Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation

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Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation

LH Wang, KG Rothberg and RG Anderson
Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas 75235.

The clathrin-coated pit lattice is held onto the plasma membrane by an integral membrane protein that binds the clathrin AP-2 subunit with high affinity. In vitro studies have suggested that this protein controls the assembly of the pit because membrane bound AP-2 is required for lattice assembly. If so, the AP-2 binding site must be a resident protein of the coated pit and recycle with other receptors that enter cells through this pathway. Proper recycling, however, would require the switching off of AP-2 binding to allow the binding site to travel through the endocytic pathway unencumbered. Evidence for this hypothesis has been revealed by the cationic amphiphilic class of drugs (CAD), which have previously been found to inhibit receptor recycling. Incubation of human fibroblasts in the presence of these drugs caused clathrin lattices to assemble on endosomal membranes and at the same time prevented coated pit assembly at the cell surface. These effects suggest that CADs reverse an on/off switch that controls AP-2 binding to membranes. We conclude that cells have a mechanism for switching on and off AP-2 binding during the endocytic cycle.
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Blumen, S. R., Cheng, K., Ramos-Nino, M. E., Taatjes, D. J., Weiss, D. J., Landry, C. C., Mossman, B. T. (2007). Unique Uptake of Acid-Prepared Mesoporous Spheres by Lung Epithelial and Mesothelioma Cells. Am. J. Respir. Cell Mol. Bio. 36: 333-342 [Abstract] [Full Text]
Cantin, C., Holguera, J., Ferreira, L., Villar, E., Munoz-Barroso, I. (2007). Newcastle disease virus may enter cells by caveolae-mediated endocytosis. J. Gen. Virol. 88: 559-569 [Abstract] [Full Text]
Veyhl, M., Keller, T., Gorboulev, V., Vernaleken, A., Koepsell, H. (2006). RS1 (RSC1A1) regulates the exocytotic pathway of Na+-D-glucose cotransporter SGLT1. Am. J. Physiol. Renal Physiol. 291: F1213-F1223 [Abstract] [Full Text]
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Long, G., Pan, X., Kormelink, R., Vlak, J. M. (2006). Functional entry of baculovirus into insect and Mammalian cells is dependent on clathrin-mediated endocytosis.. J. Virol. 80: 8830-8833 [Abstract] [Full Text]
Stuart, A. D., Brown, T. D. K. (2006). Entry of feline calicivirus is dependent on clathrin-mediated endocytosis and acidification in endosomes.. J. Virol. 80: 7500-7509 [Abstract] [Full Text]
Muller, D., Kausalya, P. J., Bockenhauer, D., Thumfart, J., Meij, I. C., Dillon, M. J., Hoff, W. v., Hunziker, W. (2006). Unusual Clinical Presentation and Possible Rescue of a Novel Claudin-16 Mutation. J. Clin. Endocrinol. Metab. 91: 3076-3079 [Abstract] [Full Text]
Blanchard, E., Belouzard, S., Goueslain, L., Wakita, T., Dubuisson, J., Wychowski, C., Rouille, Y. (2006). Hepatitis C Virus Entry Depends on Clathrin-Mediated Endocytosis. J. Virol. 80: 6964-6972 [Abstract] [Full Text]
Garcion, E., Lamprecht, A., Heurtault, B., Paillard, A., Aubert-Pouessel, A., Denizot, B., Menei, P., Benoit, J.-P. (2006). A new generation of anticancer, drug-loaded, colloidal vectors reverses multidrug resistance in glioma and reduces tumor progression in rats.. Molecular Cancer Therapeutics 5: 1710-1722 [Abstract] [Full Text]
Liu, B., Liao, M., Mielke, J. G., Ning, K., Chen, Y., Li, L., El-Hayek, Y. H., Gomez, E., Zukin, R. S., Fehlings, M. G., Wan, Q. (2006). Ischemic insults direct glutamate receptor subunit 2-lacking AMPA receptors to synaptic sites.. J. Neurosci. 26: 5309-5319 [Abstract] [Full Text]
