Aluminum fluoride stimulates surface protrusions in cells overexpressing the ARF6 GTPase

doi:10.1083/jcb.134.4.935

This Article

	Full Text (PDF, 4373K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JCB
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Radhakrishna, H.
	Articles by Donaldson, J. G.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Radhakrishna, H.
	Articles by Donaldson, J. G.


Social Bookmarking

	What's this?

ARTICLES

Aluminum fluoride stimulates surface protrusions in cells overexpressing the ARF6 GTPase

H Radhakrishna, RD Klausner and JG Donaldson
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.

To study the effector function of the ADP- ribosylation factor (ARF) 6 GTP-binding protein, we transfected HeLa cells with wild-type, epitope- tagged ARF6. Previously shown to indirectly activate the ARF1 GTPase, aluminum fluoride (AIF) treatment of ARF6-transfected cells resulted in a redistribution of both ARF6 and actin to discrete sites on the plasma membrane, which became increasingly protrusive over time. The effects of AIF were reversible, specific to cells transfected with wild-type ARF6, and resembled the cellular protrusions observed in cells expressing the GTPase defective mutant of ARF6. Importantly, the protrusions observed in cells transfected with ARF6 were distinct from the enhanced stress fibers and membrane ruffles observed in cells transfected with RhoA and Rac1, respectively. In cells forming protrusions, there was an apparent stimulation of macropinocytosis and membrane recycling within the protrusive structures. In contrast, no block in transferrin uptake or alteration of the distribution of clathrin AP-2 complexes was detected in these cells. The AIF-induced, ARF6- dependent formation of protrusive structures was blocked by cytochalasin D and inhibitors of the lipoxygenase pathway. These observations support a novel role for the ARF6 GTPase in modeling the plasma membrane and underlying cytoskeleton.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Yano, H., Kobayashi, I., Onodera, Y., Luton, F., Franco, M., Mazaki, Y., Hashimoto, S., Iwai, K., Ronai, Z., Sabe, H. (2008). Fbx8 Makes Arf6 Refractory to Function via Ubiquitination. Mol. Biol. Cell 19: 822-832 [Abstract] [Full Text]
Porat-Shliom, N., Kloog, Y., Donaldson, J. G. (2008). A Unique Platform for H-Ras Signaling Involving Clathrin-independent Endocytosis. Mol. Biol. Cell 19: 765-775 [Abstract] [Full Text]
Li, C.-C., Chiang, T.-C., Wu, T.-S., Pacheco-Rodriguez, G., Moss, J., Lee, F.-J. S. (2007). ARL4D Recruits Cytohesin-2/ARNO to Modulate Actin Remodeling. Mol. Biol. Cell 18: 4420-4437 [Abstract] [Full Text]
Bryant, D. M., Kerr, M. C., Hammond, L. A., Joseph, S. R., Mostov, K. E., Teasdale, R. D., Stow, J. L. (2007). EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin. J. Cell Sci. 120: 1818-1828 [Abstract] [Full Text]
