Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover

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Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover

LE French, M Hahne, I Viard, G Radlgruber, R Zanone, K Becker, C Muller and J Tschopp
Department of Dermatology, University of Geneva, Medical School, Switzerland.

The cell surface receptor Fas (FasR, Apo-1, CD95) and its ligand (FasL) are mediators of apoptosis that have been shown to be implicated in the peripheral deletion of autoimmune cells, activation-induced T cell death, and one of the two major cytolytic pathways mediated by CD8+ cytolytic T cells. To gain further understanding of the Fas system., we have analyzed Fas and FasL expression during mouse development and in adult tissues. In developing mouse embryos, from 16.5 d onwards, Fas mRNA is detectable in distinct cell types of the developing sinus, thymus, lung, and liver, whereas FasL expression is restricted to submaxillary gland epithelial cells and the developing nervous system. Significant Fas and FasL expression were observed in several nonlymphoid cell types during embryogenesis, and generally Fas and FasL expression were not localized to characteristic sites of programmed cell death. In the adult mouse, RNase protection analysis revealed very wide expression of both Fas and FasL. Several tissues, including the thymus, lung, spleen, small intestine, large intestine, seminal vesicle, prostate, and uterus, clearly coexpress the two genes. Most tissues constitutively coexpressing Fas and FasL in the adult mouse are characterized by apoptotic cell turnover, and many of those expressing FasL are known to be immune privileged. It may be, therefore, that the Fas system is implicated in both the regulation of physiological cell turnover and the protection of particular tissues against potential lymphocyte-mediated damage.
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Blanco-Colio, L. M., Martin-Ventura, J. L., Sol, J. M., Diaz, C., Hernandez, G., Egido, J. (2004). Decreased circulating Fas ligand in patients with familial combined hyperlipidemia or carotid atherosclerosis: Normalization by atorvastatin. J Am Coll Cardiol 43: 1188-1194 [Abstract] [Full Text]
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Huang, S.-C., Tang, M.-J., Hsu, K.-F., Cheng, Y.-M., Chou, C.-Y. (2002). Fas and Its Ligand, Caspases, and Bcl-2 Expression in Gonadotropin-Releasing Hormone Agonist-Treated Uterine Leiomyoma. J. Clin. Endocrinol. Metab. 87: 4580-4586 [Abstract] [Full Text]
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Jodo, S., Xiao, S., Hohlbaum, A., Strehlow, D., Marshak-Rothstein, A., Ju, S.-T. (2001). Apoptosis-inducing Membrane Vesicles. A NOVEL AGENT WITH UNIQUE PROPERTIES. J. Biol. Chem. 276: 39938-39944 [Abstract] [Full Text]
Yasuda, M., Tanaka, Y., Fujii, K., Yasumoto, K. (2001). CD44 stimulation down-regulates Fas expression and Fas-mediated apoptosis of lung cancer cells. Int Immunol 13: 1309-1319 [Abstract] [Full Text]
Weisberg, S., Ashkenazi, E., Israel, Z., Attia, M., Shoshan, Y., Umansky, F., Brodie, C. (2001). Anaplastic and Atypical Meningiomas Express High Levels of Fas and Undergo Apoptosis in Response to Fas Ligation. Am. J. Pathol. 159: 1193-1197 [Abstract] [Full Text]
