The Journal of Cell Biology, Vol 114, 567-576, Copyright © 1991 by The Rockefeller University Press

ARTICLES

Kalinin: an epithelium-specific basement membrane adhesion molecule that is a component of anchoring filaments

P Rousselle, GP Lunstrum, DR Keene and RE Burgeson
Shriners Hospital for Crippled Children, Portland, Oregon 97201.

Basal keratinocytes attach to the underlying dermal stroma through an ultrastructurally unique and complex basement membrane zone. Electron- dense plaques along the basal surface plasma membrane, termed hemidesmosomes, appear to attach directly to the lamina densa of the basement membrane through fine strands, called anchoring filaments. The lamina densa is secured to the stroma through a complex of type VII collagen containing anchoring fibrils and anchoring plaques. We have identified what we believe is a novel antigen unique to this tissue region. The mAbs to this antigen localize to the anchoring filaments, just below the basal-dense plate of the hemidesmosomes. In cell culture, the antigen is deposited upon the culture substate by growing and migrating human keratinocytes. Addition of mAb to the cultures causes the cells to round and detach, but does not impair them metabolically. Skin fragments incubated with antibody extensively de- epithelialize. These findings strongly suggest that this antigen is intimately involved in attachment of keratinocytes to the basement membrane. This antigen was isolated from keratinocyte cultures by immunoaffinity chromatography. Two molecules are observed. The most intact species contains three nonidentical chains, 165, 155, and 140 kD linked by interchain disulfide bonds. The second and more abundant species contains the 165- and 140-kD chains, but the 155-kD chain has been proteolytically cleaved to 105 kD. Likewise, two rotary-shadowed images are observed. The larger of the two, presumably corresponding to the most intact form, appears as an asymmetric 107-nm-long rod, with a single globule at one end and two smaller globules at the other. The more abundant species, presumably the proteolytically cleaved form, lacks the distal small globule. We propose the name "kalinin" for this new molecule.
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• Deugnier, M., Faraldo, M., Rousselle, P, Thiery, J., Glukhova, M. (1999). Cell-extracellular matrix interactions and EGF are important regulators of the basal mammary epithelial cell phenotype. J. Cell Sci. 112: 1035-1044 [Abstract]  
• Lampe, P. D., Nguyen, B. P., Gil, S., Usui, M., Olerud, J., Takada, Y., Carter, W. G. (1998). Cellular Interaction of Integrin {alpha}3{beta}1 with Laminin 5 Promotes Gap Junctional Communication. JCB 143: 1735-1747 [Abstract] [Full Text]  
• Sahlberg, C., Hormia, M., Airenne, T., Thesleffl, I. (1998). Laminin y2 Expression is Developmentally Regulated during Murine Tooth Morphogenesis and is Intense in Ameloblasts. JDR 77: 1589-1596 [Abstract]  
• Schaapveld, R. Q.J., Borradori, L., Geerts, D., van Leusden, M. R., Kuikman, I., Nievers, M. G., Niessen, C. M., Steenbergen, R. D.M., Snijders, P. J.F., Sonnenberg, A. (1998). Hemidesmosome Formation Is Initiated by the {beta}4 Integrin Subunit, Requires Complex Formation of {beta}4 and HD1/Plectin, and Involves a Direct Interaction between {beta}4 and the Bullous Pemphigoid Antigen 180. JCB 142: 271-284 [Abstract] [Full Text]  
• Virolle, T., Monthouel, M.-N., Djabari, Z., Ortonne, J.-P., Meneguzzi, G., Aberdam, D. (1998). Three Activator Protein-1-binding Sites Bound by the Fra-2·JunD Complex Cooperate for the Regulation of Murine Laminin alpha 3A (lama3A) Promoter Activity by Transforming Growth Factor-beta. J. Biol. Chem. 273: 17318-17325 [Abstract] [Full Text]  
