A novel endothelial-specific membrane protein is a marker of cell-cell contacts

doi:10.1083/jcb.118.6.1511

Quantitative Colocalization Analysis Software

This Article

Full Text (PDF, 3108K)

Alert me when this article is cited

Citation Map

Services

Email this article

Similar articles in this journal

Similar articles in PubMed

Alert me to new content in the JCB

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via CrossRef

Citing Articles via Google Scholar

Google Scholar

Articles by Lampugnani, M. G.

Articles by Dejana, E.

Search for Related Content

PubMed

PubMed Citation

Articles by Lampugnani, M. G.

Articles by Dejana, E.

Pubmed/NCBI databases

Gene	GEO Profiles
HomoloGene	Protein
UniGene

Social Bookmarking

What's this?

ARTICLES

A novel endothelial-specific membrane protein is a marker of cell-cell contacts

MG Lampugnani, M Resnati, M Raiteri, R Pigott, A Pisacane, G Houen, LP Ruco and E Dejana
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.

mAbs were raised in mice against cultured human endothelial cells (EC) and screened by indirect immunofluorescence for their ability to stain intercellular contacts. One mAb denoted 7B4 was identified which, out of many cultured cell types, specifically decorated cultured human EC. The antigen recognized by mAb 7B4 is bound at the appositional surfaces of cultured EC only as they become confluent and is stably expressed at intercellular boundaries of confluent monolayers. EC recognition specificity was maintained when the antibody was assayed by immuno- histochemistry in tissue sections of many normal and malignant tissues and in blood vessels of different size and type. The antigen recognized by 7B4 was enriched at EC intercellular boundaries similarly in vitro and in situ. In vitro, addition of mAb 7B4 to confluent EC increased permeation of macromolecules across monolayers even without any obvious changes of cell morphology. In addition, when EC permeability was increased by agents such as thrombin, elastase, and TNF/gamma IFN, its distribution pattern at intercellular contact rims was severely altered. mAb 7B4 immunoprecipitated a major protein of 140 kD from metabolically and surface-labeled cultured EC extracts which appeared to be an integral membrane glycoprotein. On the basis of its distribution in cultured cells and in tissues in situ, 7B4 antigen is distinct from other described EC proteins enriched at intercellular contacts. NH2-terminal sequencing of the antigen, immunopurified from human placenta, and sequencing of peptides from tryptic peptide maps revealed identity to the cDNA deduced sequence of a recently identified new member of the cadherin family (Suzuki, S., K. Sano, and H. Tanihara. 1991. Cell Regul. 2:261-270.) These data indicate that 7B4 antigen is an endothelial-specific cadherin that plays a role in the organization of lateral endothelial junctions and in the control of permeability properties of vascular endothelium.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Inoue, K., Sodhi, K., Puri, N., Gotlinger, K. H., Cao, J., Rezzani, R., Falck, J. R., Abraham, N. G., Laniado-Schwartzman, M. (2009). Endothelial-specific CYP4A2 overexpression leads to renal injury and hypertension via increased production of 20-HETE. Am. J. Physiol. Renal Physiol. 297: F875-F884 [Abstract] [Full Text]
