Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival

doi:10.1083/jcb.134.2.559

This Article

	Full Text (PDF, 9343K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JCB
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Dowling, J.
	Articles by Fuchs, E.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Dowling, J.
	Articles by Fuchs, E.


Social Bookmarking

	What's this?

ARTICLES

Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival

J Dowling, QC Yu and E Fuchs
Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, University of Chicago, Illinois 60637, USA.

The integrin heterodimer alpha 6 beta 4 is expressed in many epithelia and in Schwann cells. In stratified epithelia, alpha 6 beta 4 couple with BPAG1-e and BPAG2 to form hemidesmosomes, attaching externally to laminin and internally to the keratin cytoskeleton. To explore the function of this atypical integrin, and its relation to conventional actin-associated integrins, we targeted the removal of the beta 4 gene in mice. Tissues that express alpha 6 beta 4 are grossly affected. Stratified tissues are devoid of hemidesmosomes, display only a very fragile attachment to the basal lamina, and exhibit signs of degeneration and tissue disorganization. Simple epithelia which express alpha 6 beta 4 are also defective in adherence, even though they do not form hemidesmosomes. In the absence of beta 4, alpha 6 is dramatically downregulated, and other integrins do not appear to compensate for the loss of this heterodimer. These data have important implications for understanding integrin function in cell-substratum adhesion, cell survival and differentiation, and for understanding the role of alpha 6 beta 4 in junctional epidermolysis bullosa, an often lethal human disorder with pathology similar to our mice.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Yang, X., Pursell, B., Lu, S., Chang, T.-K., Mercurio, A. M. (2009). Regulation of {beta}4-integrin expression by epigenetic modifications in the mammary gland and during the epithelial-to-mesenchymal transition. J. Cell Sci. 122: 2473-2480 [Abstract] [Full Text]
Bon, G., Di Carlo, S. E., Folgiero, V., Avetrani, P., Lazzari, C., D'Orazi, G., Brizzi, M. F., Sacchi, A., Soddu, S., Blandino, G., Mottolese, M., Falcioni, R. (2009). Negative Regulation of {beta}4 Integrin Transcription by Homeodomain-Interacting Protein Kinase 2 and p53 Impairs Tumor Progression. Cancer Res. 69: 5978-5986 [Abstract] [Full Text]
Hamill, K. J., Hopkinson, S. B., DeBiase, P., Jones, J. C.R. (2009). BPAG1e Maintains Keratinocyte Polarity through {beta}4 Integrin-mediated Modulation of Rac 1 and Cofilin Activities. Mol. Biol. Cell 20: 2954-2962 [Abstract] [Full Text]
Chen, B., Goodman, E., Lu, Z., Bandyopadhyay, A., Magraw, C., He, T., Raghavan, S. (2009). Function of {beta}1 Integrin in Oral Epithelia and Tooth Bud Morphogenesis. JDR 88: 539-544 [Abstract] [Full Text]
Pontier, S. M., Muller, W. J. (2009). Integrins in mammary-stem-cell biology and breast-cancer progression - a role in cancer stem cells?. J. Cell Sci. 122: 207-214 [Abstract] [Full Text]
Margadant, C., Raymond, K., Kreft, M., Sachs, N., Janssen, H., Sonnenberg, A. (2009). Integrin {alpha}3{beta}1 inhibits directional migration and wound re-epithelialization in the skin. J. Cell Sci. 122: 278-288 [Abstract] [Full Text]
