Receptor tyrosine kinase signaling required for integrin alpha v beta 5- directed cell motility but not adhesion on vitronectin

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Receptor tyrosine kinase signaling required for integrin alpha v beta 5- directed cell motility but not adhesion on vitronectin

RL Klemke, M Yebra, EM Bayna and DA Cheresh
Scripps Research Institute, Department of Immunology, La Jolla, California 92037.

FG human pancreatic carcinoma cells adhere to vitronectin using integrin alpha v beta 5 yet are unable to migrate on this ligand whereas they readily migrate on collagen in an alpha 2 beta 1-dependent manner. We report here that epidermal growth factor receptor (EGFR) activation leads to de novo alpha v beta 5-dependent FG cell migration on vitronectin. The EGFR specific tyrosine kinase inhibitor tyrphostin 25 selectively prevents EGFR autophosphorylation thereby preventing the EGF-induced FG cell migration response on vitronectin without affecting constitutive migration on collagen. Protein kinase C (PKC) activation also leads to alpha v beta 5-directed motility on vitronectin; however, this is not blocked by tyrosine kinase inhibitors. In this case, PKC activation appears to be associated with and downstream of EGFR signaling since calphostin C, an inhibitor of PKC, blocks FG cell migration on vitronectin induced by either PKC or EGF. These findings represent the first report implicating a receptor tyrosine kinase in a specific integrin mediated cell motility event independent of adhesion.
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Eliceiri, B. P. (2001). Integrin and Growth Factor Receptor Crosstalk. Circ. Res. 89: 1104-1110 [Abstract] [Full Text]
Mechtersheimer, S., Gutwein, P., Agmon-Levin, N., Stoeck, A., Oleszewski, M., Riedle, S., Postina, R., Fahrenholz, F., Fogel, M., Lemmon, V., Altevogt, P. (2001). Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins. JCB 155: 661-674 [Abstract] [Full Text]
Paulhe, F., Racaud-Sultan, C., Ragab, A., Albiges-Rizo, C., Chap, H., Iberg, N., Morand, O., Perret, B. (2001). Differential Regulation of Phosphoinositide Metabolism by alpha Vbeta 3 and alpha Vbeta 5 Integrins upon Smooth Muscle Cell Migration. J. Biol. Chem. 276: 41832-41840 [Abstract] [Full Text]
Wang, J. F., Zhang, X.-F., Groopman, J. E. (2001). Stimulation of beta 1 Integrin Induces Tyrosine Phosphorylation of Vascular Endothelial Growth Factor Receptor-3 and Modulates Cell Migration. J. Biol. Chem. 276: 41950-41957 [Abstract] [Full Text]
Retta, S. F., Cassara, G., D'Amato, M., Alessandro, R., Pellegrino, M., Degani, S., De Leo, G., Silengo, L., Tarone, G. (2001). Cross Talk between beta 1 and alpha V Integrins: beta 1 Affects beta 3 mRNA Stability. Mol. Biol. Cell 12: 3126-3138 [Abstract] [Full Text]
van der Pluijm, G., Sijmons, B., Vloedgraven, H., van der Bent, C., Drijfhout, J.-W., Verheijen, J., Quax, P., Karperien, M., Papapoulos, S., Lowik, C. (2001). Urokinase-Receptor/Integrin Complexes Are Functionally Involved in Adhesion and Progression of Human Breast Cancer in Vivo. Am. J. Pathol. 159: 971-982 [Abstract] [Full Text]
Alt, A., Ohba, M., Li, L., Gartsbein, M., Belanger, A., Denning, Mitchell. F., Kuroki, T., Yuspa, S. H., Tennenbaum, T. (2001). Protein Kinase C{{delta}}-mediated Phosphorylation of {{alpha}}6{beta}4 Is Associated with Reduced Integrin Localization to the Hemidesmosome and Decreased Keratinocyte Attachment. Cancer Res. 61: 4591-4598 [Abstract] [Full Text]
