H36-alpha 7 is a novel integrin alpha chain that is developmentally regulated during skeletal myogenesis [published erratum appears in J Cell Biol 1992 Jul;118(1):213]

doi:10.1083/jcb.117.3.643

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H36-alpha 7 is a novel integrin alpha chain that is developmentally regulated during skeletal myogenesis [published erratum appears in J Cell Biol 1992 Jul;118(1):213]

WK Song, W Wang, RF Foster, DA Bielser and SJ Kaufman
Department of Cell and Structural Biology, University of Illinois, Urbana 61801.

H36 is a 120,000-D membrane glycoprotein that is expressed during the differentiation of skeletal muscle. H36 cDNA clones were isolated from a lambda UniZapXR rat myotube cDNA library and sequenced. The deduced amino acid sequence demonstrates that H36 is a novel integrin alpha chain that shares extensive homology with other alpha integrins that includes: (a) the GFFKR sequence found in all alpha integrins; (b) a single membrane spanning region; (c) conservation of 18 of 22 cysteines; and (d) a protease cleavage site found in the non-I region integrin alpha chains. The cytoplasmic domain of H36 is unique and additional regions of nonhomology further indicate H36 is distinct from all other alpha chains. In keeping with current nomenclature we designate this alpha chain alpha 7. Northern blots demonstrate that expression of H36-alpha 7 mRNA is regulated both early in the development of the myogenic lineage and later, during terminal differentiation. Detection of H36-alpha 7 mRNA coincides with conversion of H36- myogenic precursor cells to H36+ cells. H36-alpha 7 mRNA is present in replicating myoblasts: expression increases upon terminal differentiation and is markedly reduced in developmentally defective myoblasts. In addition, H36-alpha 7 mRNA is not detected in C3H10T1/2 cells. It is in myotubes derived from myoblasts obtained by treatment of 10T1/2 cells with azacytidine or transfection with MRF4. Immunoblots and immunofluorescence demonstrate that the H36-alpha 7 chain is associated with integrin beta 1. Affinity chromatography demonstrates that H36-alpha 7 beta 1 selectively binds to laminin. The expression of H36-alpha 7 on secondary myoblasts during the development of the limb in vivo corresponds with the appearance of laminin in the limb, with the responsiveness of secondary myoblast proliferation to laminin, and with the onset of increased muscle mass, suggesting that H36-alpha 7 modulates this stage in limb development. We conclude that H36-alpha 7 is a novel alpha integrin laminin binding protein whose expression is developmentally regulated during skeletal myogenesis.
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Saher, G., Hildt, E. (1999). Activation of c-Raf-1 Kinase Signal Transduction Pathway in alpha 7 Integrin-deficient Mice. J. Biol. Chem. 274: 27651-27657 [Abstract] [Full Text]
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Konczalik, P., Moss, J. (1999). Identification of Critical, Conserved Vicinal Aspartate Residues in Mammalian and Bacterial ADP-ribosylarginine Hydrolases. J. Biol. Chem. 274: 16736-16740 [Abstract] [Full Text]
Pinkstaff, J. K., Detterich, J., Lynch, G., Gall, C. (1999). Integrin Subunit Gene Expression Is Regionally Differentiated in Adult Brain. J. Neurosci. 19: 1541-1556 [Abstract] [Full Text]
Burkin, D. J., Gu, M., Hodges, B. L., Campanelli, J. T., Kaufman, S. J. (1998). A Functional Role for Specific Spliced Variants of the {alpha}7{beta}1 Integrin in Acetylcholine Receptor Clustering. JCB 143: 1067-1075 [Abstract] [Full Text]
Bazzoni, G., Ma, L., Blue, M.-L., Hemler, M. E. (1998). Divalent Cations and Ligands Induce Conformational Changes That Are Highly Divergent among beta 1 Integrins. J. Biol. Chem. 273: 6670-6678 [Abstract] [Full Text]