Silva, R., D'Amico, G., Hodivala-Dilke, K. M., Reynolds, L. E. (2008). Integrins: The Keys to Unlocking Angiogenesis. Arterioscler. Thromb. Vasc. Bio. 28: 1703-1713 [Abstract] [Full Text]
Gaudreault, M., Vigneault, F., Gingras, M.-E., Leclerc, S., Carrier, P., Germain, L., Guerin, S. L. (2008). Transcriptional Regulation of the Human {alpha}6 Integrin Gene by the Transcription Factor NFI during Corneal Wound Healing. IOVS 49: 3758-3767 [Abstract] [Full Text]
Nodari, A., Previtali, S. C., Dati, G., Occhi, S., Court, F. A., Colombelli, C., Zambroni, D., Dina, G., Del Carro, U., Campbell, K. P., Quattrini, A., Wrabetz, L., Feltri, M. L. (2008). {alpha}6{beta}4 Integrin and Dystroglycan Cooperate to Stabilize the Myelin Sheath. J. Neurosci. 28: 6714-6719 [Abstract] [Full Text]
Hijikata, T., Nakamura, A., Isokawa, K., Imamura, M., Yuasa, K., Ishikawa, R., Kohama, K., Takeda, S., Yorifuji, H. (2008). Plectin 1 links intermediate filaments to costameric sarcolemma through {beta}-synemin, {alpha}-dystrobrevin and actin. J. Cell Sci. 121: 2062-2074 [Abstract] [Full Text]
McCarty, J. H., Barry, M., Crowley, D., Bronson, R. T., Lacy-Hulbert, A., Hynes, R. O. (2008). Genetic Ablation of {alpha}v Integrins in Epithelial Cells of the Eyelid Skin and Conjunctiva Leads to Squamous Cell Carcinoma. Am. J. Pathol. 172: 1740-1747 [Abstract] [Full Text]
Kligys, K., Claiborne, J. N., DeBiase, P. J., Hopkinson, S. B., Wu, Y., Mizuno, K., Jones, J. C. R. (2007). The Slingshot Family of Phosphatases Mediates Rac1 Regulation of Cofilin Phosphorylation, Laminin-332 Organization, and Motility Behavior of Keratinocytes. J. Biol. Chem. 282: 32520-32528 [Abstract] [Full Text]
Ackerl, R., Walko, G., Fuchs, P., Fischer, I., Schmuth, M., Wiche, G. (2007). Conditional targeting of plectin in prenatal and adult mouse stratified epithelia causes keratinocyte fragility and lesional epidermal barrier defects. J. Cell Sci. 120: 2435-2443 [Abstract] [Full Text]
Chandramouly, G., Abad, P. C., Knowles, D. W., Lelievre, S. A. (2007). The control of tissue architecture over nuclear organization is crucial for epithelial cell fate. J. Cell Sci. 120: 1596-1606 [Abstract] [Full Text]
Schober, M., Raghavan, S., Nikolova, M., Polak, L., Pasolli, H. A., Beggs, H. E., Reichardt, L. F., Fuchs, E. (2007). Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics. JCB 176: 667-680 [Abstract] [Full Text]
Werner, M. E., Chen, F., Moyano, J. V., Yehiely, F., Jones, J. C. R., Cryns, V. L. (2007). Caspase Proteolysis of the Integrin beta4 Subunit Disrupts Hemidesmosome Assembly, Promotes Apoptosis, and Inhibits Cell Migration. J. Biol. Chem. 282: 5560-5569 [Abstract] [Full Text]
Takeda, Y., Kazarov, A. R., Butterfield, C. E., Hopkins, B. D., Benjamin, L. E., Kaipainen, A., Hemler, M. E. (2007). Deletion of tetraspanin Cd151 results in decreased pathologic angiogenesis in vivo and in vitro. Blood 109: 1524-1532 [Abstract] [Full Text]
Sugawara, K., Tsuruta, D., Kobayashi, H., Ikeda, K., Hopkinson, S. B., Jones, J. C.R., Ishii, M. (2007). Spatial and Temporal Control of Laminin-332 (5) and -511 (10) Expression During Induction of Anagen Hair Growth. J. Histochem. Cytochem. 55: 43-55 [Abstract] [Full Text]
Sehgal, B. U., DeBiase, P. J., Matzno, S., Chew, T.-L., Claiborne, J. N., Hopkinson, S. B., Russell, A., Marinkovich, M. P., Jones, J. C. R. (2006). Integrin beta4 Regulates Migratory Behavior of Keratinocytes by Determining Laminin-332 Organization. J. Biol. Chem. 281: 35487-35498 [Abstract] [Full Text]
