Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain

doi:10.1083/jcb.131.5.1327

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Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain

R Brandt, J Leger and G Lee
Institute of Neurobiology, University of Heidelberg, Germany.

The neuronal microtubule-associated protein tau is required for the development of cell polarity in cultured neurons. Using PC12 cells that stably express tau and tau amino-terminal fragments, we report that tau interacts with the neural plasma membrane through its amino-terminal projection domain. In differentiated PC12 transfectants, tau is found in growth cone-like structures in a nonmicrotubule-dependent manner. In hippocampal neurons, tau is differentially extracted by detergent and enriched in the growth cone and the distal axon when membrane is left intact. In PC12 transfectants, overexpression of tau's amino-terminal fragment, but not of full-length tau, suppresses NGF-induced process formation. Our data suggest that tau's amino-terminal projection domain has an important role in neuritic development and establishes tau as a mediator of microtubule-plasma membrane interactions.
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Rosenberg, K. J., Ross, J. L., Feinstein, H. E., Feinstein, S. C., Israelachvili, J. (2008). Complementary dimerization of microtubule-associated tau protein: Implications for microtubule bundling and tau-mediated pathogenesis. Proc. Natl. Acad. Sci. USA 105: 7445-7450 [Abstract] [Full Text]
Yu, J.-Z., Rasenick, M. M. (2006). Tau associates with actin in differentiating PC12 cells. FASEB J. 20: 1452-1461 [Abstract] [Full Text]
Sjoberg, M. K., Shestakova, E., Mansuroglu, Z., Maccioni, R. B., Bonnefoy, E. (2006). Tau protein binds to pericentromeric DNA: a putative role for nuclear tau in nucleolar organization. J. Cell Sci. 119: 2025-2034 [Abstract] [Full Text]
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Utton, M. A., Noble, W. J., Hill, J. E., Anderton, B. H., Hanger, D. P. (2005). Molecular motors implicated in the axonal transport of tau and {alpha}-synuclein. J. Cell Sci. 118: 4645-4654 [Abstract] [Full Text]
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Wang, Y., Wang, J., Gao, L., Lafyatis, R., Stamm, S., Andreadis, A. (2005). Tau Exons 2 and 10, Which Are Misregulated in Neurodegenerative Diseases, Are Partly Regulated by Silencers Which Bind a SRp30c{middle dot}SRp55 Complex That Either Recruits or Antagonizes htra2{beta}1. J. Biol. Chem. 280: 14230-14239 [Abstract] [Full Text]
Feijoo, C., Campbell, D. G., Jakes, R., Goedert, M., Cuenda, A. (2005). Evidence that phosphorylation of the microtubule-associated protein Tau by SAPK4/p38{delta} at Thr50 promotes microtubule assembly. J. Cell Sci. 118: 397-408 [Abstract] [Full Text]
Samsonov, A., Yu, J.-Z., Rasenick, M., Popov, S. V. (2004). Tau interaction with microtubules in vivo. J. Cell Sci. 117: 6129-6141 [Abstract] [Full Text]
Johnson, G. V. W., Stoothoff, W. H. (2004). Tau phosphorylation in neuronal cell function and dysfunction. J. Cell Sci. 117: 5721-5729 [Abstract] [Full Text]
Koyama, R., Yamada, M. K., Fujisawa, S., Katoh-Semba, R., Matsuki, N., Ikegaya, Y. (2004). Brain-Derived Neurotrophic Factor Induces Hyperexcitable Reentrant Circuits in the Dentate Gyrus. J. Neurosci. 24: 7215-7224 [Abstract] [Full Text]
Kawarabayashi, T., Shoji, M., Younkin, L. H., Wen-Lang, L., Dickson, D. W., Murakami, T., Matsubara, E., Abe, K., Ashe, K. H., Younkin, S. G. (2004). Dimeric Amyloid {beta} Protein Rapidly Accumulates in Lipid Rafts followed by Apolipoprotein E and Phosphorylated Tau Accumulation in the Tg2576 Mouse Model of Alzheimer's Disease. J. Neurosci. 24: 3801-3809 [Abstract] [Full Text]