Matute-Bello, G., Liles, W. C., Frevert, C. W., Nakamura, M., Ballman, K., Vathanaprida, C., Kiener, P. A., Martin, T. R. (2001). Recombinant human Fas ligand induces alveolar epithelial cell apoptosis and lung injury in rabbits. Am. J. Physiol. Lung Cell. Mol. Physiol. 281: L328-L335 [Abstract] [Full Text]
Bennett, M W, O'Connell, J, Houston, A, Kelly, J, O'Sullivan, G C, Collins, J K, Shanahan, F (2001). Fas ligand upregulation is an early event in colonic carcinogenesis. J. Clin. Pathol. 54: 598-604 [Abstract] [Full Text]
Medana, I., Li, Z., Flugel, A., Tschopp, J., Wekerle, H., Neumann, H. (2001). Fas Ligand (CD95L) Protects Neurons Against Perforin- Mediated T Lymphocyte Cytotoxicity. J. Immunol. 167: 674-681 [Abstract] [Full Text]
Wang, J., Brooks, E. G., Bamford, K. B., Denning, T. L., Pappo, J., Ernst, P. B. (2001). Negative Selection of T Cells by Helicobacter pylori as a Model for Bacterial Strain Selection by Immune Evasion. J. Immunol. 167: 926-934 [Abstract] [Full Text]
Sata, M., Luo, Z., Walsh, K. (2001). Fas Ligand Overexpression on Allograft Endothelium Inhibits Inflammatory Cell Infiltration and Transplant-Associated Intimal Hyperplasia. J. Immunol. 166: 6964-6971 [Abstract] [Full Text]
Kiba, T., Saito, S., Numata, K., Kon, Y., Mizutani, T., Sekihara, H. (2001). Expression of apoptosis on rat liver by hepatic vagus hyperactivity after ventromedial hypothalamic lesioning. Am. J. Physiol. Gastrointest. Liver Physiol. 280: G958-G967 [Abstract] [Full Text]
KITAMURA, Y., HASHIMOTO, S., MIZUTA, N., KOBAYASHI, A., KOOGUCHI, K., FUJIWARA, I., NAKAJIMA, H. (2001). Fas/FasL-dependent Apoptosis of Alveolar Cells after Lipopolysaccharide-induced Lung Injury in Mice. Am. J. Respir. Crit. Care Med. 163: 762-769 [Abstract] [Full Text]
Koji, T., Hishikawa, Y., Ando, H., Nakanishi, Y., Kobayashi, N. (2001). Expression of Fas and Fas Ligand in Normal and Ischemia-Reperfusion Testes: Involvement of the Fas System in the Induction of Germ Cell Apoptosis in the Damaged Mouse Testis. Biol. Reprod. 64: 946-954 [Abstract] [Full Text]
Gourley, T. S., Chang, C.-H. (2001). Cutting Edge: The Class II Transactivator Prevents Activation-Induced Cell Death by Inhibiting Fas Ligand Gene Expression. J. Immunol. 166: 2917-2921 [Abstract] [Full Text]
D'Alessio, A., Riccioli, A., Lauretti, P., Padula, F., Muciaccia, B., De Cesaris, P., Filippini, A., Nagata, S., Ziparo, E. (2001). Testicular FasL is expressed by sperm cells. Proc. Natl. Acad. Sci. USA 10.1073/pnas.051566098v1 [Abstract] [Full Text]
Seol, D.-W., Li, J., Seol, M.-H., Park, S.-Y., Talanian, R. V., Billiar, T. R. (2001). Signaling Events Triggered by Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL): Caspase-8 Is Required for TRAIL-induced Apoptosis. Cancer Res. 61: 1138-1143 [Abstract] [Full Text]
Hu, C.-L., Cowan, R. G., Harman, R. M., Porter, D. A., Quirk, S. M. (2001). Apoptosis of Bovine Granulosa Cells After Serum Withdrawal Is Mediated by Fas Antigen (CD95) and Fas Ligand. Biol. Reprod. 64: 518-526 [Abstract] [Full Text]
De Paepe, M. E., Rubin, L. P., Jude, C., Lesieur-Brooks, A. M., Mills, D. R., Luks, F. I. (2000). Fas ligand expression coincides with alveolar cell apoptosis in late-gestation fetal lung development. Am. J. Physiol. Lung Cell. Mol. Physiol. 279: L967-L976 [Abstract] [Full Text]
