Coexpression of GMP-140 and PAF by endothelium stimulated by histamine or thrombin: a juxtacrine system for adhesion and activation of neutrophils

doi:10.1083/jcb.115.1.223

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Coexpression of GMP-140 and PAF by endothelium stimulated by histamine or thrombin: a juxtacrine system for adhesion and activation of neutrophils

DE Lorant, KD Patel, TM McIntyre, RP McEver, SM Prescott and GA Zimmerman
Nora Eccles Harrison Cardiovascular Research and Training Institute, Salt Lake City, Utah.

The adhesion of polymorphonuclear leukocytes (PMNs) to vascular endothelial cells (EC) is an early and fundamental event in acute inflammation. This process requires the regulated expression of molecules on both the EC and PMN. EC stimulated with histamine or thrombin coexpress two proadhesive molecules within minutes: granule membrane protein 140 (GMP-140), a member of the selectin family, and platelet-activating factor (PAF), a biologically active phospholipid. Coexpression of GMP-140 and PAF is required for maximal PMN adhesion and the two molecules act in a cooperative fashion. The component of adhesion mediated by EC-associated PAF requires activation of CD11/CD18 integrins on the PMN and binding of these heterodimers to counterreceptors on the EC. GMP-140 also binds to a receptor on the PMN; however, it tethers the PMN to the EC without requiring activation of CD11/CD18 integrins. This component of the adhesive interaction is blocked by antibodies to GMP-140 or by GMP-140 in the fluid phase. Experiments with purified GMP-140 indicate that binding to its receptor on the PMN does not directly induce PMN adhesiveness but that it potentiates the CD11/CD18-dependent adhesive response to PAF by a mechanism that involves events distal to the PAF receptor. Tethering of the PMN to the EC by GMP-140 may also be required for efficient interaction of PAF with its receptor on the PMN. These observations define a complex cell recognition system in which tethering of PMNs by a selectin, GMP-140, facilitates juxtacrine activation of the leukocytes by a signaling molecule, PAF. The latter event recruits the third component of the adhesive interaction, the CD11/CD18 integrins.
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Meyer, M. C., Creer, M. H., McHowat, J. (2005). Potential role for mast cell tryptase in recruitment of inflammatory cells to endothelium. Am. J. Physiol. Cell Physiol. 289: C1485-C1491 [Abstract] [Full Text]
Gill, V., Doig, C., Knight, D., Love, E., Kubes, P. (2005). Targeting Adhesion Molecules as a Potential Mechanism of Action for Intravenous Immunoglobulin. Circulation 112: 2031-2039 [Abstract] [Full Text]
Vinson, S. M., Rickard, A., Ryerse, J. S., McHowat, J. (2005). Neutrophil Adherence to Bladder Microvascular Endothelial Cells following Platelet-Activating Factor Acetylhydrolase Inhibition. J. Pharmacol. Exp. Ther. 314: 1241-1247 [Abstract] [Full Text]
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Yang, Y, Nemoto, E M, Harvey, S A K, Subbotin, V M, Gandhi, C R (2004). Increased hepatic platelet activating factor (PAF) and PAF receptors in carbon tetrachloride induced liver cirrhosis. Gut 53: 877-883 [Abstract] [Full Text]
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Vinten-Johansen, J. (2004). Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury. Cardiovasc Res 61: 481-497 [Abstract] [Full Text]
