HIV-particles in spermatozoa of patients with AIDS and their transfer into the oocyte

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HIV-particles in spermatozoa of patients with AIDS and their transfer into the oocyte

B Baccetti, A Benedetto, AG Burrini, G Collodel, EC Ceccarini, N Crisa, A Di Caro, M Estenoz, AR Garbuglia, A Massacesi, P Piomboni, T Renieri, and D Solazzo

By immunocytochemistry and in situ hybridization at the electron microscopy level, and by the PCR technique, we have shown that HIV-1 binds and enters normal sperm; that viral particles, their antigens, and nucleic acid are present in sperm from HIV-1 infected men; and that such sperm can transfer HIV-1 like particles to normal human oocytes. We also present evidence that a galactosylceramide-like compound is present on the sperm membrane and could function as an alternative receptor for HIV.

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Baker, H W G, Mijch, A, Garland, S, Crowe, S, Dunne, M, Edgar, D, Clarke, G, Foster, P, Blood, J (2003). Use of assisted reproductive technology to reduce the risk of transmission of HIV in discordant couples wishing to have their own children where the male partner is seropositive with an undetectable viral load. J. Med. Ethics 29: 315-320 [Abstract] [Full Text]
Liu, X., Zha, J., Chen, H., Nishitani, J., Camargo, P., Cole, S. W., Zack, J. A. (2003). Human Immunodeficiency Virus Type 1 Infection and Replication in Normal Human Oral Keratinocytes. J. Virol. 77: 3470-3476 [Abstract] [Full Text]
Letur-Konirsch, H., Collin, G., Sifer, C., Devaux, A., Kuttenn, F., Madelenat, P., Brun-Vezinet, F., Feldmann, G., Benifla, J.-L. (2003). Safety of cryopreservation straws for human gametes or embryos: a study with human immunodeficiency virus-1 under cryopreservation conditions. Hum Reprod 18: 140-144 [Abstract] [Full Text]
Dulioust, E., Du, A.L., Costagliola, D., Guibert, J., Kunstmann, J.-M., Heard, I., Juillard, J.-C., Salmon, D., Leruez-Ville, M., Mandelbrot, L., Rouzioux, C., Sicard, D., Zorn, J.-R., Jouannet, P., De Almeida, M. (2002). Semen alterations in HIV-1 infected men. Hum Reprod 17: 2112-2118 [Abstract] [Full Text]
Habasque, C., Aubry, F., Jegou, B., Samson, M. (2002). Study of the HIV-1 receptors CD4, CXCR4, CCR5 and CCR3 in the human and rat testis. Mol Hum Reprod 8: 419-425 [Abstract] [Full Text]
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