Dominici, M., Rasini, V., Bussolari, R., Chen, X., Hofmann, T. J., Spano, C., Bernabei, D., Veronesi, E., Bertoni, F., Paolucci, P., Conte, P., Horwitz, E. M. (2009). Restoration and reversible expansion of the osteoblastic hematopoietic stem cell niche after marrow radioablation. Blood 114: 2333-2343 [Abstract] [Full Text]
Ho, S.-C., Lee, K.-Y., Chan, Y.-F., Kuo, L.-W., Ito, K., Adcock, I. M., Chen, B.-C., Sheu, J.-R., Lin, C.-H., Kuo, H.-P. (2009). Neutrophil Elastase Represses IL-8/CXCL8 Synthesis in Human Airway Smooth Muscle Cells through Induction of NF-{kappa}B Repressing Factor. J. Immunol. 183: 411-420 [Abstract] [Full Text]
Mourad-Zeidan, A. A., Melnikova, V. O., Wang, H., Raz, A., Bar-Eli, M. (2008). Expression Profiling of Galectin-3-Depleted Melanoma Cells Reveals its Major Role in Melanoma Cell Plasticity and Vasculogenic Mimicry. Am. J. Pathol. 173: 1839-1852 [Abstract] [Full Text]
Antonov, A., Snead, C., Gorshkov, B., Antonova, G. N., Verin, A. D., Catravas, J. D. (2008). Heat Shock Protein 90 Inhibitors Protect and Restore Pulmonary Endothelial Barrier Function. Am. J. Respir. Cell Mol. Bio. 39: 551-559 [Abstract] [Full Text]
Fainaru, O., Adini, I., Benny, O., Bazinet, L., Pravda, E., D'Amato, R., Folkman, J. (2008). Doxycycline induces membrane expression of VE-cadherin on endothelial cells and prevents vascular hyperpermeability. FASEB J. 22: 3728-3735 [Abstract] [Full Text]
Alcaide, P., Newton, G., Auerbach, S., Sehrawat, S., Mayadas, T. N., Golan, D. E., Yacono, P., Vincent, P., Kowalczyk, A., Luscinskas, F. W. (2008). p120-Catenin regulates leukocyte transmigration through an effect on VE-cadherin phosphorylation. Blood 112: 2770-2779 [Abstract] [Full Text]
Chyou, S., Ekland, E. H., Carpenter, A. C., Tzeng, T.-C. J., Tian, S., Michaud, M., Madri, J. A., Lu, T. T. (2008). Fibroblast-Type Reticular Stromal Cells Regulate the Lymph Node Vasculature. J. Immunol. 181: 3887-3896 [Abstract] [Full Text]
Beckers, C. M.L., Garcia-Vallejo, J. J., van Hinsbergh, V. W.M., van Nieuw Amerongen, G. P. (2008). Nuclear targeting of {beta}-catenin and p120ctn during thrombin-induced endothelial barrier dysfunction. Cardiovasc Res 79: 679-688 [Abstract] [Full Text]
Ma, C., Wang, X.-F. (2008). In Vitro Assays for the Extracellular Matrix Protein-Regulated Extravasation Process. CSH Protocols 2008: pdb.prot5034-pdb.prot5034 [Abstract] [Full Text]
Dejana, E., Orsenigo, F., Lampugnani, M. G. (2008). The role of adherens junctions and VE-cadherin in the control of vascular permeability. J. Cell Sci. 121: 2115-2122 [Abstract] [Full Text]
Bibert, S., Ayari, H., Riveline, D., Concord, E., Hermant, B., Vernet, T., Gulino-Debrac, D. (2008). Establishment of cell-cell junctions depends on the oligomeric states of VE-cadherin. J Biochem 143: 821-832 [Abstract] [Full Text]
Ponnuchamy, B., Khalil, R. A. (2008). Role of ADAMs in Endothelial Cell Permeability: Cadherin Shedding and Leukocyte Rolling. Circ. Res. 102: 1139-1142 [Full Text]
Prozialeck, W. C., Edwards, J. R., Nebert, D. W., Woods, J. M., Barchowsky, A., Atchison, W. D. (2008). The Vascular System as a Target of Metal Toxicity. Toxicol Sci 102: 207-218 [Abstract] [Full Text]
Dewi, B. E., Takasaki, T., Kurane, I. (2008). Peripheral blood mononuclear cells increase the permeability of dengue virus-infected endothelial cells in association with downregulation of vascular endothelial cadherin. J. Gen. Virol. 89: 642-652 [Abstract] [Full Text]
