NCAM-dependent neurite outgrowth is inhibited in neurons from Fyn-minus mice

doi:10.1083/jcb.127.3.825

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NCAM-dependent neurite outgrowth is inhibited in neurons from Fyn-minus mice

HE Beggs, P Soriano and PF Maness
Department of Biochemistry, University of North Carolina School of Medicine, Chapel Hill 27599-7260.

Src-related nonreceptor protein tyrosine kinases in nerve growth cones (p59fyn, pp60c-src, and pp62c-yes) are potential intracellular signaling molecules for cell adhesion molecule-directed axonal growth. To determine whether src-related tyrosine kinases mediate NCAM- dependent neurite outgrowth, cultures of cerebellar and sensory neurons from fyn-, src-, and yes- minus mice were analyzed for neurite outgrowth on monolayers of NCAM140-transfected L fibroblasts. NCAM- dependent neurite outgrowth was selectively inhibited in cultures of cerebellar and dorsal root ganglion neurons from fyn-, but not src- or yes- mice. Neurite outgrowth by fyn-, src-, or yes- neurons on untransfected fibroblast monolayers was unaffected, indicating that these kinases do not contribute significantly to axon growth on at least some integrins or other adhesive substrates present on fibroblasts. This study demonstrates that p59fyn is an essential component of the NCAM signaling pathway leading to axonal growth.
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Brackenbury, W. J., Djamgoz, M. B.A., Isom, L. L. (2008). An Emerging Role for Voltage-Gated Na+ Channels in Cellular Migration: Regulation of Central Nervous System Development and Potentiation of Invasive Cancers. Neuroscientist 14: 571-583 [Abstract]
Wu, B., Decourt, B., Zabidi, M. A., Wuethrich, L. T., Kim, W. H., Zhou, Z., MacIsaac, K., Suter, D. M. (2008). Microtubule-mediated Src Tyrosine Kinase Trafficking in Neuronal Growth Cones. Mol. Biol. Cell 19: 4611-4627 [Abstract] [Full Text]
Bodrikov, V., Sytnyk, V., Leshchyns'ka, I., den Hertog, J., Schachner, M. (2008). NCAM induces CaMKII{alpha}-mediated RPTP{alpha} phosphorylation to enhance its catalytic activity and neurite outgrowth. JCB 182: 1185-1200 [Abstract] [Full Text]
Brackenbury, W. J., Davis, T. H., Chen, C., Slat, E. A., Detrow, M. J., Dickendesher, T. L., Ranscht, B., Isom, L. L. (2008). Voltage-Gated Na+ Channel {beta}1 Subunit-Mediated Neurite Outgrowth Requires Fyn Kinase and Contributes to Postnatal CNS Development In Vivo. J. Neurosci. 28: 3246-3256 [Abstract] [Full Text]
Ahn, M., Beacham, D., Westenbroek, R. E., Scheuer, T., Catterall, W. A. (2007). Regulation of NaV1.2 Channels by Brain-Derived Neurotrophic Factor, TrkB, and Associated Fyn Kinase. J. Neurosci. 27: 11533-11542 [Abstract] [Full Text]
Dey, N., De, P. K., Wang, M., Zhang, H., Dobrota, E. A., Robertson, K. A., Durden, D. L. (2007). CSK Controls Retinoic Acid Receptor (RAR) Signaling: a RAR-c-SRC Signaling Axis Is Required for Neuritogenic Differentiation. Mol. Cell. Biol. 27: 4179-4197 [Abstract] [Full Text]
Liu, H., Nakazawa, T., Tezuka, T., Yamamoto, T. (2006). Physical and Functional Interaction of Fyn Tyrosine Kinase with a Brain-enriched Rho GTPase-activating Protein TCGAP. J. Biol. Chem. 281: 23611-23619 [Abstract] [Full Text]
Huang, J., Sakai, R., Furuichi, T. (2006). The Docking Protein Cas Links Tyrosine Phosphorylation Signaling to Elongation of Cerebellar Granule Cell Axons. Mol. Biol. Cell 17: 3187-3196 [Abstract] [Full Text]
He, K., Huang, J., Lagenaur, C. F., Aizenman, E. (2006). Methylisothiazolinone, A Neurotoxic Biocide, Disrupts the Association of Src Family Tyrosine Kinases with Focal Adhesion Kinase in Developing Cortical Neurons. J. Pharmacol. Exp. Ther. 317: 1320-1329 [Abstract] [Full Text]
Kuo, G., Arnaud, L., Kronstad-O'Brien, P., Cooper, J. A. (2005). Absence of Fyn and Src Causes a Reeler-Like Phenotype. J. Neurosci. 25: 8578-8586 [Abstract] [Full Text]