Nakamura, I., Lipfert, L., Rodan, G. A., Le T. Duong, (2001). Convergence of {alpha}v{beta}3Integrin-And Macrophage Colony Stimulating Factor-Mediated Signals on Phospholipase C{gamma} in Prefusion Osteoclasts. JCB 152: 361-374 [Abstract] [Full Text]
Tanno, S., Tanno, S., Mitsuuchi, Y., Altomare, D. A., Xiao, G.-H., Testa, J. R. (2001). AKT Activation Up-Regulates Insulin-like Growth Factor I Receptor Expression and Promotes Invasiveness of Human Pancreatic Cancer Cells. Cancer Res. 61: 589-593 [Abstract] [Full Text]
Petitclerc, E., Boutaud, A., Prestayko, A., Xu, J., Sado, Y., Ninomiya, Y., Sarras, M. P. Jr., Hudson, B. G., Brooks, P. C. (2000). New Functions for Non-collagenous Domains of Human Collagen Type IV. NOVEL INTEGRIN LIGANDS INHIBITING ANGIOGENESIS AND TUMOR GROWTH IN VIVO. J. Biol. Chem. 275: 8051-8061 [Abstract] [Full Text]
D'Cruz, P. M., Yasumura, D., Weir, J., Matthes, M. T., Abderrahim, H., LaVail, M. M., Vollrath, D. (2000). Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat. Hum Mol Genet 9: 645-651 [Abstract] [Full Text]
Huang, X., Griffiths, M., Wu, J., Farese, R. V. Jr., Sheppard, D. (2000). Normal Development, Wound Healing, and Adenovirus Susceptibility in beta 5-Deficient Mice. Mol. Cell. Biol. 20: 755-759 [Abstract] [Full Text]
Kamphaus, G. D., Colorado, P. C., Panka, D. J., Hopfer, H., Ramchandran, R., Torre, A., Maeshima, Y., Mier, J. W., Sukhatme, V. P., Kalluri, R. (2000). Canstatin, a Novel Matrix-derived Inhibitor of Angiogenesis and Tumor Growth. J. Biol. Chem. 275: 1209-1215 [Abstract] [Full Text]
von Schlippe, M, Marshall, J., Perry, P, Stone, M, Zhu, A., Hart, I. (2000). Functional interaction between E-cadherin and alphav-containing integrins in carcinoma cells. J. Cell Sci. 113: 425-437 [Abstract]
Inoue, M., Ross, F. P., Erdmann, J. M., Abu-Amer, Y., Wei, S., Teitelbaum, S. L. (2000). Tumor Necrosis Factor {alpha} Regulates {alpha}v{beta}5 Integrin Expression by Osteoclast Precursors in Vitro and in Vivo. Endocrinology 141: 284-290 [Abstract] [Full Text]
Webb, D., Nguyen, D., Gonias, S. (2000). Extracellular signal-regulated kinase functions in the urokinase receptor-dependent pathway by which neutralization of low density lipoprotein receptor-related protein promotes fibrosarcoma cell migration and matrigel invasion. J. Cell Sci. 113: 123-134 [Abstract]
Collins, L. R., Ricketts, W. A., Yeh, L., Cheresh, D. (1999). Bifurcation of Cell Migratory and Proliferative Signaling by the Adaptor Protein Shc. JCB 147: 1561-1568 [Abstract] [Full Text]
Akamatsu, M., Aota, S.-i., Suwa, A., Ueda, K., Amachi, T., Yamada, K. M., Akiyama, S. K., Kioka, N. (1999). Vinexin Forms a Signaling Complex with Sos and Modulates Epidermal Growth Factor-induced c-Jun N-terminal Kinase/Stress-activated Protein Kinase Activities. J. Biol. Chem. 274: 35933-35937 [Abstract] [Full Text]
Tang, S., Gao, Y., Ware, J. A. (1999). Enhancement of Endothelial Cell Migration and in Vitro Tube Formation by Tap20, a Novel {beta}5 Integrin-Modulating, Pkc{theta}-Dependent Protein. JCB 147: 1073-1084 [Abstract] [Full Text]
Ohashi, Y., Iwata, S., Kamiguchi, K., Morimoto, C. (1999). Tyrosine Phosphorylation of Crk-Associated Substrate Lymphocyte-Type Is a Critical Element in TCR- and {beta}1 Integrin-Induced T Lymphocyte Migration. J. Immunol. 163: 3727-3734 [Abstract] [Full Text]