Labelle, M., Schnittler, H. J., Aust, D. E., Friedrich, K., Baretton, G., Vestweber, D., Breier, G. (2008). Vascular Endothelial Cadherin Promotes Breast Cancer Progression via Transforming Growth Factor {beta} Signaling. Cancer Res. 68: 1388-1397 [Abstract] [Full Text]
Heyraud, S., Jaquinod, M., Durmort, C., Dambroise, E., Concord, E., Schaal, J. P., Huber, P., Gulino-Debrac, D. (2008). Contribution of Annexin 2 to the Architecture of Mature Endothelial Adherens Junctions. Mol. Cell. Biol. 28: 1657-1668 [Abstract] [Full Text]
Ma, C., Rong, Y., Radiloff, D. R., Datto, M. B., Centeno, B., Bao, S., Cheng, A. W. M., Lin, F., Jiang, S., Yeatman, T. J., Wang, X.-F. (2008). Extracellular matrix protein {beta}ig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation. Genes Dev. 22: 308-321 [Abstract] [Full Text]
Vestweber, D. (2008). VE-Cadherin: The Major Endothelial Adhesion Molecule Controlling Cellular Junctions and Blood Vessel Formation. Arterioscler. Thromb. Vasc. Bio. 28: 223-232 [Abstract] [Full Text]
Fontijn, R. D., Volger, O. L., Fledderus, J. O., Reijerkerk, A., de Vries, H. E., Horrevoets, A. J. G. (2008). SOX-18 controls endothelial-specific claudin-5 gene expression and barrier function. Am. J. Physiol. Heart Circ. Physiol. 294: H891-H900 [Abstract] [Full Text]
Muller-Marschhausen, K., Waschke, J., Drenckhahn, D. (2008). Physiological hydrostatic pressure protects endothelial monolayer integrity. Am. J. Physiol. Cell Physiol. 294: C324-C332 [Abstract] [Full Text]
Angel, C. E., Lala, A., Chen, C.-J. J., Edgar, S. G., Ostrovsky, L. L., Dunbar, P. R. (2007). CD14+ antigen-presenting cells in human dermis are less mature than their CD1a+ counterparts. Int Immunol 19: 1271-1279 [Abstract] [Full Text]
Shinoda, G., Umeda, K., Heike, T., Arai, M., Niwa, A., Ma, F., Suemori, H., Luo, H. Y., Chui, D. H. K., Torii, R., Shibuya, M., Nakatsuji, N., Nakahata, T. (2007). {alpha}4-Integrin+ endothelium derived from primate embryonic stem cells generates primitive and definitive hematopoietic cells. Blood 109: 2406-2415 [Abstract] [Full Text]
Shasby, D. M. (2007). Cell-cell adhesion in lung endothelium. Am. J. Physiol. Lung Cell. Mol. Physiol. 292: L593-L607 [Abstract] [Full Text]
Bentz, G. L., Jarquin-Pardo, M., Chan, G., Smith, M. S., Sinzger, C., Yurochko, A. D. (2006). Human Cytomegalovirus (HCMV) Infection of Endothelial Cells Promotes Naive Monocyte Extravasation and Transfer of Productive Virus To Enhance Hematogenous Dissemination of HCMV. J. Virol. 80: 11539-11555 [Abstract] [Full Text]
Orrington-Myers, J., Gao, X., Kouklis, P., Broman, M., Rahman, A., Vogel, S. M., Malik, A. B. (2006). Regulation of lung neutrophil recruitment by VE-cadherin. Am. J. Physiol. Lung Cell. Mol. Physiol. 291: L764-L771 [Abstract] [Full Text]
Celli, L., Ryckewaert, J.-J., Delachanal, E., Duperray, A. (2006). Evidence of a Functional Role for Interaction between ICAM-1 and Nonmuscle {alpha}-Actinins in Leukocyte Diapedesis. J. Immunol. 177: 4113-4121 [Abstract] [Full Text]
Webster, B., Ekland, E. H., Agle, L. M., Chyou, S., Ruggieri, R., Lu, T. T. (2006). Regulation of lymph node vascular growth by dendritic cells. JEM 203: 1903-1913 [Abstract] [Full Text]
Sharpe, E. E. III, Teleron, A. A., Li, B., Price, J., Sands, M. S., Alford, K., Young, P. P. (2006). The Origin and in Vivo Significance of Murine and Human Culture-Expanded Endothelial Progenitor Cells. Am. J. Pathol. 168: 1710-1721 [Abstract] [Full Text]