Yoon, H.-Y., Miura, K., Cuthbert, E. J., Davis, K. K., Ahvazi, B., Casanova, J. E., Randazzo, P. A. (2006). ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP. J. Cell Sci. 119: 4650-4666 [Abstract] [Full Text]
Singleton, K., Parvaze, N., Dama, K. R., Chen, K. S., Jennings, P., Purtic, B., Sjaastad, M. D., Gilpin, C., Davis, M. M., Wulfing, C. (2006). A Large T Cell Invagination with CD2 Enrichment Resets Receptor Engagement in the Immunological Synapse. J. Immunol. 177: 4402-4413 [Abstract] [Full Text]
Suzuki, T., Kanai, Y., Hara, T., Sasaki, J., Sasaki, T., Kohara, M., Maehama, T., Taya, C., Shitara, H., Yonekawa, H., Frohman, M. A., Yokozeki, T., Kanaho, Y. (2006). Crucial Role of the Small GTPase ARF6 in Hepatic Cord Formation during Liver Development.. Mol. Cell. Biol. 26: 6149-6156 [Abstract] [Full Text]
Fang, Z., Miao, Y., Ding, X., Deng, H., Liu, S., Wang, F., Zhou, R., Watson, C., Fu, C., Hu, Q., Lillard, J. W. Jr, Powell, M., Chen, Y., Forte, J. G., Yao, X. (2006). Proteomic Identification and Functional Characterization of a Novel ARF6 GTPase-activating Protein, ACAP4. Mol. Cell. Proteomics 5: 1437-1449 [Abstract] [Full Text]
Kalia, M., Kumari, S., Chadda, R., Hill, M. M., Parton, R. G., Mayor, S. (2006). Arf6-independent GPI-anchored Protein-enriched Early Endosomal Compartments Fuse with Sorting Endosomes via a Rab5/Phosphatidylinositol-3'-Kinase-dependent Machinery. Mol. Biol. Cell 17: 3689-3704 [Abstract] [Full Text]
Za, L., Albertinazzi, C., Paris, S., Gagliani, M., Tacchetti, C., de Curtis, I. (2006). {beta}PIX controls cell motility and neurite extension by regulating the distribution of GIT1. J. Cell Sci. 119: 2654-2666 [Abstract] [Full Text]
Shmuel, M., Santy, L. C., Frank, S., Avrahami, D., Casanova, J. E., Altschuler, Y. (2006). ARNO through Its Coiled-coil Domain Regulates Endocytosis at the Apical Surface of Polarized Epithelial Cells. J. Biol. Chem. 281: 13300-13308 [Abstract] [Full Text]
Madziva, M. T., Birnbaumer, M. (2006). A Role for ADP-ribosylation Factor 6 in the Processing of G-protein-coupled Receptors. J. Biol. Chem. 281: 12178-12186 [Abstract] [Full Text]
Esteban, P. F., Yoon, H.-Y., Becker, J., Dorsey, S. G., Caprari, P., Palko, M. E., Coppola, V., Saragovi, H. U., Randazzo, P. A., Tessarollo, L. (2006). A kinase-deficient TrkC receptor isoform activates Arf6-Rac1 signaling through the scaffold protein tamalin. JCB 173: 291-299 [Abstract] [Full Text]
Choi, W., Karim, Z. A., Whiteheart, S. W. (2006). Arf6 plays an early role in platelet activation by collagen and convulxin. Blood 107: 3145-3152 [Abstract] [Full Text]
Jovanovic, O. A., Brown, F. D., Donaldson, J. G. (2006). An Effector Domain Mutant of Arf6 Implicates Phospholipase D in Endosomal Membrane Recycling. Mol. Biol. Cell 17: 327-335 [Abstract] [Full Text]
Schweitzer, J. K., Burke, E. E., Goodson, H. V., D'Souza-Schorey, C. (2005). Endocytosis Resumes during Late Mitosis and Is Required for Cytokinesis. J. Biol. Chem. 280: 41628-41635 [Abstract] [Full Text]
