The Journal of Cell Biology, Vol 130, 977-986, Copyright © 1995 by The Rockefeller University Press

ARTICLES

Receptor protein tyrosine phosphatase PTPmu associates with cadherins and catenins in vivo

SM Brady-Kalnay, DL Rimm and NK Tonks
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724-2208, USA.

The extracellular segment of the receptor-type type protein tyrosine phosphatase PTPmu, possesses an MAM domain, an immunoglobulin domain, and four fibronectin type-III repeats. It binds homophilically, i.e., PTPmu on the surface of one cell binds to PTPmu on an apposing cell, and the binding site lies within the immunoglobulin domain. The intracellular segment of PTPmu has two PTP domains and a juxtamembrane segment that is homologous to the conserved intracellular domain of the cadherins. In cadherins, this segment interacts with proteins termed catenins to mediate association with the actin cytoskeleton. In this article, we demonstrate that PTPmu associates with a complex containing cadherins, alpha- and beta-catenin in mink lung (MvLu) cells, and in rat heart, lung, and brain tissues. Greater than 80% of the cadherin in the cell is cleared from Triton X-100 lysates of MvLu cells after immunoprecipitation with antibodies to PTPmu; however, the complex is dissociated when lysates are prepared in more stringent, SDS-containing RIPA buffer. In vitro binding studies demonstrated that the intracellular segment of PTPmu binds directly to the intracellular domain of E-cadherin, but not to alpha- or beta-catenin. Consistent with their ability to interact in vivo, PTPmu, cadherins, and catenins all localized to points of cell-cell contact in MvLu cells, as assessed by immunocytochemical staining. After pervanadate treatment of MvLu cells, which inhibits cellular tyrosine phosphatase activity including PTPmu, the cadherins associated with PTPmu are now found in a tyrosine- phosphorylated form, indicating that the cadherins may be an endogenous substrate for PTPmu. These data suggest that PTPmu may be one of the enzymes that regulates the dynamic tyrosine phosphorylation, and thus function, of the cadherin/catenin complex in vivo.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

• Burgoyne, A. M., Phillips-Mason, P. J., Burden-Gulley, S. M., Robinson, S., Sloan, A. E., Miller, R. H., Brady-Kalnay, S. M. (2009). Proteolytic Cleavage of Protein Tyrosine Phosphatase {micro} Regulates Glioblastoma Cell Migration. Cancer Res. 69: 6960-6968 [Abstract] [Full Text]  
• Sallee, J. L., Burridge, K. (2009). Density-enhanced Phosphatase 1 Regulates Phosphorylation of Tight Junction Proteins and Enhances Barrier Function of Epithelial Cells. J. Biol. Chem. 284: 14997-15006 [Abstract] [Full Text]  
• Yu, J., Becka, S., Zhang, P., Zhang, X., Brady-Kalnay, S. M., Wang, Z. (2008). Tumor-Derived Extracellular Mutations of PTPRT/PTP{rho} Are Defective in Cell Adhesion. Mol Cancer Res 6: 1106-1113 [Abstract] [Full Text]  
• Sakamoto, Y., Ogita, H., Komura, H., Takai, Y. (2008). Involvement of Nectin in Inactivation of Integrin {alpha}v 3 after the Establishment of Cell-Cell Adhesion. J. Biol. Chem. 283: 496-505 [Abstract] [Full Text]  
• Ezaki, T., Guo, R.-J., Li, H., Reynolds, A. B., Lynch, J. P. (2007). The homeodomain transcription factors Cdx1 and Cdx2 induce E-cadherin adhesion activity by reducing beta- and p120-catenin tyrosine phosphorylation. Am. J. Physiol. Gastrointest. Liver Physiol. 293: G54-G65 [Abstract] [Full Text]  