Petak, I., Douglas, L., Tillman, D. M., Vernes, R., Houghton, J. A. (2000). Pediatric Rhabdomyosarcoma Cell Lines Are Resistant to Fas-induced Apoptosis and Highly Sensitive to TRAIL-induced Apoptosis. Clin. Cancer Res. 6: 4119-4127 [Abstract] [Full Text]
Francavilla, S., D’Abrizio, P., Rucci, N., Silvano, G., Properzi, G., Straface, E., Cordeschi, G., Necozione, S., Gnessi, L., Arizzi, M., Ulisse, S. (2000). Fas and Fas Ligand Expression in Fetal and Adult Human Testis with Normal or Deranged Spermatogenesis. J. Clin. Endocrinol. Metab. 85: 2692-2700 [Abstract] [Full Text]
Riccioli, A., Starace, D., D'Alessio, A., Starace, G., Padula, F., De Cesaris, P., Filippini, A., Ziparo, E. (2000). TNF-{alpha} and IFN-{gamma} Regulate Expression and Function of the Fas System in the Seminiferous Epithelium. J. Immunol. 165: 743-749 [Abstract] [Full Text]
LORZ, C., ORTIZ, A., JUSTO, P., GONZÁLEZ-CUADRADO, S., DUQUE, N., GÓMEZ-GUERRERO, C., EGIDO, J. (2000). Proapoptotic Fas Ligand Is Expressed by Normal Kidney Tubular Epithelium and Injured Glomeruli. J. Am. Soc. Nephrol. 11: 1266-1277 [Abstract] [Full Text]
Ichikawa, K., Yoshida-Kato, H., Ohtsuki, M., Ohsumi, J., Yamaguchi, J., Takahashi, S., Tani, Y., Watanabe, M., Shiraishi, A., Nishioka, K., Yonehara, S., Serizawa, N. (2000). A novel murine anti-human Fas mAb which mitigates lymphadenopathy without hepatotoxicity. Int Immunol 12: 555-562 [Abstract] [Full Text]
Pinkoski, M. J., Brunner, T., Green, D. R., Lin, T. (2000). Fas and Fas ligand in gut and liver. Am. J. Physiol. Gastrointest. Liver Physiol. 278: G354-G366 [Abstract] [Full Text]
Suzuki, I., Fink, P. J. (2000). The dual functions of Fas ligand in the regulation of peripheral CD8+ and CD4+ T cells. Proc. Natl. Acad. Sci. USA 97: 1707-1712 [Abstract] [Full Text]
Guevara Patino, J. A., Ivanov, V. N., Lacy, E., Elkon, K. B., Marino, M. W., Nikolic-Zugic, J. (2000). TNF-{alpha} Is the Critical Mediator of the Cyclic AMP-Induced Apoptosis of CD8+4+ Double-Positive Thymocytes. J. Immunol. 164: 1689-1694 [Abstract] [Full Text]
Yan, W, Suominen, J, Toppari, J (2000). Stem cell factor protects germ cells from apoptosis in vitro. J. Cell Sci. 113: 161-168 [Abstract]
Vickers, S. L., Cowan, R. G., Harman, R. M., Porter, D. A., Quirk, S. M. (2000). Expression and Activity of the Fas Antigen in Bovine Ovarian Follicle Cells. Biol. Reprod. 62: 54-61 [Abstract] [Full Text]
Raoul, C., Henderson, C. E., Pettmann, B. (1999). Programmed Cell Death of Embryonic Motoneurons Triggered through the FAS Death Receptor. JCB 147: 1049-1062 [Abstract] [Full Text]
Lepple-Wienhues, A., Belka, C., Laun, T., Jekle, A., Walter, B., Wieland, U., Welz, M., Heil, L., Kun, J., Busch, G., Weller, M., Bamberg, M., Gulbins, E., Lang, F. (1999). Stimulation of CD95 (Fas) blocks T lymphocyte calcium channels through sphingomyelinase and sphingolipids. Proc. Natl. Acad. Sci. USA 96: 13795-13800 [Abstract] [Full Text]
Buzyn, A., Petit, F., Ostankovitch, M., Figueiredo, S., Varet, B., Guillet, J.-G., Ameisen, J.-C., Estaquier, J. (1999). Membrane-Bound Fas (Apo-1/CD95) Ligand on Leukemic Cells: A Mechanism of Tumor Immune Escape in Leukemia Patients. Blood 94: 3135-3140 [Abstract] [Full Text]