Modiano, N., Lu, Y. E., Cresswell, P. (2005). Golgi targeting of human guanylate-binding protein-1 requires nucleotide binding, isoprenylation, and an IFN-{gamma}-inducible cofactor. Proc. Natl. Acad. Sci. USA 102: 8680-8685 [Abstract] [Full Text]
Balana, M. E., Niedergang, F., Subtil, A., Alcover, A., Chavrier, P., Dautry-Varsat, A. (2005). ARF6 GTPase controls bacterial invasion by actin remodelling. J. Cell Sci. 118: 2201-2210 [Abstract] [Full Text]
Tanabe, K., Torii, T., Natsume, W., Braesch-Andersen, S., Watanabe, T., Satake, M. (2005). A Novel GTPase-activating Protein for ARF6 Directly Interacts with Clathrin and Regulates Clathrin-dependent Endocytosis. Mol. Biol. Cell 16: 1617-1628 [Abstract] [Full Text]
Houndolo, T., Boulay, P.-L., Claing, A. (2005). G Protein-coupled Receptor Endocytosis in ADP-ribosylation Factor 6-depleted Cells. J. Biol. Chem. 280: 5598-5604 [Abstract] [Full Text]
Kruth, H. S., Jones, N. L., Huang, W., Zhao, B., Ishii, I., Chang, J., Combs, C. A., Malide, D., Zhang, W.-Y. (2005). Macropinocytosis Is the Endocytic Pathway That Mediates Macrophage Foam Cell Formation with Native Low Density Lipoprotein. J. Biol. Chem. 280: 2352-2360 [Abstract] [Full Text]
Martinu, L., Masuda-Robens, J. M., Robertson, S. E., Santy, L. C., Casanova, J. E., Chou, M. M. (2004). The TBC (Tre-2/Bub2/Cdc16) Domain Protein TRE17 Regulates Plasma Membrane-Endosomal Trafficking through Activation of Arf6. Mol. Cell. Biol. 24: 9752-9762 [Abstract] [Full Text]
Hashimoto, S., Hashimoto, A., Yamada, A., Kojima, C., Yamamoto, H., Tsutsumi, T., Higashi, M., Mizoguchi, A., Yagi, R., Sabe, H. (2004). A Novel Mode of Action of an ArfGAP, AMAP2/PAG3/Pap{alpha}, in Arf6 Function. J. Biol. Chem. 279: 37677-37684 [Abstract] [Full Text]
Rescher, U., Ruhe, D., Ludwig, C., Zobiack, N., Gerke, V. (2004). Annexin 2 is a phosphatidylinositol (4,5)-bisphosphate binding protein recruited to actin assembly sites at cellular membranes. J. Cell Sci. 117: 3473-3480 [Abstract] [Full Text]
Macia, E., Luton, F., Partisani, M., Cherfils, J., Chardin, P., Franco, M. (2004). The GDP-bound form of Arf6 is located at the plasma membrane. J. Cell Sci. 117: 2389-2398 [Abstract] [Full Text]
Luton, F., Klein, S., Chauvin, J.-P., Le Bivic, A., Bourgoin, S., Franco, M., Chardin, P. (2004). EFA6, Exchange Factor for ARF6, Regulates the Actin Cytoskeleton and Associated Tight Junction in Response to E-Cadherin Engagement. Mol. Biol. Cell 15: 1134-1145 [Abstract] [Full Text]
Hernandez-Deviez, D. J., Roth, M. G., Casanova, J. E., Wilson, J. M. (2004). ARNO and ARF6 Regulate Axonal Elongation and Branching through Downstream Activation of Phosphatidylinositol 4-Phosphate 5-Kinase {alpha}. Mol. Biol. Cell 15: 111-120 [Abstract] [Full Text]
Zakrzewska, E., Perron, M., Laroche, A., Pallotta, D. (2003). A Role for GEA1 and GEA2 in the Organization of the Actin Cytoskeleton in Saccharomyces cerevisiae. Genetics 165: 985-995 [Abstract] [Full Text]
Arnaoutova, I., Jackson, C. L., Al-Awar, O. S., Donaldson, J. G., Loh, Y. P. (2003). Recycling of Raft-associated Prohormone Sorting Receptor Carboxypeptidase E Requires Interaction with ARF6. Mol. Biol. Cell 14: 4448-4457 [Abstract] [Full Text]