Blanpain, C., Lowry, W. E., Pasolli, H. A., Fuchs, E. (2006). Canonical notch signaling functions as a commitment switch in the epidermal lineage.. Genes Dev. 20: 3022-3035 [Abstract] [Full Text]
Winterwood, N. E., Varzavand, A., Meland, M. N., Ashman, L. K., Stipp, C. S. (2006). A Critical Role for Tetraspanin CD151 in {alpha}3beta1 and {alpha}6beta4 Integrin-dependent Tumor Cell Functions on Laminin-5. Mol. Biol. Cell 17: 2707-2721 [Abstract] [Full Text]
Wilhelmsen, K., Litjens, S. H.M., Sonnenberg, A. (2006). Multiple Functions of the Integrin {alpha}6{beta}4 in Epidermal Homeostasis and Tumorigenesis. Mol. Cell. Biol. 26: 2877-2886 [Full Text]
Greenberg, S., Kamath, P., Petrali, J., Hamilton, T., Garfield, J., Garlick, J. A. (2006). Characterization of the Initial Response of Engineered Human Skin to Sulfur Mustard. Toxicol Sci 90: 549-557 [Abstract] [Full Text]
Rashid, K. A., Stern, J. N. H., Ahmed, A. R. (2006). Identification of an Epitope within Human Integrin {alpha}6 Subunit for the Binding of Autoantibody and Its Role in Basement Membrane Separation in Oral Pemphigoid. J. Immunol. 176: 1968-1977 [Abstract] [Full Text]
Hamelers, I. H.L., Olivo, C., Mertens, A. E.E., Pegtel, D. M., van der Kammen, R. A., Sonnenberg, A., Collard, J. G. (2005). The Rac activator Tiam1 is required for {alpha}3{beta}1-mediated laminin-5 deposition, cell spreading, and cell migration. JCB 171: 871-881 [Abstract] [Full Text]
Nikolopoulos, S. N., Blaikie, P., Yoshioka, T., Guo, W., Puri, C., Tacchetti, C., Giancotti, F. G. (2005). Targeted Deletion of the Integrin {beta}4 Signaling Domain Suppresses Laminin-5-Dependent Nuclear Entry of Mitogen-Activated Protein Kinases and NF-{kappa}B, Causing Defects in Epidermal Growth and Migration. Mol. Cell. Biol. 25: 6090-6102 [Abstract] [Full Text]
Hallmann, R., Horn, N., Selg, M., Wendler, O., Pausch, F., Sorokin, L. M. (2005). Expression and Function of Laminins in the Embryonic and Mature Vasculature. Physiol. Rev. 85: 979-1000 [Abstract] [Full Text]
Raymond, K., Kreft, M., Janssen, H., Calafat, J., Sonnenberg, A. (2005). Keratinocytes display normal proliferation, survival and differentiation in conditional {beta}4-integrin knockout mice. J. Cell Sci. 118: 1045-1060 [Abstract] [Full Text]
Yang, D., Bierman, J., Tarumi, Y. S., Zhong, Y.-P., Rangwala, R., Proctor, T. M., Miyagoe-Suzuki, Y., Takeda, S., Miner, J. H., Sherman, L. S., Gold, B. G., Patton, B. L. (2005). Coordinate control of axon defasciculation and myelination by laminin-2 and -8. JCB 168: 655-666 [Abstract] [Full Text]
Oldak, M., Smola, H., Aumailley, M., Rivero, F., Pfister, H., Smola-Hess, S. (2004). The Human Papillomavirus Type 8 E2 Protein Suppresses {beta}4-Integrin Expression in Primary Human Keratinocytes. J. Virol. 78: 10738-10746 [Abstract] [Full Text]
Sigle, R. O., Gil, S. G., Bhattacharya, M., Ryan, M. C., Yang, T.-M., Brown, T. A., Boutaud, A., Miyashita, Y., Olerud, J., Carter, W. G. (2004). Globular domains 4/5 of the laminin {alpha}3 chain mediate deposition of precursor laminin 5. J. Cell Sci. 117: 4481-4494 [Abstract] [Full Text]
Manohar, A., Shome, S. G., Lamar, J., Stirling, L., Iyer, V., Pumiglia, K., DiPersio, C. M. (2004). {alpha}3{beta}1 integrin promotes keratinocyte cell survival through activation of a MEK/ERK signaling pathway. J. Cell Sci. 117: 4043-4054 [Abstract] [Full Text]
