Oocyte maturation in starfish is mediated by the beta gamma-subunit complex of a G-protein

doi:10.1083/jcb.121.4.775

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Oocyte maturation in starfish is mediated by the beta gamma-subunit complex of a G-protein

LA Jaffe, CJ Gallo, RH Lee, YK Ho and TL Jones
Physiology Department, University of Connecticut Health Center, Farmington 06032.

The stimulation of meiotic maturation of starfish oocytes by the hormone 1-methyladenine is mimicked by injection of beta gamma subunits of G-proteins from either retina or brain. Conversely, the hormone response is inhibited by injection of the GDP-bound forms of alpha i1 or alpha t subunits, or by injection of phosducin; all of these proteins should bind free beta gamma. alpha-subunit forms with reduced affinity for beta gamma (alpha i1 or alpha t bound to hydrolysis- resistant GTP analogs, or alpha i1-GMPPCP treated with trypsin to remove the amino terminus of the protein) are less effective inhibitors of 1-methyladenine action. These results indicate that the beta gamma subunit of a G-protein mediates 1-methyladenine stimulation of oocyte maturation.
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