Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis

doi:10.1083/jcb.130.1.157

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Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis

PX Petit, H Lecoeur, E Zorn, C Dauguet, B Mignotte and ML Gougeon
Centre de Genetique Moleculaire, CNRS, Gif-sur-Yvette, France.

In this paper we used a multiparametric approach to analyze extensively the events occurring during apoptotic cell death of thymocytes, and furthermore, we asked whether alterations in mitochondrial structure and function are occurring in early stages of apoptosis. A multiparametric quantitative analysis was performed on normal or apoptotic thymocytes emerging from a few-hour culture performed in culture medium or in the presence of dexamethasone. Simultaneous detection of light scattering properties, integrity of plasma membrane (trypan blue exclusion), chromatin condensation (AO/EB staining of entire cells or PI staining of nuclei), and DNA fragmentation (in situ nick-translation in apoptotic cells) allowed a precise analysis of the preapoptotic and apoptotic stages. Moreover a thorough study of mitochondrial transmembrane potential (delta psi m) assessed following in a time course study the uptake by apoptotic cells of the cationic lipophilic dye DiOC6(3) or the J-aggregate-forming cation JC-1, indicates that a drop in delta psi m occurs very early in thymocyte apoptosis, before DNA fragmentation. This is associated with alteration in mitochondrial structure assessed by cytofluorimetric study of NAO uptake in apoptotic cells. Finally these dramatic alterations in mitochondrial structure and function occurring in early stages of apoptosis were confirmed by confocal and electron microscopy analysis.
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Do, Y., McKallip, R. J., Nagarkatti, M., Nagarkatti, P. S. (2004). Activation through Cannabinoid Receptors 1 and 2 on Dendritic Cells Triggers NF-{kappa}B-Dependent Apoptosis: Novel Role for Endogenous and Exogenous Cannabinoids in Immunoregulation. J. Immunol. 173: 2373-2382 [Abstract] [Full Text]
Goudeau, B., Huetz, F., Samson, S., Di Santo, J. P., Cumano, A., Beg, A., Israel, A., Memet, S. (2003). I{kappa}B{alpha}/I{kappa}B{epsilon} deficiency reveals that a critical NF-{kappa}B dosage is required for lymphocyte survival. Proc. Natl. Acad. Sci. USA 100: 15800-15805 [Abstract] [Full Text]
Kurosaka, K., Takahashi, M., Watanabe, N., Kobayashi, Y. (2003). Silent Cleanup of Very Early Apoptotic Cells by Macrophages. J. Immunol. 171: 4672-4679 [Abstract] [Full Text]
Koni, P. A., Khanna, R., Chang, M. C., Tang, M. D., Kaczmarek, L. K., Schlichter, L. C., Flavell, R. A. (2003). Compensatory Anion Currents in Kv1.3 Channel-deficient Thymocytes. J. Biol. Chem. 278: 39443-39451 [Abstract] [Full Text]
Belmokhtar, C. A., Hillion, J., Dudognon, C., Fiorentino, S., Flexor, M., Lanotte, M., Segal-Bendirdjian, E. (2003). Apoptosome-independent Pathway for Apoptosis: BIOCHEMICAL ANALYSIS OF APAF-1 DEFECTS AND BIOLOGICAL OUTCOMES. J. Biol. Chem. 278: 29571-29580 [Abstract] [Full Text]