Mitsiades, N., Poulaki, V., Mastorakos, G., Tseleni-Balafouta, S., Kotoula, V., Koutras, D. A., Tsokos, M. (1999). Fas Ligand Expression in Thyroid Carcinomas: A Potential Mechanism of Immune Evasion. J. Clin. Endocrinol. Metab. 84: 2924-2932 [Abstract] [Full Text]
Srivastava, R. K., Sasaki, C. Y., Hardwick, J. M., Longo, D. L. (1999). Bcl-2-Mediated Drug Resistance: Inhibition of Apoptosis by Blocking Nuclear Factor of Activated T Lymphocytes (Nfat)-Induced FAS Ligand Transcription. JEM 190: 253-266 [Abstract] [Full Text]
Young, K. A., Zirkin, B. R., Nelson, R. J. (1999). Short Photoperiods Evoke Testicular Apoptosis in White-Footed Mice (Peromyscus leucopus). Endocrinology 140: 3133-3139 [Abstract] [Full Text]
Coppola, D., Saunders, B., Fu, L., Mao, W., Nicosia, S. V. (1999). The Insulin-like Growth Factor 1 Receptor Induces Transformation and Tumorigenicity of Ovarian Mesothelial Cells and Down-Regulates Their Fas-Receptor Expression. Cancer Res. 59: 3264-3270 [Abstract] [Full Text]
Martin-Villalba, A., Herr, I., Jeremias, I., Hahne, M., Brandt, R., Vogel, J., Schenkel, J., Herdegen, T., Debatin, K.-M. (1999). CD95 Ligand (Fas-L/APO-1L) and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Mediate Ischemia-Induced Apoptosis in Neurons. J. Neurosci. 19: 3809-3817 [Abstract] [Full Text]
Rich, R. F., Green, W. R. (1999). Antiretroviral Cytolytic T-Lymphocyte Nonresponsiveness: FasL/Fas-Mediated Inhibition of CD4+ and CD8+ Antiviral T Cells by Viral Antigen-Positive Veto Cells. J. Virol. 73: 3826-3834 [Abstract] [Full Text]
Uzzo, R. G., Rayman, P., Kolenko, V., Clark, P. E., Bloom, T., Ward, A. M., Molto, L., Tannenbaum, C., Worford, L. J., Bukowski, R., Tubbs, R., Hsi, E. D., Bander, N. H., Novick, A. C., Finke, J. H. (1999). Mechanisms of Apoptosis in T Cells from Patients with Renal Cell Carcinoma. Clin. Cancer Res. 5: 1219-1229 [Abstract] [Full Text]
Payne, S. G., Smith, S. C., Davidge, S. T., Baker, P. N., Guilbert, L. J. (1999). Death Receptor Fas/Apo-1/CD95 Expressed by Human Placental Cytotrophoblasts Does Not Mediate Apoptosis. Biol. Reprod. 60: 1144-1150 [Abstract] [Full Text]
Moulian, N., Renvoize, C., Desodt, C., Serraf, A., Berrih-Aknin, S. (1999). Functional Fas Expression in Human Thymic Epithelial Cells. Blood 93: 2660-2670 [Abstract] [Full Text]
Yamashita, H., Otsuki, Y., Ito, Y., Matsumoto, K., Ueki, K., Ueki, M. (1999). Fas ligand, Fas antigen and Bcl-2 expression in human endometrium during the menstrual cycle. Mol Hum Reprod 5: 358-364 [Abstract] [Full Text]
Cheema, Z. F., Wade, S. B., Sata, M., Walsh, K., Sohrabji, F., Miranda, R. C. (1999). Fas/Apo [Apoptosis]-1 and Associated Proteins in the Differentiating Cerebral Cortex: Induction of Caspase-Dependent Cell Death and Activation of NF-kappa B. J. Neurosci. 19: 1754-1770 [Abstract] [Full Text]
Saas, P., Boucraut, J., Quiquerez, A.-L., Schnuriger, V., Perrin, G., Desplat-Jego, S., Bernard, D., Walker, P. R., Dietrich, P.-Y. (1999). CD95 (Fas/Apo-1) as a Receptor Governing Astrocyte Apoptotic or Inflammatory Responses: A Key Role in Brain Inflammation?. J. Immunol. 162: 2326-2333 [Abstract] [Full Text]