Donaldson, J. G. (2003). Multiple Roles for Arf6: Sorting, Structuring, and Signaling at the Plasma Membrane. J. Biol. Chem. 278: 41573-41576 [Full Text]
Riggs, B., Rothwell, W., Mische, S., Hickson, G. R.X., Matheson, J., Hays, T. S., Gould, G. W., Sullivan, W. (2003). Actin cytoskeleton remodeling during early Drosophila furrow formation requires recycling endosomal components Nuclear-fallout and Rab11. JCB 163: 143-154 [Abstract] [Full Text]
Sabe, H. (2003). Requirement for Arf6 in Cell Adhesion, Migration, and Cancer Cell Invasion. J Biochem 134: 485-489 [Abstract] [Full Text]
Huang, C.-F., Liu, Y.-W., Tung, L., Lin, C.-H., Lee, F.-J. S. (2003). Role for Arf3p in Development of Polarity, but Not Endocytosis, in Saccharomyces cerevisiae. Mol. Biol. Cell 14: 3834-3847 [Abstract] [Full Text]
Aikawa, Y., Martin, T. F.J. (2003). ARF6 regulates a plasma membrane pool of phosphatidylinositol(4,5)bisphosphate required for regulated exocytosis. JCB 162: 647-659 [Abstract] [Full Text]
Niedergang, F., Colucci-Guyon, E., Dubois, T., Raposo, G., Chavrier, P. (2003). ADP ribosylation factor 6 is activated and controls membrane delivery during phagocytosis in macrophages. JCB 161: 1143-1150 [Abstract] [Full Text]
Albertinazzi, C., Za, L., Paris, S., de Curtis, I. (2003). ADP-Ribosylation Factor 6 and a Functional PIX/p95-APP1 Complex Are Required for Rac1B-mediated Neurite Outgrowth. Mol. Biol. Cell 14: 1295-1307 [Abstract] [Full Text]
Kim, S., Ko, J., Shin, H., Lee, J.-R., Lim, C., Han, J.-H., Altrock, W. D., Garner, C. C., Gundelfinger, E. D., Premont, R. T., Kaang, B.-K., Kim, E. (2003). The GIT Family of Proteins Forms Multimers and Associates with the Presynaptic Cytomatrix Protein Piccolo. J. Biol. Chem. 278: 6291-6300 [Abstract] [Full Text]
Araki, N., Hatae, T., Furukawa, A., Swanson, J. A. (2003). Phosphoinositide-3-kinase-independent contractile activities associated with Fc{gamma}-receptor-mediated phagocytosis and macropinocytosis in macrophages. J. Cell Sci. 116: 247-257 [Abstract] [Full Text]
Nie, Z., Stanley, K. T., Stauffer, S., Jacques, K. M., Hirsch, D. S., Takei, J., Randazzo, P. A. (2002). AGAP1, an Endosome-associated, Phosphoinositide-dependent ADP-ribosylation Factor GTPase-activating Protein That Affects Actin Cytoskeleton. J. Biol. Chem. 277: 48965-48975 [Abstract] [Full Text]
Lim, J., Yusoff, P., Wong, E. S. M., Chandramouli, S., Lao, D.-H., Fong, C. W., Guy, G. R. (2002). The Cysteine-Rich Sprouty Translocation Domain Targets Mitogen-Activated Protein Kinase Inhibitory Proteins to Phosphatidylinositol 4,5-Bisphosphate in Plasma Membranes. Mol. Cell. Biol. 22: 7953-7966 [Abstract] [Full Text]
Casanova, J. E. (2002). Epithelial Cell Cytoskeleton and Intracellular Trafficking: V. Confluence of membrane trafficking and motility in epithelial cell models. Am. J. Physiol. Gastrointest. Liver Physiol. 283: G1015-G1019 [Abstract] [Full Text]