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Gardai, S. J., Hoontrakoon, R., Goddard, C. D., Day, B. J., Chang, L. Y., Henson, P. M., Bratton, D. L. (2003). Oxidant-Mediated Mitochondrial Injury in Eosinophil Apoptosis: Enhancement by Glucocorticoids and Inhibition by Granulocyte-Macrophage Colony-Stimulating Factor. J. Immunol. 170: 556-566 [Abstract] [Full Text]
Letuve, S., Druilhe, A., Grandsaigne, M., Aubier, M., Pretolani, M. (2002). Critical Role of Mitochondria, but Not Caspases, during Glucocorticosteroid-Induced Human Eosinophil Apoptosis. Am. J. Respir. Cell Mol. Bio. 26: 565-571 [Abstract] [Full Text]
Madesh, M., Hajnoczky, G. (2001). VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release. JCB 155: 1003-1016 [Abstract] [Full Text]
Debbasch, C., Pisella, P.-J., De Saint Jean, M., Rat, P., Warnet, J.-M., Baudouin, C. (2001). Mitochondrial Activity and Glutathione Injury in Apoptosis Induced by Unpreserved and Preserved {beta}-Blockers on Chang Conjunctival Cells. IOVS 42: 2525-2533 [Abstract] [Full Text]
Delogu, G., Moretti, S., Famularo, G., Marcellini, S., Santini, G., Antonucci, A., Marandola, M., Signore, L. (2001). Mitochondrial Perturbations and Oxidant Stress in Lymphocytes From Patients Undergoing Surgery and General Anesthesia. Arch Surg 136: 1190-1196 [Abstract] [Full Text]
Arnoult, D., Tatischeff, I., Estaquier, J., Girard, M., Sureau, F., Tissier, J. P., Grodet, A., Dellinger, M., Traincard, F., Kahn, A., Ameisen, J.-C., Petit, P. X. (2001). On the Evolutionary Conservation of the Cell Death Pathway: Mitochondrial Release of an Apoptosis-inducing Factor during Dictyostelium discoideum Cell Death. Mol. Biol. Cell 12: 3016-3030 [Abstract] [Full Text]
BESSEDE, G., MIGUET, C., GAMBERT, P., NEEL, D., LIZARD, G. (2001). Efficiency of homocysteine plus copper in inducing apoptosis is inversely proportional to {gamma}-glutamyl transpeptidase activity. FASEB J. 15: 1927-1940 [Abstract] [Full Text]
Pardo, J., Perez-Galan, P., Gamen, S., Marzo, I., Monleon, I., Kaspar, A. A., Susin, S. A., Kroemer, G., Krensky, A. M., Naval, J., Anel, A. (2001). A Role of the Mitochondrial Apoptosis-Inducing Factor in Granulysin-Induced Apoptosis. J. Immunol. 167: 1222-1229 [Abstract] [Full Text]
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Legrand, O., Perrot, J.-Y., Simonin, G., Baudard, M., Marie, J.-P. (2001). JC-1: a very sensitive fluorescent probe to test Pgp activity in adult acute myeloid leukemia. Blood 97: 502-508 [Abstract] [Full Text]
Mann, C. L., Cidlowski, J. A. (2001). Glucocorticoids Regulate Plasma Membrane Potential During Rat Thymocyte Apoptosis in Vivo and in Vitro. Endocrinology 142: 421-429 [Abstract] [Full Text]
Karbowski, M, Spodnik, J., Teranishi, M, Wozniak, M, Nishizawa, Y, Usukura, J, Wakabayashi, T (2001). Opposite effects of microtubule-stabilizing and microtubule-destabilizing drugs on biogenesis of mitochondria in mammalian cells. J. Cell Sci. 114: 281-291 [Abstract]
Torres-Roca, J. F., Tung, J. W., Greenwald, D. R., Brown, J. M., Herzenberg, L. A., Herzenberg, L. A., Katsikis, P. D. (2000). An Early Oxygen-Dependent Step Is Required for Dexamethasone-Induced Apoptosis of Immature Mouse Thymocytes. J. Immunol. 165: 4822-4830 [Abstract] [Full Text]