• Siu, R., Fladd, C., Rotin, D. (2007). N-Cadherin Is an In Vivo Substrate for Protein Tyrosine Phosphatase Sigma (PTP{sigma}) and Participates in PTP{sigma}-Mediated Inhibition of Axon Growth. Mol. Cell. Biol. 27: 208-219 [Abstract] [Full Text]  
• Choe, K.-M., Prakash, S., Bright, A., Clandinin, T. R. (2006). Liprin-{alpha} is required for photoreceptor target selection in Drosophila. Proc. Natl. Acad. Sci. USA 103: 11601-11606 [Abstract] [Full Text]  
• Gao, L., Miller, R. H. (2006). Specification of optic nerve oligodendrocyte precursors by retinal ganglion cell axons.. J. Neurosci. 26: 7619-7628 [Abstract] [Full Text]  
• Sallee, J. L., Wittchen, E. S., Burridge, K. (2006). Regulation of Cell Adhesion by Protein-tyrosine Phosphatases: II. CELL-CELL ADHESION. J. Biol. Chem. 281: 16189-16192 [Abstract] [Full Text]  
• Yan, H.-X., Yang, W., Zhang, R., Chen, L., Tang, L., Zhai, B., Liu, S.-Q., Cao, H.-F., Man, X.-B., Wu, H.-P., Wu, M.-C., Wang, H.-Y. (2006). Protein-tyrosine Phosphatase PCP-2 Inhibits beta-Catenin Signaling and Increases E-cadherin-dependent Cell Adhesion. J. Biol. Chem. 281: 15423-15433 [Abstract] [Full Text]  
• Qi, J., Wang, J., Romanyuk, O., Siu, C.-H. (2006). Involvement of Src Family Kinases in N-Cadherin Phosphorylation and beta-Catenin Dissociation during Transendothelial Migration of Melanoma Cells. Mol. Biol. Cell 17: 1261-1272 [Abstract] [Full Text]  
• Phillips-Mason, P. J., Gates, T. J., Major, D. L., Sacks, D. B., Brady-Kalnay, S. M. (2006). The Receptor Protein-tyrosine Phosphatase PTP{micro} Interacts with IQGAP1. J. Biol. Chem. 281: 4903-4910 [Abstract] [Full Text]  
• Mehta, D., Malik, A. B. (2006). Signaling Mechanisms Regulating Endothelial Permeability. Physiol. Rev. 86: 279-367 [Abstract] [Full Text]  
• Vogelmann, R., Nguyen-tat, M.-D., Giehl, K., Adler, G., Wedlich, D., Menke, A. (2005). TGF{beta}-induced downregulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN. J. Cell Sci. 118: 4901-4912 [Abstract] [Full Text]  
• Schnekenburger, J, Mayerle, J, Kruger, B, Buchwalow, I, Weiss, F U, Albrecht, E, Samoilova, V E, Domschke, W, Lerch, M M (2005). Protein tyrosine phosphatase {kappa} and SHP-1 are involved in the regulation of cell-cell contacts at adherens junctions in the exocrine pancreas. Gut 54: 1445-1455 [Abstract] [Full Text]  
• Stoker, A. W (2005). Protein tyrosine phosphatases and signalling. J Endocrinol 185: 19-33 [Abstract] [Full Text]  
• Verin, A. D. (2005). Tyrosine Phosphorylation and Endothelial Cell Barrier Regulation. Am. J. Pathol. 166: 955-957 [Full Text]  
• Sui, X. F., Kiser, T. D., Hyun, S. W., Angelini, D. J., Del Vecchio, R. L., Young, B. A., Hasday, J. D., Romer, L. H., Passaniti, A., Tonks, N. K., Goldblum, S. E. (2005). Receptor Protein Tyrosine Phosphatase {micro} Regulates the Paracellular Pathway in Human Lung Microvascular Endothelia. Am. J. Pathol. 166: 1247-1258 [Abstract] [Full Text]  
• Kappert, K., Peters, K. G., Bohmer, F. D., Ostman, A. (2005). Tyrosine phosphatases in vessel wall signaling. Cardiovasc Res 65: 587-598 [Abstract] [Full Text]  
• Del Vecchio, R. L., Tonks, N. K. (2005). The Conserved Immunoglobulin Domain Controls the Subcellular Localization of the Homophilic Adhesion Receptor Protein-tyrosine Phosphatase {micro}. J. Biol. Chem. 280: 1603-1612 [Abstract] [Full Text]  
• Mruk, D. D., Cheng, C. Y. (2004). Sertoli-Sertoli and Sertoli-Germ Cell Interactions and Their Significance in Germ Cell Movement in the Seminiferous Epithelium during Spermatogenesis. Endocr. Rev. 25: 747-806 [Abstract] [Full Text]  
