A VCAM-like adhesion molecule on murine bone marrow stromal cells mediates binding of lymphocyte precursors in culture

doi:10.1083/jcb.114.3.557

This Article

	Full Text (PDF, 1199K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JCB
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Miyake, K.
	Articles by Kincade, P. W.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Miyake, K.
	Articles by Kincade, P. W.


Social Bookmarking

	What's this?

ARTICLES

A VCAM-like adhesion molecule on murine bone marrow stromal cells mediates binding of lymphocyte precursors in culture

K Miyake, K Medina, K Ishihara, M Kimoto, R Auerbach and PW Kincade
Oklahoma Medical Research Foundation, Oklahoma City 73104.

Two new mAbs (M/K-1 and M/K-2) define an adhesion molecule expressed on stromal cell clones derived from murine bone marrow. The protein is similar in size to a human endothelial cell adhesion molecule known as VCAM-1 or INCAM110. VCAM-1 is expressed on endothelial cells in inflammatory sites and recognized by the integrin VLA-4 expressed on lymphocytes and monocytes. The new stromal cell molecule is a candidate ligand for the VLA-4 expressed on immature B lineage lymphocytes and a possible homologue of human VCAM-1. We now report additional similarities in the distribution, structure, and function of these proteins. The M/K antibodies detected large cells in normal bone marrow, as well as rare cells in other tissues. The antigen was constitutively expressed and functioned as a cell adhesion molecule on cultured murine endothelial cells. It correlated with the presence of mRNA which hybridized to a human VCAM-1 cDNA probe. Partial NH2 terminal amino acid sequencing of the murine protein revealed similarities to VCAM-1 and attachment of human lymphoma cells to murine endothelial cell lines was inhibited by the M/K antibodies. All of these observations suggest that the murine and human cell adhesion proteins may be related. The antibodies selectively interfered with B lymphocyte formation when included in long term bone marrow cultures. Moreover, they caused rapid detachment of lymphocytes from the adherent layer when added to preestablished cultures. The VCAM-like cell adhesion molecule on stromal cells and VLA-4 on lymphocyte precursors may both be important for B lymphocyte formation.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Slack-Davis, J. K., Atkins, K. A., Harrer, C., Hershey, E. D., Conaway, M. (2009). Vascular Cell Adhesion Molecule-1 Is a Regulator of Ovarian Cancer Peritoneal Metastasis. Cancer Res. 69: 1469-1476 [Abstract] [Full Text]
Yamashita, T., Ohneda, O., Sakiyama, A., Iwata, F., Ohneda, K., Fujii-Kuriyama, Y. (2008). The microenvironment for erythropoiesis is regulated by HIF-2{alpha} through VCAM-1 in endothelial cells. Blood 112: 1482-1492 [Abstract] [Full Text]
Moriyama, Y., Sekine, C., Koyanagi, A., Koyama, N., Ogata, H., Chiba, S., Hirose, S., Okumura, K., Yagita, H. (2008). Delta-like 1 is essential for the maintenance of marginal zone B cells in normal mice but not in autoimmune mice. Int Immunol 20: 763-773 [Abstract] [Full Text]
Li, W., Ishihara, K., Yokota, T., Nakagawa, T., Koyama, N., Jin, J., Mizuno-Horikawa, Y., Wang, X., Miyoshi, E., Taniguchi, N., Kondo, A. (2008). Reduced {alpha}4 1 Integrin/VCAM-1 Interactions Lead to Impaired Pre-B Cell Repopulation in Alpha 1,6-Fucosyltransferase Deficient Mice. Glycobiology 18: 114-124 [Abstract] [Full Text]
Wu, X., Guo, R., Wang, Y., Cunningham, P. N. (2007). The role of ICAM-1 in endotoxin-induced acute renal failure. Am. J. Physiol. Renal Physiol. 293: F1262-F1271 [Abstract] [Full Text]
