E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton

doi:10.1083/jcb.127.6.2061

This Article

	Full Text (PDF, 1541K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JCB
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Hulsken, J.
	Articles by Behrens, J.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Hulsken, J.
	Articles by Behrens, J.


Social Bookmarking

	What's this?

ARTICLES

E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton

J Hulsken, W Birchmeier and J Behrens
Max-Delbruck-Center for Molecular Medicine, Berlin, Germany.

beta-Catenin is involved in the formation of adherens junctions of mammalian epithelia. It interacts with the cell adhesion molecule E- cadherin and also with the tumor suppressor gene product APC, and the Drosophila homologue of beta-catenin, armadillo, mediates morphogenetic signals. We demonstrate here that E-cadherin and APC directly compete for binding to the internal, armadillo-like repeats of beta-catenin; the NH2-terminal domain of beta-catenin mediates the interaction of the alternative E-cadherin and APC complexes to the cytoskeleton by binding to alpha-catenin. Plakoglobin (gamma-catenin), which is structurally related to beta-catenin, mediates identical interactions. We thus show that the APC tumor suppressor gene product forms strikingly similar associations as found in cell junctions and suggest that beta-catenin and plakoglobin are central regulators of cell adhesion, cytoskeletal interaction, and tumor suppression.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

RESTUCCI, B., MARTANO, M., DE VICO, G., LO MUZIO, L., MAIOLINO, P. (2009). Expression of E-Cadherin, {beta}-Catenin and APC protein in Canine Colorectal Tumours. Anticancer Res 29: 2919-2925 [Abstract] [Full Text]
Lee, W., Swarup, S., Chen, J., Ishitani, T., Verheyen, E. M. (2009). Homeodomain-interacting protein kinases (Hipks) promote Wnt/Wg signaling through stabilization of {beta}-catenin/Arm and stimulation of target gene expression. Development 136: 241-251 [Abstract] [Full Text]
Watt, F.M., Collins, C.A. (2008). Role of {beta}-catenin in Epidermal Stem Cell Expansion, Lineage Selection, and Cancer. Cold Spring Harb Symp Quant Biol 0: sqb.2008.73.011v1-sqb.2008.73.011 [Abstract]
Grigoryan, T., Wend, P., Klaus, A., Birchmeier, W. (2008). Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of {beta}-catenin in mice. Genes Dev. 22: 2308-2341 [Abstract] [Full Text]
Kohler, E. M., Derungs, A., Daum, G., Behrens, J., Schneikert, J. (2008). Functional definition of the mutation cluster region of adenomatous polyposis coli in colorectal tumours. Hum Mol Genet 17: 1978-1987 [Abstract] [Full Text]
Mruk, D. D., Silvestrini, B., Cheng, C. Y. (2008). Anchoring Junctions As Drug Targets: Role in Contraceptive Development. Pharmacol. Rev. 60: 146-180 [Abstract] [Full Text]
Shimizu, M., Fukunaga, Y., Ikenouchi, J., Nagafuchi, A. (2008). Defining the Roles of -Catenin and Plakoglobin in LEF/T-Cell Factor-Dependent Transcription Using -Catenin/Plakoglobin-Null F9 Cells. Mol. Cell. Biol. 28: 825-835 [Abstract] [Full Text]
Wu, W., Xu, R. F., Xiao, L., Xu, H., Gao, G. (2008). Expression of the -Catenin Gene in the Skin of Embryonic Geese During Feather Bud Development. Poult. Sci. 87: 204-211 [Abstract] [Full Text]
