Targeted Disruption of Decorin Leads to Abnormal Collagen Fibril Morphology and Skin Fragility

doi:10.1083/jcb.136.3.729

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© The Rockefeller University Press, 0021-9525/1997//729 $5.00
The Journal of Cell Biology, Volume 136, Number 3, , 1997 729-743

Article

Targeted Disruption of Decorin Leads to Abnormal Collagen Fibril Morphology and Skin Fragility

Keith G. Danielson^*, Helene Baribault, David F. Holmes, Helen Graham, Karl E. Kadler, and Renato V. Iozzo^*^,||

^* Department of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107; The Burnham Institute, La Jolla, California 92037; Wellcome Trust Centre for Cell-Matrix Research, School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom; and ^|| Kimmel Cancer Center, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107

Decorin is a member of the expanding group of widely distributedsmall leucine-rich proteoglycans that are expected to playimportant functions in tissue assembly. We report that miceharboring a targeted disruption of the decorin gene are viablebut have fragile skin with markedly reduced tensile strength.Ultrastructural analysis revealed abnormal collagen morphologyin skin and tendon, with coarser and irregular fiber outlines.Quantitative scanning transmission EM of individual collagenfibrils showed abrupt increases and decreases in mass alongtheir axes, thereby accounting for the irregular outlines andsize variability observed in cross-sections. The data indicateuncontrolled lateral fusion of collagen fibrils in the decorindeficientmice and provide an explanation for the reduced tensile strengthof the skin. These findings demonstrate a fundamental rolefor decorin in regulating collagen fiber formation in vivo.

Abbreviations used in this paper: EDS, Ehlers-Danlos syndrome; ES, embryonic stem; SLRP, small leucine-rich proteoglycan; STEM, scanning transmission EM.

K.G. Danielson and H. Baribault contributed equally to thiswork.