Matsutani, T., Tanaka, T., Tohya, K., Otani, K., Jang, M. H., Umemoto, E., Taniguchi, K., Hayasaka, H., Ueda, K., Miyasaka, M. (2007). Plasmacytoid dendritic cells employ multiple cell adhesion molecules sequentially to interact with high endothelial venule cells molecular basis of their trafficking to lymph nodes. Int Immunol 0: dxm088v1-dxm088 [Abstract] [Full Text]
Fernekorn, U., Butcher, E. C., Behrends, J., Karsten, C. M., Robke, A., Schulze, T. J., Kirchner, H., Kruse, A. (2007). Selectin, Platelet Plays a Critical Role in Granulocyte Access to the Pregnant Mouse Uterus Under Physiological and Pathological Conditions. Biol. Reprod. 76: 645-653 [Abstract] [Full Text]
Lin, K.-Y., Lu, D., Hung, C.-F., Peng, S., Huang, L., Jie, C., Murillo, F., Rowley, J., Tsai, Y.-C., He, L., Kim, D.-J., Jaffee, E., Pardoll, D., Wu, T.-C. (2007). Ectopic Expression of Vascular Cell Adhesion Molecule-1 as a New Mechanism for Tumor Immune Evasion. Cancer Res. 67: 1832-1841 [Abstract] [Full Text]
Woodside, D. G., Kram, R. M., Mitchell, J. S., Belsom, T., Billard, M. J., McIntyre, B. W., Vanderslice, P. (2006). Contrasting Roles for Domain 4 of VCAM-1 in the Regulation of Cell Adhesion and Soluble VCAM-1 Binding to Integrin {alpha}4beta1.. J. Immunol. 176: 5041-5049 [Abstract] [Full Text]
Engelhardt, B., Kempe, B., Merfeld-Clauss, S., Laschinger, M., Furie, B., Wild, M. K., Vestweber, D. (2005). P-Selectin Glycoprotein Ligand 1 Is Not Required for the Development of Experimental Autoimmune Encephalomyelitis in SJL and C57BL/6 Mice. J. Immunol. 175: 1267-1275 [Abstract] [Full Text]
Ulyanova, T., Scott, L. M., Priestley, G. V., Jiang, Y., Nakamoto, B., Koni, P. A., Papayannopoulou, T. (2005). VCAM-1 expression in adult hematopoietic and nonhematopoietic cells is controlled by tissue-inductive signals and reflects their developmental origin. Blood 106: 86-94 [Abstract] [Full Text]
Olson, D. L., Burkly, L. C., Leone, D. R., Dolinski, B. M., Lobb, R. R. (2005). Anti-{alpha}4 integrin monoclonal antibody inhibits multiple myeloma growth in a murine model. Molecular Cancer Therapeutics 4: 91-99 [Abstract] [Full Text]
Mori, Y., Shimizu, N., Dallas, M., Niewolna, M., Story, B., Williams, P. J., Mundy, G. R., Yoneda, T. (2004). Anti-{alpha}4 integrin antibody suppresses the development of multiple myeloma and associated osteoclastic osteolysis. Blood 104: 2149-2154 [Abstract] [Full Text]
Wertheim, J. A., Perera, S. A., Hammer, D. A., Ren, R., Boettiger, D., Pear, W. S. (2003). Localization of BCR-ABL to F-actin regulates cell adhesion but does not attenuate CML development. Blood 102: 2220-2228 [Abstract] [Full Text]
Oritani, K., Hirota, S., Nakagawa, T., Takahashi, I., Kawamoto, S.-i., Yamada, M., Ishida, N., Kadoya, T., Tomiyama, Y., Kincade, P. W., Matsuzawa, Y. (2003). T lymphocytes constitutively produce an interferonlike cytokine limitin characterized as a heat- and acid-stable and heparin-binding glycoprotein. Blood 101: 178-185 [Abstract] [Full Text]
Wols, H. A. M., Underhill, G. H., Kansas, G. S., Witte, P. L. (2002). The Role of Bone Marrow-Derived Stromal Cells in the Maintenance of Plasma Cell Longevity. J. Immunol. 169: 4213-4221 [Abstract] [Full Text]
Gray Parkin, K., Stephan, R. P., Apilado, R.-G., Lill-Elghanian, D. A., Lee, K. P., Saha, B., Witte, P. L. (2002). Expression of CD28 by Bone Marrow Stromal Cells and Its Involvement in B Lymphopoiesis. J. Immunol. 169: 2292-2302 [Abstract] [Full Text]
Kruse, A., Martens, N., Fernekorn, U., Hallmann, R., Butcher, E. C. (2002). Alterations in the Expression of Homing-Associated Molecules at the Maternal/Fetal Interface During the Course of Pregnancy. Biol. Reprod. 66: 333-345 [Abstract] [Full Text]