• Bazzoni, G., Dejana, E. (2004). Endothelial Cell-to-Cell Junctions: Molecular Organization and Role in Vascular Homeostasis. Physiol. Rev. 84: 869-901 [Abstract] [Full Text]  
• Lee, N. P.Y., Cheng, C. Y. (2004). Ectoplasmic specialization, a testis-specific cell-cell actin-based adherens junction type: is this a potential target for male contraceptive development?. Hum Reprod Update 10: 349-369 [Abstract] [Full Text]  
• Kellie, S., Craggs, G., Bird, I. N., Jones, G. E. (2004). The tyrosine phosphatase DEP-1 induces cytoskeletal rearrangements, aberrant cell-substratum interactions and a reduction in cell proliferation. J. Cell Sci. 117: 609-618 [Abstract] [Full Text]  
• Chattopadhyay, N., Wang, Z., Ashman, L. K., Brady-Kalnay, S. M., Kreidberg, J. A. (2003). {alpha}3{beta}1 integrin-CD151, a component of the cadherin-catenin complex, regulates PTP{micro} expression and cell-cell adhesion. JCB 163: 1351-1362 [Abstract] [Full Text]  
• Konstantoulaki, M., Kouklis, P., Malik, A. B. (2003). Protein kinase C modifications of VE-cadherin, p120, and {beta}-catenin contribute to endothelial barrier dysregulation induced by thrombin. Am. J. Physiol. Lung Cell. Mol. Physiol. 285: L434-L442 [Abstract] [Full Text]  
• Young, B. A., Sui, X., Kiser, T. D., Hyun, S. W., Wang, P., Sakarya, S., Angelini, D. J., Schaphorst, K. L., Hasday, J. D., Cross, A. S., Romer, L. H., Passaniti, A., Goldblum, S. E. (2003). Protein tyrosine phosphatase activity regulates endothelial cell-cell interactions, the paracellular pathway, and capillary tube stability. Am. J. Physiol. Lung Cell. Mol. Physiol. 285: L63-L75 [Abstract] [Full Text]  
• Lampugnani, M. G., Zanetti, A., Corada, M., Takahashi, T., Balconi, G., Breviario, F., Orsenigo, F., Cattelino, A., Kemler, R., Daniel, T. O., Dejana, E. (2003). Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, {beta}-catenin, and the phosphatase DEP-1/CD148. JCB 161: 793-804 [Abstract] [Full Text]  
• Takahashi, T., Takahashi, K., St. John, P. L., Fleming, P. A., Tomemori, T., Watanabe, T., Abrahamson, D. R., Drake, C. J., Shirasawa, T., Daniel, T. O. (2003). A Mutant Receptor Tyrosine Phosphatase, CD148, Causes Defects in Vascular Development. Mol. Cell. Biol. 23: 1817-1831 [Abstract] [Full Text]  
• Lui, W.-Y., Mruk, D. D., Lee, W. M., Cheng, C. Y. (2003). Adherens Junction Dynamics in the Testis and Spermatogenesis. J Androl 24: 1-14 [Full Text]  
• Johnson, K. G., Van Vactor, D. (2003). Receptor Protein Tyrosine Phosphatases in Nervous System Development. Physiol. Rev. 83: 1-24 [Abstract] [Full Text]  
• Xu, G., Arregui, C., Lilien, J., Balsamo, J. (2002). PTP1B Modulates the Association of beta -Catenin with N-cadherin through Binding to an Adjacent and Partially Overlapping Target Site. J. Biol. Chem. 277: 49989-49997 [Abstract] [Full Text]  
• Minnear, F. L. (2002). Vascular endothelial cells actively participate in high inflation pressure-induced permeability and edema. Am. J. Physiol. Lung Cell. Mol. Physiol. 283: L1200-L1202 [Full Text]  
• Gao, C., Negash, S., Guo, H. T., Ledee, D., Wang, H.-S., Zelenka, P. (2002). CDK5 Regulates Cell Adhesion and Migration in Corneal Epithelial Cells. Mol Cancer Res 1: 12-24 [Abstract] [Full Text]  
• Cheng, C. Y., Mruk, D. D. (2002). Cell Junction Dynamics in the Testis: Sertoli-Germ Cell Interactions and Male Contraceptive Development. Physiol. Rev. 82: 825-874 [Abstract] [Full Text]  