Minami, T., Sugiyama, A., Wu, S.-Q., Abid, R., Kodama, T., Aird, W. C. (2004). Thrombin and Phenotypic Modulation of the Endothelium. Arterioscler. Thromb. Vasc. Bio. 24: 41-53 [Abstract] [Full Text]
Kataoka, H., Hamilton, J. R., McKemy, D. D., Camerer, E., Zheng, Y.-W., Cheng, A., Griffin, C., Coughlin, S. R. (2003). Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells. Blood 102: 3224-3231 [Abstract] [Full Text]
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Alon, R., Aker, M., Feigelson, S., Sokolovsky-Eisenberg, M., Staunton, D. E., Cinamon, G., Grabovsky, V., Shamri, R., Etzioni, A. (2003). A novel genetic leukocyte adhesion deficiency in subsecond triggering of integrin avidity by endothelial chemokines results in impaired leukocyte arrest on vascular endothelium under shear flow. Blood 101: 4437-4445 [Abstract] [Full Text]
Aird, W. C. (2003). The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood 101: 3765-3777 [Abstract] [Full Text]
Nishijima, K., Kiryu, J., Tsujikawa, A., Honjo, M., Nonaka, A., Yamashiro, K., Kamizuru, H., Ieki, Y., Tanihara, H., Honda, Y., Ogura, Y. (2003). Inhibitory Effects of Antithrombin III on Interactions between Blood Cells and Endothelial Cells during Retinal Ischemia-Reperfusion Injury. IOVS 44: 332-341 [Abstract] [Full Text]
Wu, S.-Q., Minami, T., Donovan, D. J., Aird, W. C. (2002). The proximal serum response element in the Egr-1 promoter mediates response to thrombin in primary human endothelial cells. Blood 100: 4454-4461 [Abstract] [Full Text]
Matsui, N. M., Varki, A., Embury, S. H. (2002). Heparin inhibits the flow adhesion of sickle red blood cells to P-selectin. Blood 100: 3790-3796 [Abstract] [Full Text]
Pruefer, D., Makowski, J., Schnell, M., Buerke, U., Dahm, M., Oelert, H., Sibelius, U., Grandel, U., Grimminger, F., Seeger, W., Meyer, J., Darius, H., Buerke, M. (2002). Simvastatin Inhibits Inflammatory Properties of Staphylococcus aureus{alpha}-Toxin. Circulation 106: 2104-2110 [Abstract] [Full Text]
Mayer, K., Merfels, M., Muhly-Reinholz, M., Gokorsch, S., Rosseau, S., Lohmeyer, J., Schwarzer, N., Krull, M., Suttorp, N., Grimminger, F., Seeger, W. (2002). omega -3 Fatty acids suppress monocyte adhesion to human endothelial cells: role of endothelial PAF generation. Am. J. Physiol. Heart Circ. Physiol. 283: H811-H818 [Abstract] [Full Text]
Kubes, P., Payne, D., Woodman, R. C. (2002). Molecular mechanisms of leukocyte recruitment in postischemic liver microcirculation. Am. J. Physiol. Gastrointest. Liver Physiol. 283: G139-G147 [Abstract] [Full Text]
Minami, T., Aird, W. C. (2001). Thrombin Stimulation of the Vascular Cell Adhesion Molecule-1 Promoter in Endothelial Cells Is Mediated by Tandem Nuclear Factor-kappa B and GATA Motifs. J. Biol. Chem. 276: 47632-47641 [Abstract] [Full Text]
DiVietro, J. A., Smith, M. J., Smith, B. R. E., Petruzzelli, L., Larson, R. S., Lawrence, M. B. (2001). Immobilized IL-8 Triggers Progressive Activation of Neutrophils Rolling In Vitro on P-Selectin and Intercellular Adhesion Molecule-1. J. Immunol. 167: 4017-4025 [Abstract] [Full Text]
Kerfoot, S. M., Raharjo, E., Ho, M., Kaur, J., Serirom, S., McCafferty, D.-M., Burns, A. R., Patel, K. D., Kubes, P. (2001). Exclusive Neutrophil Recruitment with Oncostatin M in a Human System. Am. J. Pathol. 159: 1531-1539 [Abstract] [Full Text]