Sbih-Lammali, F., Clausse, B., Ardila-Osorio, H., Guerry, R., Talbot, M., Havouis, S., Ferradini, L., Bosq, J., Tursz, T., Busson, P. (1999). Control of Apoptosis in Epstein Barr Virus-positive Nasopharyngeal Carcinoma Cells: Opposite Effects of CD95 and CD40 Stimulation. Cancer Res. 59: 924-930 [Abstract] [Full Text]
Woolveridge, I., de Boer-Brouwer, M., Taylor, M. F., Teerds, K. J., Wu, F. C.W., Morris, I. D. (1999). Apoptosis in the Rat Spermatogenic Epithelium Following Androgen Withdrawal: Changes in Apoptosis-Related Genes. Biol. Reprod. 60: 461-470 [Abstract] [Full Text]
Stassi, G., Todaro, M., Bucchieri, F., Stoppacciaro, A., Farina, F., Zummo, G., Testi, R., Maria, R. D. (1999). Fas/Fas Ligand-Driven T Cell Apoptosis as a Consequence of Ineffective Thyroid Immunoprivilege in Hashimoto's Thyroiditis. J. Immunol. 162: 263-267 [Abstract] [Full Text]
Strater, J., Mariani, S. M., Walczak, H., Rucker, F. G., Leithauser, F., Krammer, P. H., Moller, P. (1999). CD95 Ligand (CD95L) in Normal Human Lymphoid Tissues : A Subset of Plasma Cells Are Prominent Producers of CD95L. Am. J. Pathol. 154: 193-201 [Abstract] [Full Text]
Muller, M., Wilder, S., Bannasch, D., Israeli, D., Lehlbach, K., Li-Weber, M., Friedman, S. L., Galle, P. R., Stremmel, W., Oren, M., Krammer, P. H. (1998). p53 Activates the CD95 (APO-1/Fas) Gene in Response to DNA Damage by Anticancer Drugs. JEM 188: 2033-2045 [Abstract] [Full Text]
Leo, C. P., Hsu, S. Y., McGee, E. A., Salanova, M., Hsueh, A. J. W. (1998). DEFT, a Novel Death Effector Domain-Containing Molecule Predominantly Expressed in Testicular Germ Cells. Endocrinology 139: 4839-4848 [Abstract] [Full Text]
Quirk, S. M., Porter, D. A., Huber, S. C., Cowan, R. G. (1998). Potentiation of Fas-Mediated Apoptosis of Murine Granulosa Cells by Interferon-{gamma}, Tumor Necrosis Factor-{alpha}, and Cycloheximide. Endocrinology 139: 4860-4869 [Abstract] [Full Text]
Mitsiades, N., Poulaki, V., Kotoula, V., Leone, A., Tsokos, M. (1998). Fas Ligand Is Present in Tumors of the Ewing's Sarcoma Family and Is Cleaved into a Soluble Form by a Metalloproteinase. Am. J. Pathol. 153: 1947-1956 [Abstract] [Full Text]
Vincent, M. S., Roessner, K., Sellati, T., Huston, C. D., Sigal, L. H., Behar, S. M., Radolf, J. D., Budd, R. C. (1998). Lyme Arthritis Synovial {gamma}{delta} T Cells Respond to Borrelia burgdorferi Lipoproteins and Lipidated Hexapeptides. J. Immunol. 161: 5762-5771 [Abstract] [Full Text]
Owen-Schaub, L. B., van Golen, K. L., Hill, L. L., Price, J. E. (1998). Fas and Fas Ligand Interactions Suppress Melanoma Lung Metastasis. JEM 188: 1717-1723 [Abstract] [Full Text]
Druilhe, A., Wallaert, B., Tsicopoulos, A., e Silva, J.-R. L., Tillie-Leblond, I., Tonnel, A.-B., Pretolani, M. (1998). Apoptosis, Proliferation, and Expression of Bcl-2, Fas, and Fas Ligand in Bronchial Biopsies from Asthmatics. Am. J. Respir. Cell Mol. Bio. 19: 747-757 [Abstract] [Full Text]
Benigni, F., Sacco, S., Aloe, L., Ghezzi, P. (1998). Intracerebroventricular Injection of Anti-Fas Activates the Hypothalamus-Pituitary-Adrenal Axis and Induces Peripheral Interleukin-6 and Serum Amyloid A in Mice : Comparison with Other Ligands of the Tumor Necrosis Factor/NerveGrowth Factor Receptor Superfamily. Am. J. Pathol. 153: 1377-1381 [Abstract] [Full Text]
Viard, I., Wehrli, P., Bullani, R., Schneider, P., Holler, N., Salomon, D., Hunziker, T., Saurat, J., Tschopp, J., French, L. E. (1998). Inhibition of Toxic Epidermal Necrolysis by Blockade of CD95 with Human Intravenous Immunoglobulin. Science 282: 490-493 [Abstract] [Full Text]
Kataoka, T., Schroter, M., Hahne, M., Schneider, P., Irmler, M., Thome, M., Froelich, C. J., Tschopp, J. (1998). FLIP Prevents Apoptosis Induced by Death Receptors But Not by Perforin/Granzyme B, Chemotherapeutic Drugs, and Gamma Irradiation. J. Immunol. 161: 3936-3942 [Abstract] [Full Text]
Hamann, K. J., Dorscheid, D. R., Ko, F. D., Conforti, A. E., Sperling, A. I., Rabe, K. F., White, S. R. (1998). Expression of Fas (CD95) and FasL (CD95L) in Human Airway Epithelium. Am. J. Respir. Cell Mol. Bio. 19: 537-542 [Abstract] [Full Text]
Hahne, M., Kataoka, T., Schroter, M., Hofmann, K., Irmler, M., Bodmer, J.-L., Schneider, P., Bornand, T., Holler, N., French, L. E., Sordat, B., Rimoldi, D., Tschopp, J. (1998). APRIL, a New Ligand of the Tumor Necrosis Factor Family, Stimulates Tumor Cell Growth. JEM 188: 1185-1190 [Abstract] [Full Text]
Halaas, O., Vik, R., Espevik, T. (1998). Induction of Fas Ligand in Murine Bone Marrow NK Cells by Bacterial Polysaccharides. J. Immunol. 160: 4330-4336 [Abstract] [Full Text]
Schneider, P., Holler, N., Bodmer, J.-L., Hahne, M., Frei, K., Fontana, A., Tschopp, J. (1998). Conversion of Membrane-bound Fas(CD95) Ligand to Its Soluble Form Is Associated with Downregulation of Its Proapoptotic Activity and Loss of Liver Toxicity. JEM 187: 1205-1213 [Abstract] [Full Text]
Fleck, M., Zhou, T., Tatsuta, T., Yang, P., Wang, Z., Mountz, J. D. (1998). Fas/Fas Ligand Signaling During Gestational T Cell Development. J. Immunol. 160: 3766-3775 [Abstract] [Full Text]
Bauer, M. K.�A., Vogt, M., Los, M., Siegel, J., Wesselborg, S., Schulze-Osthoff, K. (1998). Role of Reactive Oxygen Intermediates in Activation-induced CD95 (APO-1/Fas) Ligand Expression. J. Biol. Chem. 273: 8048-8055 [Abstract] [Full Text]
Gochuico, B. R., Miranda, K. M., Hessel, E. M., De Bie, J. J., Van Oosterhout, A. J.�M., Cruikshank, W. W., Fine, A. (1998). Airway epithelial Fas ligand expression: potential role in modulating bronchial inflammation. Am. J. Physiol. Lung Cell. Mol. Physiol. 274: L444-L449 [Abstract] [Full Text]
Sata, M., Perlman, H., Muruve, D. A., Silver, M., Ikebe, M., Libermann, T. A., Oettgen, P., Walsh, K. (1998). Fas ligand gene transfer to the vessel wall inhibits neointima formation and overrides the adenovirus-mediated T cell�response. Proc. Natl. Acad. Sci. USA 95: 1213-1217 [Abstract] [Full Text]
Smith, D. R., Weiner, H. L. (1997). Immunologic Aspects of Neurologic and Neuromuscular Diseases. JAMA 278: 1956-1961 [Abstract]
Quirk, S. M., Cowan, R. G., Huber, S. H. (1997). Fas Antigen-Mediated Apoptosis of Ovarian Surface Epithelial Cells. Endocrinology 138: 4558-4566 [Abstract] [Full Text]
Houghton, J. A., Harwood, F. G., Tillman, D. M. (1997). Thymineless death in colon carcinoma cells is mediated via�Fas�signaling. Proc. Natl. Acad. Sci. USA 94: 8144-8149 [Abstract] [Full Text]
Lee, J., Richburg, J. H., Younkin, S. C., Boekelheide, K. (1997). The Fas System Is a Key Regulator of Germ Cell Apoptosis in the Testis. Endocrinology 138: 2081-2088 [Abstract] [Full Text]