Santy, L. C. (2002). Characterization of a Fast Cycling ADP-ribosylation Factor 6 Mutant. J. Biol. Chem. 277: 40185-40188 [Abstract] [Full Text]
Delaney, K. A., Murph, M. M., Brown, L. M., Radhakrishna, H. (2002). Transfer of M2 Muscarinic Acetylcholine Receptors to Clathrin-derived Early Endosomes following Clathrin-independent Endocytosis. J. Biol. Chem. 277: 33439-33446 [Abstract] [Full Text]
Schweitzer, J. K., D'Souza-Schorey, C. (2002). Localization and Activation of the ARF6 GTPase during Cleavage Furrow Ingression and Cytokinesis. J. Biol. Chem. 277: 27210-27216 [Abstract] [Full Text]
Matafora, V., Paris, S., Dariozzi, S., Curtis, I. d. (2002). Molecular mechanisms regulating the subcellular localization of p95-APP1 between the endosomal recycling compartment and sites of actin organization at the cell surface. J. Cell Sci. 114: 4509-4520 [Abstract] [Full Text]
Furman, C., Short, S. M., Subramanian, R. R., Zetter, B. R., Roberts, T. M. (2002). DEF-1/ASAP1 Is a GTPase-activating Protein (GAP) for ARF1 That Enhances Cell Motility through a GAP-dependent Mechanism. J. Biol. Chem. 277: 7962-7969 [Abstract] [Full Text]
Park, J. G., Bose, A., Leszyk, J., Czech, M. P. (2001). PYK2 as a Mediator of Endothelin-1/Galpha 11 Signaling to GLUT4 Glucose Transporters. J. Biol. Chem. 276: 47751-47754 [Abstract] [Full Text]
Claing, A., Chen, W., Miller, W. E., Vitale, N., Moss, J., Premont, R. T., Lefkowitz, R. J. (2001). beta -Arrestin-mediated ADP-ribosylation Factor 6 Activation and beta 2-Adrenergic Receptor Endocytosis. J. Biol. Chem. 276: 42509-42513 [Abstract] [Full Text]
Brown, F. D., Rozelle, A. L., Yin, H. L., Balla, T., Donaldson, J. G. (2001). Phosphatidylinositol 4,5-bisphosphate and Arf6-regulated membrane traffic. JCB 154: 1007-1018 [Abstract] [Full Text]
Bose, A., Cherniack, A. D., Langille, S. E., Nicoloro, S. M. C., Buxton, J. M., Park, J. G., Chawla, A., Czech, M. P. (2001). G{alpha}11 Signaling through ARF6 Regulates F-Actin Mobilization and GLUT4 Glucose Transporter Translocation to the Plasma Membrane. Mol. Cell. Biol. 21: 5262-5275 [Abstract] [Full Text]
Lawrence, J. T. R., Birnbaum, M. J. (2001). ADP-Ribosylation Factor 6 Delineates Separate Pathways Used by Endothelin 1 and Insulin for Stimulating Glucose Uptake in 3T3-L1 Adipocytes. Mol. Cell. Biol. 21: 5276-5285 [Abstract] [Full Text]
Uchida, H., Kondo, A., Yoshimura, Y., Mazaki, Y., Sabe, H. (2001). Pag3/Pap{alpha}/Kiaa0400, a Gtpase-Activating Protein for Adp-Ribosylation Factor (Arf), Regulates Arf6 in Fc{gamma} Receptor-Mediated Phagocytosis of Macrophages. JEM 193: 955-966 [Abstract] [Full Text]
Mazaki, Y., Hashimoto, S., Okawa, K., Tsubouchi, A., Nakamura, K., Yagi, R., Yano, H., Kondo, A., Iwamatsu, A., Mizoguchi, A., Sabe, H. (2001). An ADP-Ribosylation Factor GTPase-activating Protein Git2-short/KIAA0148 Is Involved in Subcellular Localization of Paxillin and Actin Cytoskeletal Organization. Mol. Biol. Cell 12: 645-662 [Abstract] [Full Text]