Marin, V., Montero-Julian, F. A., Gres, S., Boulay, V., Bongrand, P., Farnarier, C., Kaplanski, G. (2001). The IL-6-Soluble IL-6R{alpha} Autocrine Loop of Endothelial Activation as an Intermediate Between Acute and Chronic Inflammation: an Experimental Model Involving Thrombin. J. Immunol. 167: 3435-3442 [Abstract] [Full Text]
Al-Saady, N.M., Sopher, M. (2001). Prothrombotic markers in atrial fibrillation: what is new?. Eur Heart J 22: 1635-1639
Opal, S. M. (2001). Protein C Levels in Severe Sepsis. Chest 120: 699-701 [Full Text]
Zimmerman, G. A. (2001). Two by two: The pairings of P-selectin and P-selectin glycoprotein ligand 1. Proc. Natl. Acad. Sci. USA 98: 10023-10024 [Full Text]
Lindemann, S., Tolley, N. D., Dixon, D. A., McIntyre, T. M., Prescott, S. M., Zimmerman, G. A., Weyrich, A. S. (2001). Activated platelets mediate inflammatory signaling by regulated interleukin 1{beta} synthesis. JCB 154: 485-490 [Abstract] [Full Text]
Kaur, J., Woodman, R. C., Ostrovsky, L., Kubes, P. (2001). Selective recruitment of neutrophils and lymphocytes by thrombin: a role for NF-{kappa}B. Am. J. Physiol. Heart Circ. Physiol. 281: H784-H795 [Abstract] [Full Text]
Cinamon, G., Grabovsky, V., Winter, E., Franitza, S., Feigelson, S., Shamri, R., Dwir, O., Alon, R. (2001). Novel chemokine functions in lymphocyte migration through vascular endothelium under shear flow. J. Leukoc. Biol. 69: 860-866 [Abstract] [Full Text]
Tremblay, C., Paradis, M., Dore, M. (2001). Expression of E- and P-selectin in Tumor Necrosis Factor-induced Dermatitis in Dogs. Vet Pathol 38: 261-268 [Abstract] [Full Text]
Lefer, A. M. (2000). Platelets : Unindicted Coconspirators in Inflammatory Tissue Injury. Circ. Res. 87: 1077-1078 [Full Text]
Lindner, J. R., Kahn, M. L., Coughlin, S. R., Sambrano, G. R., Schauble, E., Bernstein, D., Foy, D., Hafezi-Moghadam, A., Ley, K. (2000). Delayed Onset of Inflammation in Protease-Activated Receptor-2-Deficient Mice. J. Immunol. 165: 6504-6510 [Abstract] [Full Text]
Lidington, E. A., Haskard, D. O., Mason, J. C. (2000). Induction of decay-accelerating factor by thrombin through a protease-activated receptor 1 and protein kinase C-dependent pathway protects vascular endothelial cells from complement-mediated injury. Blood 96: 2784-2792 [Abstract] [Full Text]
Kim, C. D., Kim, Y. K., Lee, S. H., Hong, K. W. (2000). Rebamipide Inhibits Neutrophil Adhesion to Hypoxia/Reoxygenation-Stimulated Endothelial Cells via Nuclear Factor-kappa B-Dependent Pathway. J. Pharmacol. Exp. Ther. 294: 864-869 [Abstract] [Full Text]
Davenpeck, K. L., Brummet, M. E., Hudson, S. A., Mayer, R. J., Bochner, B. S. (2000). Activation of Human Leukocytes Reduces Surface P-Selectin Glycoprotein Ligand-1 (PSGL-1, CD162) and Adhesion to P-Selectin In Vitro. J. Immunol. 165: 2764-2772 [Abstract] [Full Text]
Grabovsky, V., Feigelson, S., Chen, C., Bleijs, D. A., Peled, A., Cinamon, G., Baleux, F., Arenzana-Seisdedos, F., Lapidot, T., van Kooyk, Y., Lobb, R. R., Alon, R. (2000). Subsecond Induction of {alpha}4 Integrin Clustering by Immobilized Chemokines Stimulates Leukocyte Tethering and Rolling on Endothelial Vascular Cell Adhesion Molecule 1 under Flow Conditions. JEM 192: 495-506 [Abstract] [Full Text]
