Zip1-induced changes in synaptonemal complex structure and polycomplex assembly

doi:10.1083/jcb.128.4.455

This Article

Full Text (PDF, 3503K)

Alert me when this article is cited

Citation Map

Services

Email this article

Similar articles in this journal

Similar articles in PubMed

Alert me to new content in the JCB

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via CrossRef

Citing Articles via Google Scholar

Google Scholar

Articles by Sym, M.

Articles by Roeder, G. S.

Search for Related Content

PubMed

PubMed Citation

Articles by Sym, M.

Articles by Roeder, G. S.

Pubmed/NCBI databases

Substance via MeSH

Social Bookmarking

What's this?

ARTICLES

Zip1-induced changes in synaptonemal complex structure and polycomplex assembly

M Sym and GS Roeder
Department of Biology, Yale University, New Haven, Connecticut 06520- 8103.

The yeast Zip1 protein is a component of the synaptonemal complex (SC), which is an elaborate macromolecular structure found along the lengths of chromosomes during meiosis. Mutations that increase the length of the predicted coiled coil region of the Zip1 protein show that Zip1 influences the width of the SC. Overexpression of the ZIP1 gene results in the formation of two distinct types of higher order structures that are found in the nucleus, but not associated with chromatin. One of these structures resembles the polycomplexes that have been observed in many organisms and are thought to be aggregates of SC components. The second type of structure, which we have termed "networks," does not resemble any previously identified SC-related structure. Assembly of both polycomplexes and networks can occur independently of the Hop1 or Red1 protein, which are thought to be SC components. Our results demonstrate that Zip1 is a structural component of the central region of the SC. More specifically, we speculate that Zip1 is a component of the transverse filaments that lie perpendicular to the long axis of the complex.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Jordan, P., Copsey, A., Newnham, L., Kolar, E., Lichten, M., Hoffmann, E. (2009). Ipl1/Aurora B kinase coordinates synaptonemal complex disassembly with cell cycle progression and crossover formation in budding yeast meiosis. Genes Dev. 23: 2237-2251 [Abstract] [Full Text]
Brar, G. A., Hochwagen, A., Ee, L.-s. S., Amon, A. (2009). The Multiple Roles of Cohesin in Meiotic Chromosome Morphogenesis and Pairing. Mol. Biol. Cell 20: 1030-1047 [Abstract] [Full Text]
Tsubouchi, T., MacQueen, A. J., Roeder, G. S. (2008). Initiation of meiotic chromosome synapsis at centromeres in budding yeast. Genes Dev. 22: 3217-3226 [Abstract] [Full Text]
Jeffress, J. K., Page, S. L., Royer, S. M., Belden, E. D., Blumenstiel, J. P., Anderson, L. K., Hawley, R. S. (2007). The Formation of the Central Element of the Synaptonemal Complex May Occur by Multiple Mechanisms: The Roles of the N- and C-Terminal Domains of the Drosophila C(3)G Protein in Mediating Synapsis and Recombination. Genetics 177: 2445-2456 [Abstract] [Full Text]
Mitra, N., Roeder, G. S. (2007). A Novel Nonnull ZIP1 Allele Triggers Meiotic Arrest With Synapsed Chromosomes in Saccharomyces cerevisiae. Genetics 176: 773-787 [Abstract] [Full Text]
Bolcun-Filas, E., Costa, Y., Speed, R., Taggart, M., Benavente, R., De Rooij, D. G, Cooke, H. J (2007). SYCE2 is required for synaptonemal complex assembly, double strand break repair, and homologous recombination. JCB 176: 741-747 [Abstract] [Full Text]
Arya, G. H., Lodico, M. J. P., Ahmad, O. I., Amin, R., Tomkiel, J. E. (2006). Molecular Characterization of teflon, a Gene Required for Meiotic Autosome Segregation in Male Drosophila melanogaster. Genetics 174: 125-134 [Abstract] [Full Text]
