Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6)

doi:10.1083/jcb.120.2.493

This Article

	Full Text (PDF, 4629K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JCB
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Wall, N. A.
	Articles by Hogan, B. L.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Wall, N. A.
	Articles by Hogan, B. L.


Social Bookmarking

	What's this?

ARTICLES

Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6)

NA Wall, M Blessing, CV Wright and BL Hogan
Department of Cell Biology, Vanderbilt University Medical School, Nashville, Tennessee 37232.

DVR-6 (BMP-6 or Vgr-1) is a member of the TGF-beta superfamily of polypeptide signaling molecules. In situ hybridization studies have previously shown that DVR-6 RNA is expressed in a variety of cell types in the mouse embryo, but no information has been available on protein localization and biosynthesis. We have produced a polyclonal antibody to the proregion of DVR-6 and used it to localize the protein in whole mount and sectioned embryonic, newborn, and adult mouse tissues. DVR-6 protein is expressed in the mouse nervous system beginning at 9.5 days postcoitum (d.p.c.) and continues through adulthood. A variety of epithelial tissues also produce DVR-6 protein, including the suprabasal layer of the skin, bronchiolar epithelium, and the cornea. Additionally, a stably transfected cell line, BMGE+H/D6c4, is used to study the biosynthesis of DVR-6 protein and evidence is presented for translational regulation of DVR-6 expression.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