Sriuranpong, V., Mutirangura, A., Gillespie, J. W., Patel, V., Amornphimoltham, P., Molinolo, A. A., Kerekhanjanarong, V., Supanakorn, S., Supiyaphun, P., Rangdaeng, S., Voravud, N., Gutkind, J. S. (2004). Global Gene Expression Profile of Nasopharyngeal Carcinoma by Laser Capture Microdissection and Complementary DNA Microarrays. Clin. Cancer Res. 10: 4944-4958 [Abstract] [Full Text]
Chung, J., Yoon, S.-O., Lipscomb, E. A., Mercurio, A. M. (2004). The Met Receptor and {alpha}6{beta}4 Integrin Can Function Independently to Promote Carcinoma Invasion. J. Biol. Chem. 279: 32287-32293 [Abstract] [Full Text]
Pal-Ghosh, S., Pajoohesh-Ganji, A., Brown, M., Stepp, M. A. (2004). A Mouse Model for the Study of Recurrent Corneal Epithelial Erosions: {alpha}9{beta}1 Integrin Implicated in Progression of the Disease. IOVS 45: 1775-1788 [Abstract] [Full Text]
Tasanen, K., Tunggal, L., Chometon, G., Bruckner-Tuderman, L., Aumailley, M. (2004). Keratinocytes from Patients Lacking Collagen XVII Display a Migratory Phenotype. Am. J. Pathol. 164: 2027-2038 [Abstract] [Full Text]
Rabinovitz, I., Tsomo, L., Mercurio, A. M. (2004). Protein Kinase C-{alpha} Phosphorylation of Specific Serines in the Connecting Segment of the {beta}4 Integrin Regulates the Dynamics of Type II Hemidesmosomes. Mol. Cell. Biol. 24: 4351-4360 [Abstract] [Full Text]
Koster, J., van Wilpe, S., Kuikman, I., Litjens, S.H.M., Sonnenberg, A. (2004). Role of Binding of Plectin to the Integrin {beta}4 Subunit in the Assembly of Hemidesmosomes. Mol. Biol. Cell 15: 1211-1223 [Abstract] [Full Text]
Herlevsen, M., Schmidt, D.-S., Miyazaki, K., Zoller, M. (2003). The association of the tetraspanin D6.1A with the {alpha}6{beta}4 integrin supports cell motility and liver metastasis formation. J. Cell Sci. 116: 4373-4390 [Abstract] [Full Text]
Tsuruta, D., Hopkinson, S. B., Lane, K. D., Werner, M. E., Cryns, V. L., Jones, J. C. R. (2003). Crucial Role of the Specificity-determining Loop of the Integrin {beta}4 Subunit in the Binding of Cells to Laminin-5 and Outside-in Signal Transduction. J. Biol. Chem. 278: 38707-38714 [Abstract] [Full Text]
Litjens, S. H.M., Koster, J., Kuikman, I., van Wilpe, S., de Pereda, J. M., Sonnenberg, A. (2003). Specificity of Binding of the Plectin Actin-binding Domain to {beta}4 Integrin. Mol. Biol. Cell 14: 4039-4050 [Abstract] [Full Text]
Hiran, T. S., Mazurkiewicz, J. E., Kreienberg, P., Rice, F. L., LaFlamme, S. E. (2003). Endothelial expression of the {alpha}6{beta}4 integrin is negatively regulated during angiogenesis. J. Cell Sci. 116: 3771-3781 [Abstract] [Full Text]
Koster, J., Geerts, D., Favre, B., Borradori, L., Sonnenberg, A. (2003). Analysis of the interactions between BP180, BP230, plectin and the integrin {alpha}6{beta}4 important for hemidesmosome assembly. J. Cell Sci. 116: 387-399 [Abstract] [Full Text]
Jiang, F.-X., Naselli, G., Harrison, L. C. (2002). Distinct Distribution of Laminin and Its Integrin Receptors in the Pancreas. J. Histochem. Cytochem. 50: 1625-1632 [Abstract] [Full Text]
Muschler, J., Levy, D., Boudreau, R., Henry, M., Campbell, K., Bissell, M. J. (2002). A Role for Dystroglycan in Epithelial Polarization: Loss of Function in Breast Tumor Cells. Cancer Res. 62: 7102-7109 [Abstract] [Full Text]