Mehta, D., Malik, A. B. (2006). Signaling Mechanisms Regulating Endothelial Permeability. Physiol. Rev. 86: 279-367 [Abstract] [Full Text]
Sumanas, S., Jorniak, T., Lin, S. (2005). Identification of novel vascular endothelial-specific genes by the microarray analysis of the zebrafish cloche mutants. Blood 106: 534-541 [Abstract] [Full Text]
Ohara-Imaizumi, M., Ohtsuka, T., Matsushima, S., Akimoto, Y., Nishiwaki, C., Nakamichi, Y., Kikuta, T., Nagai, S., Kawakami, H., Watanabe, T., Nagamatsu, S. (2005). ELKS, a Protein Structurally Related to the Active Zone-associated Protein CAST, Is Expressed in Pancreatic {beta} Cells and Functions in Insulin Exocytosis: Interaction of ELKS with Exocytotic Machinery Analyzed by Total Internal Reflection Fluorescence Microscopy. Mol. Biol. Cell 16: 3289-3300 [Abstract] [Full Text]
Hisatsune, H., Matsumura, K., Ogawa, M., Uemura, A., Kondo, N., Yamashita, J. K., Katsuta, H., Nishikawa, S., Chiba, T., Nishikawa, S.-I. (2005). High level of endothelial cell-specific gene expression by a combination of the 5' flanking region and the 5' half of the first intron of the VE-cadherin gene. Blood 105: 4657-4663 [Abstract] [Full Text]
Martinez-Estrada, O. M., Manzi, L., Tonetti, P., Dejana, E., Bazzoni, G. (2005). Opposite effects of tumor necrosis factor and soluble fibronectin on junctional adhesion molecule-A in endothelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 288: L1081-L1088 [Abstract] [Full Text]
Roussoulieres, A.L.S., Raisky, O., Chalabreysse, L., Dureau, G., Cerutti, C., Thieblemont, C., Boissonnat, P., Sebbag, L., Obadia, J.-F., Ninet, J., Bastien, O., Thivolet-Bejui, F., McGregor, J.L. (2005). Identification and Characterization of Two Genes (MIP-1{beta}, VE-CADHERIN) Implicated in Acute Rejection in Human Heart Transplantation: Use of Murine Models in Tandem With cDNA Arrays. Circulation 111: 2636-2644 [Abstract] [Full Text]
Crosby, C. V., Fleming, P. A., Argraves, W. S., Corada, M., Zanetta, L., Dejana, E., Drake, C. J. (2005). VE-cadherin is not required for the formation of nascent blood vessels but acts to prevent their disassembly. Blood 105: 2771-2776 [Abstract] [Full Text]
Lambeng, N., Wallez, Y., Rampon, C., Cand, F., Christe, G., Gulino-Debrac, D., Vilgrain, I., Huber, P. (2005). Vascular Endothelial-Cadherin Tyrosine Phosphorylation in Angiogenic and Quiescent Adult Tissues. Circ. Res. 96: 384-391 [Abstract] [Full Text]
Sengupta, N., Caballero, S., Mames, R. N., Timmers, A. M., Saban, D., Grant, M. B. (2005). Preventing Stem Cell Incorporation into Choroidal Neovascularization by Targeting Homing and Attachment Factors. IOVS 46: 343-348 [Abstract] [Full Text]
Nwariaku, F. E., Liu, Z., Zhu, X., Nahari, D., Ingle, C., Wu, R. F., Gu, Y., Sarosi, G., Terada, L. S. (2004). NADPH oxidase mediates vascular endothelial cadherin phosphorylation and endothelial dysfunction. Blood 104: 3214-3220 [Abstract] [Full Text]
Carman, C. V., Springer, T. A. (2004). A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them. JCB 167: 377-388 [Abstract] [Full Text]
Vincent, P. A., Xiao, K., Buckley, K. M., Kowalczyk, A. P. (2004). VE-cadherin: adhesion at arm's length. Am. J. Physiol. Cell Physiol. 286: C987-C997 [Abstract] [Full Text]
Kouklis, P., Konstantoulaki, M., Vogel, S., Broman, M., Malik, A. B. (2004). Cdc42 Regulates the Restoration of Endothelial Barrier Function. Circ. Res. 94: 159-166 [Abstract] [Full Text]