Yumoto, R., Nishikawa, H., Okamoto, M., Katayama, H., Nagai, J., Takano, M. (2006). Clathrin-mediated endocytosis of FITC-albumin in alveolar type II epithelial cell line RLE-6TN. Am. J. Physiol. Lung Cell. Mol. Physiol. 290: L946-L955 [Abstract] [Full Text]
Khalil, I. A., Kogure, K., Akita, H., Harashima, H. (2006). Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery.. Pharmacol. Rev. 58: 32-45 [Abstract] [Full Text]
Crowther, J. E., Schlesinger, L. S. (2006). Endocytic pathway for surfactant protein A in human macrophages: binding, clathrin-mediated uptake, and trafficking through the endolysosomal pathway. Am. J. Physiol. Lung Cell. Mol. Physiol. 290: L334-L342 [Abstract] [Full Text]
Balzac, F., Avolio, M., Degani, S., Kaverina, I., Torti, M., Silengo, L., Small, J. V., Retta, S. F. (2005). E-cadherin endocytosis regulates the activity of Rap1: a traffic light GTPase at the crossroads between cadherin and integrin function. J. Cell Sci. 118: 4765-4783 [Abstract] [Full Text]
Zhu, J.-X., Goldoni, S., Bix, G., Owens, R. T., McQuillan, D. J., Reed, C. C., Iozzo, R. V. (2005). Decorin Evokes Protracted Internalization and Degradation of the Epidermal Growth Factor Receptor via Caveolar Endocytosis. J. Biol. Chem. 280: 32468-32479 [Abstract] [Full Text]
Janvier, K., Bonifacino, J. S. (2005). Role of the Endocytic Machinery in the Sorting of Lysosome-associated Membrane Proteins. Mol. Biol. Cell 16: 4231-4242 [Abstract] [Full Text]
Diederich, S., Moll, M., Klenk, H.-D., Maisner, A. (2005). The Nipah Virus Fusion Protein Is Cleaved within the Endosomal Compartment. J. Biol. Chem. 280: 29899-29903 [Abstract] [Full Text]
Lecot, S., Belouzard, S., Dubuisson, J., Rouille, Y. (2005). Bovine Viral Diarrhea Virus Entry Is Dependent on Clathrin-Mediated Endocytosis. J. Virol. 79: 10826-10829 [Abstract] [Full Text]
O'Donnell, V., LaRocco, M., Duque, H., Baxt, B. (2005). Analysis of Foot-and-Mouth Disease Virus Internalization Events in Cultured Cells. J. Virol. 79: 8506-8518 [Abstract] [Full Text]
Krey, T., Thiel, H.-J., Rumenapf, T. (2005). Acid-Resistant Bovine Pestivirus Requires Activation for pH-Triggered Fusion during Entry. J. Virol. 79: 4191-4200 [Abstract] [Full Text]
Palliser, D., Guillen, E., Ju, M., Eisen, H. N. (2005). Multiple Intracellular Routes in the Cross-Presentation of a Soluble Protein by Murine Dendritic Cells. J. Immunol. 174: 1879-1887 [Abstract] [Full Text]
Schlecht, G., Loucka, J., Najar, H., Sebo, P., Leclerc, C. (2004). Antigen Targeting to CD11b Allows Efficient Presentation of CD4+ and CD8+ T Cell Epitopes and In Vivo Th1-Polarized T Cell Priming. J. Immunol. 173: 6089-6097 [Abstract] [Full Text]
Triantafilou, M., Manukyan, M., Mackie, A., Morath, S., Hartung, T., Heine, H., Triantafilou, K. (2004). Lipoteichoic Acid and Toll-like Receptor 2 Internalization and Targeting to the Golgi Are Lipid Raft-dependent. J. Biol. Chem. 279: 40882-40889 [Abstract] [Full Text]
de Haan, C. A. M., Stadler, K., Godeke, G.-J., Bosch, B. J., Rottier, P. J. M. (2004). Cleavage Inhibition of the Murine Coronavirus Spike Protein by a Furin-Like Enzyme Affects Cell-Cell but Not Virus-Cell Fusion. J. Virol. 78: 6048-6054 [Abstract] [Full Text]
Sanchez-San Martin, C., Lopez, T., Arias, C. F., Lopez, S. (2004). Characterization of Rotavirus Cell Entry. J. Virol. 78: 2310-2318 [Abstract] [Full Text]
Moron, V. G., Rueda, P., Sedlik, C., Leclerc, C. (2003). In Vivo, Dendritic Cells Can Cross-Present Virus-Like Particles Using an Endosome-to-Cytosol Pathway. J. Immunol. 171: 2242-2250 [Abstract] [Full Text]
Husain, M., Moss, B. (2003). Intracellular Trafficking of a Palmitoylated Membrane-Associated Protein Component of Enveloped Vaccinia Virus. J. Virol. 77: 9008-9019 [Abstract] [Full Text]