Moresco, E. M. Y., Donaldson, S., Williamson, A., Koleske, A. J. (2005). Integrin-Mediated Dendrite Branch Maintenance Requires Abelson (Abl) Family Kinases. J. Neurosci. 25: 6105-6118 [Abstract] [Full Text]
Santuccione, A., Sytnyk, V., Leshchyns'ka, I., Schachner, M. (2005). Prion protein recruits its neuronal receptor NCAM to lipid rafts to activate p59fyn and to enhance neurite outgrowth. JCB 169: 341-354 [Abstract] [Full Text]
Bodrikov, V., Leshchyns'ka, I., Sytnyk, V., Overvoorde, J., den Hertog, J., Schachner, M. (2005). RPTP{alpha} is essential for NCAM-mediated p59fyn activation and neurite elongation. JCB 168: 127-139 [Abstract] [Full Text]
Davis, T. H., Chen, C., Isom, L. L. (2004). Sodium Channel {beta}1 Subunits Promote Neurite Outgrowth in Cerebellar Granule Neurons. J. Biol. Chem. 279: 51424-51432 [Abstract] [Full Text]
Dityatev, A., Dityateva, G., Sytnyk, V., Delling, M., Toni, N., Nikonenko, I., Muller, D., Schachner, M. (2004). Polysialylated Neural Cell Adhesion Molecule Promotes Remodeling and Formation of Hippocampal Synapses. J. Neurosci. 24: 9372-9382 [Abstract] [Full Text]
Knoll, B., Drescher, U. (2004). Src Family Kinases Are Involved in EphA Receptor-Mediated Retinal Axon Guidance. J. Neurosci. 24: 6248-6257 [Abstract] [Full Text]
Chang, C., Yu, T. W., Bargmann, C. I., Tessier-Lavigne, M. (2004). Inhibition of Netrin-Mediated Axon Attraction by a Receptor Protein Tyrosine Phosphatase. Science 305: 103-106 [Abstract] [Full Text]
Feng, Z., Li, L., Ng, P. Y., Porter, A. G. (2002). Neuronal Differentiation and Protection from Nitric Oxide-Induced Apoptosis Require c-Jun-Dependent Expression of NCAM140. Mol. Cell. Biol. 22: 5357-5366 [Abstract] [Full Text]
Yang, L.-T., Alexandropoulos, K., Sap, J. (2002). c-SRC Mediates Neurite Outgrowth through Recruitment of Crk to the Scaffolding Protein Sin/Efs without Altering the Kinetics of ERK Activation. J. Biol. Chem. 277: 17406-17414 [Abstract] [Full Text]
Niethammer, P., Delling, M., Sytnyk, V., Dityatev, A., Fukami, K., Schachner, M. (2002). Cosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis. JCB 157: 521-532 [Abstract] [Full Text]
Prag, S., Lepekhin, E. A., Kolkova, K., Hartmann-Petersen, R., Kawa, A., Walmod, P. S., Belman, V., Gallagher, H. C., Berezin, V., Bock, E., Pedersen, N. (2002). NCAM regulates cell motility. J. Cell Sci. 115: 283-292 [Abstract] [Full Text]
Suter, D. M., Forscher, P. (2001). Transmission of growth cone traction force through apCAM-cytoskeletal linkages is regulated by Src family tyrosine kinase activity. JCB 155: 427-438 [Abstract] [Full Text]
Zamora-Leon, S. P., Lee, G., Davies, P., Shafit-Zagardo, B. (2001). Binding of Fyn to MAP-2c through an SH3 Binding Domain. REGULATION OF THE INTERACTION BY ERK2. J. Biol. Chem. 276: 39950-39958 [Abstract] [Full Text]
Franceschini, I., Angata, K., Ong, E., Hong, A., Doherty, P., Fukuda, M. (2001). Polysialyltransferase ST8Sia II (STX) polysialylates all of the major isoforms of NCAM and facilitates neurite outgrowth. Glycobiology 11: 231-239 [Abstract] [Full Text]
Kolkova, K., Novitskaya, V., Pedersen, N., Berezin, V., Bock, E. (2000). Neural Cell Adhesion Molecule-Stimulated Neurite Outgrowth Depends on Activation of Protein Kinase C and the Ras-Mitogen-Activated Protein Kinase Pathway. J. Neurosci. 20: 2238-2246 [Abstract] [Full Text]
Takei, K., Chan, T. A., Wang, F.-S., Deng, H., Rutishauser, U., Jay, D. G. (1999). The Neural Cell Adhesion Molecules L1 and NCAM-180 Act in Different Steps of Neurite Outgrowth. J. Neurosci. 19: 9469-9479 [Abstract] [Full Text]
Huang, C.-C., Hsu, K.-S. (1999). Protein tyrosine kinase is required for the induction of long-term potentiation in the rat hippocampus. J. Physiol. 520: 783-796 [Abstract] [Full Text]
Burden-Gulley, S. M., Brady-Kalnay, S. M. (1999). PTP{micro} Regulates N-Cadherin-dependent Neurite Outgrowth. JCB 144: 1323-1336 [Abstract] [Full Text]