PAYNE, G. W., MADRI, J. A., SESSA, W. C., SEGAL, S. S. (2004). Histamine inhibits conducted vasodilation through endothelium-derived NO production in arterioles of mouse skeletal muscle. FASEB J. 18: 280-286 [Abstract] [Full Text]
Hur, J., Yoon, C.-H., Kim, H.-S., Choi, J.-H., Kang, H.-J., Hwang, K.-K., Oh, B.-H., Lee, M.-M., Park, Y.-B. (2004). Characterization of Two Types of Endothelial Progenitor Cells and Their Different Contributions to Neovasculogenesis. Arterioscler. Thromb. Vasc. Bio. 24: 288-293 [Abstract] [Full Text]
Feng, D., Nagy, J. A., Pyne, K., Dvorak, H. F., Dvorak, A. M. (2004). Ultrastructural Localization of Platelet Endothelial Cell Adhesion Molecule (PECAM-1, CD31) in Vascular Endothelium. J. Histochem. Cytochem. 52: 87-102 [Abstract] [Full Text]
Timmerman, L. A., Grego-Bessa, J., Raya, A., Bertran, E., Perez-Pomares, J. M., Diez, J., Aranda, S., Palomo, S., McCormick, F., Izpisua-Belmonte, J. C., de la Pompa, J. L. (2004). Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev. 18: 99-115 [Abstract] [Full Text]
Konstantoulaki, M., Kouklis, P., Malik, A. B. (2003). Protein kinase C modifications of VE-cadherin, p120, and {beta}-catenin contribute to endothelial barrier dysregulation induced by thrombin. Am. J. Physiol. Lung Cell. Mol. Physiol. 285: L434-L442 [Abstract] [Full Text]
Ding, S., Merkulova-Rainon, T., Han, Z. C., Tobelem, G. (2003). HGF receptor up-regulation contributes to the angiogenic phenotype of human endothelial cells and promotes angiogenesis in vitro. Blood 101: 4816-4822 [Abstract] [Full Text]
Lampugnani, M. G., Zanetti, A., Corada, M., Takahashi, T., Balconi, G., Breviario, F., Orsenigo, F., Cattelino, A., Kemler, R., Daniel, T. O., Dejana, E. (2003). Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, {beta}-catenin, and the phosphatase DEP-1/CD148. JCB 161: 793-804 [Abstract] [Full Text]
Hermant, B., Bibert, S., Concord, E., Dublet, B., Weidenhaupt, M., Vernet, T., Gulino-Debrac, D. (2003). Identification of Proteases Involved in the Proteolysis of Vascular Endothelium Cadherin during Neutrophil Transmigration. J. Biol. Chem. 278: 14002-14012 [Abstract] [Full Text]
Quadri, S. K., Bhattacharjee, M., Parthasarathi, K., Tanita, T., Bhattacharya, J. (2003). Endothelial Barrier Strengthening by Activation of Focal Adhesion Kinase. J. Biol. Chem. 278: 13342-13349 [Abstract] [Full Text]
Roca, C., Primo, L., Valdembri, D., Cividalli, A., Declerck, P., Carmeliet, P., Gabriele, P., Bussolino, F. (2003). Hyperthermia Inhibits Angiogenesis by a Plasminogen Activator Inhibitor 1-dependent Mechanism. Cancer Res. 63: 1500-1507 [Abstract] [Full Text]
Burns, A. R., Smith, C. W., Walker, D. C. (2003). Unique Structural Features That Influence Neutrophil Emigration Into the Lung. Physiol. Rev. 83: 309-336 [Abstract] [Full Text]
Roda, O., Valero, M. L., Peiro, S., Andreu, D., Real, F. X., Navarro, P. (2003). New Insights into the tPA-Annexin A2 Interaction. IS ANNEXIN A2 CYS8 THE SOLE REQUIREMENT FOR THIS ASSOCIATION?. J. Biol. Chem. 278: 5702-5709 [Abstract] [Full Text]
Zhang, Y., Gu, Y., Lucas, M. J., Wang, Y. (2003). Antioxidant Superoxide Dismutase Attenuates Increased Endothelial Permeability Induced By Platelet-Activating Factor. Reproductive Sciences 10: 5-10 [Abstract]
Cebotari, S., Mertsching, H., Kallenbach, K., Kostin, S., Repin, O., Batrinac, A., Kleczka, C., Ciubotaru, A., Haverich, A. (2002). Construction of Autologous Human Heart Valves Based on an Acellular Allograft Matrix. Circulation 106: I-63-I-68 [Abstract] [Full Text]