Jackson, T. R., Brown, F. D., Nie, Z., Miura, K., Foroni, L., Sun, J., Hsu, V. W., Donaldson, J. G., Randazzo, P. A. (2000). Acaps Are Arf6 Gtpase-Activating Proteins That Function in the Cell Periphery. JCB 151: 627-638 [Abstract] [Full Text]
Al-Awar, O., Radhakrishna, H., Powell, N. N., Donaldson, J. G. (2000). Separation of Membrane Trafficking and Actin Remodeling Functions of ARF6 with an Effector Domain Mutant. Mol. Cell. Biol. 20: 5998-6007 [Abstract] [Full Text]
Martin, M. E., Hidalgo, J., Rosa, J. L., Crottet, P., Velasco, A. (2000). Effect of Protein Kinase A Activity on the Association of ADP-ribosylation Factor 1 to Golgi Membranes. J. Biol. Chem. 275: 19050-19059 [Abstract] [Full Text]
Nevrivy, D. J., Peterson, V. J., Avram, D., Ishmael, J. E., Hansen, S. G., Dowell, P., Hruby, D. E., Dawson, M. I., Leid, M. (2000). Interaction of GRASP, a Protein encoded by a Novel Retinoic Acid-induced Gene, with Members of the Cytohesin Family of Guanine Nucleotide Exchange Factors. J. Biol. Chem. 275: 16827-16836 [Abstract] [Full Text]
Boshans, R. L., Szanto, S., van Aelst, L., D'Souza-Schorey, C. (2000). ADP-Ribosylation Factor 6 Regulates Actin Cytoskeleton Remodeling in Coordination with Rac1 and RhoA. Mol. Cell. Biol. 20: 3685-3694 [Abstract] [Full Text]
Dell'Angelica, E. C., Puertollano, R., Mullins, C., Aguilar, R. C., Vargas, J. D., Hartnell, L. M., Bonifacino, J. S. (2000). Ggas: A Family of Adp Ribosylation Factor-Binding Proteins Related to Adaptors and Associated with the Golgi Complex. JCB 149: 81-94 [Abstract] [Full Text]
Kondo, A., Hashimoto, S., Yano, H., Nagayama, K., Mazaki, Y., Sabe, H. (2000). A New Paxillin-binding Protein, PAG3/Papalpha /KIAA0400, Bearing an ADP-Ribosylation Factor GTPase-activating Protein Activity, Is Involved in Paxillin Recruitment to Focal Adhesions and Cell Migration. Mol. Biol. Cell 11: 1315-1327 [Abstract] [Full Text]
Kam, J. L., Miura, K., Jackson, T. R., Gruschus, J., Roller, P., Stauffer, S., Clark, J., Aneja, R., Randazzo, P. A. (2000). Phosphoinositide-dependent Activation of the ADP-ribosylation Factor GTPase-activating Protein ASAP1. EVIDENCE FOR THE PLECKSTRIN HOMOLOGY DOMAIN FUNCTIONING AS AN ALLOSTERIC SITE. J. Biol. Chem. 275: 9653-9663 [Abstract] [Full Text]
Gu, F., Gruenberg, J. (2000). ARF1 Regulates pH-dependent COP Functions in the Early Endocytic Pathway. J. Biol. Chem. 275: 8154-8160 [Abstract] [Full Text]
Llorente, A, van Deurs, B, Garred, O, Eker, P, Sandvig, K (2000). Apical endocytosis of ricin in MDCK cells is regulated by the cyclooxygenase pathway. J. Cell Sci. 113: 1213-1221 [Abstract]
Zhang, Q., Calafat, J., Janssen, H., Greenberg, S. (1999). ARF6 Is Required for Growth Factor- and Rac-Mediated Membrane Ruffling in Macrophages at a Stage Distal to Rac Membrane Targeting. Mol. Cell. Biol. 19: 8158-8168 [Abstract] [Full Text]
Altschuler, Y., Liu, S.-H., Katz, L., Tang, K., Hardy, S., Brodsky, F., Apodaca, G., Mostov, K. (1999). Adp-Ribosylation Factor 6 and Endocytosis at the Apical Surface of Madin-Darby Canine Kidney Cells. JCB 147: 7-12 [Abstract] [Full Text]