Manabe, N., Kawaguchi, H., Chikuda, H., Miyaura, C., Inada, M., Nagai, R., Nabeshima, Y.-i., Nakamura, K., Sinclair, A. M., Scheuermann, R. H., Kuro-o, M. (2001). Connection Between B Lymphocyte and Osteoclast Differentiation Pathways. J. Immunol. 167: 2625-2631 [Abstract] [Full Text]
Levesque, J.-P., Takamatsu, Y., Nilsson, S. K., Haylock, D. N., Simmons, P. J. (2001). Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor. Blood 98: 1289-1297 [Abstract] [Full Text]
Tu, Z., Kelley, V. R., Collins, T., Lee, F. S. (2001). I{{kappa}}B Kinase Is Critical for TNF-{{alpha}}-Induced VCAM1 Gene Expression in Renal Tubular Epithelial Cells. J. Immunol. 166: 6839-6846 [Abstract] [Full Text]
Leuker, C. E., Labow, M., Muller, W., Wagner, N. (2001). Neonatally Induced Inactivation of the Vascular Cell Adhesion Molecule 1 Gene Impairs B Cell Localization and T Cell-Dependent Humoral Immune Response. JEM 193: 755-768 [Abstract] [Full Text]
Koni, P. A., Joshi, S. K., Temann, U.-A., Olson, D., Burkly, L., Flavell, R. A. (2001). Conditional Vascular Cell Adhesion Molecule 1 Deletion in Mice: Impaired Lymphocyte Migration to Bone Marrow. JEM 193: 741-754 [Abstract] [Full Text]
Pender, S. L. F., Salmela, M. T., Monteleone, G., Schnapp, D., McKenzie, C., Spencer, J., Fong, S., Saarialho-Kere, U., MacDonald, T. T. (2000). Ligation of {{alpha}}4{beta}1 Integrin on Human Intestinal Mucosal Mesenchymal Cells Selectively Up-Regulates Membrane Type-1 Matrix Metalloproteinase and Confers a Migratory Phenotype. Am. J. Pathol. 157: 1955-1962 [Abstract] [Full Text]
Wong, C. W.Y., Wiedle, G., Ballestrem, C., Wehrle-Haller, B., Etteldorf, S., Bruckner, M., Engelhardt, B., Gisler, R. H., Imhof, B. A. (2000). PECAM-1/CD31 Trans-homophilic Binding at the Intercellular Junctions Is Independent of Its Cytoplasmic Domain; Evidence for Heterophilic Interaction with Integrin alpha vbeta 3 in Cis. Mol. Biol. Cell 11: 3109-3121 [Abstract] [Full Text]
Mudry, R. E., Fortney, J. E., York, T., Hall, B. M., Gibson, L. F. (2000). Stromal cells regulate survival of B-lineage leukemic cells during chemotherapy. Blood 96: 1926-1932 [Abstract] [Full Text]
Michigami, T., Shimizu, N., Williams, P. J., Niewolna, M., Dallas, S. L., Mundy, G. R., Yoneda, T. (2000). Cell-cell contact between marrow stromal cells and myeloma cells via VCAM-1 and alpha 4beta 1-integrin enhances production of osteoclast-stimulating activity. Blood 96: 1953-1960 [Abstract] [Full Text]
Komatsu, S., Berg, R. D., Russell, J. M., Nimura, Y., Granger, D. N. (2000). Enteric microflora contribute to constitutive ICAM-1 expression on vascular endothelial cells. Am. J. Physiol. Gastrointest. Liver Physiol. 279: G186-G191 [Abstract] [Full Text]
Lalancette, M., Aoudjit, F., Potworowski, E. F., St-Pierre, Y. (2000). Resistance of ICAM-1-deficient mice to metastasis overcome by increased aggressiveness of lymphoma cells. Blood 95: 314-319 [Abstract] [Full Text]
Izawa, D., Tanaka, T., Saito, K., Ogihara, H., Usui, T., Kawamoto, S., Matsubara, K., Okubo, K., Miyasaka, M. (1999). Expression profile of active genes in mouse lymph node high endothelial cells. Int Immunol 11: 1989-1998 [Abstract] [Full Text]
Kruse, A., Hallmann, R., Butcher, E. C. (1999). Specialized Patterns of Vascular Differentiation Antigens in the Pregnant Mouse Uterus and the Placenta. Biol. Reprod. 61: 1393-1401 [Abstract] [Full Text]