Bahmanyar, S., Kaplan, D. D., DeLuca, J. G., Giddings, T. H. Jr., O'Toole, E. T., Winey, M., Salmon, E. D., Casey, P. J., Nelson, W. J., Barth, A. I.M. (2008). {beta}-Catenin is a Nek2 substrate involved in centrosome separation. Genes Dev. 22: 91-105 [Abstract] [Full Text]
Xu, W., Kimelman, D. (2007). Mechanistic insights from structural studies of beta-catenin and its binding partners. J. Cell Sci. 120: 3337-3344 [Abstract] [Full Text]
Graham, N. A., Pope, M. D., Rimchala, T., Huang, B. K., Asthagiri, A. R. (2007). A Microtiter Assay for Quantifying Protein-Protein Interactions Associated with Cell-Cell Adhesion. J Biomol Screen 12: 683-693 [Abstract]
Fang, D., Hawke, D., Zheng, Y., Xia, Y., Meisenhelder, J., Nika, H., Mills, G. B., Kobayashi, R., Hunter, T., Lu, Z. (2007). Phosphorylation of beta-Catenin by AKT Promotes beta-Catenin Transcriptional Activity. J. Biol. Chem. 282: 11221-11229 [Abstract] [Full Text]
Schneikert, J., Behrens, J. (2007). The canonical Wnt signalling pathway and its APC partner in colon cancer development. Gut 56: 417-425 [Full Text]
Chu, Q., Ling, M.-T., Feng, H., Cheung, H. W., Tsao, S. W., Wang, X., Wong, Y. C. (2006). A novel anticancer effect of garlic derivatives: inhibition of cancer cell invasion through restoration of E-cadherin expression. Carcinogenesis 27: 2180-2189 [Abstract] [Full Text]
Krieghoff, E., Behrens, J., Mayr, B. (2006). Nucleo-cytoplasmic distribution of {beta}-catenin is regulated by retention.. J. Cell Sci. 119: 1453-1463 [Abstract] [Full Text]
Mulholland, D. J., Dedhar, S., Coetzee, G. A., Nelson, C. C. (2005). Interaction of Nuclear Receptors with the Wnt/{beta}-Catenin/Tcf Signaling Axis: Wnt You Like to Know?. Endocr. Rev. 26: 898-915 [Abstract] [Full Text]
Huang, L., Chen, D., Liu, D., Yin, L., Kharbanda, S., Kufe, D. (2005). MUC1 Oncoprotein Blocks Glycogen Synthase Kinase 3{beta}-Mediated Phosphorylation and Degradation of {beta}-Catenin. Cancer Res. 65: 10413-10422 [Abstract] [Full Text]
Basuroy, S., Sheth, P., Mansbach, C. M., Rao, R. K. (2005). Acetaldehyde disrupts tight junctions and adherens junctions in human colonic mucosa: protection by EGF and L-glutamine. Am. J. Physiol. Gastrointest. Liver Physiol. 289: G367-G375 [Abstract] [Full Text]
Nair, K S, Naidoo, R, Chetty, R (2005). Expression of cell adhesion molecules in oesophageal carcinoma and its prognostic value. J. Clin. Pathol. 58: 343-351 [Abstract] [Full Text]
Sui, X. F., Kiser, T. D., Hyun, S. W., Angelini, D. J., Del Vecchio, R. L., Young, B. A., Hasday, J. D., Romer, L. H., Passaniti, A., Tonks, N. K., Goldblum, S. E. (2005). Receptor Protein Tyrosine Phosphatase {micro} Regulates the Paracellular Pathway in Human Lung Microvascular Endothelia. Am. J. Pathol. 166: 1247-1258 [Abstract] [Full Text]
Gonzalez-Quevedo, R., Shoffer, M., Horng, L., Oro, A. E. (2005). Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4. JCB 168: 453-463 [Abstract] [Full Text]
Grossmann, K. S., Grund, C., Huelsken, J., Behrend, M., Erdmann, B., Franke, W. W., Birchmeier, W. (2004). Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation. JCB 167: 149-160 [Abstract] [Full Text]
Moran, A. E., Hunt, D. H., Javid, S. H., Redston, M., Carothers, A. M., Bertagnolli, M. M. (2004). Apc Deficiency Is Associated with Increased Egfr Activity in the Intestinal Enterocytes and Adenomas of C57BL/6J-Min/+ Mice. J. Biol. Chem. 279: 43261-43272 [Abstract] [Full Text]
Hoffmans, R., Basler, K. (2004). Identification and in vivo role of the Armadillo-Legless interaction. Development 131: 4393-4400 [Abstract] [Full Text]
