Peripherin expression in hippocampal neurons induced by muscle soluble factor(s)

doi:10.1083/jcb.123.5.1197

This Article

	Full Text (PDF, 4988K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JCB
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Djabali, K.
	Articles by Dotti, C. G.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Djabali, K.
	Articles by Dotti, C. G.


Social Bookmarking

	What's this?

ARTICLES

Peripherin expression in hippocampal neurons induced by muscle soluble factor(s)

K Djabali, A Zissopoulou, MJ de Hoop, SD Georgatos and CG Dotti
Cell Biology Program, European Molecular Biology Laboratory, Heidelberg, Germany.

Previous studies have shown that neuronal cells in culture can switch neurotransmitters when grown in the presence of different target cells. To examine whether this plasticity extends to structural proteins, we cocultured hippocampal neurons and pituitary-derived neuroendocrine (AtT20) cells with astrocytes, kidney epithelial cells, or skeletal muscle cells. As a marker of phenotypic change we used the cytoskeletal protein peripherin, a type III intermediate filament (IF) subunit which is not expressed in hippocampal neurons and AtT20 cells. We show here that soluble factor(s) secreted specifically from skeletal muscle cells can induce the expression and de novo assembly of peripherin in a subset of post-mitotic neurons. We further demonstrate that one of these factors is the Leukemia Inhibitory Factor/Cholinergic Neuronal Differentiation Factor. The environmentally regulated expression of peripherin implies a remarkable degree of plasticity in the cytoskeletal organization of postmitotic CNS cells and provides a noninvasive model system to examine the de novo assembly of IF proteins under in vivo conditions.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Styers, M. L., Salazar, G., Love, R., Peden, A. A., Kowalczyk, A. P., Faundez, V. (2004). The Endo-Lysosomal Sorting Machinery Interacts with the Intermediate Filament Cytoskeleton. Mol. Biol. Cell 15: 5369-5382 [Abstract] [Full Text]
Ferzaz, B., Brault, E., Bourliaud, G., Robert, J.-P., Poughon, G., Claustre, Y., Marguet, F., Liere, P., Schumacher, M., Nowicki, J.-P., Fournier, J., Marabout, B., Sevrin, M., George, P., Soubrie, P., Benavides, J., Scatton, B. (2002). SSR180575 (7-Chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide), a Peripheral Benzodiazepine Receptor Ligand, Promotes Neuronal Survival and Repair. J. Pharmacol. Exp. Ther. 301: 1067-1078 [Abstract] [Full Text]
Beaulieu, J.-M., Nguyen, M. D., Julien, J.-P. (1999). Late Onset Death of Motor Neurons in Mice Overexpressing Wild-Type Peripherin. JCB 147: 531-544 [Abstract] [Full Text]
Djabali, K, de Nechaud, B, Landon, F, Portier, M. (1997). AlphaB-crystallin interacts with intermediate filaments in response to stress. J. Cell Sci. 110: 2759-2769 [Abstract]
Roobol, A, Holmes, F., Hayes, N., Baines, A., Carden, M. (1995). Cytoplasmic chaperonin complexes enter neurites developing in vitro and differ in subunit composition within single cells. J. Cell Sci. 108: 1477-1488 [Abstract]