Sayama, K., Yamasaki, K., Hanakawa, Y., Shirakata, Y., Tokumaru, S., Ijuin, T., Takenawa, T., Hashimoto, K. (2002). Phosphatidylinositol 3-Kinase Is a Key Regulator of Early Phase Differentiation in Keratinocytes. J. Biol. Chem. 277: 40390-40396 [Abstract] [Full Text]
Esco, M. A., Wang, Z., McDermott, M. L., Kurpakus-Wheater, M. (2002). Potential role for laminin 5 in hypoxia-mediated apoptosis of human corneal epithelial cells. J. Cell Sci. 114: 4033-4040 [Abstract] [Full Text]
Rabinovitz, I., Gipson, I. K., Mercurio, A. M. (2001). Traction Forces Mediated by alpha 6beta 4 Integrin: Implications for Basement Membrane Organization and Tumor Invasion. Mol. Biol. Cell 12: 4030-4043 [Abstract] [Full Text]
Mariotti, A., Kedeshian, P. A., Dans, M., Curatola, A. M., Gagnoux-Palacios, L., Giancotti, F. G. (2001). EGF-R signaling through Fyn kinase disrupts the function of integrin {alpha}6{beta}4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion. JCB 155: 447-458 [Abstract] [Full Text]
Alper, O., Bergmann-Leitner, E. S., Bennett, T. A., Hacker, N. F., Stromberg, K., Stetler-Stevenson, W. G. (2001). Epidermal Growth Factor Receptor Signaling and the Invasive Phenotype of Ovarian Carcinoma Cells. JNCI J Natl Cancer Inst 93: 1375-1384 [Abstract] [Full Text]
Shaw, L. M. (2001). Identification of Insulin Receptor Substrate 1 (IRS-1) and IRS-2 as Signaling Intermediates in the {alpha}6{beta}4 Integrin-Dependent Activation of Phosphoinositide 3-OH Kinase and Promotion of Invasion. Mol. Cell. Biol. 21: 5082-5093 [Abstract] [Full Text]
Bouvard, D., Brakebusch, C., Gustafsson, E., Aszodi, A., Bengtsson, T., Berna, A., Fassler, R. (2001). Functional Consequences of Integrin Gene Mutations in Mice. Circ. Res. 89: 211-223 [Abstract] [Full Text]
Sheppard, D. (2001). Integrin-Mediated Activation of Transforming Growth Factor-{beta}1 in Pulmonary Fibrosis. Chest 120 : 49S-53S [Abstract] [Full Text]
Alt, A., Ohba, M., Li, L., Gartsbein, M., Belanger, A., Denning, Mitchell. F., Kuroki, T., Yuspa, S. H., Tennenbaum, T. (2001). Protein Kinase C{{delta}}-mediated Phosphorylation of {{alpha}}6{beta}4 Is Associated with Reduced Integrin Localization to the Hemidesmosome and Decreased Keratinocyte Attachment. Cancer Res. 61: 4591-4598 [Abstract] [Full Text]
Kumari, S., Bhol, K. C., Simmons, R. K., Razzaque, M. S., Letko, E., Foster, C. S., Ahmed, A. R. (2001). Identification of Ocular Cicatricial Pemphigoid Antibody Binding Site(s) in Human {beta}4 Integrin. IOVS 42: 379-385 [Abstract] [Full Text]
Tani, H., Morris, R. J., Kaur, P. (2000). Enrichment for murine keratinocyte stem cells based on cell surface phenotype. Proc. Natl. Acad. Sci. USA 97: 10960-10965 [Abstract] [Full Text]
Raghavan, S., Bauer, C., Mundschau, G., Li, Q., Fuchs, E. (2000). Conditional Ablation of {beta}1 Integrin in Skin: Severe Defects in Epidermal Proliferation, Basement Membrane Formation, and Hair Follicle Invagination. JCB 150: 1149-1160 [Abstract] [Full Text]
Hong, T.-M., Yang, P.-C., Peck, K., Chen, J. J. W., Yang, S.-C., Chen, Y.-C., Wu, C.-W. (2000). Profiling the Downstream Genes of Tumor Suppressor PTEN in Lung Cancer Cells by Complementary DNA Microarray. Am. J. Respir. Cell Mol. Bio. 23: 355-363 [Abstract] [Full Text]
Sterk, L. M.Th., Geuijen, C. A.W., Oomen, L. C.J.M., Calafat, J., Janssen, H., Sonnenberg, A. (2000). The Tetraspan Molecule Cd151, a Novel Constituent of Hemidesmosomes, Associates with the Integrin {alpha}6{beta}4 and May Regulate the Spatial Organization of Hemidesmosomes. JCB 149: 969-982 [Abstract] [Full Text]
