The muscle regulatory gene, Myf-6, has a biphasic pattern of expression during early mouse development

doi:10.1083/jcb.113.6.1255

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The muscle regulatory gene, Myf-6, has a biphasic pattern of expression during early mouse development

E Bober, GE Lyons, T Braun, G Cossu, M Buckingham and HH Arnold
Department of Toxicology, Medical School, University of Hamburg, Germany.

The spatial and temporal expression pattern of the muscle regulatory gene Myf-6 (MRF4/herculin) has been investigated by in situ hybridization during embryonic and fetal mouse development. Here, we report that the Myf-6 gene shows a biphasic pattern of expression. Myf- 6 transcripts are first detected in the most rostral somites of the mouse embryo at 9 d of gestation and accumulate progressively in myotomal cells along the rostro-caudal axis. This expression is transient and Myf-6 mRNA can no longer be detected in myotomal cells after day 12 post coitum (p.c.). In contrast to other muscle determination genes (MyoD1, myogenin, Myf-5), Myf-6 mRNA is not detected in limb buds or visceral arches and skeletal muscle of the mouse embryo (day 8-15 p.c.). In fetal mice, Myf-6 transcripts appear at day 16 p.c. in all skeletal muscles, and the gene continues to be expressed at a high level after birth. These results suggest that early Myf-6 expression may be restricted to a population of myogenic cells that does not contribute to the embryonic muscle masses in limb buds and visceral arches. The reappearance of Myf-6 mRNA in fetal skeletal muscle coincides approximately with secondary muscle fiber formation and the onset of innervation.
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Teboul, L., Hadchouel, J., Daubas, P., Summerbell, D., Buckingham, M., Rigby, P. W. J. (2002). The early epaxial enhancer is essential for the initial expression of the skeletal muscle determination gene Myf5 but not for subsequent, multiple phases of somitic myogenesis. Development 129: 4571-4580 [Abstract] [Full Text]
Marshall, W. F., Rosenbaum, J. L. (2001). Intraflagellar transport balances continuous turnover of outer doublet microtubules: implications for flagellar length control. JCB 155: 405-414 [Abstract] [Full Text]
Launay, T., Armand, A.-S., Charbonnier, F., Mira, J.-C., Donsez, E., Gallien, C. L., Chanoine, C. (2001). Expression and Neural Control of Myogenic Regulatory Factor Genes During Regeneration of Mouse Soleus. J. Histochem. Cytochem. 49: 887-900 [Abstract] [Full Text]
Carvajal, J., Cox, D, Summerbell, D, Rigby, P. (2001). A BAC transgenic analysis of the Mrf4/Myf5 locus reveals interdigitated elements that control activation and maintenance of gene expression during muscle development. Development 128: 1857-1868 [Abstract]
Brohmann, H, Jagla, K, Birchmeier, C (2000). The role of Lbx1 in migration of muscle precursor cells. Development 127: 437-445 [Abstract]
Wilson-Rawls, J, Hurt, C., Parsons, S., Rawls, A (1999). Differential regulation of epaxial and hypaxial muscle development by paraxis. Development 126: 5217-5229 [Abstract]
Kucharczuk, K., Love, C., Dougherty, N., Goldhamer, D. (1999). Fine-scale transgenic mapping of the MyoD core enhancer: MyoD is regulated by distinct but overlapping mechanisms in myotomal and non-myotomal muscle lineages. Development 126: 1957-1965 [Abstract]
Dietrich, S, Abou-Rebyeh, F, Brohmann, H, Bladt, F, Sonnenberg-Riethmacher, E, Yamaai, T, Lumsden, A, Brand-Saberi, B, Birchmeier, C (1999). The role of SF/HGF and c-Met in the development of skeletal muscle. Development 126: 1621-1629 [Abstract]
Hacker, A, Guthrie, S (1998). A distinct developmental programme for the cranial paraxial mesoderm in the chick embryo. Development 125: 3461-3472 [Abstract]
Rawls, A, Valdez, M., Zhang, W, Richardson, J, Klein, W., Olson, E. (1998). Overlapping functions of the myogenic bHLH genes MRF4 and MyoD revealed in double mutant mice. Development 125: 2349-2358 [Abstract]
Dietrich, S, Schubert, F., Healy, C, Sharpe, P., Lumsden, A (1998). Specification of the hypaxial musculature. Development 125: 2235-2249 [Abstract]
Fontaine-Perus, J, Halgand, P, Cheraud, Y, Rouaud, T, Velasco, M., Cifuentes Diaz, C, Rieger, F (1997). Mouse-chick chimera: a developmental model of murine neurogenic cells. Development 124: 3025-3036 [Abstract]
Wang, Y, Jaenisch, R (1997). Myogenin can substitute for Myf5 in promoting myogenesis but less efficiently. Development 124: 2507-2513 [Abstract]