Delogu, G., Moretti, S., Antonucci, A., Marcellini, S., Masciangelo, R., Famularo, G., Signore, L., De Simone, C. (2000). Apoptosis and Surgical Trauma: Dysregulated Expression of Death and Survival Factors on Peripheral Lymphocytes. Arch Surg 135: 1141-1147 [Abstract] [Full Text]
Rolo, A. P., Oliveira, P. J., Moreno, A. J. M., Palmeira, C. M. (2000). Bile Acids Affect Liver Mitochondrial Bioenergetics: Possible Relevance for Cholestasis Therapy. Toxicol Sci 57: 177-185 [Abstract] [Full Text]
Pierce, R. H., Campbell, J. S., Stephenson, A. B., Franklin, C. C., Chaisson, M., Poot, M., Kavanagh, T. J., Rabinovitch, P. S., Fausto, N. (2000). Disruption of Redox Homeostasis in Tumor Necrosis Factor-Induced Apoptosis in a Murine Hepatocyte Cell Line. Am. J. Pathol. 157: 221-236 [Abstract] [Full Text]
Liu, L., Trimarchi, J. R., Keefe, D. L. (2000). Involvement of Mitochondria in Oxidative Stress-Induced Cell Death in Mouse Zygotes. Biol. Reprod. 62: 1745-1753 [Abstract] [Full Text]
Bajpai, U. D., Zhang, K., Teutsch, M., Sen, R., Wortis, H. H. (2000). Bruton's Tyrosine Kinase Links the B Cell Receptor to Nuclear Factor {kappa}b Activation. JEM 191: 1735-1744 [Abstract] [Full Text]
Ponzanelli, I., Gianni, M., Giavazzi, R., Garofalo, A., Nicoletti, I., Reichert, U., Erba, E., Rambaldi, A., Terao, M., Garattini, E. (2000). Isolation and characterization of an acute promyelocytic leukemia cell line selectively resistant to the novel antileukemic and apoptogenic retinoid 6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene carboxylic acid. Blood 95: 2672-2682 [Abstract] [Full Text]
Liu, D., Martino, G., Thangaraju, M., Sharma, M., Halwani, F., Shen, S.-H., Patel, Y. C., Srikant, C. B. (2000). Caspase-8-mediated Intracellular Acidification Precedes Mitochondrial Dysfunction in Somatostatin-induced Apoptosis. J. Biol. Chem. 275: 9244-9250 [Abstract] [Full Text]
Mann, C. L., Hughes, F. M. Jr., Cidlowski, J. A. (2000). Delineation of the Signaling Pathways Involved in Glucocorticoid-Induced and Spontaneous Apoptosis of Rat Thymocytes. Endocrinology 141: 528-538 [Abstract] [Full Text]
Isenberg, J. S., Klaunig, J. E. (2000). Role of the Mitochondrial Membrane Permeability Transition (MPT) in Rotenone-Induced Apoptosis in Liver Cells. Toxicol Sci 53: 340-351 [Abstract] [Full Text]
Bauer, M. K.A., Schubert, A., Rocks, O., Grimm, S. (1999). Adenine Nucleotide Translocase-1, a Component of the Permeability Transition Pore, Can Dominantly Induce Apoptosis. JCB 147: 1493-1502 [Abstract] [Full Text]
Vacca, A., Iurlaro, M., Ribatti, D., Minischetti, M., Nico, B., Ria, R., Pellegrino, A., Dammacco, F. (1999). Antiangiogenesis Is Produced by Nontoxic Doses of Vinblastine. Blood 94: 4143-4155 [Abstract] [Full Text]
Kawabata, Y., Hirokawa, M., Kitabayashi, A., Horiuchi, T., Kuroki, J., Miura, A. B. (1999). Defective Apoptotic Signal Transduction Pathway Downstream of Caspase-3 in Human B-Lymphoma Cells: A Novel Mechanism of Nuclear Apoptosis Resistance. Blood 94: 3523-3530 [Abstract] [Full Text]
Erkkilä, K., Pentikäinen, V., Wikström, M., Parvinen, M., Dunkel, L. (1999). Partial Oxygen Pressure and Mitochondrial Permeability Transition Affect Germ Cell Apoptosis in the Human Testis. J. Clin. Endocrinol. Metab. 84: 4253-4259 [Abstract] [Full Text]
Lipton, P. (1999). Ischemic Cell Death in Brain Neurons. Physiol. Rev. 79: 1431-1568 [Abstract] [Full Text]