Nasdala, I., Wolburg-Buchholz, K., Wolburg, H., Kuhn, A., Ebnet, K., Brachtendorf, G., Samulowitz, U., Kuster, B., Engelhardt, B., Vestweber, D., Butz, S. (2002). A Transmembrane Tight Junction Protein Selectively Expressed on Endothelial Cells and Platelets. J. Biol. Chem. 277: 16294-16303 [Abstract] [Full Text]
Skovseth, D. K., Yamanaka, T., Brandtzaeg, P., Butcher, E. C., Haraldsen, G. (2002). Vascular Morphogenesis and Differentiation after Adoptive Transfer of Human Endothelial Cells to Immunodeficient Mice. Am. J. Pathol. 160: 1629-1637 [Abstract] [Full Text]
Khayyamian, S., Hutloff, A., Buchner, K., Grafe, M., Henn, V., Kroczek, R. A., Mages, H. W. (2002). ICOS-ligand, expressed on human endothelial cells, costimulates Th1 and Th2 cytokine secretion by memory CD4+ T cells. Proc. Natl. Acad. Sci. USA 99: 6198-6203 [Abstract] [Full Text]
Bibert, S., Jaquinod, M., Concord, E., Ebel, C., Hewat, E., Vanbelle, C., Legrand, P., Weidenhaupt, M., Vernet, T., Gulino-Debrac, D. (2002). Synergy between Extracellular Modules of Vascular Endothelial Cadherin Promotes Homotypic Hexameric Interactions. J. Biol. Chem. 277: 12790-12801 [Abstract] [Full Text]
Levenberg, S., Golub, J. S., Amit, M., Itskovitz-Eldor, J., Langer, R. (2002). Endothelial cells derived from human embryonic stem cells. Proc. Natl. Acad. Sci. USA 99: 4391-4396 [Abstract] [Full Text]
Zanetti, A., Lampugnani, M. G., Balconi, G., Breviario, F., Corada, M., Lanfrancone, L., Dejana, E. (2002). Vascular Endothelial Growth Factor Induces Shc Association With Vascular Endothelial Cadherin: A Potential Feedback Mechanism to Control Vascular Endothelial Growth Factor Receptor-2 Signaling. Arterioscler. Thromb. Vasc. Bio. 22: 617-622 [Abstract] [Full Text]
Moy, A. B., Blackwell, K., Kamath, A. (2002). Differential effects of histamine and thrombin on endothelial barrier function through actin-myosin tension. Am. J. Physiol. Heart Circ. Physiol. 282: H21-H29 [Abstract] [Full Text]
Kevil, C. G., Okayama, N., Alexander, J. S. (2001). H2O2-mediated permeability II: importance of tyrosine phosphatase and kinase activity. Am. J. Physiol. Cell Physiol. 281: C1940-C1947 [Abstract] [Full Text]
Zhao, X., Alexander, J. S., Zhang, S., Zhu, Y., Sieber, N. J., Aw, T. Y., Carden, D. L. (2001). Redox regulation of endothelial barrier integrity. Am. J. Physiol. Lung Cell. Mol. Physiol. 281: L879-L886 [Abstract] [Full Text]
Shaw, S. K., Bamba, P. S., Perkins, B. N., Luscinskas, F. W. (2001). Real-Time Imaging of Vascular Endothelial-Cadherin During Leukocyte Transmigration Across Endothelium. J. Immunol. 167: 2323-2330 [Abstract] [Full Text]
Hendrix, M. J. C., Seftor, E. A., Meltzer, P. S., Gardner, L. M. G., Hess, A. R., Kirschmann, D. A., Schatteman, G. C., Seftor, R. E. B. (2001). Expression and functional significance of VE-cadherin in aggressive human melanoma cells: Role in vasculogenic mimicry. Proc. Natl. Acad. Sci. USA 10.1073/pnas.131209798v1 [Abstract] [Full Text]
Corada, M., Liao, F., Lindgren, M., Lampugnani, M. G., Breviario, F., Frank, R., Muller, W. A., Hicklin, D. J., Bohlen, P., Dejana, E. (2001). Monoclonal antibodies directed to different regions of vascular endothelial cadherin extracellular domain affect adhesion and clustering of the protein and modulate endothelial permeability. Blood 97: 1679-1684 [Abstract] [Full Text]
