Text]
Rahman, A., Anwar, K. N., Uddin, S., Xu, N., Ye, R. D., Platanias, L. C., Malik, A. B. (2001). Protein Kinase C-{delta} Regulates Thrombin-Induced ICAM-1 Gene Expression in Endothelial Cells via Activation of p38 Mitogen-Activated Protein Kinase. Mol. Cell. Biol. 21: 5554-5565 [Abstract] [Full Text]
Berkova, N., Lemay, A., Dresser, D. W., Fontaine, J.-Y., Kerizit, J., Goupil, S. (2001). Haptoglobin is present in human endometrium and shows elevated levels in the decidua during pregnancy. Mol Hum Reprod 7: 747-754 [Abstract] [Full Text]
Kobayashi, A., Imamura, H., Isobe, M., Matsuyama, Y., Soeda, J., Matsunaga, K., Kawasaki, S. (2001). Mac-1 (CD11b/CD18) and intercellular adhesion molecule-1 in ischemia-reperfusion injury of rat liver. Am. J. Physiol. Gastrointest. Liver Physiol. 281: G577-G585 [Abstract] [Full Text]
Danilov, S. M., Gavrilyuk, V. D., Franke, F. E., Pauls, K., Harshaw, D. W., McDonald, T. D., Miletich, D. J., Muzykantov, V. R. (2001). Lung uptake of antibodies to endothelial antigens: key determinants of vascular immunotargeting. Am. J. Physiol. Lung Cell. Mol. Physiol. 280: L1335-L1347 [Abstract] [Full Text]
Takami, M., Herrera, R., Petruzzelli, L. (2001). Mac-1-dependent tyrosine phosphorylation during neutrophil adhesion. Am. J. Physiol. Cell Physiol. 280: C1045-C1056 [Abstract] [Full Text]
Hafezi-Moghadam, A., Thomas, K. L., Prorock, A. J., Huo, Y., Ley, K. (2001). L-Selectin Shedding Regulates Leukocyte Recruitment. JEM 193: 863-872 [Abstract] [Full Text]
Christensen, J. E., Andreasen, S. O., Christensen, J. P., Thomsen, A. R. (2001). CD11b expression as a marker to distinguish between recently activated effector CD8+ T cells and memory cells. Int Immunol 13: 593-600 [Abstract] [Full Text]
Huang, G. T.-J., Kim, D., Lee, J. K.-H., Kuramitsu, H. K., Haake, S. K. (2001). Interleukin-8 and Intercellular Adhesion Molecule 1 Regulation in Oral Epithelial Cells by Selected Periodontal Bacteria: Multiple Effects of Porphyromonas gingivalis via Antagonistic Mechanisms. Infect. Immun. 69: 1364-1372 [Abstract] [Full Text]
Smorenburg, S. M., Van Noorden, C. J. F. (2001). The Complex Effects of Heparins on Cancer Progression and Metastasis in Experimental Studies. Pharmacol. Rev. 53: 93-106 [Abstract] [Full Text]
Forlow, S. B., Ley, K. (2001). Selectin-independent leukocyte rolling and adhesion in mice deficient in E-, P-, and L-selectin and ICAM-1. Am. J. Physiol. Heart Circ. Physiol. 280: H634-H641 [Abstract] [Full Text]
May, R., Machesky, L. (2001). Phagocytosis and the actin cytoskeleton. J. Cell Sci. 114: 1061-1077 [Abstract]
Sans, E., Delachanal, E., Duperray, A. (2001). Analysis of the Roles of ICAM-1 in Neutrophil Transmigration Using a Reconstituted Mammalian Cell Expression Model: Implication of ICAM-1 Cytoplasmic Domain and Rho-Dependent Signaling Pathway. J. Immunol. 166: 544-551 [Abstract] [Full Text]
Ghiran, I., Barbashov, S. F., Klickstein, L. B., Tas, S. W., Jensenius, J. C., Nicholson-Weller, A. (2000). Complement Receptor 1/Cd35 Is a Receptor for Mannan-Binding Lectin. JEM 192: 1797-1808 [Abstract] [Full Text]
Seki, M., Higashiyama, Y., Kadota, J.-i., Mukae, H., Yanagihara, K., Tomono, K., Kohno, S. (2000). Elevated Levels of Soluble Adhesion Molecules in Sera and BAL Fluid of Individuals Infected With Human T-Cell Lymphotropic Virus Type 1. Chest 118: 1754-1761 [Abstract] [Full Text]
Orchekowski, R. P., Plescia, J., Altieri, D. C., Bajt, M. L. (2000). {alpha}M{beta}2 (CD11b/CD18, Mac-1) integrin activation by a unique monoclonal antibody to {alpha}M I domain that is divalent cation-sensitive. J. Leukoc. Biol. 68: 641-649 [Abstract] [Full Text]