Montanaro, F., Gee, S. H., Jacobson, C., Lindenbaum, M. H., Froehner, S. C., Carbonetto, S. (1998). Laminin and alpha -Dystroglycan Mediate Acetylcholine Receptor Aggregation via a MuSK-Independent Pathway. J. Neurosci. 18: 1250-1260 [Abstract] [Full Text]
Russo, S, Tomatis, D, Collo, G, Tarone, G, Tato, F (1998). Myogenic conversion of NIH3T3 cells by exogenous MyoD family members: dissociation of terminal differentiation from myotube formation. J. Cell Sci. 111: 691-700 [Abstract]
Hodges, B., Hayashi, Y., Nonaka, I, Wang, W, Arahata, K, Kaufman, S. (1997). Altered expression of the alpha7beta1 integrin in human and murine muscular dystrophies. J. Cell Sci. 110: 2873-2881 [Abstract]
Martin, P., Sanes, J. (1997). Integrins mediate adhesion to agrin and modulate agrin signaling. Development 124: 3909-3917 [Abstract]
Yao, C.-C., Ziober, B. L., Squillace, R. M., Kramer, R. H. (1996). alpha 7 Integrin Mediates Cell Adhesion and Migration on Specific Laminin Isoforms. J. Biol. Chem. 271: 25598-25603 [Abstract] [Full Text]
Ziober, B. L., Kramer, R. H. (1996). Identification and Characterization of the Cell Type-specific and Developmentally Regulated alpha 7 Integrin Gene Promoter. J. Biol. Chem. 271: 22915-22922 [Abstract] [Full Text]
Echtermeyer, F., Sch�ber, S., P�schl, E., von der Mark, H., von der Mark, K. (1996). Specific Induction of Cell Motility on Laminin by alpha7 Integrin. J. Biol. Chem. 271: 2071-2075 [Abstract] [Full Text]
Zolkiewska, A., Moss, J. (1995). Processing of ADP-ribosylated Integrin [IMAGE]7 in Skeletal Muscle Myotubes. J. Biol. Chem. 270: 9227-9233 [Abstract] [Full Text]
Taylor, J. M., Davies, J. D., Peterson, C. A. (1995). Regulation of the Myoblast-specific Expression of the Human beta-Enolase Gene. J. Biol. Chem. 270: 2535-2540 [Abstract] [Full Text]
Milner, R, Ffrench-Constant, C (1994). A developmental analysis of oligodendroglial integrins in primary cells: changes in alpha v-associated beta subunits during differentiation. Development 120: 3497-3506 [Abstract]
Clyman, R., Tannenbaum, J, Chen, Y., Cooper, D, Yurchenco, P., Kramer, R., Waleh, N. (1994). Ductus arteriosus smooth muscle cell migration on collagen: dependence on laminin and its receptors. J. Cell Sci. 107: 1007-1018 [Abstract]
Gu, M, Wang, W, Song, W., Cooper, D., Kaufman, S. (1994). Selective modulation of the interaction of alpha 7 beta 1 integrin with fibronectin and laminin by L-14 lectin during skeletal muscle differentiation. J. Cell Sci. 107: 175-181 [Abstract]
Song, W., Wang, W, Sato, H, Bielser, D., Kaufman, S. (1993). Expression of alpha 7 integrin cytoplasmic domains during skeletal muscle development: alternate forms, conformational change, and homologies with serine/threonine kinases and tyrosine phosphatases. J. Cell Sci. 106: 1139-1152 [Abstract]
Bao, Z., Lakonishok, M, Kaufman, S, Horwitz, A. (1993). Alpha 7 beta 1 integrin is a component of the myotendinous junction on skeletal muscle. J. Cell Sci. 106: 579-589 [Abstract]
Grenz, H, Carbonetto, S, Goodman, S. (1993). Alpha 3 beta 1 integrin is moved into focal contacts in kidney mesangial cells. J. Cell Sci. 105: 739-751 [Abstract]
Zambruno, G, Marchisio, P., Melchiori, A, Bondanza, S, Cancedda, R, De Luca, M (1993). Expression of integrin receptors and their role in adhesion, spreading and migration of normal human melanocytes. J. Cell Sci. 105: 179-190 [Abstract]
Whittaker, C., DeSimone, D. (1993). Integrin alpha subunit mRNAs are differentially expressed in early Xenopus embryos. Development 117: 1239-1249 [Abstract]
Dickson, G., Azad, A., Morris, G. E., Simon, H., Noursadeghi, M., Walsh, F. S. (1992). Co-localization and molecular association of dystrophin with laminin at the surface of mouse and human myotubes. J. Cell Sci. 103: 1223-1233 [Abstract]