Langille, S. E., Patki, V., Klarlund, J. K., Buxton, J. M., Holik, J. J., Chawla, A., Corvera, S., Czech, M. P. (1999). ADP-ribosylation Factor 6 as a Target of Guanine Nucleotide Exchange Factor GRP1. J. Biol. Chem. 274: 27099-27104 [Abstract] [Full Text]
Yang, C. Z., Mueckler, M. (1999). ADP-ribosylation Factor 6 (ARF6) Defines Two Insulin-regulated Secretory Pathways in Adipocytes. J. Biol. Chem. 274: 25297-25300 [Abstract] [Full Text]
Gaschet, J., Hsu, V. W. (1999). Distribution of ARF6 between Membrane and Cytosol Is Regulated by Its GTPase Cycle. J. Biol. Chem. 274: 20040-20045 [Abstract] [Full Text]
Blader, I. J., Cope, M. J. T.�V., Jackson, T. R., Profit, A. A., Greenwood, A. F., Drubin, D. G., Prestwich, G. D., Theibert, A. B. (1999). GCS1, an Arf Guanosine Triphosphatase-activating Protein in Saccharomyces cerevisiae, Is Required for Normal Actin Cytoskeletal Organization In Vivo and Stimulates Actin Polymerization In Vitro. Mol. Biol. Cell 10: 581-596 [Abstract] [Full Text]
Sivaguru, M., Volkmann, D., Felle, H. H., Horst, W. J. (1999). Impacts of Aluminum on the Cytoskeleton of the Maize Root Apex. Short-Term Effects on the Distal Part of the Transition Zone. Plant Physiol. 119: 1073-1082 [Abstract] [Full Text]
Mains, R. E., Alam, M. R., Johnson, R. C., Darlington, D. N., Back, N., Hand, T. A., Eipper, B. A. (1999). Kalirin, a Multifunctional PAM COOH-terminal Domain Interactor Protein, Affects Cytoskeletal Organization and ACTH Secretion from AtT-20 Cells. J. Biol. Chem. 274: 2929-2937 [Abstract] [Full Text]
Radhakrishna, H, Al-Awar, O, Khachikian, Z, Donaldson, J. (1999). ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements. J. Cell Sci. 112: 855-866 [Abstract]
Brown, M. T., Andrade, J., Radhakrishna, H., Donaldson, J. G., Cooper, J. A., Randazzo, P. A. (1998). ASAP1, a Phospholipid-Dependent Arf GTPase-Activating Protein That Associates with and Is Phosphorylated by Src. Mol. Cell. Biol. 18: 7038-7051 [Abstract] [Full Text]
Stamnes, M., Schiavo, G., Stenbeck, G., Sollner, T. H., Rothman, J. E. (1998). ADP-ribosylation factor and phosphatidic acid levels in Golgi membranes during budding of coatomer-coated vesicles. Proc. Natl. Acad. Sci. USA 95: 13676-13680 [Abstract] [Full Text]
Frank, S. R., Hatfield, J. C., Casanova, J. E. (1998). Remodeling of the Actin Cytoskeleton Is Coordinately Regulated by Protein Kinase C and the ADP-Ribosylation Factor Nucleotide Exchange Factor ARNO. Mol. Biol. Cell 9: 3133-3146 [Abstract] [Full Text]
Franco, M., Boretto, J., Robineau, S., Monier, S., Goud, B., Chardin, P., Chavrier, P. (1998). ARNO3, a Sec7-domain guanine nucleotide exchange factor for ADP ribosylation factor 1,�is involved in the control of Golgi structure and function. Proc. Natl. Acad. Sci. USA 95: 9926-9931 [Abstract] [Full Text]
Zhang, Q., Cox, D., Tseng, C.-C., Donaldson, J. G., Greenberg, S. (1998). A Requirement for ARF6 in Fcgamma Receptor-mediated Phagocytosis in Macrophages. J. Biol. Chem. 273: 19977-19981 [Abstract] [Full Text]
