Hydrolysis of bound GTP by ARF protein triggers uncoating of Golgi- derived COP-coated vesicles

doi:10.1083/jcb.123.6.1365

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Hydrolysis of bound GTP by ARF protein triggers uncoating of Golgi- derived COP-coated vesicles

G Tanigawa, L Orci, M Amherdt, M Ravazzola, JB Helms and JE Rothman
Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York 10021.

The cycle of nucleotide exchange and hydrolysis by a small GTP-binding protein, ADP-ribosylation factor (ARF), helps to provide vectoriality to vesicle transport. Coat assembly is triggered when ARF binds GTP, initiating transport vesicle budding, and coat disassembly is triggered when ARF hydrolyzes GTP, allowing the uncoated vesicle to fuse.
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