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Li, X., Velleman, S. G. (2009). Effect of transforming growth factor-{beta}1 on decorin expression and muscle morphology during chicken embryonic and posthatch growth and development. Poult. Sci. 88: 387-397 [Abstract] [Full Text]
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Iacob, D., Cai, J., Tsonis, M., Babwah, A., Chakraborty, C., Bhattacharjee, R. N., Lala, P. K. (2008). Decorin-Mediated Inhibition of Proliferation and Migration of the Human Trophoblast via Different Tyrosine Kinase Receptors. Endocrinology 149: 6187-6197 [Abstract] [Full Text]
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Kalamajski, S., Oldberg, A. (2007). Fibromodulin Binds Collagen Type I via Glu-353 and Lys-355 in Leucine-rich Repeat 11. J. Biol. Chem. 282: 26740-26745 [Abstract] [Full Text]
Prante, C., Milting, H., Kassner, A., Farr, M., Ambrosius, M., Schon, S., Seidler, D. G., Banayosy, A. E., Korfer, R., Kuhn, J., Kleesiek, K., Gotting, C. (2007). Transforming Growth Factor beta1-regulated Xylosyltransferase I Activity in Human Cardiac Fibroblasts and Its Impact for Myocardial Remodeling. J. Biol. Chem. 282: 26441-26449 [Abstract] [Full Text]
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Rentz, T. J., Poobalarahi, F., Bornstein, P., Sage, E. H., Bradshaw, A. D. (2007). SPARC Regulates Processing of Procollagen I and Collagen Fibrillogenesis in Dermal Fibroblasts. J. Biol. Chem. 282: 22062-22071 [Abstract] [Full Text]
Agren, M. S., Werthen, M. (2007). The Extracellular Matrix in Wound Healing: A Closer Look at Therapeutics for Chronic Wounds. INT J LOW EXTREM WOUNDS 6: 82-97 [Abstract]
Kalamajski, S., Aspberg, A., Oldberg, A. (2007). The Decorin Sequence SYIRIADTNIT Binds Collagen Type I. J. Biol. Chem. 282: 16062-16067 [Abstract] [Full Text]
Heegaard, A.-M., Corsi, A., Danielsen, C. C., Nielsen, K. L., Jorgensen, H. L., Riminucci, M., Young, M. F., Bianco, P. (2007). Biglycan Deficiency Causes Spontaneous Aortic Dissection and Rupture in Mice. Circulation 115: 2731-2738 [Abstract] [Full Text]
Takaluoma, K., Hyry, M., Lantto, J., Sormunen, R., Bank, R. A., Kivirikko, K. I., Myllyharju, J., Soininen, R. (2007). Tissue-specific Changes in the Hydroxylysine Content and Cross-links of Collagens and Alterations in Fibril Morphology in Lysyl Hydroxylase 1 Knock-out Mice. J. Biol. Chem. 282: 6588-6596 [Abstract] [Full Text]
Schaefer, L., Tsalastra, W., Babelova, A., Baliova, M., Minnerup, J., Sorokin, L., Grone, H.-J., Reinhardt, D. P., Pfeilschifter, J., Iozzo, R. V., Schaefer, R. M. (2007). Decorin-Mediated Regulation of Fibrillin-1 in the Kidney Involves the Insulin-Like Growth Factor-I Receptor and Mammalian Target of Rapamycin. Am. J. Pathol. 170: 301-315 [Abstract] [Full Text]
Dugan, T. A., Yang, V. W.-C., McQuillan, D. J., Hook, M. (2006). Decorin Modulates Fibrin Assembly and Structure. J. Biol. Chem. 281: 38208-38216 [Abstract] [Full Text]
Sullivan, M. M., Barker, T. H., Funk, S. E., Karchin, A., Seo, N. S., Hook, M., Sanders, J., Starcher, B., Wight, T. N., Puolakkainen, P., Sage, E. H. (2006). Matricellular Hevin Regulates Decorin Production and Collagen Assembly. J. Biol. Chem. 281: 27621-27632 [Abstract] [Full Text]
Seidler, D. G., Goldoni, S., Agnew, C., Cardi, C., Thakur, M. L., Owens, R. T., McQuillan, D. J., Iozzo, R. V. (2006). Decorin Protein Core Inhibits in Vivo Cancer Growth and Metabolism by Hindering Epidermal Growth Factor Receptor Function and Triggering Apoptosis via Caspase-3 Activation. J. Biol. Chem. 281: 26408-26418 [Abstract] [Full Text]
Cooper, L. J., Bentley, A. J., Nieduszynski, I. A., Talabani, S., Thomson, A., Utani, A., Shinkai, H., Fullwood, N. J., Brown, G. M. (2006). The role of dermatopontin in the stromal organization of the cornea.. IOVS 47: 3303-3310 [Abstract] [Full Text]