AVILA, J., LUCAS, J. J., PEREZ, M., HERNANDEZ, F. (2004). Role of Tau Protein in Both Physiological and Pathological Conditions. Physiol. Rev. 84: 361-384 [Abstract] [Full Text]
Van Deerlin, V. M., Gill, L. H., Farmer, J. M., Trojanowski, J. Q., Lee, V. M-Y. (2003). Familial Frontotemporal Dementia: From Gene Discovery to Clinical Molecular Diagnostics. Clin. Chem. 49: 1717-1725 [Abstract] [Full Text]
Italiano, J. E. Jr, Bergmeier, W., Tiwari, S., Falet, H., Hartwig, J. H., Hoffmeister, K. M., Andre, P., Wagner, D. D., Shivdasani, R. A. (2003). Mechanisms and implications of platelet discoid shape. Blood 101: 4789-4796 [Abstract] [Full Text]
Dou, F., Netzer, W. J., Tanemura, K., Li, F., Hartl, F. U., Takashima, A., Gouras, G. K., Greengard, P., Xu, H. (2003). Chaperones increase association of tau protein with microtubules. Proc. Natl. Acad. Sci. USA 100: 721-726 [Abstract] [Full Text]
Cho, J.-H., Johnson, G. V. W. (2003). Glycogen Synthase Kinase 3beta Phosphorylates Tau at Both Primed and Unprimed Sites. DIFFERENTIAL IMPACT ON MICROTUBULE BINDING. J. Biol. Chem. 278: 187-193 [Abstract] [Full Text]
Fath, T., Eidenmuller, J., Brandt, R. (2002). Tau-Mediated Cytotoxicity in a Pseudohyperphosphorylation Model of Alzheimer's Disease. J. Neurosci. 22: 9733-9741 [Abstract] [Full Text]
Biernat, J., Wu, Y.-Z., Timm, T., Zheng-Fischhofer, Q., Mandelkow, E., Meijer, L., Mandelkow, E.-M. (2002). Protein Kinase MARK/PAR-1 Is Required for Neurite Outgrowth and Establishment of Neuronal Polarity. Mol. Biol. Cell 13: 4013-4028 [Abstract] [Full Text]
Utton, M. A., Connell, J., Asuni, A. A., van Slegtenhorst, M., Hutton, M., de Silva, R., Lees, A. J., Miller, C. C. J., Anderton, B. H. (2002). The Slow Axonal Transport of the Microtubule-Associated Protein Tau and the Transport Rates of Different Isoforms and Mutants in Cultured Neurons. J. Neurosci. 22: 6394-6400 [Abstract] [Full Text]
Stamer, K., Vogel, R., Thies, E., Mandelkow, E., Mandelkow, E.-M. (2002). Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress. JCB 156: 1051-1063 [Abstract] [Full Text]
Klein, C., Kramer, E.-M., Cardine, A.-M., Schraven, B., Brandt, R., Trotter, J. (2002). Process Outgrowth of Oligodendrocytes Is Promoted by Interaction of Fyn Kinase with the Cytoskeletal Protein Tau. J. Neurosci. 22: 698-707 [Abstract] [Full Text]
Kunda, P., Paglini, G., Quiroga, S., Kosik, K., Caceres, A. (2001). Evidence for the Involvement of Tiam1 in Axon Formation. J. Neurosci. 21: 2361-2372 [Abstract] [Full Text]
Pigino, G., Pelsman, A., Mori, H., Busciglio, J. (2001). Presenilin-1 Mutations Reduce Cytoskeletal Association, Deregulate Neurite Growth, and Potentiate Neuronal Dystrophy and Tau Phosphorylation. J. Neurosci. 21: 834-842 [Abstract] [Full Text]
Takei, Y., Teng, J., Harada, A., Hirokawa, N. (2000). Defects in Axonal Elongation and Neuronal Migration in Mice with Disrupted tau and map1b Genes. JCB 150: 989-1000 [Abstract] [Full Text]
Zmuda, J., Rivas, R. (2000). Actin disruption alters the localization of tau in the growth cones of cerebellar granule neurons. J. Cell Sci. 113: 2797-2809 [Abstract]
Davis, P. K., Johnson, G. V. W. (1999). The Microtubule Binding of Tau and High Molecular Weight Tau in Apoptotic PC12 Cells Is Impaired because of Altered Phosphorylation. J. Biol. Chem. 274: 35686-35692 [Abstract] [Full Text]
Spittaels, K., Van den Haute, C., Van Dorpe, J., Bruynseels, K., Vandezande, K., Laenen, I., Geerts, H., Mercken, M., Sciot, R., Van Lommel, A., Loos, R., Van Leuven, F. (1999). Prominent Axonopathy in the Brain and Spinal Cord of Transgenic Mice Overexpressing Four-Repeat Human tau Protein. Am. J. Pathol. 155: 2153-2165 [Abstract] [Full Text]
Higgins, J. J., Adler, R. L., Loveless, J. M. (1999). Mutational analysis of the tau gene in progressive supranuclear palsy. Neurology 53: 1421-1421 [Abstract] [Full Text]