Finnemann, S. C., Rodriguez-Boulan, E. (1999). Macrophage and Retinal Pigment Epithelium Phagocytosis: Apoptotic Cells and Photoreceptors Compete for {alpha}v{beta}3 and {alpha}v{beta}5 Integrins, and Protein Kinase C Regulates {alpha}v{beta}5 Binding and Cytoskeletal Linkage. JEM 190: 861-874 [Abstract] [Full Text]
Nguyen, D. H.D., Catling, A. D., Webb, D. J., Sankovic, M., Walker, L. A., Somlyo, A. V., Weber, M. J., Gonias, S. L. (1999). Myosin Light Chain Kinase Functions Downstream of Ras/ERK to Promote Migration of Urokinase-Type Plasminogen Activator-Stimulated Cells in an Integrin-Selective Manner. JCB 146: 149-164 [Abstract] [Full Text]
Kottke, T. J., Blajeski, A. L., Martins, L. M., Mesner, P. W. Jr., Davidson, N. E., Earnshaw, W. C., Armstrong, D. K., Kaufmann, S. H. (1999). Comparison of Paclitaxel-, 5-Fluoro-2'-deoxyuridine-, and Epidermal Growth Factor (EGF)-induced Apoptosis. EVIDENCE FOR EGF-INDUCED ANOIKIS. J. Biol. Chem. 274: 15927-15936 [Abstract] [Full Text]
Li, J., Lin, M.-L., Wiepz, G. J., Guadarrama, A. G., Bertics, P. J. (1999). Integrin-mediated Migration of Murine B82L Fibroblasts Is Dependent on the Expression of an Intact Epidermal Growth Factor Receptor. J. Biol. Chem. 274: 11209-11219 [Abstract] [Full Text]
Zheng, D.-Q., Woodard, A. S., Fornaro, M., Tallini, G., Languino, L. R. (1999). Prostatic Carcinoma Cell Migration via {{alpha}}v{beta}3Integrin Is Modulated by a Focal Adhesion Kinase Pathway. Cancer Res. 59: 1655-1664 [Abstract] [Full Text]
McCawley, L. J., Li, S., Wattenberg, E. V., Hudson, L. G. (1999). Sustained Activation of the Mitogen-activated Protein Kinase Pathway. A MECHANISM UNDERLYING RECEPTOR TYROSINE KINASE SPECIFICITY FOR MATRIX METALLOPROTEINASE-9 INDUCTION AND CELL MIGRATION. J. Biol. Chem. 274: 4347-4353 [Abstract] [Full Text]
Fang, K., Ionides, E, Oster, G, Nuccitelli, R, Isseroff, R. (1999). Epidermal growth factor receptor relocalization and kinase activity are necessary for directional migration of keratinocytes in DC electric fields. J. Cell Sci. 112: 1967-1978 [Abstract]
Bhullar, I. S., Li, Y.-S., Miao, H., Zandi, E., Kim, M., Shyy, J. Y.-J., Chien, S. (1998). Fluid Shear Stress Activation of Ikappa B Kinase Is Integrin-dependent. J. Biol. Chem. 273: 30544-30549 [Abstract] [Full Text]
Suzuki, T., Shoji, S., Yamamoto, K., Nada, S., Okada, M., Yamamoto, T., Honda, Z.-i. (1998). Essential Roles of Lyn in Fibronectin-Mediated Filamentous Actin Assembly and Cell Motility in Mast Cells. J. Immunol. 161: 3694-3701 [Abstract] [Full Text]
Trusolino, L., Serini, G., Cecchini, G., Besati, C., Ambesi-Impiombato, F. S., Marchisio, P. C., De Filippi, R. (1998). Growth Factor-dependent Activation of {alpha}v{beta}3 Integrin in Normal Epithelial Cells: Implications for Tumor Invasion. JCB 142: 1145-1156 [Abstract] [Full Text]
Chang, B. Y., Conroy, K. B., Machleder, E. M., Cartwright, C. A. (1998). RACK1, a Receptor for Activated C Kinase and a Homolog of the beta �Subunit of G Proteins, Inhibits Activity of Src Tyrosine Kinases and Growth of NIH 3T3 Cells. Mol. Cell. Biol. 18: 3245-3256 [Abstract] [Full Text]