• Burden-Gulley, S. M., Ensslen, S. E., Brady-Kalnay, S. M. (2002). Protein Tyrosine Phosphatase-{micro} Differentially Regulates Neurite Outgrowth of Nasal and Temporal Neurons in the Retina. J. Neurosci. 22: 3615-3627 [Abstract] [Full Text]  
• Hellberg, C. B., Burden-Gulley, S. M., Pietz, G. E., Brady-Kalnay, S. M. (2002). Expression of the Receptor Protein-tyrosine Phosphatase, PTP{micro}, Restores E-cadherin-dependent Adhesion in Human Prostate Carcinoma Cells. J. Biol. Chem. 277: 11165-11173 [Abstract] [Full Text]  
• Carothers, A. M., Melstrom, K. A. Jr., Mueller, J. D., Weyant, M. J., Bertagnolli, M. M. (2001). Progressive Changes in Adherens Junction Structure during Intestinal Adenoma Formation in Apc Mutant Mice. J. Biol. Chem. 276: 39094-39102 [Abstract] [Full Text]  
• Thompson, L. J., Jiang, J., Madamanchi, N., Runge, M. S., Patterson, C. (2001). PTP-{epsilon}, a tyrosine phosphatase expressed in endothelium, negatively regulates endothelial cell proliferation. Am. J. Physiol. Heart Circ. Physiol. 281: H396-H403 [Abstract] [Full Text]  
• Hamm-Alvarez, S. F., Chang, A., Wang, Y., Jerdeva, G., Lin, H. H., Kim, K.-J., Ann, D. K. (2001). Etk/Bmx activation modulates barrier function in epithelial cells. Am. J. Physiol. Cell Physiol. 280: C1657-C1668 [Abstract] [Full Text]  
• Auersperg, N., Wong, A. S. T., Choi, K.-C., Kang, S. K., Leung, P. C. K. (2001). Ovarian Surface Epithelium: Biology, Endocrinology, and Pathology. Endocr. Rev. 22: 255-288 [Abstract] [Full Text]  
• Trapasso, F., Iuliano, R., Boccia, A., Stella, A., Visconti, R., Bruni, P., Baldassarre, G., Santoro, M., Viglietto, G., Fusco, A. (2000). Rat Protein Tyrosine Phosphatase eta Suppresses the Neoplastic Phenotype of Retrovirally Transformed Thyroid Cells through the Stabilization of p27Kip1. Mol. Cell. Biol. 20: 9236-9246 [Abstract] [Full Text]  
• Zondag, G. C. M., Reynolds, A. B., Moolenaar, W. H. (2000). Receptor Protein-tyrosine Phosphatase RPTP{micro} Binds to and Dephosphorylates the Catenin p120ctn. J. Biol. Chem. 275: 11264-11269 [Abstract] [Full Text]  
• Gumbiner, B. M. (2000). Regulation of Cadherin Adhesive Activity. JCB 148: 399-404 [Full Text]  
• Lammers, R., Lerch, M. M., Ullrich, A. (2000). The Carboxyl-terminal Tyrosine Residue of Protein-tyrosine Phosphatase alpha Mediates Association with Focal Adhesion Plaques. J. Biol. Chem. 275: 3391-3396 [Abstract] [Full Text]  
• Hershman, K. M., Levitan, E. S. (2000). RPTP{micro} and protein tyrosine phosphorylation regulate K+ channel mRNA expression in adult cardiac myocytes. Am. J. Physiol. Cell Physiol. 278: C397-C403 [Abstract] [Full Text]  
• Petrone, A, Sap, J (2000). Emerging issues in receptor protein tyrosine phosphatase function: lifting fog or simply shifting?. J. Cell Sci. 113: 2345-2354 [Abstract]  
• Taniguchi, Y., London, R., Schinkmann, K., Jiang, S., Avraham, H. (1999). The Receptor Protein Tyrosine Phosphatase, PTP-RO, Is Upregulated During Megakaryocyte Differentiation and Is Associated With the c-Kit Receptor. Blood 94: 539-549 [Abstract] [Full Text]  
• Goldblum, S. E., Young, B. A., Wang, P., Murphy-Ullrich, J. E. (1999). Thrombospondin-1 Induces Tyrosine Phosphorylation of Adherens Junction Proteins and Regulates an Endothelial Paracellular Pathway. Mol. Biol. Cell 10: 1537-1551 [Abstract] [Full Text]  