Liu, Z.-J., Tanaka, Y., Fujimoto, H., Mine, S., Morinobu, A., Yagita, H., Okumura, K., Oishi, I., Udagawa, J., Yamamura, H., Minami, Y. (1999). A Novel Role for H-Ras in the Regulation of Very Late Antigen-4 Integrin and VCAM-1 Via c-Myc-Dependent and -Independent Mechanisms. J. Immunol. 163: 4901-4908 [Abstract] [Full Text]
Node, K., Huo, Y., Ruan, X., Yang, B., Spiecker, M., Ley, K., Zeldin, D. C., Liao, J. K. (1999). Anti-inflammatory Properties of Cytochrome P450 Epoxygenase-Derived Eicosanoids. Science 285: 1276-1279 [Abstract] [Full Text]
Estess, P., Nandi, A., Mohamadzadeh, M., Siegelman, M. H. (1999). Interleukin 15 Induces Endothelial Hyaluronan Expression in Vitro and Promotes Activated T Cell Extravasation through a Cd44-Dependent Pathway in Vivo. JEM 190: 9-20 [Abstract] [Full Text]
Ramos, C. L., Huo, Y., Jung, U., Ghosh, S., Manka, D. R., Sarembock, I. J., Ley, K. (1999). Direct Demonstration of P-Selectin� and VCAM-1�Dependent Mononuclear Cell Rolling in Early Atherosclerotic Lesions of Apolipoprotein E�Deficient Mice. Circ. Res. 84: 1237-1244 [Abstract] [Full Text]
Berlin-Rufenach, C., Otto, F., Mathies, M., Westermann, J., Owen, M. J., Hamann, A., Hogg, N. (1999). Lymphocyte Migration in Lymphocyte Function-associated Antigen (LFA)-1-deficient Mice. JEM 189: 1467-1478 [Abstract] [Full Text]
Oritani, K., Tomiyama, Y., Kincade, P. W., Aoyama, K., Yokota, T., Matsumura, I., Kanakura, Y., Nakajima, K., Hirano, T., Matsuzawa, Y. (1999). Both Stat3-Activation and Stat3-Independent BCL2 Downregulation Are Important for Interleukin-6-Induced Apoptosis of 1A9-M Cells. Blood 93: 1346-1354 [Abstract] [Full Text]
Mori, N, Horie, Y, Gerritsen, M E, Anderson, D C, Granger, D N (1999). Anti-inflammatory drugs and endothelial cell adhesion molecule expression in murine vascular beds. Gut 44: 186-195 [Abstract] [Full Text]
Cortes, F., Deschaseaux, F., Uchida, N., Labastie, M.-C., Friera, A. M., He, D., Charbord, P., Peault, B. (1999). HCA, an Immunoglobulin-Like Adhesion Molecule Present on the Earliest Human Hematopoietic Precursor Cells, Is Also Expressed by Stromal Cells in Blood-Forming Tissues. Blood 93: 826-837 [Abstract] [Full Text]
Wülfing, C., Davis, M. M. (1998). A Receptor/Cytoskeletal Movement Triggered by Costimulation During T Cell Activation. Science 282: 2266-2269 [Abstract] [Full Text]
Liu, Z.-J., Tanaka, Y., Mine, S., Morinobu, A., Yagita, H., Okumura, K., Taniguchi, T., Yamamura, H., Minami, Y. (1998). Functional Cooperation of Cyclin C and c-Myc in Mediating Homotypic Cell Adhesion Via Very Late Antigen-4 Activation and Vascular Cell Adhesion Molecule-1 Induction. Blood 92: 4700-4711 [Abstract] [Full Text]
Frenette, P. S., Subbarao, S., Mazo, I. B., von Andrian, U. H., Wagner, D. D. (1998). Endothelial selectins and vascular cell adhesion molecule-1 promote hematopoietic progenitor homing to bone marrow. Proc. Natl. Acad. Sci. USA 95: 14423-14428 [Abstract] [Full Text]
Bauer, S. R., Ruiz-Hidalgo, M. J., Rudikoff, E. K., Goldstein, J., Laborda, J. (1998). Modulated Expression of the Epidermal Growth Factor-Like Homeotic Protein dlk Influences Stromal-Cell-Pre-B-Cell Interactions, Stromal Cell Adipogenesis, and Pre-B-Cell Interleukin-7 Requirements. Mol. Cell. Biol. 18: 5247-5255 [Abstract] [Full Text]
Aoudjit, F., Potworowski, E. F., Springer, T. A., St-Pierre, Y. (1998). Protection from Lymphoma Cell Metastasis in ICAM-1 Mutant Mice: A Posthoming Event. J. Immunol. 161: 2333-2338 [Abstract] [Full Text]
Vermeulen, M., Le Pesteur, F., Gagnerault, M.-C., Mary, J.-Y., Sainteny, F., Lepault, F. (1998). Role of Adhesion Molecules in the Homing and Mobilization of Murine Hematopoietic Stem and Progenitor Cells. Blood 92: 894-900 [Abstract] [Full Text]