Zacksenhaus, E, Jiang, Z, Chung, D, Marth, J D, Phillips, R A, Gallie, B L (1996). pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis.. Genes Dev. 10: 3051-3064 [Abstract]
Pownall, M., Strunk, K., Emerson, C. (1996). Notochord signals control the transcriptional cascade of myogenic bHLH genes in somites of quail embryos. Development 122: 1475-1488 [Abstract]
Grass, S, Arnold, H., Braun, T (1996). Alterations in somite patterning of Myf-5-deficient mice: a possible role for FGF-4 and FGF-6. Development 122: 141-150 [Abstract]
Zhang, W, Behringer, R R, Olson, E N (1995). Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies.. Genes Dev. 9: 1388-1399 [Abstract]
Black, B. L., Martin, J. F., Olson, E. N. (1995). The Mouse MRF4 Promoter Is trans-Activated Directly and Indirectly by Muscle-specific Transcription Factors. J. Biol. Chem. 270: 2889-2892 [Abstract] [Full Text]
Patapoutian, A, Yoon, J., Miner, J., Wang, S, Stark, K, Wold, B (1995). Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome. Development 121: 3347-3358 [Abstract]
Munsterberg, A., Lassar, A. (1995). Combinatorial signals from the neural tube, floor plate and notochord induce myogenic bHLH gene expression in the somite. Development 121: 651-660 [Abstract]
Hayashi, K, Ozawa, E (1995). Myogenic cell migration from somites is induced by tissue contact with medial region of the presumptive limb mesoderm in chick embryos. Development 121: 661-669 [Abstract]
Sarnat, H. B. (1994). New Insights Into the Pathogenesis of Congenital Myopathies. J Child Neurol 9: 193-201 [Abstract]
Bober, E, Brand-Saberi, B, Ebensperger, C, Wilting, J, Balling, R, Paterson, B., Arnold, H., Christ, B (1994). Initial steps of myogenesis in somites are independent of influence from axial structures. Development 120: 3073-3082 [Abstract]
Braun, T, Bober, E, Rudnicki, M., Jaenisch, R, Arnold, H. (1994). MyoD expression marks the onset of skeletal myogenesis in Myf-5 mutant mice. Development 120: 3083-3092 [Abstract]
Cusella-De Angelis, M., Molinari, S, Le Donne, A, Coletta, M, Vivarelli, E, Bouche, M, Molinaro, M, Ferrari, S, Cossu, G (1994). Differential response of embryonic and fetal myoblasts to TGF beta: a possible regulatory mechanism of skeletal muscle histogenesis. Development 120: 925-933 [Abstract]
Bober, E, Franz, T, Arnold, H., Gruss, P, Tremblay, P (1994). Pax-3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells. Development 120: 603-612 [Abstract]
Cheng, T., Wallace, M., Merlie, J., Olson, E. (1993). Separable regulatory elements governing myogenin transcription in mouse embryogenesis. Science 261: 215-218 [Abstract]
Yee, S P, Rigby, P W (1993). The regulation of myogenin gene expression during the embryonic development of the mouse.. Genes Dev. 7: 1277-1289 [Abstract]
Brand, M, Jarman, A., Jan, L., Jan, Y. (1993). asense is a Drosophila neural precursor gene and is capable of initiating sense organ formation. Development 119: 1-17 [Abstract]
Hughes, S., Taylor, J., Tapscott, S., Gurley, C., Carter, W., Peterson, C. (1993). Selective accumulation of MyoD and myogenin mRNAs in fast and slow adult skeletal muscle is controlled by innervation and hormones. Development 118: 1137-1147 [Abstract]
Faerman, A, Shani, M (1993). The expression of the regulatory myosin light chain 2 gene during mouse embryogenesis. Development 118: 919-929 [Abstract]
Patapoutian, A, Miner, J., Lyons, G., Wold, B (1993). Isolated sequences from the linked Myf-5 and MRF4 genes drive distinct patterns of muscle-specific expression in transgenic mice. Development 118: 61-69 [Abstract]
Ontell, M, Ontell, M., Sopper, M., Mallonga, R, Lyons, G, Buckingham, M (1993). Contractile protein gene expression in primary myotubes of embryonic mouse hindlimb muscles. Development 117: 1435-1444 [Abstract]
Smith, T., Block, N., Rhodes, S., Konieczny, S., Miller, J. (1993). A unique pattern of expression of the four muscle regulatory factor proteins distinguishes somitic from embryonic, fetal and newborn mouse myogenic cells. Development 117: 1125-1133 [Abstract]
Braun, T, Bober, E, Arnold, H H (1992). Inhibition of muscle differentiation by the adenovirus E1a protein: repression of the transcriptional activating function of the HLH protein Myf-5.. Genes Dev. 6: 888-902 [Abstract]
Goldhamer, D., Faerman, A, Shani, M, Emerson, C. Jr (1992). Regulatory elements that control the lineage-specific expression of myoD. Science 256: 538-542 [Abstract]