Sundberg, C., Nagy, J. A., Brown, L. F., Feng, D., Eckelhoefer, I. A., Manseau, E. J., Dvorak, A. M., Dvorak, H. F. (2001). Glomeruloid Microvascular Proliferation Follows Adenoviral Vascular Permeability Factor/Vascular Endothelial Growth Factor-164 Gene Delivery. Am. J. Pathol. 158: 1145-1160 [Abstract] [Full Text]
Sans, E., Delachanal, E., Duperray, A. (2001). Analysis of the Roles of ICAM-1 in Neutrophil Transmigration Using a Reconstituted Mammalian Cell Expression Model: Implication of ICAM-1 Cytoplasmic Domain and Rho-Dependent Signaling Pathway. J. Immunol. 166: 544-551 [Abstract] [Full Text]
Gao, X., Kouklis, P., Xu, N., Minshall, R. D., Sandoval, R., Vogel, S. M., Malik, A. B. (2000). Reversibility of increased microvessel permeability in response to VE-cadherin disassembly. Am. J. Physiol. Lung Cell. Mol. Physiol. 279: L1218-L1225 [Abstract] [Full Text]
Groten, T., Kreienberg, R., Fialka, I., Huber, L., Wedlich, D. (2000). Altered subcellular distribution of cadherin-5 in endothelial cells caused by the serum of pre-eclamptic patients. Mol Hum Reprod 6: 1027-1032 [Abstract] [Full Text]
Wyder, L., Vitaliti, A., Schneider, H., Hebbard, L. W., Moritz, D. R., Wittmer, M., Ajmo, M., Klemenz, R. (2000). Increased Expression of H/T-Cadherin in Tumor-penetrating Blood Vessels. Cancer Res. 60: 4682-4688 [Abstract] [Full Text]
Balconi, G., Spagnuolo, R., Dejana, E. (2000). Development of Endothelial Cell Lines From Embryonic Stem Cells : A Tool for Studying Genetically Manipulated Endothelial Cells In Vitro. Arterioscler. Thromb. Vasc. Bio. 20: 1443-1451 [Abstract] [Full Text]
Drake, C. J., Fleming, P. A. (2000). Vasculogenesis in the day 6.5 to 9.5 mouse embryo. Blood 95: 1671-1679 [Abstract] [Full Text]
Ukropec, J. A., Hollinger, M. K., Salva, S. M., Woolkalis, M. J. (2000). SHP2 Association with VE-Cadherin Complexes in Human Endothelial Cells Is Regulated by Thrombin. J. Biol. Chem. 275: 5983-5986 [Abstract] [Full Text]
Johnson-Leger, C, Aurrand-Lions, M, Imhof, B. (2000). The parting of the endothelium: miracle, or simply a junctional affair?. J. Cell Sci. 113: 921-933 [Abstract]
Andriopoulou, P., Navarro, P., Zanetti, A., Lampugnani, M. G., Dejana, E. (1999). Histamine Induces Tyrosine Phosphorylation of Endothelial Cell-to-Cell Adherens Junctions. Arterioscler. Thromb. Vasc. Bio. 19: 2286-2297 [Abstract] [Full Text]
Rahimi, N., Kazlauskas, A. (1999). A Role for Cadherin-5 in Regulation of Vascular Endothelial Growth Factor Receptor 2 Activity in Endothelial Cells. Mol. Biol. Cell 10: 3401-3407 [Abstract] [Full Text]
Noria, S., Cowan, D. B., Gotlieb, A. I., Langille, B. L. (1999). Transient and Steady-State Effects of Shear Stress on Endothelial Cell Adherens Junctions. Circ. Res. 85: 504-514 [Abstract] [Full Text]
Bobryshev, Y. V, Cherian, S. M, Inder, S. J, Lord, R. S.A (1999). Neovascular expression of VE-cadherin in human atherosclerotic arteries and its relation to intimal inflammation. Cardiovasc Res 43: 1003-1017 [Abstract] [Full Text]
Corada, M., Mariotti, M., Thurston, G., Smith, K., Kunkel, R., Brockhaus, M., Lampugnani, M. G., Martin-Padura, I., Stoppacciaro, A., Ruco, L., McDonald, D. M., Ward, P. A., Dejana, E. (1999). Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo. Proc. Natl. Acad. Sci. USA 96: 9815-9820 [Abstract] [Full Text]