Narisawa-Saito, M., Silva, A. J., Yamaguchi, T., Hayashi, T., Yamamoto, T., Nawa, H. (1999). Growth factor-mediated Fyn signaling regulates alpha -amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor expression in rodent neocortical neurons. Proc. Natl. Acad. Sci. USA 96: 2461-2466 [Abstract] [Full Text]
Takayama, Y., Tanaka, S., Nagai, K., Okada, M. (1999). Adenovirus-mediated Overexpression of C-terminal Src Kinase (Csk) in Type I Astrocytes Interferes with Cell Spreading and Attachment to Fibronectin. CORRELATION WITH TYROSINE PHOSPHORYLATIONS OF PAXILLIN AND FAK. J. Biol. Chem. 274: 2291-2297 [Abstract] [Full Text]
Wright, J., Snyder, M., Schwinof, K., Combes, S, Copenhaver, P. (1999). A role for fasciclin II in the guidance of neuronal migration. Development 126: 3217-3228 [Abstract]
Aplin, A. E., Howe, A., Alahari, S. K., Juliano, R. L. (1998). Signal Transduction and Signal Modulation by Cell Adhesion Receptors: The Role of Integrins, Cadherins, Immunoglobulin-Cell Adhesion Molecules, and Selectins. Pharmacol. Rev. 50: 197-264 [Abstract] [Full Text]
Bhandari, V., Lim, K. L., Pallen, C. J. (1998). Physical and Functional Interactions between Receptor-like Protein-tyrosine Phosphatase alpha �and p59fyn. J. Biol. Chem. 273: 8691-8698 [Abstract] [Full Text]
Fujita, N., Kemper, A., Dupree, J., Nakayasu, H., Bartsch, U., Schachner, M., Maeda, N., Suzuki, K., Suzuki, K., Popko, B. (1998). The Cytoplasmic Domain of the Large Myelin-Associated Glycoprotein Isoform Is Needed for Proper CNS But Not Peripheral Nervous System Myelination. J. Neurosci. 18: 1970-1978 [Abstract] [Full Text]
Kobayashi, S., Okumura, N., Nakamoto, T., Okada, M., Hirai, H., Nagai, K. (1997). Activation of pp60c-src Depending on Cell Density in PC12h Cells. J. Biol. Chem. 272: 16262-16267 [Abstract] [Full Text]
Kojima, N., Wang, J., Mansuy, I. M., Grant, S. G.�N., Mayford, M., Kandel, E. R. (1997). Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing Fyn transgene. Proc. Natl. Acad. Sci. USA 94: 4761-4765 [Abstract] [Full Text]
Beggs, H. E., Baragona, S. C., Hemperly, J. J., Maness, P. F. (1997). NCAM140 Interacts with the Focal Adhesion Kinase p125fak and the SRC-related Tyrosine Kinase p59fyn. J. Biol. Chem. 272: 8310-8319 [Abstract] [Full Text]
Varela-Echavarria, A, Guthrie, S (1997). Molecules making waves in axon guidance.. Genes Dev. 11: 545-557
Desai, C., Krueger, N., Saito, H, Zinn, K (1997). Competition and cooperation among receptor tyrosine phosphatases control motoneuron growth cone guidance in Drosophila. Development 124: 1941-1952 [Abstract]
Tsiotra, P. C., Theodorakis, K., Papamatheakis, J., Karagogeos, D. (1996). The Fibronectin Domains of the Neural Adhesion Molecule TAX-1 Are Necessary and Sufficient for Homophilic Binding. J. Biol. Chem. 271: 29216-29222 [Abstract] [Full Text]
Lowell, C A, Soriano, P (1996). Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories.. Genes Dev. 10: 1845-1857
Cervello, M., Matranga, V., Durbec, P., Rougon, G., Gomez, S. (1996). The GPI-anchored adhesion molecule F3 induces tyrosine phosphorylation: involvement of the FNIII repeats. J. Cell Sci. 109: 699-704 [Abstract]
Zhao, X., Siu, C.-H. (1995). Colocalization of the Homophilic Binding Site and the Neuritogenic Activity of the Cell Adhesion Molecule L1 to Its Second Ig-like Domain. J. Biol. Chem. 270: 29413-29421 [Abstract] [Full Text]
Grant, S G, Karl, K A, Kiebler, M A, Kandel, E R (1995). Focal adhesion kinase in the brain: novel subcellular localization and specific regulation by Fyn tyrosine kinase in mutant mice.. Genes Dev. 9: 1909-1921 [Abstract]
Prinetti, A., Chigorno, V., Prioni, S., Loberto, N., Marano, N., Tettamanti, G., Sonnino, S. (2001). Changes in the Lipid Turnover, Composition, and Organization, as Sphingolipid-enriched Membrane Domains, in Rat Cerebellar Granule Cells Developing in Vitro. J. Biol. Chem. 276: 21136-21145 [Abstract] [Full Text]
Niethammer, P., Delling, M., Sytnyk, V., Dityatev, A., Fukami, K., Schachner, M. (2002). Cosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis. JCB 157: 521-532 [Abstract] [Full Text]