Two alternatively spliced mouse urokinase receptor mRNAs with different histological localization in the gastrointestinal tract

doi:10.1083/jcb.115.6.1763

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Two alternatively spliced mouse urokinase receptor mRNAs with different histological localization in the gastrointestinal tract

P Kristensen, J Eriksen, F Blasi and K Dano
Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark.

Two mouse urokinase-type plasminogen activator receptor (muPAR) cDNAs were isolated: muPAR1 is homologous to the human urokinase-type plasminogen activator receptor while muPAR2 codes for a 199 residue protein sharing the first 133 residues with muPAR1. Mouse genomic DNA sequencing indicates that the two different mRNAs arise by alternative splicing. In situ hybridization showed differential expression of the two mRNAs in mouse gastric mucosa. muPAR1 mRNA is located in luminal epithelial cells situated close to urokinase-type plasminogen activator- producing connective tissue cells of the lamina propria, pointing to plasmin generation controlled by the cooperation of different cells that may play a role in the release of gastric epithelial cells. muPAR2 mRNA is expressed in the basal epithelial cells, and the deduced protein sequence includes the receptor ligand binding domain, but omits the region involved in glycolipid-mediated membrane anchoring, suggesting that muPAR2 may code for a secreted uPA binding protein.
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Busso, N., Péclat, V., So, A., Sappino, A.-P. (1997). Plasminogen activation in synovial tissues: differences between normal, osteoarthritis, and rheumatoid arthritis joints. Ann Rheum Dis 56: 550-557 [Abstract] [Full Text]
Lund, L., Romer, J, Thomasset, N, Solberg, H, Pyke, C, Bissell, M., Dano, K, Werb, Z (1996). Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways. Development 122: 181-193 [Abstract]
Bugge, T. H., Suh, T. T., Flick, M. J., Daugherty, C. C., R, J., Solberg, H., Ellis, V., Dan�, K., Degen, J. L. (1995). The Receptor for Urokinase-type Plasminogen Activator Is Not Essential for Mouse Development or Fertility. J. Biol. Chem. 270: 16886-16894 [Abstract] [Full Text]
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Thomas, J., Stieber, A, Gonatas, N (1994). Two proteins associated with secretory granule membranes identified in chicken regulated secretory cells. J. Cell Sci. 107: 1297-1308 [Abstract]