Kravtsov, V. D., Daniel, T. O., Koury, M. J. (1999). Comparative Analysis of Different Methodological Approaches to the in Vitro Study of Drug-Induced Apoptosis. Am. J. Pathol. 155: 1327-1339 [Abstract] [Full Text]
Shinoura, N., Yoshida, Y., Nishimura, M., Muramatsu, Y., Asai, A., Kirino, T., Hamada, H. (1999). Expression Level of Bcl-2 Determines Anti- or Proapoptotic Function. Cancer Res. 59: 4119-4128 [Abstract] [Full Text]
Bortner, C. D., Cidlowski, J. A. (1999). Caspase Independent/Dependent Regulation of K+, Cell Shrinkage, and Mitochondrial Membrane Potential during Lymphocyte Apoptosis. J. Biol. Chem. 274: 21953-21962 [Abstract] [Full Text]
Sudbeck, E. A., Liu, X.-P., Narla, R. K., Mahajan, S., Ghosh, S., Mao, C., Uckun, F. M. (1999). Structure-based Design of Specific Inhibitors of Janus Kinase 3 as Apoptosis-inducing Antileukemic Agents. Clin. Cancer Res. 5: 1569-1582 [Abstract] [Full Text]
Dallaporta, B., Marchetti, P., de Pablo, M. A., Maisse, C., Duc, H.-T., Metivier, D., Zamzami, N., Geuskens, M., Kroemer, G. (1999). Plasma Membrane Potential in Thymocyte Apoptosis. J. Immunol. 162: 6534-6542 [Abstract] [Full Text]
Suzuki, A., Tsutomi, Y., Yamamoto, N., Shibutani, T., Akahane, K. (1999). Mitochondrial Regulation of Cell Death: Mitochondria Are Essential for Procaspase 3-p21 Complex Formation To Resist Fas-Mediated Cell Death. Mol. Cell. Biol. 19: 3842-3847 [Abstract] [Full Text]
Mihara, S., Suzuki, N., Wakisaka, S., Suzuki, S., Sekita, N., Yamamoto, S., Saito, N., Hoshino, T., Sakane, T. (1999). Effects of Thyroid Hormones on Apoptotic Cell Death of Human Lymphocytes. J. Clin. Endocrinol. Metab. 84: 1378-1385 [Abstract] [Full Text]
McGargill, M. A., Hogquist, K. A. (1999). Antigen-Induced Coreceptor Down-Regulation on Thymocytes Is Not a Result of Apoptosis. J. Immunol. 162: 1237-1245 [Abstract] [Full Text]
Chen, Q., Takeyama, N., Brady, G., Watson, A. J.M., Dive, C. (1998). Blood Cells With Reduced Mitochondrial Membrane Potential and Cytosolic Cytochrome C Can Survive and Maintain Clonogenicity Given Appropriate Signals to Suppress Apoptosis. Blood 92: 4545-4553 [Abstract] [Full Text]
Angermüller, S., Künstle, G., Tiegs, G. (1998). Pre-apoptotic Alterations in Hepatocytes of TNF{alpha}-treated Galactosamine-sensitized Mice. J. Histochem. Cytochem. 46: 1175-1184 [Abstract] [Full Text]
Back, S. A., Gan, X., Li, Y., Rosenberg, P. A., Volpe, J. J. (1998). Maturation-Dependent Vulnerability of Oligodendrocytes to Oxidative Stress-Induced Death Caused by Glutathione Depletion. J. Neurosci. 18: 6241-6253 [Abstract] [Full Text]
Haunstetter, A., Izumo, S. (1998). Apoptosis : Basic Mechanisms and Implications for Cardiovascular Disease. Circ. Res. 82: 1111-1129 [Full Text]
Dallaporta, B., Hirsch, T., Susin, S. A., Zamzami, N., Larochette, N., Brenner, C., Marzo, I., Kroemer, G. (1998). Potassium Leakage During the Apoptotic Degradation Phase. J. Immunol. 160: 5605-5615 [Abstract] [Full Text]
Moretti, S., Alesse, E., Di Marzio, L., Zazzeroni, F., Ruggeri, B., Marcellini, S., Famularo, G., Steinberg, S. M., Boschini, A., Cifone, M. G., De Simone, C. (1998). Effect of L-Carnitine on Human Immunodeficiency Virus-1 Infection-Associated Apoptosis: A Pilot Study. Blood 91: 3817-3824 [Abstract] [Full Text]