Nguyen, D. H.�D., Hussaini, I. M., Gonias, S. L. (1998). Binding of Urokinase-type Plasminogen Activator to Its Receptor in MCF-7 Cells Activates Extracellular Signal-regulated Kinase 1�and 2�Which Is Required for Increased Cellular Motility. J. Biol. Chem. 273: 8502-8507 [Abstract] [Full Text]
Klemke, R. L., Leng, J., Molander, R., Brooks, P. C., Vuori, K., Cheresh, D. A. (1998). CAS/Crk Coupling Serves as a "Molecular Switch" for Induction of Cell Migration. JCB 140: 961-972 [Abstract] [Full Text]
Rigot, V, Lehmann, M, Andre, F, Daemi, N, Marvaldi, J, Luis, J (1998). Integrin ligation and PKC activation are required for migration of colon carcinoma cells. J. Cell Sci. 111: 3119-3127 [Abstract]
Huang, X, Wu, J, Spong, S, Sheppard, D (1998). The integrin alphavbeta6 is critical for keratinocyte migration on both its known ligand, fibronectin, and on vitronectin. J. Cell Sci. 111: 2189-2195 [Abstract]
Memmo, L., McKeown-Longo, P (1998). The alphavbeta5 integrin functions as an endocytic receptor for vitronectin. J. Cell Sci. 111: 425-433 [Abstract]
Ullian, M. E., Raymond, J. R., Willingham, M. C., Paul, R. V. (1997). Regulation of vascular angiotensin II receptors by EGF. Am. J. Physiol. Cell Physiol. 273: C1241-C1249 [Abstract] [Full Text]
Lin, E. C.�K., Ratnikov, B. I., Tsai, P. M., Carron, C. P., Myers, D. M., Barbas III, C. F., Smith, J. W. (1997). Identification of a Region in the Integrin beta 3 Subunit That Confers Ligand Binding Specificity. J. Biol. Chem. 272: 23912-23920 [Abstract] [Full Text]
Schofield, K. P., Rushton, G., Humphries, M. J., Dexter, T. M., Gallagher, J. T. (1997). Influence of Interleukin-3 and Other Growth Factors on alpha 4beta 1 Integrin-Mediated Adhesion and Migration of Human Hematopoietic Progenitor Cells. Blood 90: 1858-1866 [Abstract] [Full Text]
Monier-Gavelle, F., Duband, J.-L. (1997). Cross Talk between Adhesion Molecules: Control of N-cadherin Activity by Intracellular Signals Elicited by {beta}1 and {beta}3 Integrins in Migrating Neural Crest Cells. JCB 137: 1663-1681 [Abstract] [Full Text]
Klemke, R. L., Cai, S., Giannini, A. L., Gallagher, P. J., Lanerolle, P. d., Cheresh, D. A. (1997). Regulation of Cell Motility by Mitogen-activated Protein Kinase. JCB 137: 481-492 [Abstract] [Full Text]
Pijuan-Thompson, V., Gladson, C. L. (1997). Ligation of Integrin alpha 5beta 1 Is Required for Internalization of Vitronectin by Integrin alpha vbeta 3. J. Biol. Chem. 272: 2736-2743 [Abstract] [Full Text]
Benoliel, A., Kahn-Peries, B, Imbert, J, Verrando, P (1997). Insulin stimulates haptotactic migration of human epidermal keratinocytes through activation of NF-kappa B transcription factor. J. Cell Sci. 110: 2089-2097 [Abstract]
Yebra, M., Parry, G. C.N., Stromblad, S., Mackman, N., Rosenberg, S., Mueller, B. M., Cheresh, D. A. (1996). Requirement of Receptor-bound Urokinase-type Plasminogen Activator for Integrin alpha vbeta 5-directed Cell Migration. J. Biol. Chem. 271: 29393-29399 [Abstract] [Full Text]
Wei, Y., Lukashev, M., Simon, D. I., Bodary, S. C., Rosenberg, S., Doyle, M. V., Chapman, H. A. (1996). Regulation of Integrin Function by the Urokinase Receptor. Science 273: 1551-1555 [Abstract]
Deryugina, E. I., Bourdon, M. A. (1996). Tenascin mediates human glioma cell migration and modulates cell migration on fibronectin. J. Cell Sci. 109: 643-652 [Abstract]