Orgel, J. P. R. O., Irving, T. C., Miller, A., Wess, T. J. (2006). Microfibrillar structure of type I collagen in situ. Proc. Natl. Acad. Sci. USA 103: 9001-9005 [Abstract] [Full Text]
Scott, P. G., Dodd, C. M., Bergmann, E. M., Sheehan, J. K., Bishop, P. N. (2006). Crystal Structure of the Biglycan Dimer and Evidence That Dimerization Is Essential for Folding and Stability of Class I Small Leucine-rich Repeat Proteoglycans. J. Biol. Chem. 281: 13324-13332 [Abstract] [Full Text]
Malfait, F., Hakim, A. J., De Paepe, A., Grahame, R. (2006). The genetic basis of the joint hypermobility syndromes. Rheumatology (Oxford) 45: 502-507 [Full Text]
van Someren, E. P., Vaes, B. L. T., Steegenga, W. T., Sijbers, A. M., Dechering, K. J., Reinders, M. J. T. (2006). Least absolute regression network analysis of the murine osteoblast differentiation network. Bioinformatics 22: 477-484 [Abstract] [Full Text]
Timmons, B. C., Mahendroo, M. S. (2006). Timing of Neutrophil Activation and Expression of Proinflammatory Markers Do Not Support a Role for Neutrophils in Cervical Ripening in the Mouse. Biol. Reprod. 74: 236-245 [Abstract] [Full Text]
Steiglitz, B. M., Kreider, J. M., Frankenburg, E. P., Pappano, W. N., Hoffman, G. G., Meganck, J. A., Liang, X., Hook, M., Birk, D. E., Goldstein, S. A., Greenspan, D. S. (2006). Procollagen C Proteinase Enhancer 1 Genes Are Important Determinants of the Mechanical Properties and Geometry of Bone and the Ultrastructure of Connective Tissues. Mol. Cell. Biol. 26: 238-249 [Abstract] [Full Text]
Taylor, K. R., Gallo, R. L. (2006). Glycosaminoglycans and their proteoglycans: host-associated molecular patterns for initiation and modulation of inflammation. FASEB J. 20: 9-22 [Abstract] [Full Text]
Koninger, J, Giese, N A, Bartel, M, di Mola, F F, Berberat, P O, di Sebastiano, P, Giese, T, Buchler, M W, Friess, H (2006). The ECM proteoglycan decorin links desmoplasia and inflammation in chronic pancreatitis. J. Clin. Pathol. 59: 21-27 [Abstract] [Full Text]
Bi, Y., Stuelten, C. H., Kilts, T., Wadhwa, S., Iozzo, R. V., Robey, P. G., Chen, X.-D., Young, M. F. (2005). Extracellular Matrix Proteoglycans Control the Fate of Bone Marrow Stromal Cells. J. Biol. Chem. 280: 30481-30489 [Abstract] [Full Text]
Bhide, V. M., Laschinger, C. A., Arora, P. D., Lee, W., Hakkinen, L., Larjava, H., Sodek, J., McCulloch, C. A. (2005). Collagen Phagocytosis by Fibroblasts Is Regulated by Decorin. J. Biol. Chem. 280: 23103-23113 [Abstract] [Full Text]
Schonherr, E., Sunderkotter, C., Iozzo, R. V., Schaefer, L. (2005). Decorin, a Novel Player in the Insulin-like Growth Factor System. J. Biol. Chem. 280: 15767-15772 [Abstract] [Full Text]
Docheva, D., Hunziker, E. B., Fassler, R., Brandau, O. (2005). Tenomodulin Is Necessary for Tenocyte Proliferation and Tendon Maturation. Mol. Cell. Biol. 25: 699-705 [Abstract] [Full Text]
Fust, A., LeBellego, F., Iozzo, R. V., Roughley, P. J., Ludwig, M. S. (2005). Alterations in lung mechanics in decorin-deficient mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 288: L159-L166 [Abstract] [Full Text]
Wenstrup, R. J., Florer, J. B., Brunskill, E. W., Bell, S. M., Chervoneva, I., Birk, D. E. (2004). Type V Collagen Controls the Initiation of Collagen Fibril Assembly. J. Biol. Chem. 279: 53331-53337 [Abstract] [Full Text]
Fischer, J. W., Steitz, S. A., Johnson, P. Y., Burke, A., Kolodgie, F., Virmani, R., Giachelli, C., Wight, T. N. (2004). Decorin Promotes Aortic Smooth Muscle Cell Calcification and Colocalizes to Calcified Regions in Human Atherosclerotic Lesions. Arterioscler. Thromb. Vasc. Bio. 24: 2391-2396 [Abstract] [Full Text]
Lee, P. H. A., Trowbridge, J. M., Taylor, K. R., Morhenn, V. B., Gallo, R. L. (2004). Dermatan Sulfate Proteoglycan and Glycosaminoglycan Synthesis Is Induced in Fibroblasts by Transfer to a Three-dimensional Extracellular Environment. J. Biol. Chem. 279: 48640-48646 [Abstract] [Full Text]