Cuzzocrea, S., Mazzon, E., Costantino, G., Serraino, I., De Sarro, A., Caputi, A. P. (2000). Effects of n-acetylcysteine in a rat model of ischemia and reperfusion injury. Cardiovasc Res 47: 537-548 [Abstract] [Full Text]
CUZZOCREA, S., MISKO, T. P., COSTANTINO, G., MAZZON, E., MICALI, A., CAPUTI, A. P., MACARTHUR, H., SALVEMINI, D. (2000). Beneficial effects of peroxynitrite decomposition catalyst in a rat model of splanchnic artery occlusion and reperfusion. FASEB J. 14: 1061-1072 [Abstract] [Full Text]
Simon, S. I., Hu, Y., Vestweber, D., Smith, C. W. (2000). Neutrophil Tethering on E-Selectin Activates {beta}2 Integrin Binding to ICAM-1 Through a Mitogen-Activated Protein Kinase Signal Transduction Pathway. J. Immunol. 164: 4348-4358 [Abstract] [Full Text]
Ostrovsky, L., Carvalho-Tavares, J., Woodman, R. C., Kubes, P. (2000). Translational inhibition of E-selectin expression stimulates P-selectin-dependent neutrophil recruitment. Am. J. Physiol. Heart Circ. Physiol. 278: H1225-H1232 [Abstract] [Full Text]
Hoshida, S., Yamashita, N., Otsu, K., Kuzuya, T., Hori, M. (2000). Cholesterol feeding exacerbates myocardial injury in Zucker diabetic fatty rats. Am. J. Physiol. Heart Circ. Physiol. 278: H256-H262 [Abstract] [Full Text]
Owaki, T., Meneshian, A., Maemura, K., Takao, S., Wang, D., Fuh, K. C., Bulkley, G. B., Klein, A. S. (2000). Endothelial cells potentiate phagocytic killing by macrophages via platelet-activating factor release. Am. J. Physiol. Heart Circ. Physiol. 278: H269-H276 [Abstract] [Full Text]
Pruefer, D., Scalia, R., Lefer, A. M. (1999). Simvastatin Inhibits Leukocyte-Endothelial Cell Interactions and Protects Against Inflammatory Processes in Normocholesterolemic Rats. Arterioscler. Thromb. Vasc. Bio. 19: 2894-2900 [Abstract] [Full Text]
Vergnolle, N. (1999). Proteinase-Activated Receptor-2-Activating Peptides Induce Leukocyte Rolling, Adhesion, and Extravasation In Vivo. J. Immunol. 163: 5064-5069 [Abstract] [Full Text]
Soede, R. D. M., Driessens, M. H. E., Ruuls-Van Stalle, L., Van Hulten, P. E. M., Brink, A., Roos, E. (1999). LFA-1 to LFA-1 Signals Involve {zeta}-Associated Protein-70 (ZAP-70) Tyrosine Kinase: Relevance for Invasion and Migration of a T Cell Hybridoma. J. Immunol. 163: 4253-4261 [Abstract] [Full Text]
Jordan, J. E., Zhao, Z.-Q., Vinten-Johansen, J. (1999). The role of neutrophils in myocardial ischemia-reperfusion injury. Cardiovasc Res 43: 860-878 [Abstract] [Full Text]
Arai, M., Masui, Y., Goldschmidt-Clermont, P., DiPaula, A., Siu, C., Kondo, T., Becker, L. C. (1999). P-selectin inhibition prevents early neutrophil activation but provides only modest protection against myocardial injury in dogs with ischemia and forty-eight hours reperfusion. J Am Coll Cardiol 34: 280-288 [Abstract] [Full Text]
Zimmerman, G. A., Albertine, K. H., Carveth, H. J., Gill, E. A., Grissom, C. K., Hoidal, J. R., Imaizumi, T.-a., Maloney, C. G., McIntyre, T. M., Michael, J. R., Orme, J. F., Prescott, S. M., Topham, M. S. (1999). Endothelial Activation in ARDS. Chest 116 : 18S-24S [Full Text]
Carvalho-Tavares, J., Fox-Robichaud, A., Kubes, P. (1999). Assessment of the mechanism of juxtacrine activation and adhesion of leukocytes in liver microcirculation. Am. J. Physiol. Gastrointest. Liver Physiol. 276: G828-G834 [Abstract] [Full Text]