Aznavoorian, S., Stracke, M. L., Parsons, J., McClanahan, J., Liotta, L. A. (1996). Integrin alpha(v)beta(3) Mediates Chemotactic and Haptotactic Motility in Human Melanoma Cells through Different Signaling Pathways. J. Biol. Chem. 271: 3247-3254 [Abstract] [Full Text]
Doerr, M. E., Jones, J. I. (1996). The Roles of Integrins and Extracellular Matrix Proteins in the Insulin-like Growth Factor I-stimulated Chemotaxis of Human Breast Cancer Cells. J. Biol. Chem. 271: 2443-2447 [Abstract] [Full Text]
Ng-Sikorski, J, Linden, L, Eierman, D, Franzen, L, Molony, L, Andersson, T (1996). Engagement of L-selectin impairs the actin polymerizing capacity of beta 2-integrins on neutrophils. J. Cell Sci. 109: 2361-2369 [Abstract]
Filardo, E., Deming, S., Cheresh, D. (1996). Regulation of cell migration by the integrin beta subunit ectodomain. J. Cell Sci. 109: 1615-1622 [Abstract]
Friedlander, M., Brooks, P. C., Shaffer, R. W., Kincaid, C. M., Varner, J. A., Cheresh, D. A. (1995). Definition of Two Angiogenic Pathways by Distinct alpha(v) Integrins. Science 270: 1500-1502 [Abstract]
Shaw, A. R. E., Domanska, A., Mak, A., Gilchrist, A., Dobler, K., Visser, L., Poppema, S., Fliegel, L., Letarte, M., Willett, B. J. (1995). Ectopic Expression of Human and Feline CD9 in a Human B Cell Line Confers beta1 Integrin-dependent Motility on Fibronectin and Laminin Substrates and Enhanced Tyrosine Phosphorylation. J. Biol. Chem. 270: 24092-24099 [Abstract] [Full Text]
Bhattacharya, S., Fu, C., Bhattacharya, J., Greenberg, S. (1995). Soluble Ligands of the [IMAGE][IMAGE][IMAGE][IMAGE] Integrin Mediate Enhanced Tyrosine Phosphorylation of Multiple Proteins in Adherent Bovine Pulmonary Artery Endothelial Cells. J. Biol. Chem. 270: 16781-16787 [Abstract] [Full Text]
Clark, E., Brugge, J. (1995). Integrins and signal transduction pathways: the road taken. Science 268: 233-239 [Abstract]
Behrendtsen, O, Alexander, C., Werb, Z (1995). Cooperative interactions between extracellular matrix, integrins and parathyroid hormone-related peptide regulate parietal endoderm differentiation in mouse embryos. Development 121: 4137-4148 [Abstract]
Zheng, D.-Q., Woodard, A. S., Tallini, G., Languino, L. R. (2000). Substrate Specificity of alpha vbeta 3 Integrin-mediated Cell Migration and Phosphatidylinositol 3-Kinase/AKT Pathway Activation. J. Biol. Chem. 275: 24565-24574 [Abstract] [Full Text]
Even-Ram, S. C., Maoz, M., Pokroy, E., Reich, R., Katz, B.-Z., Gutwein, P., Altevogt, P., Bar-Shavit, R. (2001). Tumor Cell Invasion Is Promoted by Activation of Protease Activated Receptor-1 in Cooperation with the alpha vbeta 5 Integrin. J. Biol. Chem. 276: 10952-10962 [Abstract] [Full Text]
Carlson, T. R., Feng, Y., Maisonpierre, P. C., Mrksich, M., Morla, A. O. (2001). Direct Cell Adhesion to the Angiopoietins Mediated by Integrins. J. Biol. Chem. 276: 26516-26525 [Abstract] [Full Text]
Grzeszkiewicz, T. M., Kirschling, D. J., Chen, N., Lau, L. F. (2001). CYR61 Stimulates Human Skin Fibroblast Migration through Integrin alpha vbeta 5 and Enhances Mitogenesis through Integrin alpha vbeta 3, Independent of Its Carboxyl-terminal Domain. J. Biol. Chem. 276: 21943-21950 [Abstract] [Full Text]
Eliceiri, B. P., Puente, X. S., Hood, J. D., Stupack, D. G., Schlaepfer, D. D., Huang, X. Z., Sheppard, D., Cheresh, D. A. (2002). Src-mediated coupling of focal adhesion kinase to integrin {alpha}v{beta}5 in vascular endothelial growth factor signaling. JCB 157: 149-160 [Abstract] [Full Text]