Hogan, C., Serpente, N., Cogram, P., Hosking, C. R., Bialucha, C. U., Feller, S. M., Braga, V. M. M., Birchmeier, W., Fujita, Y. (2004). Rap1 Regulates the Formation of E-Cadherin-Based Cell-Cell Contacts. Mol. Cell. Biol. 24: 6690-6700 [Abstract] [Full Text]
Lee, N. P.Y., Cheng, C. Y. (2004). Adaptors, Junction Dynamics, and Spermatogenesis. Biol. Reprod. 71: 392-404 [Abstract] [Full Text]
Temburni, M. K., Rosenberg, M. M., Pathak, N., McConnell, R., Jacob, M. H. (2004). Neuronal Nicotinic Synapse Assembly Requires the Adenomatous Polyposis Coli Tumor Suppressor Protein. J. Neurosci. 24: 6776-6784 [Abstract] [Full Text]
Keller, M. S., Ezaki, T., Guo, R.-J., Lynch, J. P. (2004). Cdx1 or Cdx2 expression activates E-cadherin-mediated cell-cell adhesion and compaction in human COLO 205 cells. Am. J. Physiol. Gastrointest. Liver Physiol. 287: G104-G114 [Abstract] [Full Text]
Graham, N. A., Asthagiri, A. R. (2004). Epidermal Growth Factor-mediated T-cell Factor/Lymphoid Enhancer Factor Transcriptional Activity Is Essential but Not Sufficient for Cell Cycle Progression in Nontransformed Mammary Epithelial Cells. J. Biol. Chem. 279: 23517-23524 [Abstract] [Full Text]
Gottardi, C. J., Gumbiner, B. M. (2004). Role for ICAT in {beta}-catenin-dependent nuclear signaling and cadherin functions. Am. J. Physiol. Cell Physiol. 286: C747-C756 [Abstract] [Full Text]
Chen, X., Kojima, S.-i., Borisy, G. G., Green, K. J. (2003). p120 catenin associates with kinesin and facilitates the transport of cadherin-catenin complexes to intercellular junctions. JCB 163: 547-557 [Abstract] [Full Text]
Nishimura, M., Saito, T., Yamasaki, H., Kudo, R. (2003). Suppression of gap junctional intercellular communication via 5' CpG island methylation in promoter region of E-cadherin gene in endometrial cancer cells. Carcinogenesis 24: 1615-1623 [Abstract] [Full Text]
Yamashita, Y. M., Jones, D. L., Fuller, M. T. (2003). Orientation of Asymmetric Stem Cell Division by the APC Tumor Suppressor and Centrosome. Science 301: 1547-1550 [Abstract] [Full Text]
Soshnikova, N., Zechner, D., Huelsken, J., Mishina, Y., Behringer, R. R., Taketo, M. M., Crenshaw, E. B. III, Birchmeier, W. (2003). Genetic interaction between Wnt/{beta}-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb. Genes Dev. 17: 1963-1968 [Abstract] [Full Text]
Li, Y., Yu, W.-h., Ren, J., Chen, W., Huang, L., Kharbanda, S., Loda, M., Kufe, D. (2003). Heregulin Targets {gamma}-Catenin to the Nucleolus by a Mechanism Dependent on the DF3/MUC1 Oncoprotein. Mol Cancer Res 1: 765-775 [Abstract] [Full Text]
Elul, T. M., Kimes, N. E., Kohwi, M., Reichardt, L. F. (2003). N- and C-Terminal Domains of {beta}-Catenin, Respectively, Are Required to Initiate and Shape Axon Arbors of Retinal Ganglion Cells In Vivo. J. Neurosci. 23: 6567-6575 [Abstract] [Full Text]
Song, D. H., Dominguez, I., Mizuno, J., Kaut, M., Mohr, S. C., Seldin, D. C. (2003). CK2 Phosphorylation of the Armadillo Repeat Region of {beta}-Catenin Potentiates Wnt Signaling. J. Biol. Chem. 278: 24018-24025 [Abstract] [Full Text]
Magie, C. R., Pinto-Santini, D., Parkhurst, S. M. (2003). Rho1 interacts with p120ctn and {alpha}-catenin, and regulates cadherin-based adherens junction components in Drosophila. Development 129: 3771-3782 [Abstract] [Full Text]
Lui, W.-Y., Mruk, D. D., Lee, W. M., Cheng, C. Y. (2003). Adherens Junction Dynamics in the Testis and Spermatogenesis. J Androl 24: 1-14 [Full Text]