Scott, P. G., McEwan, P. A., Dodd, C. M., Bergmann, E. M., Bishop, P. N., Bella, J. (2004). Crystal structure of the dimeric protein core of decorin, the archetypal small leucine-rich repeat proteoglycan. Proc. Natl. Acad. Sci. USA 101: 15633-15638 [Abstract] [Full Text]
Ge, G., Seo, N.-S., Liang, X., Hopkins, D. R., Hook, M., Greenspan, D. S. (2004). Bone Morphogenetic Protein-1/Tolloid-related Metalloproteinases Process Osteoglycin and Enhance Its Ability to Regulate Collagen Fibrillogenesis. J. Biol. Chem. 279: 41626-41633 [Abstract] [Full Text]
Liang, F. T., Brown, E. L., Wang, T., Iozzo, R. V., Fikrig, E. (2004). Protective Niche for Borrelia burgdorferi to Evade Humoral Immunity. Am. J. Pathol. 165: 977-985 [Abstract] [Full Text]
Schaefer, L., Mihalik, D., Babelova, A., Krzyzankova, M., Grone, H.-J., Iozzo, R. V., Young, M. F., Seidler, D. G., Lin, G., Reinhardt, D. P., Schaefer, R. M. (2004). Regulation of Fibrillin-1 by Biglycan and Decorin Is Important for Tissue Preservation in the Kidney During Pressure-Induced Injury. Am. J. Pathol. 165: 383-396 [Abstract] [Full Text]
Jokinen, J., Dadu, E., Nykvist, P., Kapyla, J., White, D. J., Ivaska, J., Vehvilainen, P., Reunanen, H., Larjava, H., Hakkinen, L., Heino, J. (2004). Integrin-mediated Cell Adhesion to Type I Collagen Fibrils. J. Biol. Chem. 279: 31956-31963 [Abstract] [Full Text]
Koninger, J., Giese, N. A., di Mola, F. F., Berberat, P., Giese, T., Esposito, I., Bachem, M. G., Buchler, M. W., Friess, H. (2004). Overexpressed Decorin in Pancreatic Cancer: Potential Tumor Growth Inhibition and Attenuation of Chemotherapeutic Action. Clin. Cancer Res. 10: 4776-4783 [Abstract] [Full Text]
KJAeR, M. (2004). Role of Extracellular Matrix in Adaptation of Tendon and Skeletal Muscle to Mechanical Loading. Physiol. Rev. 84: 649-698 [Abstract] [Full Text]
Heathfield, T. F., Onnerfjord, P., Dahlberg, L., Heinegard, D. (2004). Cleavage of Fibromodulin in Cartilage Explants Involves Removal of the N-terminal Tyrosine Sulfate-rich Region by Proteolysis at a Site That Is Sensitive to Matrix Metalloproteinase-13. J. Biol. Chem. 279: 6286-6295 [Abstract] [Full Text]
Goldoni, S., Owens, R. T., McQuillan, D. J., Shriver, Z., Sasisekharan, R., Birk, D. E., Campbell, S., Iozzo, R. V. (2004). Biologically Active Decorin Is a Monomer in Solution. J. Biol. Chem. 279: 6606-6612 [Abstract] [Full Text]
Feng, J.Q., Huang, H., Lu, Y., Ye, L., Xie, Y., Tsutsui, T.W., Kunieda, T., Castranio, T., Scott, G., Bonewald, L.B., Mishina, Y. (2003). The Dentin Matrix Protein 1 (Dmp1) is Specifically Expressed in Mineralized, but not Soft, Tissues during Development. JDR 82: 776-780 [Abstract] [Full Text]
Hansen, U., Bruckner, P. (2003). Macromolecular Specificity of Collagen Fibrillogenesis: FIBRILS OF COLLAGENS I AND XI CONTAIN A HETEROTYPIC ALLOYED CORE AND A COLLAGEN I SHEATH. J. Biol. Chem. 278: 37352-37359 [Abstract] [Full Text]
Radermecker, M.A., Limet, R., Lapiere, C.M., Nusgens, B. (2003). Increased mRNA expression of decorin in the prolapsing posterior leaflet of the mitral valve. ICVTS 2: 389-394 [Abstract] [Full Text]
Li, S., Van Den Diepstraten, C., D'Souza, S. J., Chan, B. M. C., Pickering, J. G. (2003). Vascular Smooth Muscle Cells Orchestrate the Assembly of Type I Collagen via {alpha}2{beta}1 Integrin, RhoA, and Fibronectin Polymerization. Am. J. Pathol. 163: 1045-1056 [Abstract] [Full Text]
Ross, M. D., Bruggeman, L. A., Hanss, B., Sunamoto, M., Marras, D., Klotman, M. E., Klotman, P. E. (2003). Podocan, a Novel Small Leucine-rich Repeat Protein Expressed in the Sclerotic Glomerular Lesion of Experimental HIV-associated Nephropathy. J. Biol. Chem. 278: 33248-33255 [Abstract] [Full Text]
