Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10

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Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10

DM Bradham, A Igarashi, RL Potter and GR Grotendorst
Department of Ophthalmology, University of South Florida College of Medicine, Tampa 33620.

Human umbilical vein endothelial (HUVE) cells have been previously reported to express the genes for the A and B chains of PDGF and to secrete PDGF-related factors into culture media. Antihuman PDGF IgG affinity chromatography was used to purify PDGF-related activity from HUVE cell-conditioned media. Immunoblot analysis of the affinity- purified proteins with anti-PDGF IgG and antibodies specific for the A or B chain peptides of PDGF combined with chemotactic and mitogenic assays revealed that the major PDGF immunorelated molecule secreted by HUVE cells is a monomer of approximately 36-38 kD and that less than 10% of the purified biologically active molecules are PDGF A or B chain peptides. Screening of an HUVE cell cDNA library in the expression vector lambda gtl 1 with the anti-PDGF antibody resulted in the cloning and sequencing of a cDNA with an open reading frame encoding a 38-kD cysteine-rich secreted protein which we show to be the major PDGF- related mitogen secreted by human vascular endothelial cells. The protein has a 45% overall homology to the translation product of the v- src-induced CEF-10 mRNA from chick embryo fibroblasts. We have termed this new mitogen connective tissue growth factor.
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Vorwerk, P, Wex, H, Hohmann, B, Mohnike, K, Schmidt, U, Mittler, U (2002). Expression of components of the IGF signalling system in childhood acute lymphoblastic leukaemia. Mol. Pathol. 55: 40-45 [Abstract] [Full Text]
Xie, D., Nakachi, K., Wang, H., Elashoff, R., Koeffler, H. P. (2001). Elevated Levels of Connective Tissue Growth Factor, WISP-1, and CYR61 in Primary Breast Cancers Associated with More Advanced Features. Cancer Res. 61: 8917-8923 [Abstract] [Full Text]
Folger, P. A., Zekaria, D., Grotendorst, G., Masur, S. K. (2001). Transforming Growth Factor-{beta}-Stimulated Connective Tissue Growth Factor Expression during Corneal Myofibroblast Differentiation. IOVS 42: 2534-2541 [Abstract] [Full Text]
Gupta, N, Wang, H, McLeod, T L, Naus, C C G, Kyurkchiev, S, Advani, S, Yu, J, Perbal, B, Weichselbaum, R R (2001). Inhibition of glioma cell growth and tumorigenic potential by CCN3 (NOV). Mol. Pathol. 54: 293-299 [Abstract] [Full Text]
HEUSINGER-RIBEIRO, J., EBERLEIN, M., WAHAB, N. A., GOPPELT-STRUEBE, M. (2001). Expression of Connective Tissue Growth Factor in Human Renal Fibroblasts: Regulatory Roles of RhoA and cAMP. J. Am. Soc. Nephrol. 12: 1853-1861 [Abstract] [Full Text]
Martinerie, C., Gicquel, C., Louvel, A., Laurent, M., Schofield, P. N., Le Bouc, Y. (2001). Altered Expression of novH Is Associated with Human Adrenocortical Tumorigenesis. J. Clin. Endocrinol. Metab. 86: 3929-3940 [Abstract] [Full Text]
Maillard, M, Cadot, B, Ball, R Y, Sethia, K, Edwards, D R, Perbal, B, Tatoud, R (2001). Differential expression of the ccn3 (nov) proto-oncogene in human prostate cell lines and tissues. Mol. Pathol. 54: 275-280 [Abstract] [Full Text]
Pan, L-H., Yamauchi, K., Uzuki, M., Nakanishi, T., Takigawa, M., Inoue, H., Sawai, T. (2001). Type II alveolar epithelial cells and interstitial fibroblasts express connective tissue growth factor in IPF. Eur Respir J 17: 1220-1227 [Abstract] [Full Text]