Egydio de Carvalho, C., Colaiacovo, M. P. (2006). SUMO-mediated regulation of synaptonemal complex formation during meiosis. Genes Dev. 20: 1986-1992 [Full Text]
Nonomura, K.-I., Nakano, M., Eiguchi, M., Suzuki, T., Kurata, N. (2006). PAIR2 is essential for homologous chromosome synapsis in rice meiosis I. J. Cell Sci. 119: 217-225 [Abstract] [Full Text]
Niu, H., Wan, L., Baumgartner, B., Schaefer, D., Loidl, J., Hollingsworth, N. M. (2005). Partner Choice during Meiosis Is Regulated by Hop1-promoted Dimerization of Mek1. Mol. Biol. Cell 16: 5804-5818 [Abstract] [Full Text]
Couteau, F., Zetka, M. (2005). HTP-1 coordinates synaptonemal complex assembly with homolog alignment during meiosis in C. elegans. Genes Dev. 19: 2744-2756 [Abstract] [Full Text]
Trelles-Sticken, E., Bonfils, S., Sollier, J., Geli, V., Scherthan, H., de La Roche Saint-Andre, C. (2005). Set1- and Clb5-deficiencies disclose the differential regulation of centromere and telomere dynamics in Saccharomyces cerevisiae meiosis. J. Cell Sci. 118: 4985-4994 [Abstract] [Full Text]
Ollinger, R., Alsheimer, M., Benavente, R. (2005). Mammalian Protein SCP1 Forms Synaptonemal Complex-like Structures in the Absence of Meiotic Chromosomes. Mol. Biol. Cell 16: 212-217 [Abstract] [Full Text]
Bhuiyan, H., Schmekel, K. (2004). Meiotic Chromosome Synapsis in Yeast Can Occur Without Spo11-Induced DNA Double-Strand Breaks. Genetics 168: 775-783 [Abstract] [Full Text]
Anuradha, S., Muniyappa, K. (2004). Saccharomyces cerevisiae Hop1 Zinc Finger Motif Is the Minimal Region Required for Its Function in Vitro. J. Biol. Chem. 279: 28961-28969 [Abstract] [Full Text]
White, E. J., Cowan, C., Cande, W. Z., Kaback, D. B. (2004). In Vivo Analysis of Synaptonemal Complex Formation During Yeast Meiosis. Genetics 167: 51-63 [Abstract] [Full Text]
Anuradha, S., Muniyappa, K. (2004). Meiosis-specific yeast Hop1 protein promotes synapsis of double-stranded DNA helices via the formation of guanine quartets. Nucleic Acids Res 32: 2378-2385 [Abstract] [Full Text]
Henderson, K. A., Keeney, S. (2004). Tying synaptonemal complex initiation to the formation and programmed repair of DNA double-strand breaks. Proc. Natl. Acad. Sci. USA 101: 4519-4524 [Abstract] [Full Text]
Yu, H.-G., Koshland, D. E. (2003). Meiotic condensin is required for proper chromosome compaction, SC assembly, and resolution of recombination-dependent chromosome linkages. JCB 163: 937-947 [Abstract] [Full Text]
Shinohara, M., Sakai, K., Shinohara, A., Bishop, D. K. (2003). Crossover Interference in Saccharomyces cerevisiae Requires a TID1/RDH54- and DMC1-Dependent Pathway. Genetics 163: 1273-1286 [Abstract] [Full Text]
de los Santos, T., Loidl, J., Larkin, B., Hollingsworth, N. M. (2001). A Role for MMS4 in the Processing of Recombination Intermediates During Meiosis in Saccharomyces cerevisiae. Genetics 159: 1511-1525 [Abstract] [Full Text]
Shanks, R. M. Q., Kamieniecki, R. J., Dawson, D. S. (2001). The Kar3-Interacting Protein Cik1p Plays a Critical Role in Passage Through Meiosis I in Saccharomyces cerevisiae. Genetics 159: 939-951 [Abstract] [Full Text]
Pelttari, J., Hoja, M.-R., Yuan, L., Liu, J.-G., Brundell, E., Moens, P., Santucci-Darmanin, S., Jessberger, R., Barbero, J. L., Heyting, C., Hoog, C. (2001). A Meiotic Chromosomal Core Consisting of Cohesin Complex Proteins Recruits DNA Recombination Proteins and Promotes Synapsis in the Absence of an Axial Element in Mammalian Meiotic Cells. Mol. Cell. Biol. 21: 5667-5677 [Abstract] [Full Text]
Novak, J. E., Ross-Macdonald, P. B., Roeder, G. S. (2001). The Budding Yeast Msh4 Protein Functions in Chromosome Synapsis and the Regulation of Crossover Distribution. Genetics 158: 1013-1025 [Abstract] [Full Text]