Ooi, C. E., Dell'Angelica, E. C., Bonifacino, J. S. (1998). ADP-Ribosylation Factor 1 (ARF1) Regulates Recruitment of the AP-3 Adaptor Complex to Membranes. JCB 142: 391-402 [Abstract] [Full Text]
Yang, C. Z., Heimberg, H., D'Souza-Schorey, C., Mueckler, M. M., Stahl, P. D. (1998). Subcellular Distribution and Differential Expression of Endogenous ADP-ribosylation Factor 6�in Mammalian Cells. J. Biol. Chem. 273: 4006-4011 [Abstract] [Full Text]
D'Souza-Schorey, C., van Donselaar, E., Hsu, V. W., Yang, C., Stahl, P. D., Peters, P. J. (1998). ARF6 Targets Recycling Vesicles to the Plasma Membrane: Insights from an Ultrastructural Investigation. JCB 140: 603-616 [Abstract] [Full Text]
Monier, S, Chardin, P, Robineau, S, Goud, B (1998). Overexpression of the ARF1 exchange factor ARNO inhibits the early secretory pathway and causes the disassembly of the Golgi complex. J. Cell Sci. 111: 3427-3436 [Abstract]
Song, J, Khachikian, Z, Radhakrishna, H, Donaldson, J. (1998). Localization of endogenous ARF6 to sites of cortical actin rearrangement and involvement of ARF6 in cell spreading. J. Cell Sci. 111: 2257-2267 [Abstract]
Veithen, A, Amyere, M, Van Der Smissen, P, Cupers, P, Courtoy, P. (1998). Regulation of macropinocytosis in v-Src-transformed fibroblasts: cyclic AMP selectively promotes regurgitation of macropinosomes. J. Cell Sci. 111: 2329-2335 [Abstract]
Weed, S., Du, Y, Parsons, J. (1998). Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1. J. Cell Sci. 111: 2433-2443 [Abstract]
Frank, S., Upender, S., Hansen, S. H., Casanova, J. E. (1998). ARNO Is a Guanine Nucleotide Exchange Factor for ADP-ribosylation Factor 6. J. Biol. Chem. 273: 23-27 [Abstract] [Full Text]
Lee, F.-J. S., Huang, C.-F., Yu, W.-L., Buu, L.-M., Lin, C.-Y., Huang, M.-C., Moss, J., Vaughan, M. (1997). Characterization of an ADP-ribosylation Factor-like 1�Protein in Saccharomyces cerevisiae. J. Biol. Chem. 272: 30998-31005 [Abstract] [Full Text]
Radhakrishna, H., Donaldson, J. G. (1997). ADP-Ribosylation Factor 6 Regulates a Novel Plasma Membrane Recycling Pathway. JCB 139: 49-61 [Abstract] [Full Text]
Van Aelst, L., D'Souza-Schorey, C. (1997). Rho GTPases and signaling networks. Genes Dev. 11: 2295-2322 [Full Text]
Dana, R. R., Eigsti, C., Holmes, K. L., Leto, T. L. (2000). A Regulatory Role for ADP-ribosylation Factor 6 (ARF6) in Activation of the Phagocyte NADPH Oxidase. J. Biol. Chem. 275: 32566-32571 [Abstract] [Full Text]
Lee, S., Park, J. B., Kim, J. H., Kim, Y., Kim, J. H., Shin, K.-J., Lee, J. S., Ha, S. H., Suh, P.-G., Ryu, S. H. (2001). Actin Directly Interacts with Phospholipase D, Inhibiting Its Activity. J. Biol. Chem. 276: 28252-28260 [Abstract] [Full Text]
Santy, L. C., Casanova, J. E. (2001). Activation of ARF6 by ARNO stimulates epithelial cell migration through downstream activation of both Rac1 and phospholipase D. JCB 154: 599-610 [Abstract] [Full Text]