De Rosa, L., Antonini, D., Ferone, G., Russo, M. T., Yu, P. B., Han, R., Missero, C. (2009). p63 Suppresses Non-epidermal Lineage Markers in a Bone Morphogenetic Protein-dependent Manner via Repression of Smad7. J. Biol. Chem. 284: 30574-30582 [Abstract] [Full Text]
Beites, C. L., Hollenbeck, P. L. W., Kim, J., Lovell-Badge, R., Lander, A. D., Calof, A. L. (2009). Follistatin modulates a BMP autoregulatory loop to control the size and patterning of sensory domains in the developing tongue. Development 136: 2187-2197 [Abstract] [Full Text]
Wordinger, R. J., Clark, A. F. (2007). Bone Morphogenetic Proteins and Their Receptors in the Eye. Exp. Biol. Med. 232: 979-992 [Abstract] [Full Text]
Ohnemus, U., Uenalan, M., Inzunza, J., Gustafsson, J.-A., Paus, R. (2006). The Hair Follicle as an Estrogen Target and Source. Endocr. Rev. 27: 677-706 [Abstract] [Full Text]
Akiyoshi, T., Uchida, K., Tateyama, S. (2004). Expression of Bone Morphogenetic Protein-6 and Bone Morphogenetic Protein Receptors in Myoepithelial Cells of Canine Mammary Gland Tumors. Vet Pathol 41: 154-163 [Abstract] [Full Text]
Plikus, M., Wang, W. P., Liu, J., Wang, X., Jiang, T.-X., Chuong, C.-M. (2004). Morpho-Regulation of Ectodermal Organs: Integument Pathology and Phenotypic Variations in K14-Noggin Engineered Mice through Modulation of Bone Morphogenic Protein Pathway. Am. J. Pathol. 164: 1099-1114 [Abstract] [Full Text]
Lein, P. J., Beck, H. N., Chandrasekaran, V., Gallagher, P. J., Chen, H.-L., Lin, Y., Guo, X., Kaplan, P. L., Tiedge, H., Higgins, D. (2002). Glia Induce Dendritic Growth in Cultured Sympathetic Neurons by Modulating the Balance between Bone Morphogenetic Proteins (BMPs) and BMP Antagonists. J. Neurosci. 22: 10377-10387 [Abstract] [Full Text]
Kochanowska, I. E., Wlodarski, K., Wojtowicz, A., Kinsner, A., Ostrowski, K. (2002). BMP-4 and BMP-6 Involvement in the Osteogenic Properties of the HeLa Cell Line. Exp. Biol. Med. 227: 57-62 [Abstract] [Full Text]
Tateyama, S., Uchida, K., Hidaka, T., Hirao, M., Yamaguchi, R. (2001). Expression of Bone Morphogenetic Protein-6 (BMP-6) in Myoepithelial Cells in Canine Mammary Gland Tumors. Vet Pathol 38: 703-709 [Abstract] [Full Text]
Wang, Y., Chang, C.-F., Morales, M., Chou, J., Chen, H.-L., Chiang, Y.-H., Lin, S.-Z., Cadet, J. L., Deng, X., Wang, J.-Y., Chen, S.-Y., Kaplan, P. L., Hoffer, B. J. (2001). Bone Morphogenetic Protein-6 Reduces Ischemia-Induced Brain Damage in Rats. Stroke 32: 2170-2178 [Abstract] [Full Text]
Heikinheimo, A. K., Laine, M. A., Ritvos, O. V-P., Voutilainen, R. J., Hogan, B. L. M., Leivo, I. V. (1999). Bone Morphogenetic Protein-6 Is a Marker of Serous Acinar Cell Differentiation in Normal and Neoplastic Human Salivary Gland. Cancer Res. 59: 5815-5821 [Abstract] [Full Text]
Iwasaki, S., Iguchi, M., Watanabe, K., Hoshino, R., Tsujimoto, M., Kohno, M. (1999). Specific Activation of the p38 Mitogen-activated Protein Kinase Signaling Pathway and Induction of Neurite Outgrowth in PC12 Cells by Bone Morphogenetic Protein-2. J. Biol. Chem. 274: 26503-26510 [Abstract] [Full Text]
Hollnagel, A., Oehlmann, V., Heymer, J., Ruther, U., Nordheim, A. (1999). Id Genes Are Direct Targets of Bone Morphogenetic Protein Induction in Embryonic Stem Cells. J. Biol. Chem. 274: 19838-19845 [Abstract] [Full Text]
Sasaki, H, Nishizaki, Y, Hui, C, Nakafuku, M, Kondoh, H (1999). Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development 126: 3915-3924 [Abstract]
Helder, M.N., Karg, H., Bervoets, T.J.M., Vukicevic, S., Burger, E.H., D'Souza, R.N., Woltgens, J.H.M., Karsenty, G., Bronckers, A.L.J.J. (1998). Bone Morphogenetic Protein-7 (Osteogenic Protein-1, OP-1) and Tooth Development. JDR 77: 545-554 [Abstract]
Boden, S. D., Hair, G., Titus, L., Racine, M., McCuaig, K., Wozney, J. M., Nanes, M. S. (1997). Glucocorticoid-Induced Differentiation of Fetal Rat Calvarial Osteoblasts Is Mediated by Bone Morphogenetic Protein-6. Endocrinology 138: 2820-2828 [Abstract] [Full Text]
Iwasaki, S., Hattori, A., Sato, M., Tsujimoto, M., Kohno, M. (1996). Characterization of the Bone Morphogenetic Protein-2 as a Neurotrophic Factor. INDUCTION OF NEURONAL DIFFERENTIATION OF PC12 CELLS IN THE ABSENCE OF MITOGEN-ACTIVATED PROTEIN KINASE ACTIVATION. J. Biol. Chem. 271: 17360-17365 [Abstract] [Full Text]
Hogan, B L (1996). Bone morphogenetic proteins: multifunctional regulators of vertebrate development.. Genes Dev. 10: 1580-1594
Iwasaki, S., Tsuruoka, N., Hattori, A., Sato, M., Tsujimoto, M., Kohno, M. (1995). Distribution and Characterization of Specific Cellular Binding Proteins for Bone Morphogenetic Protein-2. J. Biol. Chem. 270: 5476-5482 [Abstract] [Full Text]
Rutherford, B., Fitzgerald, M. (1995). A New Biological Approach To Vital Pulp Therapy. CROBM 6: 218-229 [Abstract] [Full Text]
Heikinheimo, K. (1994). Stage-specific Expression of Decapentaplegic-Vg-related Genes 2, 4, and 6 (Bone Morphogenetic Proteins 2, 4, and 6) During Human Tooth Morphogenesis. JDR 73: 590-597 [Abstract]