Schütze, N, Rücker, N, Müller, J, Adamski, J, Jakob, F (2001). 5' flanking sequence of the human immediate early responsive gene ccn1 (cyr61) and mapping of polymorphic CA repeat sequence motifs in the human ccn1 (cyr61) locus. Mol. Pathol. 54: 170-175 [Abstract] [Full Text]
Leask, A, Sa, S, Holmes, A, Shiwen, X, Black, C M, Abraham, D J (2001). The control of ccn2 (ctgf) gene expression in normal and scleroderma fibroblasts. Mol. Pathol. 54: 180-183 [Abstract] [Full Text]
Riewald, M., Kravchenko, V. V., Petrovan, R. J., O'Brien, P. J., Brass, L. F., Ulevitch, R. J., Ruf, W. (2001). Gene induction by coagulation factor Xa is mediated by activation of protease-activated receptor 1. Blood 97: 3109-3116 [Abstract] [Full Text]
Perbal, B (2001). NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issues. Mol. Pathol. 54: 57-79 [Abstract] [Full Text]
Perbal, B (2001). The CCN family of genes: a brief history. Mol. Pathol. 54: 103-104 [Full Text]
Sedlaczek, N., Jia, J.-D., Bauer, M., Herbst, H., Ruehl, M., Hahn, E. G., Schuppan, D. (2001). Proliferating Bile Duct Epithelial Cells Are a Major Source of Connective Tissue Growth Factor in Rat Biliary Fibrosis. Am. J. Pathol. 158: 1239-1244 [Abstract] [Full Text]
Slee, R. B., Hillier, S. G., Largue, P., Harlow, C. R., Miele, G., Clinton, M. (2001). Differentiation-Dependent Expression of Connective Tissue Growth Factor and Lysyl Oxidase Messenger Ribonucleic Acids in Rat Granulosa Cells. Endocrinology 142: 1082-1089 [Abstract] [Full Text]
ITO, Y., GOLDSCHMEDING, R., BENDE, R. J., CLAESSEN, N., CHAND, M. A., KLEIJ, L., RABELINK, T. J., WEENING, J. J., ATEN, J. (2001). Kinetics of Connective Tissue Growth Factor Expression during Experimental Proliferative Glomerulonephritis. J. Am. Soc. Nephrol. 12: 472-484 [Abstract] [Full Text]
Grotendorst, G. R., Lau, L. F., Perbal, B. (2001). CCN Proteins Are Distinct from, and Should Not Be Considered Members of, the Insulin-Like Growth Factor-Binding Protein Superfamily. J. Clin. Endocrinol. Metab. 86: 944-945 [Full Text]
Yamashiro, T., Fukunaga, T., Kobashi, N., Kamioka, H., Nakanishi, T., Takigawa, M., Takano-Yamamoto, T. (2001). Mechanical Stimulation Induces CTGF Expression in Rat Osteocytes. JDR 80: 461-465 [Abstract]
Uzumcu, M., Homsi, M.F.A., Ball, D.K., Coskun, S., Jaroudi, K., Hollanders, J.M.G., Brigstock, D.R. (2000). Localization of connective tissue growth factor in human uterine tissues. Mol Hum Reprod 6: 1093-1098 [Abstract] [Full Text]
Lopez-Bermejo, A., Buckway, C. K., Devi, G. R., Hwa, V., Plymate, S. R., Oh, Y., Rosenfeld, R. G. (2000). Characterization of Insulin-Like Growth Factor-Binding Protein-Related Proteins (IGFBP-rPs) 1, 2, and 3 in Human Prostate Epithelial Cells: Potential Roles for IGFBP-rP1 and 2 in Senescence of the Prostatic Epithelium. Endocrinology 141: 4072-4080 [Abstract] [Full Text]
Croix, B. St., Rago, C., Velculescu, V., Traverso, G., Romans, K. E., Montgomery, E., Lal, A., Riggins, G. J., Lengauer, C., Vogelstein, B., Kinzler, K. W. (2000). Genes Expressed in Human Tumor Endothelium. Science 289: 1197-1202 [Abstract] [Full Text]
Frazier, K. S., Paredes, A., Dube, P., Styer, E. (2000). Connective Tissue Growth Factor Expression in the Rat Remnant Kidney Model and Association with Tubular Epithelial Cells Undergoing Transdifferentiation. Vet Pathol 37: 328-335 [Abstract] [Full Text]