An analysis of vertebrate mRNA sequences: intimations of translational control

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An analysis of vertebrate mRNA sequences: intimations of translational control

M Kozak
Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Piscataway 08854.

Five structural features in mRNAs have been found to contribute to the fidelity and efficiency of initiation by eukaryotic ribosomes. Scrutiny of vertebrate cDNA sequences in light of these criteria reveals a set of transcripts--encoding oncoproteins, growth factors, transcription factors, and other regulatory proteins--that seem designed to be translated poorly. Thus, throttling at the level of translation may be a critical component of gene regulation in vertebrates. An alternative interpretation is that some (perhaps many) cDNAs with encumbered 5' noncoding sequences represent mRNA precursors, which would imply extensive regulation at a posttranscriptional step that precedes translation.
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Matsuo, H., Kanai, Y., Kim, J. Y., Chairoungdua, A., Kim, D. K., Inatomi, J., Shigeta, Y., Ishimine, H., Chaekuntode, S., Tachampa, K., Choi, H. W., Babu, E., Fukuda, J., Endou, H. (2002). Identification of a Novel Na+-independent Acidic Amino Acid Transporter with Structural Similarity to the Member of a Heterodimeric Amino Acid Transporter Family Associated with Unknown Heavy Chains. J. Biol. Chem. 277: 21017-21026 [Abstract] [Full Text]
Wang, J., Vock, V. M., Li, S., Olivas, O. R., Wilkinson, M. F. (2002). A Quality Control Pathway That Down-regulates Aberrant T-cell Receptor (TCR) Transcripts by a Mechanism Requiring UPF2 and Translation. J. Biol. Chem. 277: 18489-18493 [Abstract] [Full Text]
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Doi, M., Thyboll, J., Kortesmaa, J., Jansson, K., Iivanainen, A., Parvardeh, M., Timpl, R., Hedin, U., Swedenborg, J., Tryggvason, K. (2002). Recombinant Human Laminin-10 (alpha 5beta 1gamma 1). PRODUCTION, PURIFICATION, AND MIGRATION-PROMOTING ACTIVITY ON VASCULAR ENDOTHELIAL CELLS. J. Biol. Chem. 277: 12741-12748 [Abstract] [Full Text]
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