Merhi, Y., Provost, P., Chauvet, P., Theoret, J.-F., Phillips, M. L., Latour, J.-G. (1999). Selectin Blockade Reduces Neutrophil Interaction With Platelets at the Site of Deep Arterial Injury by Angioplasty in Pigs. Arterioscler. Thromb. Vasc. Bio. 19: 372-377 [Abstract] [Full Text]
Evangelista, V., Manarini, S., Sideri, R., Rotondo, S., Martelli, N., Piccoli, A., Totani, L., Piccardoni, P., Vestweber, D., de Gaetano, G., Cerletti, C. (1999). Platelet/Polymorphonuclear Leukocyte Interaction: P-Selectin Triggers Protein-Tyrosine Phosphorylation-Dependent CD11b/CD18 Adhesion: Role of PSGL-1 as a Signaling Molecule. Blood 93: 876-885 [Abstract] [Full Text]
Tofukuji, M., Metais, C., Collard, C. D., Morse, D. S., Stahl, G. L., Nelson, D. P., Li, J., Simons, M., Sellke, F. W. (1999). Effect of sialyl Lewisx oligosaccharide on myocardial and cerebral injury in the pig. Ann. Thorac. Surg. 67: 112-119 [Abstract] [Full Text]
Reinhardt, P. H., Kubes, P. (1998). Differential Leukocyte Recruitment From Whole Blood Via Endothelial Adhesion Molecules Under Shear Conditions. Blood 92: 4691-4699 [Abstract] [Full Text]
Utgaard, J. O., Jahnsen, F. L., Bakka, A., Brandtzaeg, P., Haraldsen, G. (1998). Rapid Secretion of Prestored Interleukin 8 from Weibel-Palade Bodies of Microvascular Endothelial Cells. JEM 188: 1751-1756 [Abstract] [Full Text]
Qu, X.-W., Rozenfeld, R. A, Huang, W., Crawford, S. E, Gonzalez-Crussi, F, Hsueh, W. (1998). Interaction of platelet-activating factor, spleen and atrial natriuretic peptide in plasma volume regulation during endotoxaemia in rats. J. Physiol. 512: 227-234 [Abstract] [Full Text]
Huang, Q., Wu, M., Meininger, C., Kelly, K., Yuan, Y. (1998). Neutrophil-dependent augmentation of PAF-induced vasoconstriction and albumin flux in coronary arterioles. Am. J. Physiol. Heart Circ. Physiol. 275: H1138-H1147 [Abstract] [Full Text]
Ramsay, P. L., O'Brian Smith, E., Hegemier, S., Welty, S. E. (1998). Early Clinical Markers for the Development of Bronchopulmonary Dysplasia: Soluble E-Selectin and ICAM-1. Pediatrics 102: 927-932 [Abstract] [Full Text]
Lefer, A. M., Campbell, B., Scalia, R., Lefer, D. J. (1998). Synergism Between Platelets and Neutrophils in Provoking Cardiac Dysfunction After Ischemia and Reperfusion : Role of Selectins. Circulation 98: 1322-1328 [Abstract] [Full Text]
Lorenzon, P., Vecile, E., Nardon, E., Ferrero, E., Harlan, J.M., Tedesco, F., Dobrina, A. (1998). Endothelial Cell E- and P-Selectin and Vascular Cell Adhesion Molecule-1 Function as Signaling Receptors. JCB 142: 1381-1391 [Abstract] [Full Text]
Soede, R. D.M., Wijnands, Y. M., Van Kouteren-Cobzaru, I., Roos, E. (1998). ZAP-70 Tyrosine Kinase Is Required for LFA-1-dependent T Cell Migration. JCB 142: 1371-1379 [Abstract] [Full Text]
Aoki, N., Tomoda, H. (1998). Plasma Soluble P-Selectin in Acute Myocardial Infarction: Effects of Coronary Recanalization Therapy. ANGIOLOGY 49: 807-813 [Abstract]
Kaplanski, G., Marin, V., Fabrigoule, M., Boulay, V., Benoliel, A.-M., Bongrand, P., Kaplanski, S., Farnarier, C. (1998). Thrombin-Activated Human Endothelial Cells Support Monocyte Adhesion In Vitro Following Expression of Intercellular Adhesion Molecule-1 (ICAM-1; CD54) and Vascular Cell Adhesion Molecule-1 (VCAM-1; CD106). Blood 92: 1259-1267 [Abstract] [Full Text]