• Hormia, M., Sahlberg, C., Thesleff, I., Airenne, T. (1998). The Epithelium-Tooth Interface-- A Basal Lamina Rich in Laminin-5 and Lacking Other Known Laminin Isoforms. JDR 77: 1479-1485 [Abstract]  
• Matsui, C., Pereira, P., Wang, C. K., Nelson, C. F., Kutzkey, T., Lanigan, C., Woodley, D., Morohashi, M., Welsh, E. A., Hoeffler, W. K. (1998). Extent of Laminin-5 Assembly and Secretion Effect Junctional Epidermolysis Bullosa Phenotype. JEM 187: 1273-1283 [Abstract] [Full Text]  
• Goldfinger, L. E., Stack, M. S., Jones, J. C.R. (1998). Processing of Laminin-5 and Its Functional Consequences: Role of Plasmin and Tissue-type Plasminogen Activator. JCB 141: 255-265 [Abstract] [Full Text]  
• Nievers, M., Schaapveld, R., Oomen, L., Fontao, L, Geerts, D, Sonnenberg, A (1998). Ligand-independent role of the beta 4 integrin subunit in the formation of hemidesmosomes. J. Cell Sci. 111: 1659-1672 [Abstract]  
• Dogic, D, Rousselle, P, Aumailley, M (1998). Cell adhesion to laminin 1 or 5 induces isoform-specific clustering of integrins and other focal adhesion components. J. Cell Sci. 111: 793-802 [Abstract]  
• Dabelsteen, E. (1998). Molecular Biological Aspects of Acquired Bullous Diseases. CROBM 9: 162-178 [Abstract] [Full Text]  
• Iivanainen, A., Kortesmaa, J., Sahlberg, C., Morita, T., Bergmann, U., Thesleff, I., Tryggvason, K. (1997). Primary Structure, Developmental Expression, and Immunolocalization of the Murine Laminin alpha 4 Chain. J. Biol. Chem. 272: 27862-27868 [Abstract] [Full Text]  
• Shimizu, H., Sato, M., Ban, M., Kitajima, Y., Ishizaki, S., Harada, T., Bruckner-Tuderman, L., Fine, J.-D., Burgeson, R., Kon, A., McGrath, J. A., Christiano, A. M., Uitto, J., Nishikawa, T. (1997). Immunohistochemical, Ultrastructural, and Molecular Features of Kindler Syndrome Distinguish It From Dystrophic Epidermolysis Bullosa. Arch Dermatol 133: 1111-1117 [Abstract]  
• Ferrigno, O., Virolle, T., Galliano, M.-F., Chauvin, N., Ortonne, J.-P., Meneguzzi, G., Aberdam, D. (1997). Murine Laminin alpha 3A and alpha 3B Isoform Chains Are Generated by Usage of Two Promoters and Alternative Splicing. J. Biol. Chem. 272: 20502-20507 [Abstract] [Full Text]  
• Rousselle, P., Keene, D. R., Ruggiero, F., Champliaud, M.-F., Rest, M. v. d., Burgeson, R. E. (1997). Laminin 5 Binds the NC-1 Domain of Type VII Collagen. JCB 138: 719-728 [Abstract] [Full Text]  
• Lee, S., Solow-Cordero, D. E., Kessler, E., Takahara, K., Greenspan, D. S. (1997). Transforming Growth Factor-beta Regulation of Bone Morphogenetic Protein-1/Procollagen C-proteinase and Related Proteins in Fibrogenic Cells and Keratinocytes. J. Biol. Chem. 272: 19059-19066 [Abstract] [Full Text]  
• Chen, M., Marinkovich, M. P., Veis, A., Cai, X., Rao, C. N., O'Toole, E. A., Woodley, D. T. (1997). Interactions of the Amino-terminal Noncollagenous (NC1) Domain of Type VII Collagen with Extracellular Matrix Components. A POTENTIAL ROLE IN EPIDERMAL-DERMAL ADHERENCE IN HUMAN SKIN. J. Biol. Chem. 272: 14516-14522 [Abstract] [Full Text]  
• Miner, J. H., Patton, B. L., Lentz, S. I., Gilbert, D. J., Snider, W. D., Jenkins, N. A., Copeland, N. G., Sanes, J. R. (1997). The Laminin {alpha} Chains: Expression, Developmental Transitions, and Chromosomal Locations of {alpha}1-5, Identification of Heterotrimeric Laminins 8-11, and Cloning of a Novel {alpha}3 Isoform. JCB 137: 685-701 [Abstract] [Full Text]  
• DiPersio, C. M., Hodivala-Dilke, K. M., Jaenisch, R., Kreidberg, J. A., Hynes, R. O. (1997). {alpha}3{beta}1 Integrin Is Required for Normal Development of the Epidermal Basement Membrane. JCB 137: 729-742 [Abstract] [Full Text]  

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