Characterization of a cis-Golgi matrix protein, GM130

doi:10.1083/jcb.131.6.1715

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Characterization of a cis-Golgi matrix protein, GM130

N Nakamura, C Rabouille, R Watson, T Nilsson, N Hui, P Slusarewicz, TE Kreis and G Warren
Cell Biology Laboratory, Imperial Cancer Research Fund, London, UK.

Antisera raised to a detergent- and salt-resistant matrix fraction from rat liver Golgi stacks were used to screen an expression library from rat liver cDNA. A full-length clone was obtained encoding a protein of 130 kD (termed GM130), the COOH-terminal domain of which was highly homologous to a Golgi human auto-antigen, golgin-95 (Fritzler et al., 1993). Biochemical data showed that GM130 is a peripheral cytoplasmic protein that is tightly bound to Golgi membranes and part of a larger oligomeric complex. Predictions from the protein sequence suggest that GM130 is an extended rod-like protein with coiled-coil domains. Immunofluorescence microscopy showed partial overlap with medial- and trans-Golgi markers but almost complete overlap with the cis-Golgi network (CGN) marker, syntaxin5. Immunoelectron microscopy confirmed this location showing that most of the GM130 was located in the CGN and in one or two cisternae on the cis-side of the Golgi stack. GM130 was not re-distributed to the ER in the presence of brefeldin A but maintained its overlap with syntaxin5 and a partial overlap with the ER- Golgi intermediate compartment marker, p53. Together these results suggest that GM130 is part of a cis-Golgi matrix and has a role in maintaining cis-Golgi structure.
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Oka, T., Ungar, D., Hughson, F. M., Krieger, M. (2004). The COG and COPI Complexes Interact to Control the Abundance of GEARs, a Subset of Golgi Integral Membrane Proteins. Mol. Biol. Cell 15: 2423-2435 [Abstract] [Full Text]
Volchuk, A., Ravazzola, M., Perrelet, A., Eng, W. S., Di Liberto, M., Varlamov, O., Fukasawa, M., Engel, T., Sollner, T. H., Rothman, J. E., Orci, L. (2004). Countercurrent Distribution of Two Distinct SNARE Complexes Mediating Transport within the Golgi Stack. Mol. Biol. Cell 15: 1506-1518 [Abstract] [Full Text]
Verges, M., Bensadoun, A., Herz, J., Belcher, J. D., Havel, R. J. (2004). Endocytosis of Hepatic Lipase and Lipoprotein Lipase into Rat Liver Hepatocytes in Vivo Is Mediated by the Low Density Lipoprotein Receptor-related Protein. J. Biol. Chem. 279: 9030-9036 [Abstract] [Full Text]
Yoshimura, S.-i., Yamamoto, A., Misumi, Y., Sohda, M., Barr, F. A., Fujii, G., Shakoori, A., Ohno, H., Mihara, K., Nakamura, N. (2004). Dynamics of Golgi Matrix Proteins after the Blockage of ER to Golgi Transport. J Biochem 135: 201-216 [Abstract] [Full Text]
Andrade, J., Zhao, H., Titus, B., Timm Pearce, S., Barroso, M. (2004). The EF-Hand Ca2+-binding Protein p22 Plays a Role in Microtubule and Endoplasmic Reticulum Organization and Dynamics with Distinct Ca2+-binding Requirements. Mol. Biol. Cell 15: 481-496 [Abstract] [Full Text]
Puri, S., Telfer, H., Velliste, M., Murphy, R. F., Linstedt, A. D. (2004). Dispersal of Golgi matrix proteins during mitotic Golgi disassembly. J. Cell Sci. 117: 451-456 [Abstract] [Full Text]
Aarts, L. H. J., Roovers, O., Ward, A. C., Touw, I. P. (2004). Receptor activation and 2 distinct COOH-terminal motifs control G-CSF receptor distribution and internalization kinetics. Blood 103: 571-579 [Abstract] [Full Text]
Percival, J. M., Hughes, J. A. I., Brown, D. L., Schevzov, G., Heimann, K., Vrhovski, B., Bryce, N., Stow, J. L., Gunning, P. W. (2004). Targeting of a Tropomyosin Isoform to Short Microfilaments Associated with the Golgi Complex. Mol. Biol. Cell 15: 268-280 [Abstract] [Full Text]
Becker, K. P., Hannun, Y. A. (2003). cPKC-dependent Sequestration of Membrane-recycling Components in a Subset of Recycling Endosomes. J. Biol. Chem. 278: 52747-52754 [Abstract] [Full Text]
Ohta, E., Misumi, Y., Sohda, M., Fujiwara, T., Yano, A., Ikehara, Y. (2003). Identification and Characterization of GCP16, a Novel Acylated Golgi Protein That Interacts with GCP170. J. Biol. Chem. 278: 51957-51967 [Abstract] [Full Text]