• Muller, T., Choidas, A., Reichmann, E., Ullrich, A. (1999). Phosphorylation and Free Pool of beta -Catenin Are Regulated by Tyrosine Kinases and Tyrosine Phosphatases during Epithelial Cell Migration. J. Biol. Chem. 274: 10173-10183 [Abstract] [Full Text]  
• Pötter, E., Bergwitz, C., Brabant, G. (1999). The Cadherin-Catenin System: Implications for Growth and Differentiation of Endocrine Tissues. Endocr. Rev. 20: 207-239 [Abstract] [Full Text]  
• Burden-Gulley, S. M., Brady-Kalnay, S. M. (1999). PTP{micro} Regulates N-Cadherin-dependent Neurite Outgrowth. JCB 144: 1323-1336 [Abstract] [Full Text]  
• Gulino, D., Delachanal, E., Concord, E., Genoux, Y., Morand, B., Valiron, M.-O., Sulpice, E., Scaife, R., Alemany, M., Vernet, T. (1998). Alteration of Endothelial Cell Monolayer Integrity Triggers Resynthesis of Vascular Endothelium Cadherin. J. Biol. Chem. 273: 29786-29793 [Abstract] [Full Text]  
• Bauer, A., Lickert, H., Kemler, R., Stappert, J. (1998). Modification of the E-cadherin-Catenin Complex in Mitotic Madin-Darby Canine Kidney Epithelial Cells. J. Biol. Chem. 273: 28314-28321 [Abstract] [Full Text]  
• Balsamo, J., Arregui, C., Leung, T., Lilien, J. (1998). The Nonreceptor Protein Tyrosine Phosphatase PTP1B Binds to the Cytoplasmic Domain of N-Cadherin and Regulates the Cadherin-Actin Linkage. JCB 143: 523-532 [Abstract] [Full Text]  
• Aplin, A. E., Howe, A., Alahari, S. K., Juliano, R. L. (1998). Signal Transduction and Signal Modulation by Cell Adhesion Receptors: The Role of Integrins, Cadherins, Immunoglobulin-Cell Adhesion Molecules, and Selectins. Pharmacol. Rev. 50: 197-264 [Abstract] [Full Text]  
• Adamson, R. H., Liu, B., Fry, G. N., Rubin, L. L., Curry, F. E. (1998). Microvascular permeability and number of tight junctions are modulated by cAMP. Am. J. Physiol. Heart Circ. Physiol. 274: H1885-H1894 [Abstract] [Full Text]  
• Edwards, G. M., Wilford, F. H., Liu, X., Hennighausen, L., Djiane, J., Streuli, C. H. (1998). Regulation of Mammary Differentiation by Extracellular Matrix Involves Protein-tyrosine Phosphatases. J. Biol. Chem. 273: 9495-9500 [Abstract] [Full Text]  
• Brady-Kalnay, S. M., Mourton, T., Nixon, J. P., Pietz, G. E., Kinch, M., Chen, H., Brackenbury, R., Rimm, D. L., Del Vecchio, R. L., Tonks, N. K. (1998). Dynamic Interaction of PTP{micro} with Multiple Cadherins In Vivo. JCB 141: 287-296 [Abstract] [Full Text]  
• Ozawa, M., Kemler, R. (1998). Altered Cell Adhesion Activity by Pervanadate Due to the Dissociation of alpha -Catenin from the E-Cadherin·Catenin Complex. J. Biol. Chem. 273: 6166-6170 [Abstract] [Full Text]  
• Esser, S, Lampugnani, M., Corada, M, Dejana, E, Risau, W (1998). Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells. J. Cell Sci. 111: 1853-1865 [Abstract]  
• Hoffmann, K. M. V., Tonks, N. K., Barford, D. (1997). The Crystal Structure of Domain 1 of Receptor Protein-tyrosine Phosphatase µ. J. Biol. Chem. 272: 27505-27508 [Abstract] [Full Text]  
• Spencer, S., Dowbenko, D., Cheng, J., Li, W., Brush, J., Utzig, S., Simanis, V., Lasky, L. A. (1997). PSTPIP: A Tyrosine Phosphorylated Cleavage Furrow-associated Protein that Is a Substrate for a PEST Tyrosine Phosphatase. JCB 138: 845-860 [Abstract] [Full Text]  
• Aicher, B., Lerch, M. M., Muller, T., Schilling, J., Ullrich, A. (1997). Cellular Redistribution of Protein Tyrosine Phosphatases LAR and PTP{sigma} by Inducible Proteolytic Processing. JCB 138: 681-696 [Abstract] [Full Text]  
• Braga, V. M.M., Machesky, L. M., Hall, A., Hotchin, N. A. (1997). The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell-Cell Contacts. JCB 137: 1421-1431 [Abstract] [Full Text]  