Nawa, M., Takasaki, T., Yamada, K.-I., Kurane, I., Akatsuka, T. (2003). Interference in Japanese encephalitis virus infection of Vero cells by a cationic amphiphilic drug, chlorpromazine. J. Gen. Virol. 84: 1737-1741 [Abstract] [Full Text]
Petris, M. J., Smith, K., Lee, J., Thiele, D. J. (2003). Copper-stimulated Endocytosis and Degradation of the Human Copper Transporter, hCtr1. J. Biol. Chem. 278: 9639-9646 [Abstract] [Full Text]
Ashbourne Excoffon, K. J. D., Moninger, T., Zabner, J. (2003). The Coxsackie B Virus and Adenovirus Receptor Resides in a Distinct Membrane Microdomain. J. Virol. 77: 2559-2567 [Abstract] [Full Text]
Diaz-Griffero, F., Hoschander, S. A., Brojatsch, J. (2002). Endocytosis Is a Critical Step in Entry of Subgroup B Avian Leukosis Viruses. J. Virol. 76: 12866-12876 [Abstract] [Full Text]
Yao, D., Ehrlich, M., Henis, Y. I., Leof, E. B. (2002). Transforming Growth Factor-beta Receptors Interact with AP2 by Direct Binding to beta 2 Subunit. Mol. Biol. Cell 13: 4001-4012 [Abstract] [Full Text]
Bultel-Brienne, S., Lestavel, S., Pilon, A., Laffont, I., Tailleux, A., Fruchart, J.-C., Siest, G., Clavey, V. (2002). Lipid Free Apolipoprotein E Binds to the Class B Type I Scavenger Receptor I (SR-BI) and Enhances Cholesteryl Ester Uptake from Lipoproteins. J. Biol. Chem. 277: 36092-36099 [Abstract] [Full Text]
Sieczkarski, S. B., Whittaker, G. R. (2002). Influenza Virus Can Enter and Infect Cells in the Absence of Clathrin-Mediated Endocytosis. J. Virol. 76: 10455-10464 [Abstract] [Full Text]
Stuart, A. D., Eustace, H. E., McKee, T. A., Brown, T. D. K. (2002). A Novel Cell Entry Pathway for a DAF-Using Human Enterovirus Is Dependent on Lipid Rafts. J. Virol. 76: 9307-9322 [Abstract] [Full Text]
Patel, H. K., Willhite, D. C., Patel, R. M., Ye, D., Williams, C. L., Torres, E. M., Marty, K. B., MacDonald, R. A., Blanke, S. R. (2002). Plasma Membrane Cholesterol Modulates Cellular Vacuolation Induced by the Helicobacter pylori Vacuolating Cytotoxin. Infect. Immun. 70: 4112-4123 [Abstract] [Full Text]
Marella, M., Lehmann, S., Grassi, J., Chabry, J. (2002). Filipin Prevents Pathological Prion Protein Accumulation by Reducing Endocytosis and Inducing Cellular PrP Release. J. Biol. Chem. 277: 25457-25464 [Abstract] [Full Text]
Sieczkarski, S. B., Whittaker, G. R. (2002). Dissecting virus entry via endocytosis. J. Gen. Virol. 83: 1535-1545 [Abstract] [Full Text]
Zuhorn, I. S., Kalicharan, R., Hoekstra, D. (2002). Lipoplex-mediated Transfection of Mammalian Cells Occurs through the Cholesterol-dependent Clathrin-mediated Pathway of Endocytosis. J. Biol. Chem. 277: 18021-18028 [Abstract] [Full Text]
Wissel, H., Lehfeldt, A., Klein, P., Muller, T., Stevens, P. A. (2001). Endocytosed SP-A and surfactant lipids are sorted to different organelles in rat type II pneumocytes. Am. J. Physiol. Lung Cell. Mol. Physiol. 281: L345-L360 [Abstract] [Full Text]
Joki-Korpela, P., Marjomäki, V., Krogerus, C., Heino, J., Hyypiä, T. (2001). Entry of Human Parechovirus 1. J. Virol. 75: 1958-1967 [Abstract] [Full Text]
Cortes-Bratti, X., Chaves-Olarte, E., Lagergard, T., Thelestam, M. (2000). Cellular Internalization of Cytolethal Distending Toxin from Haemophilus ducreyi. Infect. Immun. 68: 6903-6911 [Abstract] [Full Text]
Rowe, D. J., Bobilya, D. J. (2000). Albumin Facilitates Zinc Acquisition by Endothelial Cells. Exp. Biol. Med. 224: 178-186 [Abstract] [Full Text]
Baritussio, A., Alberti, A., Armanini, D., Meloni, F., Bruttomesso, D. (2000). Different pathways of degradation of SP-A and saturated phosphatidylcholine by alveolar macrophages. Am. J. Physiol. Lung Cell. Mol. Physiol. 279: L91-L99 [Abstract] [Full Text]