Tyagi, S., Klickstein, L. B., Nicholson-Weller, A. (2000). C5a-stimulated human neutrophils use a subset of {beta}2 integrins to support the adhesion-dependent phase of superoxide production. J. Leukoc. Biol. 68: 679-686 [Abstract] [Full Text]
Greenstein, S., Barnard, J., Zhou, K., Fong, M., Hendey, B. (2000). Fas activation reduces neutrophil adhesion to endothelial cells. J. Leukoc. Biol. 68: 715-722 [Abstract] [Full Text]
Belcher, J. D., Marker, P. H., Weber, J. P., Hebbel, R. P., Vercellotti, G. M. (2000). Activated monocytes in sickle cell disease: potential role in the activation of vascular endothelium and vaso-occlusion. Blood 96: 2451-2459 [Abstract] [Full Text]
Tan, S.-M., Hyland, R. H., Al-Shamkhani, A., Douglass, W. A., Shaw, J. M., Law, S. K. A. (2000). Effect of Integrin {beta}2 Subunit Truncations on LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) Assembly, Surface Expression, and Function. J. Immunol. 165: 2574-2581 [Abstract] [Full Text]
Willeke, T., Behrens, S., Scharffetter-Kochanek, K., Gaehtgens, P., Walzog, B. (2000). {beta}2 Integrin (CD11/CD18)-mediated signaling involves tyrosine phosphorylation of c-Cbl in human neutrophils. J. Leukoc. Biol. 68: 284-292 [Abstract] [Full Text]
Gopalan, P. K., Burns, A. R., Simon, S. I., Sparks, S., McIntire, L. V., Smith, C. W. (2000). Preferential sites for stationary adhesion of neutrophils to cytokine-stimulated HUVEC under flow conditions. J. Leukoc. Biol. 68: 47-57 [Abstract] [Full Text]
Lu, H., Ballantyne, C., Smith, C. W. (2000). LFA-1 (CD11a/CD18) triggers hydrogen peroxide production by canine neutrophils. J. Leukoc. Biol. 68: 73-80 [Abstract] [Full Text]
Wanten, G. J. A., Geijtenbeek, T. B. H., Raymakers, R. A. P., van Kooyk, Y., Roos, D., Jansen, J. B. M. J., Naber, A. H. J. (2000). Medium-Chain, Triglyceride-Containing Lipid Emulsions Increase Human Neutrophil {beta} 2 Integrin Expression, Adhesion, and Degranulation. JPEN J Parenter Enteral Nutr 24: 228-233 [Abstract]
Sheng, N., Fairbanks, M. B., Heinrikson, R. L., Canziani, G., Chaiken, I. M., Mosser, D. M., Zhang, H., Colman, R. W. (2000). Cleaved high molecular weight kininogen binds directly to the integrin CD11b/CD18 (Mac-1) and blocks adhesion to fibrinogen and ICAM-1. Blood 95: 3788-3795 [Abstract] [Full Text]
Olson, K. K., Townson, D. H. (2000). Prolactin-Induced Expression of Intercellular Adhesion Molecule-1 and the Accumulation of Monocytes/Macrophages During Regression of the Rat Corpus Luteum. Biol. Reprod. 62: 1571-1578 [Abstract] [Full Text]
Yu, X, Miyamoto, S, Mekada, E (2000). Integrin alpha 2 beta 1-dependent EGF receptor activation at cell-cell contact sites. J. Cell Sci. 113: 2139-2147 [Abstract]
Kelly, T. A., Jeanfavre, D. D., McNeil, D. W., Woska, J. R. Jr., Reilly, P. L., Mainolfi, E. A., Kishimoto, K. M., Nabozny, G. H., Zinter, R., Bormann, B.-J., Rothlein, R. (1999). Cutting Edge: A Small Molecule Antagonist of LFA-1-Mediated Cell Adhesion. J. Immunol. 163: 5173-5177 [Abstract] [Full Text]
Tas, S. W., Klickstein, L. B., Barbashov, S. F., Nicholson-Weller, A. (1999). C1q and C4b Bind Simultaneously to CR1 and Additively Support Erythrocyte Adhesion. J. Immunol. 163: 5056-5063 [Abstract] [Full Text]
WALZOG, B., WEINMANN, P., JEBLONSKI, F., SCHARFFETTER-KOCHANEK, K., BOMMERT, K., GAEHTGENS, P. (1999). A role for {beta}2 integrins (CD11/CD18) in the regulation of cytokine gene expression of polymorphonuclear neutrophils during the inflammatory response. FASEB J. 13: 1855-1865 [Abstract] [Full Text]