• Xu, Y., Guo, D.-F., Davidson, M., Inagami, T., Carpenter, G. (1997). Interaction of the Adaptor Protein Shc and the Adhesion Molecule Cadherin. J. Biol. Chem. 272: 13463-13466 [Abstract] [Full Text]  
• Garver, T. D., Ren, Q., Tuvia, S., Bennett, V. (1997). Tyrosine Phosphorylation at a Site Highly Conserved in the L1 Family of Cell Adhesion Molecules Abolishes Ankyrin Binding and Increases Lateral Mobility of Neurofascin. JCB 137: 703-714 [Abstract] [Full Text]  
• Cheng, J., Wu, K., Armanini, M., O'Rourke, N., Dowbenko, D., Lasky, L. A. (1997). A Novel Protein-Tyrosine Phosphatase Related to the Homotypically Adhering kappa andµReceptors. J. Biol. Chem. 272: 7264-7277 [Abstract] [Full Text]  
• Papkoff, J., Papkoff, J. (1997). Regulation of Complexed and Free Catenin Pools by Distinct Mechanisms. DIFFERENTIAL EFFECTS OF Wnt-1 AND v-Src. J. Biol. Chem. 272: 4536-4543 [Abstract] [Full Text]  
• Wasmeier, C., Hutton, J. C. (1996). Molecular Cloning of Phogrin, a Protein-tyrosine Phosphatase Homologue Localized to Insulin Secretory Granule Membranes. J. Biol. Chem. 271: 18161-18170 [Abstract] [Full Text]  
• Fuchs, M., Muller, T., Lerch, M. M., Ullrich, A. (1996). Association of Human Protein-tyrosine Phosphatase kappa with Members of the Armadillo Family. J. Biol. Chem. 271: 16712-16719 [Abstract] [Full Text]  
• Sörby, M., Ostman, A. (1996). Protein-tyrosine Phosphatase-mediated Decrease of Epidermal Growth Factor and Platelet-derived Growth Factor Receptor Tyrosine Phosphorylation in High Cell Density Cultures. J. Biol. Chem. 271: 10963-10966 [Abstract] [Full Text]  
• Suzuki, S. (1996). Protocadherins and diversity of the cadherin superfamily. J. Cell Sci. 109: 2609-2611 [Abstract]  
• Pani, G., Colavitti, R., Bedogni, B., Anzevino, R., Borrello, S., Galeotti, T. (2000). A Redox Signaling Mechanism for Density-dependent Inhibition of Cell Growth. J. Biol. Chem. 275: 38891-38899 [Abstract] [Full Text]  
• Huber, A. H., Stewart, D. B., Laurents, D. V., Nelson, W. J., Weis, W. I. (2001). The Cadherin Cytoplasmic Domain Is Unstructured in the Absence of beta -Catenin. A POSSIBLE MECHANISM FOR REGULATING CADHERIN TURNOVER. J. Biol. Chem. 276: 12301-12309 [Abstract] [Full Text]  
• Mourton, T., Hellberg, C. B., Burden-Gulley, S. M., Hinman, J., Rhee, A., Brady-Kalnay, S. M. (2001). The PTP{micro} Protein-tyrosine Phosphatase Binds and Recruits the Scaffolding Protein RACK1 to Cell-Cell Contacts. J. Biol. Chem. 276: 14896-14901 [Abstract] [Full Text]  
• Shinohara, M., Kodama, A., Matozaki, T., Fukuhara, A., Tachibana, K., Nakanishi, H., Takai, Y. (2001). Roles of Cell-Cell Adhesion-dependent Tyrosine Phosphorylation of Gab-1. J. Biol. Chem. 276: 18941-18946 [Abstract] [Full Text]  
• Fadel, M. P., Szewczenko-Pawlikowski, M., Leclerc, P., Dziak, E., Symonds, J. M., Blaschuk, O., Michalak, M., Opas, M. (2001). Calreticulin Affects beta -Catenin-associated Pathways. J. Biol. Chem. 276: 27083-27089 [Abstract] [Full Text]  
• Mariner, D. J., Anastasiadis, P., Keilhack, H., Bohmer, F.-D., Wang, J., Reynolds, A. B. (2001). Identification of Src Phosphorylation Sites in the Catenin p120ctn. J. Biol. Chem. 276: 28006-28013 [Abstract] [Full Text]  
• Xu, F., Zhao, R., Peng, Y., Guerrah, A., Zhao, Z. J. (2001). Association of Tyrosine Phosphatase SHP-2 with F-actin at Low Cell Densities. J. Biol. Chem. 276: 29479-29484 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents