A v-SNARE implicated in intra-Golgi transport

doi:10.1083/jcb.133.3.507

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A v-SNARE implicated in intra-Golgi transport

M Nagahama, L Orci, M Ravazzola, M Amherdt, L Lacomis, P Tempst, JE Rothman and TH Sollner
Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York 10021, USA.

We report the identification of a putative v-SNARE (GOS-28), localized primarily to transport vesicles at the terminal rims of Golgi stacks. In vitro, GOS-28, A Golgi SNARE of 28 kD, is efficiently packaged into Golgi-derived vesicles, which are most likely COPI coated. Antibodies directed against GOS-28 block its ability to bind alpha-SNAP, partially inhibit transport from the cis to the medial cisternae, and do not inhibit budding of COP-coated vesicles, but do accumulate docked uncoated vesicles.
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