Bussolati, B., Mariano, F., Cignetti, A., Guarini, A., Cambi, V., Foa, R., Piccoli, G., Camussi, G. (1998). Platelet-Activating Factor Synthesized by IL-12-Stimulated Polymorphonuclear Neutrophils and NK Cells Mediates Chemotaxis. J. Immunol. 161: 1493-1500 [Abstract] [Full Text]
Shi, J., Kokubo, Y., Wake, K. (1998). Expression of P-Selectin on Hepatic Endothelia and Platelets Promoting Neutrophil Removal by Liver Macrophages. Blood 92: 520-528 [Abstract] [Full Text]
Buerke, M., Prüfer, D., Dahm, M., Oelert, H., Meyer, J., Darius, H. (1998). Blocking of Classical Complement Pathway Inhibits Endothelial Adhesion Molecule Expression and Preserves Ischemic Myocardium from Reperfusion Injury. J. Pharmacol. Exp. Ther. 286: 429-438 [Abstract] [Full Text]
Kilgore, K. S., Powers, K. L., Imlay, M. M., Malani, A., Allen, D. I., Beyer, J. T., Anderson, M. B., Warren, J. S. (1998). The Carbohydrate Sialyl Lewisx (sLex) Sulfated Glycomimetic GM2941 Attenuates Glucan-Induced Pulmonary Granulomatous Vasculitis in the Rat. J. Pharmacol. Exp. Ther. 286: 439-446 [Abstract] [Full Text]
Straley, K. S., Daugherty, B. L., Aeder, S. E., Hockenson, A. L., Kim, K., Green, S. A. (1998). An Atypical Sorting Determinant in the Cytoplasmic Domain of P-Selectin Mediates Endosomal Sorting. Mol. Biol. Cell 9: 1683-1694 [Abstract] [Full Text]
Topham, M. K., Carveth, H. J., Mcintyre, T. M., Prescott, S. M., Zimmerman, G. A. (1998). Human endothelial cells regulate polymorphonuclear leukocyte degranulation. FASEB J. 12: 733-746 [Abstract] [Full Text]
Aplin, A. E., Howe, A., Alahari, S. K., Juliano, R. L. (1998). Signal Transduction and Signal Modulation by Cell Adhesion Receptors: The Role of Integrins, Cadherins, Immunoglobulin-Cell Adhesion Molecules, and Selectins. Pharmacol. Rev. 50: 197-264 [Abstract] [Full Text]
Ostrovsky, L., King, A. J., Bond, S., Mitchell, D., Lorant, D. E., Zimmerman, G. A., Larsen, R., Niu, X. F., Kubes, P. (1998). A Juxtacrine Mechanism for Neutrophil Adhesion on Platelets Involves Platelet-Activating Factor and a Selectin-Dependent Activation Process. Blood 91: 3028-3036 [Abstract] [Full Text]
Arai, T., Bhunia, A. K., Chatterjee, S., Bulkley, G. B. (1998). Lactosylceramide Stimulates Human Neutrophils to Upregulate Mac-1, Adhere to Endothelium, and Generate Reactive Oxygen Metabolites In Vitro. Circ. Res. 82: 540-547 [Abstract] [Full Text]
Miotla, J. M., Jeffery, P. K., Hellewell, P. G. (1998). Platelet-activating Factor Plays a Pivotal Role in the Induction of Experimental Lung Injury. Am. J. Respir. Cell Mol. Bio. 18: 197-204 [Abstract] [Full Text]
Kelly, S. A., Goldschmidt-Clermont, P. J., Milliken, E. E., Arai, T., Smith, E. H., Bulkley, G. B. (1998). Protein tyrosine phosphorylation mediates TNF-induced endothelial-neutrophil adhesion in vitro. Am. J. Physiol. Heart Circ. Physiol. 274: H513-H519 [Abstract] [Full Text]
Eppihimer, M. J., Russell, J., Anderson, D. C., Epstein, C. J., Laroux, S., Granger, D. N. (1997). Modulation of P-selectin expression in the postischemic intestinal microvasculature. Am. J. Physiol. Gastrointest. Liver Physiol. 273: G1326-G1332 [Abstract] [Full Text]
Hidari, K. I.-P. J., Weyrich, A. S., Zimmerman, G. A., McEver, R. P. (1997). Engagement of P-selectin Glycoprotein Ligand-1 Enhances Tyrosine Phosphorylation and Activates Mitogen-activated Protein Kinases in Human Neutrophils. J. Biol. Chem. 272: 28750-28756 [Abstract] [Full Text]