Lotz, M. M., Rabinovitz, I., Mercurio, A. M. (2000). Intestinal Restitution: Progression of Actin Cytoskeleton Rearrangements and Integrin Function in a Model of Epithelial Wound Healing. Am. J. Pathol. 156: 985-996 [Abstract] [Full Text]
DiPersio, C., van der Neut, R, Georges-Labouesse, E, Kreidberg, J., Sonnenberg, A, Hynes, R. (2000). alpha3beta1 and alpha6beta4 integrin receptors for laminin-5 are not essential for epidermal morphogenesis and homeostasis during skin development. J. Cell Sci. 113: 3051-3062 [Abstract]
Nievers, M., Kuikman, I, Geerts, D, Leigh, I., Sonnenberg, A (2000). Formation of hemidesmosome-like structures in the absence of ligand binding by the (alpha)6(beta)4 integrin requires binding of HD1/plectin to the cytoplasmic domain of the (beta)4 integrin subunit. J. Cell Sci. 113: 963-973 [Abstract]
Bachelder, R. E., Ribick, M. J., Marchetti, A., Falcioni, R., Soddu, S., Davis, K. R., Mercurio, A. M. (1999). P53 Inhibits {alpha}6{beta}4 Integrin Survival Signaling by Promoting the Caspase 3-Dependent Cleavage of Akt/PKB. JCB 147: 1063-1072 [Abstract] [Full Text]
Geerts, D., Fontao, L., Nievers, M. G., Schaapveld, R. Q.J., Purkis, P. E., Wheeler, G. N., Lane, E. B., Leigh, I. M., Sonnenberg, A. (1999). Binding of Integrin {alpha}6{beta}4 to Plectin Prevents Plectin Association with F-Actin but Does Not Interfere with Intermediate Filament Binding. JCB 147: 417-434 [Abstract] [Full Text]
Basora, N., Herring-Gillam, F. E., Boudreau, F., Perreault, N., Pageot, L.-P., Simoneau, M., Bouatrouss, Y., Beaulieu, J.-F. (1999). Expression of Functionally Distinct Variants of the beta 4A Integrin Subunit in Relation to the Differentiation State in Human Intestinal Cells. J. Biol. Chem. 274: 29819-29825 [Abstract] [Full Text]
Dank, J. P., Kim, S., Parisi, M. A., Brown, T., Smith, L. T., Waldhausen, J., Sybert, V. P. (1999). Outcome After Surgical Repair of Junctional Epidermolysis Bullosa-Pyloric Atresia Syndrome: A Report of 3 Cases and Review of the Literature. Arch Dermatol 135: 1243-1247 [Abstract] [Full Text]
Rabinovitz, I., Toker, A., Mercurio, A. M. (1999). Protein Kinase C-Dependent Mobilization of the {alpha}6{beta}4 Integrin from Hemidesmosomes and Its Association with Actin-Rich Cell Protrusions Drive the Chemotactic Migration of Carcinoma Cells. JCB 146: 1147-1160 [Abstract] [Full Text]
Muschler, J., Lochter, A., Roskelley, C. D., Yurchenco, P., Bissell, M. J. (1999). Division of Labor among the alpha 6beta 4 Integrin, beta 1 Integrins, and an E3 Laminin Receptor to Signal Morphogenesis and beta -Casein Expression in Mammary Epithelial Cells. Mol. Biol. Cell 10: 2817-2828 [Abstract] [Full Text]
Hresko, M. C., Schriefer, L. A., Shrimankar, P., Waterston, R. H. (1999). Myotactin, a Novel Hypodermal Protein Involved in Muscle-Cell Adhesion inCaenorhabditis elegans. JCB 146: 659-672 [Abstract] [Full Text]
Vasioukhin, V., Degenstein, L., Wise, B., Fuchs, E. (1999). The magical touch: Genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin. Proc. Natl. Acad. Sci. USA 96: 8551-8556 [Abstract] [Full Text]
Bachelder, R. E., Marchetti, A., Falcioni, R., Soddu, S., Mercurio, A. M. (1999). Activation of p53 Function in Carcinoma Cells by the alpha 6beta 4 Integrin. J. Biol. Chem. 274: 20733-20737 [Abstract] [Full Text]