IPPOLITI, R., LENDARO, E., BENEDETTI, P. A., TORRISI, M. R., BELLEUDI, F., CARPANI, D., SORIA, M. R., FABBRINI, M. S. (2000). Endocytosis of a chimera between human pro-urokinase and the plant toxin saporin: an unusual internalization mechanism. FASEB J. 14: 1335-1344 [Abstract] [Full Text]
Contamin, S., Galmiche, A., Doye, A., Flatau, G., Benmerah, A., Boquet, P. (2000). The p21 Rho-activating Toxin Cytotoxic Necrotizing Factor 1 Is Endocytosed by a Clathrin-independent Mechanism and Enters the Cytosol by an Acidic-dependent Membrane Translocation Step. Mol. Biol. Cell 11: 1775-1787 [Abstract] [Full Text]
Okamoto, Y., Ninomiya, H., Miwa, S., Masaki, T. (2000). Cholesterol Oxidation Switches the Internalization Pathway of Endothelin Receptor Type A from Caveolae to Clathrin-coated Pits in Chinese Hamster Ovary Cells. J. Biol. Chem. 275: 6439-6446 [Abstract] [Full Text]
Takahashi, Y., Smith, J. D. (1999). Cholesterol efflux to apolipoprotein AI involves endocytosis and resecretion in a calcium-dependent pathway. Proc. Natl. Acad. Sci. USA 96: 11358-11363 [Abstract] [Full Text]
Arneson, L. S., Kunz, J., Anderson, R. A., Traub, L. M. (1999). Coupled Inositide Phosphorylation and Phospholipase D Activation Initiates Clathrin-coat Assembly on Lysosomes. J. Biol. Chem. 274: 17794-17805 [Abstract] [Full Text]
Zhu, Y., Drake, M. T., Kornfeld, S. (1999). ADP-ribosylation factor 1�dependent clathrin-coat assembly on synthetic liposomes. Proc. Natl. Acad. Sci. USA 96: 5013-5018 [Abstract] [Full Text]
Bradbury, N. A., Clark, J. A., Watkins, S. C., Widnell, C. C., Smith, H. S. IV, Bridges, R. J. (1999). Characterization of the internalization pathways for the cystic fibrosis transmembrane conductance regulator. Am. J. Physiol. Lung Cell. Mol. Physiol. 276: L659-L668 [Abstract] [Full Text]
Pauloin, A, Tooze, S., Michelutti, I, Delpal, S, Ollivier-Bousquet, M (1999). The majority of clathrin coated vesicles from lactating rabbit mammary gland arises from the secretory pathway. J. Cell Sci. 112: 4089-4100 [Abstract]
Sorkina, T, Bild, A, Tebar, F, Sorkin, A (1999). Clathrin, adaptors and eps15 in endosomes containing activated epidermal growth factor receptors. J. Cell Sci. 112: 317-327 [Abstract]
Kitchens, R. L., Wang, P.-y., Munford, R. S. (1998). Bacterial Lipopolysaccharide Can Enter Monocytes Via Two CD14-Dependent Pathways. J. Immunol. 161: 5534-5545 [Abstract] [Full Text]
Orlandi, P. A., Fishman, P. H. (1998). Filipin-dependent Inhibition of Cholera Toxin: Evidence for Toxin Internalization and Activation through Caveolae-like Domains. JCB 141: 905-915 [Abstract] [Full Text]
Brown, C., Petersen, N. (1998). An image correlation analysis of the distribution of clathrin associated adaptor protein (AP-2) at the plasma membrane. J. Cell Sci. 111: 271-281 [Abstract]
Fire, E., Brown, C. M., Roth, M. G., Henis, Y. I., Petersen, N. O. (1997). Partitioning of Proteins into Plasma Membrane Microdomains. CLUSTERING OF MUTANT INFLUENZA VIRUS HEMAGGLUTININS INTO COATED PITS DEPENDS ON THE STRENGTH OF THE INTERNALIZATION SIGNAL. J. Biol. Chem. 272: 29538-29545 [Abstract] [Full Text]
West, M. A., Bright, N. A., Robinson, M. S. (1997). The Role of ADP-ribosylation Factor and Phospholipase D in Adaptor Recruitment. JCB 138: 1239-1254 [Abstract] [Full Text]
Sofer, A., Futerman, A. H. (1995). Cationic Amphiphilic Drugs Inhibit the Internalization of Cholera Toxin to the Golgi Apparatus and the Subsequent Elevation of Cyclic AMP. J. Biol. Chem. 270: 12117-12122 [Abstract] [Full Text]
Subtil, A, Hemar, A, Dautry-Varsat, A (1994). Rapid endocytosis of interleukin 2 receptors when clathrin-coated pit endocytosis is inhibited. J. Cell Sci. 107: 3461-3468 [Abstract]
von Poser, C., Zhang, J. Z., Mineo, C., Ding, W., Ying, Y., Sudhof, T. C., Anderson, R. G. W. (2000). Synaptotagmin Regulation of Coated Pit Assembly. J. Biol. Chem. 275: 30916-30924 [Abstract] [Full Text]