Scatter factor and the c-met receptor: a paradigm for mesenchymal/epithelial interaction

doi:10.1083/jcb.127.6.1783

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MINI-REVIEWS

Scatter factor and the c-met receptor: a paradigm for mesenchymal/epithelial interaction

EM Rosen, SK Nigam and ID Goldberg
Long Island Jewish Medical Center, Long Island Campus for Albert Einstein College of Medicine, Department of Radiation Oncology, New Hyde Park, New York 11042.

Epithelia and mesenchyme interact during various physiologic and pathologic processes. Scatter factor is a mesenchyme-derived cytokine that stimulates motility, proliferation, and morphogenesis of epithelia. Recent studies suggest that scatter factor and its receptor (c-met) mediate mesenchyme/epithelia signalling and even interconversion. In this mini-review, we will discuss how scatter factor and c-met may mediate interactions between mesenchyme and epithelia during embryogenesis, organ repair, and neoplasia.
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