Ray, R. J., Stoddart, A., Pennycook, J. L., Huner, H. O., Furlonger, C., Wu, G. E., Paige, C. J. (1998). Stromal Cell-Independent Maturation of IL-7-Responsive Pro-B Cells. J. Immunol. 160: 5886-5897 [Abstract] [Full Text]
Broide, D. H., Humber, D., Sriramarao, P. (1998). Inhibition of Eosinophil Rolling and Recruitment in P-Selectin- and Intracellular Adhesion Molecule-1-Deficient Mice. Blood 91: 2847-2856 [Abstract] [Full Text]
Jesse, T. L., LaChance, R., Iademarco, M. F., Dean, D. C. (1998). Interferon Regulatory Factor-2 Is a Transcriptional Activator in Muscle Where It Regulates Expression of Vascular Cell Adhesion Molecule-1. JCB 140: 1265-1276 [Abstract] [Full Text]
Stephan, R. P., Reilly, C. R., Witte, P. L. (1998). Impaired Ability of Bone Marrow Stromal Cells to Support B-Lymphopoiesis With Age. Blood 91: 75-88 [Abstract] [Full Text]
Oritani, K., Kanakura, Y., Aoyama, K., Yokota, T., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Tomiyama, Y., Matsuzawa, Y., Kincade, P. W. (1997). Matrix Glycoprotein SC1/ECM2 Augments B Lymphopoiesis. Blood 90: 3404-3413 [Abstract] [Full Text]
Miyaura, C., Onoe, Y., Inada, M., Maki, K., Ikuta, K., Ito, M., Suda, T. (1997). Increased B-lymphopoiesis by interleukin 7�induces bone loss in mice with intact ovarian function: Similarity to estrogen�deficiency. Proc. Natl. Acad. Sci. USA 94: 9360-9365 [Abstract] [Full Text]
Henninger, D. D., Gerritsen, M. E., Granger, D. N. (1997). Low-Density Lipoprotein Receptor Knockout Mice Exhibit Exaggerated Microvascular Responses to Inflammatory Stimuli. Circ. Res. 81: 274-281 [Abstract] [Full Text]
Salomon, D. R., Crisa, L., Mojcik, C. F., Ishii, J. K., Klier, G., Shevach, E. M. (1997). Vascular Cell Adhesion Molecule-1 Is Expressed by Cortical Thymic Epithelial Cells and Mediates Thymocyte Adhesion. Implications for the Function of alpha 4beta 1 (VLA4) Integrin in T-Cell Development. Blood 89: 2461-2471 [Abstract] [Full Text]
Isobe, T., Hisaoka, T., Shimizu, A., Okuno, M., Aimoto, S., Takada, Y., Saito, Y., Takagi, J. (1997). Propolypeptide of von Willebrand Factor Is a Novel Ligand for Very Late Antigen-4 Integrin. J. Biol. Chem. 272: 8447-8453 [Abstract] [Full Text]
Kimble, R. B., Srivastava, S., Ross, F. P., Matayoshi, A., Pacifici, R. (1996). Estrogen Deficiency Increases the Ability of Stromal Cells to Support Murine Osteoclastogenesis via an Interleukin-1and Tumor Necrosis Factor-mediated Stimulation of Macrophage Colony-stimulating Factor Production. J. Biol. Chem. 271: 28890-28897 [Abstract] [Full Text]
Kwee, L, Baldwin, H., Shen, H., Stewart, C., Buck, C, Buck, C., Labow, M. (1995). Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice. Development 121: 489-503 [Abstract]
Yang, J., Rayburn, H, Hynes, R. (1995). Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development. Development 121: 549-560 [Abstract]
Gurtner, G C, Davis, V, Li, H, McCoy, M J, Sharpe, A, Cybulsky, M I (1995). Targeted disruption of the murine VCAM1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentation.. Genes Dev. 9: 1-14 [Abstract]
Prakapas, Z, Denoyelle, M, Dargemont, C, Kroese, F., Thiery, J., Deugnier, M. (1993). Enrichment and characterization of thymus-repopulating cells in stroma-dependent cultures of rat bone marrow. J. Cell Sci. 104: 1039-1048 [Abstract]
Tulin, E. E., Onoda, N., Maeda, M., Hasegawa, M., Nosaka, T., Nomura, H., Asano, S., Kitamura, T. (2001). A Novel Secreted Form of Immune Suppressor Factor with High Homology to Vacuolar ATPases Identified by a Forward Genetic Approach of Functional Screening Based on Cell Proliferation. J. Biol. Chem. 276: 27519-27526 [Abstract] [Full Text]