Ireton, R. C., Davis, M. A., van Hengel, J., Mariner, D. J., Barnes, K., Thoreson, M. A., Anastasiadis, P. Z., Matrisian, L., Bundy, L. M., Sealy, L., Gilbert, B., van Roy, F., Reynolds, A. B. (2002). A novel role for p120 catenin in E-cadherin function. JCB 159: 465-476 [Abstract] [Full Text]
Martin, B., Schneider, R., Janetzky, S., Waibler, Z., Pandur, P., Kuhl, M., Behrens, J., von der Mark, K., Starzinski-Powitz, A., Wixler, V. (2002). The LIM-only protein FHL2 interacts with {beta}-catenin and promotes differentiation of mouse myoblasts. JCB 159: 113-122 [Abstract] [Full Text]
Cheng, C. Y., Mruk, D. D. (2002). Cell Junction Dynamics in the Testis: Sertoli-Germ Cell Interactions and Male Contraceptive Development. Physiol. Rev. 82: 825-874 [Abstract] [Full Text]
Lee, M. S., D'Amour, K. A., Papkoff, J. (2002). A yeast model system for functional analysis of {beta}-catenin signaling. JCB 158: 1067-1078 [Abstract] [Full Text]
Castano, J., Raurell, I., Piedra, J. A., Miravet, S., Dunach, M., de Herreros, A. G. (2002). beta -Catenin N- and C-terminal Tails Modulate the Coordinated Binding of Adherens Junction Proteins to beta -Catenin. J. Biol. Chem. 277: 31541-31550 [Abstract] [Full Text]
Conacci-Sorrell, M. E., Ben-Yedidia, T., Shtutman, M., Feinstein, E., Einat, P., Ben-Ze'ev, A. (2002). Nr-CAM is a target gene of the beta -catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis. Genes Dev. 16: 2058-2072 [Abstract] [Full Text]
Chan, T. A., Wang, Z., Dang, L. H., Vogelstein, B., Kinzler, K. W. (2002). Targeted inactivation of CTNNB1 reveals unexpected effects of beta -catenin mutation. Proc. Natl. Acad. Sci. USA 99: 8265-8270 [Abstract] [Full Text]
Li, B., Mackay, D. R., Dai, Q., Li, T. W. H., Nair, M., Fallahi, M., Schonbaum, C. P., Fantes, J., Mahowald, A. P., Waterman, M. L., Fuchs, E., Dai, X. (2002). The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation. Proc. Natl. Acad. Sci. USA 99: 6064-6069 [Abstract] [Full Text]
Barth, A. I. M., Siemers, K. A., Nelson, W. J. (2002). Dissecting interactions between EB1, microtubules and APC in cortical clusters at the plasma membrane. J. Cell Sci. 115: 1583-1590 [Abstract] [Full Text]
Yang, F., Li, X., Sharma, M., Sasaki, C. Y., Longo, D. L., Lim, B., Sun, Z. (2002). Linking beta -Catenin to Androgen-signaling Pathway. J. Biol. Chem. 277: 11336-11344 [Abstract] [Full Text]
Laprise, P., Chailler, P., Houde, M., Beaulieu, J.-F., Boucher, M.-J., Rivard, N. (2002). Phosphatidylinositol 3-Kinase Controls Human Intestinal Epithelial Cell Differentiation by Promoting Adherens Junction Assembly and p38 MAPK Activation. J. Biol. Chem. 277: 8226-8234 [Abstract] [Full Text]
Wong, N. A. C. S., Pignatelli, M. (2002). {beta}-Catenin--A Linchpin in Colorectal Carcinogenesis?. Am. J. Pathol. 160: 389-401 [Abstract] [Full Text]
Sadot, E., Conacci-Sorrell, M., Zhurinsky, J., Shnizer, D., Lando, Z., Zharhary, D., Kam, Z., Ben-Ze'ev, A., Geiger, B. (2002). Regulation of S33/S37 phosphorylated {beta}-catenin in normal and transformed cells. J. Cell Sci. 115: 2771-2780 [Abstract] [Full Text]
Liu, L., Li, H., Underwood, T., Lloyd, M., David, M., Sperl, G., Pamukcu, R., Thompson, W. J. (2001). Cyclic GMP-Dependent Protein Kinase Activation and Induction by Exisulind and CP461 in Colon Tumor Cells. J. Pharmacol. Exp. Ther. 299: 583-592 [Abstract] [Full Text]