Trinczek, B, Ebneth, A, Mandelkow, E., Mandelkow, E (1999). Tau regulates the attachment/detachment but not the speed of motors in microtubule-dependent transport of single vesicles and organelles. J. Cell Sci. 112: 2355-2367 [Abstract]
Paglini, G., Pigino, G., Kunda, P., Morfini, G., Maccioni, R., Quiroga, S., Ferreira, A., Caceres, A. (1998). Evidence for the Participation of the Neuron-Specific CDK5 Activator P35 during Laminin-Enhanced Axonal Growth. J. Neurosci. 18: 9858-9869 [Abstract] [Full Text]
Ebneth, A., Godemann, R., Stamer, K., Illenberger, S., Trinczek, B., Mandelkow, E.-M., Mandelkow, E. (1998). Overexpression of Tau Protein Inhibits Kinesin-dependent Trafficking of Vesicles, Mitochondria, and Endoplasmic Reticulum: Implications for Alzheimer's Disease. JCB 143: 777-794 [Abstract] [Full Text]
Tint, I., Slaughter, T., Fischer, I., Black, M. M. (1998). Acute Inactivation of Tau Has No Effect on Dynamics of Microtubules in Growing Axons of Cultured Sympathetic Neurons. J. Neurosci. 18: 8660-8673 [Abstract] [Full Text]
Paglini, G., Kunda, P., Quiroga, S., Kosik, K., Caceres, A. (1998). Suppression of Radixin and Moesin Alters Growth Cone Morphology, Motility, and Process Formation In Primary Cultured Neurons. JCB 143: 443-455 [Abstract] [Full Text]
Canu, N., Dus, L., Barbato, C., Ciotti, M. T., Brancolini, C., Rinaldi, A. M., Novak, M., Cattaneo, A., Bradbury, A., Calissano, P. (1998). Tau Cleavage and Dephosphorylation in Cerebellar Granule Neurons Undergoing Apoptosis. J. Neurosci. 18: 7061-7074 [Abstract] [Full Text]
Liao, H., Li, Y., Brautigan, D. L., Gundersen, G. G. (1998). Protein Phosphatase 1�Is Targeted to Microtubules by the Microtubule-associated Protein Tau. J. Biol. Chem. 273: 21901-21908 [Abstract] [Full Text]
Endres, M., Laufs, U., Huang, Z., Nakamura, T., Huang, P., Moskowitz, M. A., Liao, J. K. (1998). Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. Proc. Natl. Acad. Sci. USA 95: 8880-8885 [Abstract] [Full Text]
Lee, G, Newman, S., Gard, D., Band, H, Panchamoorthy, G (1998). Tau interacts with src-family non-receptor tyrosine kinases. J. Cell Sci. 111: 3167-3177 [Abstract]
Vanier, M., Neuville, P, Michalik, L, Launay, J. (1998). Expression of specific tau exons in normal and tumoral pancreatic acinar cells. J. Cell Sci. 111: 1419-1432 [Abstract]
Preuss, U, Biernat, J, Mandelkow, E., Mandelkow, E (1997). The 'jaws' model of tau-microtubule interaction examined in CHO cells. J. Cell Sci. 110: 789-800 [Abstract]
Pigino, G, Paglini, G, Ulloa, L, Avila, J, Caceres, A (1997). Analysis of the expression, distribution and function of cyclin dependent kinase 5 (cdk5) in developing cerebellar macroneurons. J. Cell Sci. 110: 257-270 [Abstract]
Arnold, C. S., Johnson, G. V.W., Cole, R. N., Dong, D. L.-Y., Lee, M., Hart, G. W. (1996). The Microtubule-associated Protein Tau Is Extensively Modified with O-linked N-acetylglucosamine. J. Biol. Chem. 271: 28741-28744 [Abstract] [Full Text]
Kempf, M., Clement, A., Faissner, A., Lee, G., Brandt, R. (1996). Tau Binds to the Distal Axon Early in Development of Polarity in a Microtubule- and Microfilament-Dependent Manner. J. Neurosci. 16: 5583-5592 [Abstract] [Full Text]
Mandell, J. W., Banker, G. A. (1996). A Spatial Gradient of Tau Protein Phosphorylation in Nascent Axons. J. Neurosci. 16: 5727-5740 [Abstract] [Full Text]
Black, M. M., Slaughter, T., Moshiach, S., Obrocka, M., Fischer, I. (1996). Tau Is Enriched on Dynamic Microtubules in the Distal Region of Growing Axons. J. Neurosci. 16: 3601-3619 [Abstract] [Full Text]
Maas, T., Eidenmuller, J., Brandt, R. (2000). Interaction of Tau with the Neural Membrane Cortex Is Regulated by Phosphorylation at Sites That Are Modified in Paired Helical Filaments. J. Biol. Chem. 275: 15733-15740 [Abstract] [Full Text]