Cepinskas, G., Noseworthy, R., Kvietys, P. R. (1997). Transendothelial Neutrophil Migration : Role of Neutrophil-Derived Proteases and Relationship to Transendothelial Protein Movement. Circ. Res. 81: 618-626 [Abstract] [Full Text]
Ostrovsky, L., Woodman, R. C., Payne, D., Teoh, D., Kubes, P. (1997). Antithrombin III Prevents and Rapidly Reverses Leukocyte Recruitment in Ischemia/Reperfusion. Circulation 96: 2302-2310 [Abstract] [Full Text]
Scalia, R., Gefen, J., Petasis, N. A., Serhan, C. N., Lefer, A. M. (1997). Lipoxin A4 stable analogs inhibit leukocyte rolling and adherence in the rat mesenteric microvasculature: Role of�P-selectin. Proc. Natl. Acad. Sci. USA 94: 9967-9972 [Abstract] [Full Text]
Imaizumi, T.-a., Albertine, K. H., Jicha, D. L., McIntyre, T. M., Prescott, S. M., Zimmerman, G. A. (1997). Human Endothelial Cells Synthesize ENA-78: Relationship to IL-8 and to Signaling of PMN Adhesion. Am. J. Respir. Cell Mol. Bio. 17: 181-192 [Abstract] [Full Text]
Pedersen, K. E., Bochner, B. S., Undem, B. J. (1997). Cysteinyl Leukotrienes Induce P-Selectin Expression in Human Endothelial Cells via a Non-CysLT1 Receptor-Mediated Mechanism. J. Pharmacol. Exp. Ther. 281: 655-662 [Abstract] [Full Text]
Renesto, P., Si-Tahar, M., Moniatte, M., Balloy, V., Van Dorsselaer, A., Pidard, D., Chignard, M. (1997). Specific Inhibition of Thrombin-Induced Cell Activation by the Neutrophil Proteinases Elastase, Cathepsin G, and Proteinase 3: Evidence for Distinct Cleavage Sites Within the Aminoterminal Domain of the Thrombin Receptor. Blood 89: 1944-1953 [Abstract] [Full Text]
Giuffre, L., Cordey, A.-S., Monai, N., Tardy, Y., Schapira, M., Spertini, O. (1997). Monocyte Adhesion to Activated Aortic Endothelium: Role of L-Selectin and Heparan Sulfate Proteoglycans. JCB 136: 945-956 [Abstract] [Full Text]
Naka, Y., Toda, K., Kayano, K., Oz, M.�C., Pinsky, D.�J. (1997). Failure to express the P-selectin gene or P-selectin blockade confers early pulmonary protection after lung ischemia�or�transplantation. Proc. Natl. Acad. Sci. USA 94: 757-761 [Abstract] [Full Text]
Gumina, R. J., Schultz, J. E., Yao, Z., Kenny, D., Warltier, D. C., Newman, P. J., Gross, G. J. (1996). Antibody to Platelet/Endothelial Cell Adhesion Molecule-1 Reduces Myocardial Infarct Size in a Rat Model of Ischemia-Reperfusion Injury. Circulation 94: 3327-3333 [Abstract] [Full Text]
Montrucchio, G., Lupia, E., De Martino, A., Silvestro, L., Savu, S. R., Cacace, G., De Filippi, P.G., Emanuelli, G., Camussi, G. (1996). Plasmin Promotes an Endothelium-Dependent Adhesion of Neutrophils : Involvement of Platelet Activating Factor and P-Selectin. Circulation 93: 2152-2160 [Abstract] [Full Text]
Revelle, B. M., Scott, D., Kogan, T. P., Zheng, J., Beck, P. J. (1996). Structure-Function Analysis of P-selectin-Sialyl Lewis^X Binding Interactions. J. Biol. Chem. 271: 4289-4297 [Abstract] [Full Text]
Ryu, K. H., Hindman, B. J., Reasoner, D. K., Dexter, F. (1996). Heparin Reduces Neurological Impairment After Cerebral Arterial Air Embolism in the Rabbit. Stroke 27: 303-310 [Abstract] [Full Text]
Murohara, T., Parkinson, S. J., Waldman, S. A., Lefer, A. M. (1995). Inhibition of Nitric Oxide Biosynthesis Promotes P-selectin Expression in Platelets : Role of Protein Kinase C. Arterioscler. Thromb. Vasc. Bio. 15: 2068-2075 [Abstract] [Full Text]