Liu, T., Chen, J., Salahshor, S., Kuismanen, S., Holmberg, E., Gronberg, H., Peltomaki, P., Lindblom, A. (2001). Screening families with endometrial and colorectal cancers for germline mutations. J. Med. Genet. 38: e29-29 [Full Text]
Fearnhead, N. S., Britton, M. P., Bodmer, W. F. (2001). The ABC of APC. Hum Mol Genet 10: 721-733 [Abstract] [Full Text]
Decaens, C., Cassio, D. (2001). Spatiotemporal expression of catenins, ZO-1, and occludin during early polarization of hepatic WIF-B9 cells. Am. J. Physiol. Cell Physiol. 280: C527-C539 [Abstract] [Full Text]
Brault, V, Moore, R, Kutsch, S, Ishibashi, M, Rowitch, D., McMahon, A., Sommer, L, Boussadia, O, Kemler, R (2001). Inactivation of the (&bgr;)-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development 128: 1253-1264 [Abstract]
Ozawa, M, Ohkubo, T (2001). Tyrosine phosphorylation of p120(ctn) in v-Src transfected L cells depends on its association with E-cadherin and reduces adhesion activity. J. Cell Sci. 114: 503-512 [Abstract]
Lo Muzio, L. (2001). A Possible Role for the Wnt~1 Pathway in Oral Carcinogenesis. CROBM 12: 152-165 [Abstract] [Full Text]
Noren, N. K., Liu, B. P., Burridge, K., Kreft, B. (2000). P120 Catenin Regulates the Actin Cytoskeleton via Rho Family Gtpases. JCB 150: 567-580 [Abstract] [Full Text]
Kawasoe, T., Furukawa, Y., Daigo, Y., Nishiwaki, T., Ishiguro, H., Fujita, M., Satoh, S., Miwa, N., Nagasawa, Y., Miyoshi, Y., Ogawa, M., Nakamura, Y. (2000). Isolation and Characterization of a Novel Human Gene, DRCTNNB1A, the Expression of Which Is Down-Regulated by {beta}-Catenin. Cancer Res. 60: 3354-3358 [Abstract] [Full Text]
Waterman-Storer, C. M., Salmon, W. C., Salmon, E.D. (2000). Feedback Interactions between Cell-Cell Adherens Junctions and Cytoskeletal Dynamics in Newt Lung Epithelial Cells. Mol. Biol. Cell 11: 2471-2483 [Abstract] [Full Text]
Zhurinsky, J., Shtutman, M., Ben-Ze'ev, A. (2000). Differential Mechanisms of LEF/TCF Family-Dependent Transcriptional Activation by beta -Catenin and Plakoglobin. Mol. Cell. Biol. 20: 4238-4252 [Abstract] [Full Text]
Anna, C. H., Sills, R. C., Foley, J. F., Stockton, P. S., Ton, T.-V., Devereux, T. R. (2000). {beta}-Catenin Mutations and Protein Accumulation in All Hepatoblastomas Examined from B6C3F1 Mice Treated with Anthraquinone or Oxazepam. Cancer Res. 60: 2864-2868 [Abstract] [Full Text]
Kolligs, F. T., Kolligs, B., Hajra, K. M., Hu, G., Tani, M., Cho, K. R., Fearon, E. R. (2000). gamma -Catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta -catenin. Genes Dev. 14: 1319-1331 [Abstract] [Full Text]
Zondag, G. C. M., Reynolds, A. B., Moolenaar, W. H. (2000). Receptor Protein-tyrosine Phosphatase RPTP{micro} Binds to and Dephosphorylates the Catenin p120ctn. J. Biol. Chem. 275: 11264-11269 [Abstract] [Full Text]
Sorkin, B. C., Wang, M. Y., Dobeck, J. M., Albergo, K. L., Skobe, Z. (2000). The Cadherin-Catenin Complex Is Expressed Alternately with the Adenomatous Polyposis Coli Protein During Rat Incisor Amelogenesis. J. Histochem. Cytochem. 48: 397-406 [Abstract] [Full Text]
Shih, I.-M., Yu, J., He, T.-C., Vogelstein, B., Kinzler, K. W. (2000). The {beta}-Catenin Binding Domain of Adenomatous Polyposis Coli Is Sufficient for Tumor Suppression. Cancer Res. 60: 1671-1676 [Abstract] [Full Text]
Lickert, H., Bauer, A., Kemler, R., Stappert, J. (2000). Casein Kinase II Phosphorylation of E-cadherin Increases E-cadherin/beta -Catenin Interaction and Strengthens Cell-Cell Adhesion. J. Biol. Chem. 275: 5090-5095 [Abstract] [Full Text]