Ryan, M. C., Lee, K., Miyashita, Y., Carter, W. G. (1999). Targeted Disruption of the LAMA3 Gene in Mice Reveals Abnormalities in Survival and Late Stage Differentiation of Epithelial Cells. JCB 145: 1309-1324 [Abstract] [Full Text]
Crowe, D.L., Milo, G.E., Shuler, C.E. (1999). Keratin 19 Downregulation by Oral Squamous Cell Carcinoma Lines Increases Invasive Potential. JDR 78: 1256-1263 [Abstract]
Sanvito, F., Piatti, S., Villa, A., Bossi, M., Lucchini, G., Marchisio, P. C., Biffo, S. (1999). The {beta}4 Integrin Interactor p27BBP/eIF6 Is an Essential Nuclear Matrix Protein Involved in 60S Ribosomal Subunit Assembly. JCB 144: 823-838 [Abstract] [Full Text]
Leung, C. L., Sun, D., Liem, R. K.H. (1999). The Intermediate Filament Protein Peripherin Is the Specific Interaction Partner of Mouse BPAG1-n (Dystonin) in Neurons. JCB 144: 435-446 [Abstract] [Full Text]
van der Neut, R, Cachaco, A., Thorsteinsdottir, S, Janssen, H, Prins, D, Bulthuis, J, van der Valk, M, Calafat, J, Sonnenberg, A (1999). Partial rescue of epithelial phenotype in integrin beta4 null mice by a keratin-5 promoter driven human integrin beta4 transgene. J. Cell Sci. 112: 3911-3922 [Abstract]
Anderson, R, Fassler, R, Georges-Labouesse, E, Hynes, R., Bader, B., Kreidberg, J., Schaible, K, Heasman, J, Wylie, C (1999). Mouse primordial germ cells lacking beta1 integrins enter the germline but fail to migrate normally to the gonads. Development 126: 1655-1664 [Abstract]
Rojas, A.I., Ahmed, A.R. (1999). Adhesion Receptors in Health and Disease. CROBM 10: 337-358 [Abstract] [Full Text]
O'Connor, K. L., Shaw, L. M., Mercurio, A. M. (1998). Release of cAMP Gating by the {alpha}6{beta}4 Integrin Stimulates Lamellae Formation and the Chemotactic Migration of Invasive Carcinoma Cells. JCB 143: 1749-1760 [Abstract] [Full Text]
Takaoka, A. S., Yamada, T., Gotoh, M., Kanai, Y., Imai, K., Hirohashi, S. (1998). Cloning and Characterization of the Human beta 4-Integrin Gene Promoter and Enhancers. J. Biol. Chem. 273: 33848-33855 [Abstract] [Full Text]
Gimond, C., Baudoin, C., van der Neut, R., Kramer, D., Calafat, J., Sonnenberg, A. (1998). Cre-loxP-mediated Inactivation of the {alpha}6A Integrin Splice Variant In Vivo: Evidence for a Specific Functional Role of {alpha}6A in Lymphocyte Migration but Not in Heart Development. JCB 143: 253-266 [Abstract] [Full Text]
Hodivala-Dilke, K. M., Michael DiPersio, C., Kreidberg, J. A., Hynes, R. O. (1998). Novel Roles for {alpha}3{beta}1 Integrin as a Regulator of Cytoskeletal Assembly and as a Trans-dominant Inhibitor of Integrin Receptor Function in Mouse Keratinocytes. JCB 142: 1357-1369 [Abstract] [Full Text]
Schaapveld, R. Q.J., Borradori, L., Geerts, D., van Leusden, M. R., Kuikman, I., Nievers, M. G., Niessen, C. M., Steenbergen, R. D.M., Snijders, P. J.F., Sonnenberg, A. (1998). Hemidesmosome Formation Is Initiated by the {beta}4 Integrin Subunit, Requires Complex Formation of {beta}4 and HD1/Plectin, and Involves a Direct Interaction between {beta}4 and the Bullous Pemphigoid Antigen 180. JCB 142: 271-284 [Abstract] [Full Text]
Hirako, Y., Usukura, J., Uematsu, J., Hashimoto, T., Kitajima, Y., Owaribe, K. (1998). Cleavage of BP180, a 180-kDa Bullous Pemphigoid Antigen, Yields a 120-kDa Collagenous Extracellular Polypeptide. J. Biol. Chem. 273: 9711-9717 [Abstract] [Full Text]