Mancini, M., Nicholson, D. W., Roy, S., Thornberry, N. A., Peterson, E. P., Casciola-Rosen, L. A., Rosen, A. (1998). The Caspase-3 Precursor Has a Cytosolic and Mitochondrial Distribution: Implications for Apoptotic Signaling. JCB 140: 1485-1495 [Abstract] [Full Text]
Summerfield, A., Knotig, S. M., McCullough, K. C. (1998). Lymphocyte Apoptosis during Classical Swine Fever: Implication of Activation-Induced Cell Death. J. Virol. 72: 1853-1861 [Abstract] [Full Text]
Xiang, H., Kinoshita, Y., Knudson, C. M., Korsmeyer, S. J., Schwartzkroin, P. A., Morrison, R. S. (1998). Bax Involvement in p53-Mediated Neuronal Cell Death. J. Neurosci. 18: 1363-1373 [Abstract] [Full Text]
Lavoie, J. N., Nguyen, M., Marcellus, R.C., Branton, P.E., Shore, G.C. (1998). E4orf4, a Novel Adenovirus Death Factor That Induces p53-independent Apoptosis by a Pathway That Is Not Inhibited by zVAD-fmk. JCB 140: 637-645 [Abstract] [Full Text]
Wadia, J. S., Chalmers-Redman, R. M.�E., Ju, W. J.�H., Carlile, G. W., Phillips, J. L., Fraser, A. D., Tatton, W. G. (1998). Mitochondrial Membrane Potential and Nuclear Changes in Apoptosis Caused by Serum and Nerve Growth Factor Withdrawal: Time Course and Modification by (-)-Deprenyl. J. Neurosci. 18: 932-947 [Abstract] [Full Text]
Parker, B. W., Kaur, G., Nieves-Neira, W., Taimi, M., Kohlhagen, G., Shimizu, T., Losiewicz, M. D., Pommier, Y., Sausville, E. A., Senderowicz, A. M. (1998). Early Induction of Apoptosis in Hematopoietic Cell Lines After Exposure to Flavopiridol. Blood 91: 458-465 [Abstract] [Full Text]
Mancini, M., Anderson, B. O., Caldwell, E., Sedghinasab, M., Paty, P. B., Hockenbery, D. M. (1997). Mitochondrial Proliferation and Paradoxical Membrane Depolarization during Terminal Differentiation and Apoptosis in a Human Colon Carcinoma Cell Line. JCB 138: 449-469 [Abstract] [Full Text]
Hentosh, P., Tibudan, M. (1997). 2-Chloro-2'-deoxyadenosine, an Antileukemic Drug, Has an Early Effect on Cellular Mitochondrial Function. Mol. Pharmacol. 51: 613-619 [Abstract] [Full Text]
Srivastava, I. K., Rottenberg, H., Vaidya, A. B. (1997). Atovaquone, a Broad Spectrum Antiparasitic Drug, Collapses Mitochondrial Membrane Potential in a Malarial Parasite. J. Biol. Chem. 272: 3961-3966 [Abstract] [Full Text]
Simpson, P. B., Russell, J. T. (1996). Mitochondria Support Inositol 1,4,5-Trisphosphate-mediated Ca2+ Waves in Cultured Oligodendrocytes. J. Biol. Chem. 271: 33493-33501 [Abstract] [Full Text]
Krippner, A., Matsuno-Yagi, A., Gottlieb, R. A., Babior, B. M. (1996). Loss of Function of Cytochrome c in Jurkat Cells Undergoing Fas-mediated Apoptosis. J. Biol. Chem. 271: 21629-21636 [Abstract] [Full Text]
Nicolli, A., Basso, E., Petronilli, V., Wenger, R. M., Bernardi, P. (1996). Interactions of Cyclophilin with the Mitochondrial Inner Membrane and Regulation of the Permeability Transition Pore, a Cyclosporin A-sensitive Channel. J. Biol. Chem. 271: 2185-2192 [Abstract] [Full Text]
Chauvin, C., De Oliveira, F., Ronot, X., Mousseau, M., Leverve, X., Fontaine, E. (2001). Rotenone Inhibits the Mitochondrial Permeability Transition-induced Cell Death in U937 and KB Cells. J. Biol. Chem. 276: 41394-41398 [Abstract] [Full Text]