Mimori-Kiyosue, Y., Shiina, N., Tsukita, S. (2000). Adenomatous Polyposis Coli (APC) Protein Moves along Microtubules and Concentrates at Their Growing Ends in Epithelial Cells. JCB 148: 505-518 [Abstract] [Full Text]
Huelsken, J., Vogel, R., Brinkmann, V., Erdmann, B., Birchmeier, C., Birchmeier, W. (2000). Requirement for {beta}-Catenin in Anterior-Posterior Axis Formation in Mice. JCB 148: 567-578 [Abstract] [Full Text]
Thoreson, M. A., Anastasiadis, P. Z., Daniel, J. M., Ireton, R. C., Wheelock, M. J., Johnson, K. R., Hummingbird, D. K., Reynolds, A. B. (2000). Selective Uncoupling of P120ctn from E-Cadherin Disrupts Strong Adhesion. JCB 148: 189-202 [Abstract] [Full Text]
Zhurinsky, J, Shtutman, M, Ben-Ze'ev, A (2000). Plakoglobin and beta-catenin: protein interactions, regulation and biological roles. J. Cell Sci. 113: 3127-3139 [Abstract]
Behrens, J (2000). Cross-regulation of the Wnt signalling pathway: a role of MAP kinases. J. Cell Sci. 113: 911-919 [Abstract]
Roura, S., Miravet, S., Piedra, J., de Herreros, A. G., Dunach, M. (1999). Regulation of E-cadherin/Catenin Association by Tyrosine Phosphorylation. J. Biol. Chem. 274: 36734-36740 [Abstract] [Full Text]
Klymkowsky, M. W., Williams, B. O., Barish, G. D., Varmus, H. E., Vourgourakis, Y. E. (1999). Membrane-anchored Plakoglobins Have Multiple Mechanisms of Action in Wnt Signaling. Mol. Biol. Cell 10: 3151-3169 [Abstract] [Full Text]
Kodama, S., Ikeda, S., Asahara, T., Kishida, M., Kikuchi, A. (1999). Axin Directly Interacts with Plakoglobin and Regulates Its Stability. J. Biol. Chem. 274: 27682-27688 [Abstract] [Full Text]
Kolligs, F. T., Hu, G., Dang, C. V., Fearon, E. R. (1999). Neoplastic Transformation of RK3E by Mutant beta -Catenin Requires Deregulation of Tcf/Lef Transcription but Not Activation of c-myc Expression. Mol. Cell. Biol. 19: 5696-5706 [Abstract] [Full Text]
Nagasawa, Y., Miyoshi, Y., Iwao, K., Shinomura, Y., Matsuzawa, Y., Nakamura, Y. (1999). Transformation and Morphological Changes of Murine L Cells by Transfection with a Mutated Form of {beta}-Catenin. Cancer Res. 59: 3539-3542 [Abstract] [Full Text]
Romagnolo, B., Berrebi, D., Saadi-Keddoucci, S., Porteu, A., Pichard, A.-l., Peuchmaur, M., Vandewalle, A., Kahn, A., Perret, C. (1999). Intestinal Dysplasia and Adenoma in Transgenic Mice after Overexpression of an Activated {beta}-Catenin. Cancer Res. 59: 3875-3879 [Abstract] [Full Text]
Ohkubo, T., Ozawa, M. (1999). p120ctn Binds to the Membrane-proximal Region of the E-cadherin Cytoplasmic Domain and Is Involved in Modulation of Adhesion Activity. J. Biol. Chem. 274: 21409-21415 [Abstract] [Full Text]
Prieve, M. G., Waterman, M. L. (1999). Nuclear Localization and Formation of beta -Catenin-Lymphoid Enhancer Factor 1�Complexes Are Not Sufficient for Activation of Gene Expression. Mol. Cell. Biol. 19: 4503-4515 [Abstract] [Full Text]
Caca, K., Kolligs, F. T., Ji, X., Hayes, M., Qian, J.-m., Yahanda, A., Rimm, D. L., Costa, J., Fearon, E. R. (1999). {beta}- and {{gamma}}-Catenin Mutations, but not E-Cadherin Inactivation, Underlie T-Cell Factor/Lymphoid Enhancer Factor Transcriptional Deregulation in Gastric and Pancreatic Cancer. Cell Growth Differ. 10: 369-376 [Abstract] [Full Text]