Trelles-Sticken, E., Dresser, M. E., Scherthan, H. (2000). Meiotic Telomere Protein Ndj1p Is Required for Meiosis-Specific Telomere Distribution, Bouquet Formation and Efficient Homologue Pairing. JCB 151: 95-106 [Abstract] [Full Text]
San-Segundo, P. A., Roeder, G. S. (2000). Role for the Silencing Protein Dot1 in Meiotic Checkpoint Control. Mol. Biol. Cell 11: 3601-3615 [Abstract] [Full Text]
Bailis, J. M., Smith, A. V., Roeder, G. S. (2000). Bypass of a Meiotic Checkpoint by Overproduction of Meiotic Chromosomal Proteins. Mol. Cell. Biol. 20: 4838-4848 [Abstract] [Full Text]
Muniyappa, K., Anuradha, S., Byers, B. (2000). Yeast Meiosis-Specific Protein Hop1 Binds to G4 DNA and Promotes Its Formation. Mol. Cell. Biol. 20: 1361-1369 [Abstract] [Full Text]
Dong, H., Roeder, G. S. (2000). Organization of the Yeast Zip1 Protein within the Central Region of the Synaptonemal Complex. JCB 148: 417-426 [Abstract] [Full Text]
Oh, J., Baksa, K., Steward, R. (2000). Functional Domains of the Drosophila Bicaudal-D Protein. Genetics 154: 713-724 [Abstract] [Full Text]
Tarsounas, M., Morita, T., Pearlman, R. E., Moens, P. B. (1999). Rad51 and Dmc1 Form Mixed Complexes Associated with Mouse Meiotic Chromosome Cores and Synaptonemal Complexes. JCB 147: 207-220 [Abstract] [Full Text]
Grushcow, J. M., Holzen, T. M., Park, K. J., Weinert, T., Lichten, M., Bishop, D. K. (1999). Saccharomyces cerevisiae Checkpoint Genes MEC1, RAD17 and RAD24 Are Required for Normal Meiotic Recombination Partner Choice. Genetics 153: 607-620 [Abstract] [Full Text]
Thompson, D. A., Stahl, F. W. (1999). Genetic Control of Recombination Partner Preference in Yeast Meiosis: Isolation and Characterization of Mutants Elevated for Meiotic Unequal Sister-Chromatid Recombination. Genetics 153: 621-641 [Abstract] [Full Text]
Kaback, D. B., Barber, D., Mahon, J., Lamb, J., You, J. (1999). Chromosome Size-Dependent Control of Meiotic Reciprocal Recombination in Saccharomyces cerevisiae: The Role of Crossover Interference. Genetics 152: 1475-1486 [Abstract] [Full Text]
Paques, F., Haber, J. E. (1999). Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 63: 349-404 [Abstract] [Full Text]
Yuan, L., Pelttari, J., Brundell, E., Bjorkroth, B., Zhao, J., Liu, J.-G., Brismar, H., Daneholt, B., Hoog, C. (1998). The Synaptonemal Complex Protein SCP3 Can Form Multistranded, Cross-striated Fibers In Vivo. JCB 142: 331-339 [Abstract] [Full Text]
Tung, K.-S., Roeder, G. S. (1998). Meiotic Chromosome Morphology and Behavior in zip1 Mutants of Saccharomyces cerevisiae. Genetics 149: 817-832 [Abstract] [Full Text]
Bascom-Slack, C. A., Dawson, D. S. (1997). The Yeast Motor Protein, Kar3p, Is Essential for Meiosis I. JCB 139: 459-467 [Abstract] [Full Text]
Roeder, G. S. (1997). Meiotic chromosomes: it takes two to�tango. Genes Dev. 11: 2600-2621 [Full Text]
Chua, P R, Roeder, G S (1997). Tam1, a telomere-associated meiotic protein, functions in chromosome synapsis and crossover interference.. Genes Dev. 11: 1786-1800 [Abstract]
Smith, A. V., Roeder, G. S. (1997). The Yeast Red1 Protein Localizes to the Cores of Meiotic Chromosomes. JCB 136: 957-967 [Abstract] [Full Text]
Cook, P. (1997). The transcriptional basis of chromosome pairing. J. Cell Sci. 110: 1033-1040 [Abstract]
Rockmill, B, Sym, M, Scherthan, H, Roeder, G S (1995). Roles for two RecA homologs in promoting meiotic chromosome synapsis.. Genes Dev. 9: 2684-2695 [Abstract]
Tung, K.-S., Hong, E.-J. E., Roeder, G. S. (2000). The pachytene checkpoint prevents accumulation and phosphorylation of the meiosis-specific transcription factor Ndt80. Proc. Natl. Acad. Sci. USA 97: 12187-12192 [Abstract] [Full Text]
Ohta, T., Essner, R., Ryu, J.-H., Palazzo, R. E., Uetake, Y., Kuriyama, R. (2002). Characterization of Cep135, a novel coiled-coil centrosomal protein involved in microtubule organization in mammalian cells. JCB 156: 87-100 [Abstract] [Full Text]