Monini, P., Colombini, S., Sturzl, M., Goletti, D., Cafaro, A., Sgadari, C., Butto, S., Franco, M., Leone, P., Fais, S., Leone, P., Melucci-Vigo, G., Chiozzini, C., Carlini, F., Ascherl, G., Cornali, E., Zietz, C., Ramazzotti, E., Ensoli, F., Andreoni, M., Pezzotti, P., Rezza, G., Yarchoan, R., Gallo, R. C., Ensoli, B. (1999). Reactivation and Persistence of Human Herpesvirus-8 Infection in B Cells and Monocytes by Th-1 Cytokines Increased in Kaposi's Sarcoma. Blood 93: 4044-4058 [Abstract] [Full Text]
Vouret-Craviari, V., Grall, D., Flatau, G., Pouyssegur, J., Boquet, P., Van Obberghen-Schilling, E. (1999). Effects of Cytotoxic Necrotizing Factor 1�and Lethal Toxin on Actin Cytoskeleton and VE-Cadherin Localization in Human Endothelial Cell Monolayers. Infect. Immun. 67: 3002-3008 [Abstract] [Full Text]
Lagunoff, D., Rickard, A. (1999). Mast Cell Granule Heparin Proteoglycan Induces Lacunae in Confluent Endothelial Cell Monolayers. Am. J. Pathol. 154: 1591-1600 [Abstract] [Full Text]
Hurst, V. IV, Goldberg, P. L., Minnear, F. L., Heimark, R. L., Vincent, P. A. (1999). Rearrangement of adherens junctions by transforming growth factor-beta 1: role of contraction. Am. J. Physiol. Lung Cell. Mol. Physiol. 276: L582-L595 [Abstract] [Full Text]
Hirashima, M., Kataoka, H., Nishikawa, S., Matsuyoshi, N., Nishikawa, S.-I. (1999). Maturation of Embryonic Stem Cells Into Endothelial Cells in an In Vitro Model of Vasculogenesis. Blood 93: 1253-1263 [Abstract] [Full Text]
Wong, R. K., Baldwin, A. L., Heimark, R. L. (1999). Cadherin-5 redistribution at sites of TNF-alpha and IFN-gamma -induced permeability in mesenteric venules. Am. J. Physiol. Heart Circ. Physiol. 276: H736-H748 [Abstract] [Full Text]
Gory-Faure, S, Prandini, M., Pointu, H, Roullot, V, Pignot-Paintrand, I, Vernet, M, Huber, P (1999). Role of vascular endothelial-cadherin in vascular morphogenesis. Development 126: 2093-2102 [Abstract]
Braga, V. M.M., Del Maschio, A., Machesky, L., Dejana, E. (1999). Regulation of Cadherin Function by Rho and Rac: Modulation by Junction Maturation and Cellular Context. Mol. Biol. Cell 10: 9-22 [Abstract] [Full Text]
Gory, S., Vernet, M., Laurent, M., Dejana, E., Dalmon, J., Huber, P. (1999). The Vascular Endothelial-Cadherin Promoter Directs Endothelial-Specific Expression in Transgenic Mice. Blood 93: 184-192 [Abstract] [Full Text]
Bach, T. L., Barsigian, C., Yaen, C. H., Martinez, J. (1998). Endothelial Cell VE-cadherin Functions as a Receptor for the beta 15-42 Sequence of Fibrin. J. Biol. Chem. 273: 30719-30728 [Abstract] [Full Text]
Gulino, D., Delachanal, E., Concord, E., Genoux, Y., Morand, B., Valiron, M.-O., Sulpice, E., Scaife, R., Alemany, M., Vernet, T. (1998). Alteration of Endothelial Cell Monolayer Integrity Triggers Resynthesis of Vascular Endothelium Cadherin. J. Biol. Chem. 273: 29786-29793 [Abstract] [Full Text]
Hanspal, M., Smockova, Y., Uong, Q. (1998). Molecular Identification and Functional Characterization of a Novel Protein That Mediates the Attachment of Erythroblasts to Macrophages. Blood 92: 2940-2950 [Abstract] [Full Text]
Carden, D., Xiao, F., Moak, C., Willis, B. H., Robinson-Jackson, S., Alexander, S. (1998). Neutrophil elastase promotes lung microvascular injury and proteolysis of endothelial cadherins. Am. J. Physiol. Heart Circ. Physiol. 275: H385-H392 [Abstract] [Full Text]
Martin-Padura, I., Lostaglio, S., Schneemann, M., Williams, L., Romano, M., Fruscella, P., Panzeri, C., Stoppacciaro, A., Ruco, L., Villa, A., Simmons, D., Dejana, E. (1998). Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration. JCB 142: 117-127 [Abstract] [Full Text]