Kang, D. E., Soriano, S., Frosch, M. P., Collins, T., Naruse, S., Sisodia, S. S., Leibowitz, G., Levine, F., Koo, E. H. (1999). Presenilin 1�Facilitates the Constitutive Turnover of beta -Catenin: Differential Activity of Alzheimer's Disease-Linked PS1 Mutants in the beta -Catenin-Signaling Pathway. J. Neurosci. 19: 4229-4237 [Abstract] [Full Text]
Daniel, J. M., Reynolds, A. B. (1999). The Catenin p120ctn Interacts with Kaiso, a Novel BTB/POZ Domain Zinc Finger Transcription Factor. Mol. Cell. Biol. 19: 3614-3623 [Abstract] [Full Text]
Pötter, E., Bergwitz, C., Brabant, G. (1999). The Cadherin-Catenin System: Implications for Growth and Differentiation of Endocrine Tissues. Endocr. Rev. 20: 207-239 [Abstract] [Full Text]
Efstathiou, J. A., Liu, D., Wheeler, J. M.�D., Kim, H. C., Beck, N. E., Ilyas, M., Karayiannakis, A. J., Mortensen, N. J.�McC., Kmiot, W., Playford, R. J., Pignatelli, M., Bodmer, W. F. (1999). Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2�in colon carcinoma cells. Proc. Natl. Acad. Sci. USA 96: 2316-2321 [Abstract] [Full Text]
Chen, Y.-T., Stewart, D. B., Nelson, W. J. (1999). Coupling Assembly of the E-Cadherin/{beta}-Catenin Complex to Efficient Endoplasmic Reticulum Exit and Basal-lateral Membrane Targeting of E-Cadherin in Polarized MDCK Cells. JCB 144: 687-699 [Abstract] [Full Text]
Mann, B., Gelos, M., Siedow, A., Hanski, M. L., Gratchev, A., Ilyas, M., Bodmer, W. F., Moyer, M. P., Riecken, E. O., Buhr, H. J., Hanski, C. (1999). Target genes of beta -catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas. Proc. Natl. Acad. Sci. USA 96: 1603-1608 [Abstract] [Full Text]
Zhu, A., Watt, F. (1999). beta-catenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion. Development 126: 2285-2298 [Abstract]
Orsulic, S, Huber, O, Aberle, H, Arnold, S, Kemler, R (1999). E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation. J. Cell Sci. 112: 1237-1245 [Abstract]
Bierkamp, C, Schwarz, H, Huber, O, Kemler, R (1999). Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice. Development 126: 371-381 [Abstract]
Bannerman, D. D., Sathyamoorthy, M., Goldblum, S. E. (1998). Bacterial Lipopolysaccharide Disrupts Endothelial Monolayer Integrity and Survival Signaling Events through Caspase Cleavage of Adherens Junction Proteins. J. Biol. Chem. 273: 35371-35380 [Abstract] [Full Text]
Sadot, E., Simcha, I., Shtutman, M., Ben-Ze'ev, A., Geiger, B. (1998). Inhibition of beta -catenin-mediated transactivation by cadherin derivatives. Proc. Natl. Acad. Sci. USA 95: 15339-15344 [Abstract] [Full Text]
Li, Y., Bharti, A., Chen, D., Gong, J., Kufe, D. (1998). Interaction of Glycogen Synthase Kinase 3beta with the DF3/MUC1 Carcinoma-Associated Antigen and beta -Catenin. Mol. Cell. Biol. 18: 7216-7224 [Abstract] [Full Text]
Ozawa, M. (1998). Identification of the Region of alpha -Catenin That Plays an Essential Role in Cadherin-mediated Cell Adhesion. J. Biol. Chem. 273: 29524-29529 [Abstract] [Full Text]
Gulino, D., Delachanal, E., Concord, E., Genoux, Y., Morand, B., Valiron, M.-O., Sulpice, E., Scaife, R., Alemany, M., Vernet, T. (1998). Alteration of Endothelial Cell Monolayer Integrity Triggers Resynthesis of Vascular Endothelium Cadherin. J. Biol. Chem. 273: 29786-29793 [Abstract] [Full Text]
Ratner, N., Bloom, G. S., Brady, S. T. (1998). A Role for Cyclin-Dependent Kinase(s) in the Modulation of Fast Anterograde Axonal Transport: Effects Defined by Olomoucine and the APC Tumor Suppressor Protein. J. Neurosci. 18: 7717-7726 [Abstract] [Full Text]