Rezniczek, G. A., de Pereda, J. M., Reipert, S., Wiche, G. (1998). Linking Integrin {alpha}6{beta}4-based Cell Adhesion to the Intermediate Filament Cytoskeleton: Direct Interaction between the {beta}4 Subunit and Plectin at Multiple Molecular Sites. JCB 141: 209-225 [Abstract] [Full Text]
Li, A., Simmons, P. J., Kaur, P. (1998). Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype. Proc. Natl. Acad. Sci. USA 95: 3902-3907 [Abstract] [Full Text]
Nievers, M., Schaapveld, R., Oomen, L., Fontao, L, Geerts, D, Sonnenberg, A (1998). Ligand-independent role of the beta 4 integrin subunit in the formation of hemidesmosomes. J. Cell Sci. 111: 1659-1672 [Abstract]
Bernier, G, De Repentigny, Y, Mathieu, M, David, S, Kothary, R (1998). Dystonin is an essential component of the Schwann cell cytoskeleton at the time of myelination. Development 125: 2135-2148 [Abstract]
Dogic, D, Rousselle, P, Aumailley, M (1998). Cell adhesion to laminin 1 or 5 induces isoform-specific clustering of integrins and other focal adhesion components. J. Cell Sci. 111: 793-802 [Abstract]
Rabinovitz, I., Mercurio, A. M. (1997). The Integrin {alpha}6{beta}4 Functions in Carcinoma Cell Migration on Laminin-1 by Mediating the Formation and Stabilization of Actin-containing Motility Structures. JCB 139: 1873-1884 [Abstract] [Full Text]
Andra, K., Lassmann, H., Bittner, R., Shorny, S., Fassler, R., Propst, F., Wiche, G. (1997). Targeted inactivation of plectin reveals essential function in maintaining the integrity of skin, muscle, and heart�cytoarchitecture. Genes Dev. 11: 3143-3156 [Abstract] [Full Text]
Biffo, S., Sanvito, F., Costa, S., Preve, L., Pignatelli, R., Spinardi, L., Marchisio, P. C. (1997). Isolation of a Novel beta 4 Integrin-binding Protein (p27BBP) Highly Expressed in Epithelial Cells. J. Biol. Chem. 272: 30314-30321 [Abstract] [Full Text]
Price, A. A., Cumberbatch, M., Kimber, I., Ager, A. (1997). {alpha}6 Integrins Are Required for Langerhans Cell Migration from the Epidermis. JEM 186: 1725-1735 [Abstract] [Full Text]
Rousselle, P., Keene, D. R., Ruggiero, F., Champliaud, M.-F., Rest, M. v. d., Burgeson, R. E. (1997). Laminin 5 Binds the NC-1 Domain of Type VII Collagen. JCB 138: 719-728 [Abstract] [Full Text]
DiPersio, C. M., Hodivala-Dilke, K. M., Jaenisch, R., Kreidberg, J. A., Hynes, R. O. (1997). {alpha}3{beta}1 Integrin Is Required for Normal Development of the Epidermal Basement Membrane. JCB 137: 729-742 [Abstract] [Full Text]
Weaver, V.M., Petersen, O.W., Wang, F., Larabell, C.A., Briand, P., Damsky, C., Bissell, M.J. (1997). Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies. JCB 137: 231-245 [Abstract] [Full Text]
Lo, S. H., Yu, Q.-C., Degenstein, L., Chen, L. B., Fuchs, E. (1997). Progressive Kidney Degeneration in Mice Lacking Tensin. JCB 136: 1349-1361 [Abstract] [Full Text]
Niessen, C., Hulsman, E., Oomen, L., Kuikman, I, Sonnenberg, A (1997). A minimal region on the integrin beta4 subunit that is critical to its localization in hemidesmosomes regulates the distribution of HD1/plectin in COS-7 cells. J. Cell Sci. 110: 1705-1716 [Abstract]
Sanchez-Aparicio, P, Martinez de Velasco, A., Niessen, C., Borradori, L, Kuikman, I, Hulsman, E., Fassler, R, Owaribe, K, Sonnenberg, A (1997). The subcellular distribution of the high molecular mass protein, HD1, is determined by the cytoplasmic domain of the integrin beta 4 subunit. J. Cell Sci. 110: 169-178 [Abstract]