Pikas, D. S., Brown, E. L., Gurusiddappa, S., Lee, L. Y., Xu, Y., Hook, M. (2003). Decorin-binding Sites in the Adhesin DbpA from Borrelia burgdorferi: A SYNTHETIC PEPTIDE APPROACH. J. Biol. Chem. 278: 30920-30926 [Abstract] [Full Text]
Xaus, J., Besalduch, N., Comalada, M., Marcoval, J., Pujol, R., Mana, J., Celada, A. (2003). High expression of p21Waf1 in sarcoid granulomas: a putative role for long-lasting inflammation. J. Leukoc. Biol. 74: 295-301 [Abstract] [Full Text]
Chakravarti, S., Paul, J., Roberts, L., Chervoneva, I., Oldberg, A., Birk, D. E. (2003). Ocular and Scleral Alterations in Gene-Targeted Lumican-Fibromodulin Double-Null Mice. IOVS 44: 2422-2432 [Abstract] [Full Text]
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Carrino, D. A., Onnerfjord, P., Sandy, J. D., Cs-Szabo, G., Scott, P. G., Sorrell, J. M., Heinegard, D., Caplan, A. I. (2003). Age-related Changes in the Proteoglycans of Human Skin. SPECIFIC CLEAVAGE OF DECORIN TO YIELD A MAJOR CATABOLIC FRAGMENT IN ADULT SKIN. J. Biol. Chem. 278: 17566-17572 [Abstract] [Full Text]
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Dugan, T. A., Yang, V. W-C., McQuillan, D. J., Hook, M. (2003). Decorin Binds Fibrinogen in a Zn2+-dependent Interaction. J. Biol. Chem. 278: 13655-13662 [Abstract] [Full Text]
Gendelman, R., Burton-Wurster, N. I., MacLeod, J. N., Lust, G. (2003). The Cartilage-specific Fibronectin Isoform Has a High Affinity Binding Site for the Small Proteoglycan Decorin. J. Biol. Chem. 278: 11175-11181 [Abstract] [Full Text]
Shimizukawa, M., Ebina, M., Narumi, K., Kikuchi, T., Munakata, H., Nukiwa, T. (2003). Intratracheal gene transfer of decorin reduces subpleural fibroproliferation induced by bleomycin. Am. J. Physiol. Lung Cell. Mol. Physiol. 284: L526-L532 [Abstract] [Full Text]
Troup, S., Njue, C., Kliewer, E. V., Parisien, M., Roskelley, C., Chakravarti, S., Roughley, P. J., Murphy, L. C., Watson, P. H. (2003). Reduced Expression of the Small Leucine-rich Proteoglycans, Lumican, and Decorin Is Associated with Poor Outcome in Node-negative Invasive Breast Cancer. Clin. Cancer Res. 9: 207-214 [Abstract] [Full Text]
Wiberg, C., Heinegard, D., Wenglen, C., Timpl, R., Morgelin, M. (2002). Biglycan Organizes Collagen VI into Hexagonal-like Networks Resembling Tissue Structures. J. Biol. Chem. 277: 49120-49126 [Abstract] [Full Text]
Velling, T., Risteli, J., Wennerberg, K., Mosher, D. F., Johansson, S. (2002). Polymerization of Type I and III Collagens Is Dependent On Fibronectin and Enhanced By Integrins alpha 11beta 1 and alpha 2beta 1. J. Biol. Chem. 277: 37377-37381 [Abstract] [Full Text]
Jepsen, K. J., Wu, F., Peragallo, J. H., Paul, J., Roberts, L., Ezura, Y., Oldberg, A., Birk, D. E., Chakravarti, S. (2002). A Syndrome of Joint Laxity and Impaired Tendon Integrity in Lumican- and Fibromodulin-deficient Mice. J. Biol. Chem. 277: 35532-35540 [Abstract] [Full Text]
Santra, M., Reed, C. C., Iozzo, R. V. (2002). Decorin Binds to a Narrow Region of the Epidermal Growth Factor (EGF) Receptor, Partially Overlapping but Distinct from the EGF-binding Epitope. J. Biol. Chem. 277: 35671-35681 [Abstract] [Full Text]
Ameye, L., Young, M. F. (2002). Mice deficient in small leucine-rich proteoglycans: novel in vivo models for osteoporosis, osteoarthritis, Ehlers-Danlos syndrome, muscular dystrophy, and corneal diseases. Glycobiology 12: 107R-116R [Abstract] [Full Text]
Trowbridge, J. M., Gallo, R. L. (2002). Dermatan sulfate: new functions from an old glycosaminoglycan. Glycobiology 12: 117R-125R [Abstract] [Full Text]
Guidetti, G., Bertoni, A., Viola, M., Tira, E., Balduini, C., Torti, M. (2002). The small proteoglycan decorin supports adhesion and activation of human platelets. Blood 100: 1707-1714 [Abstract] [Full Text]
Xu, G., Guimond, M.-J., Chakraborty, C., Lala, P. K. (2002). Control of Proliferation, Migration, and Invasiveness of Human Extravillous Trophoblast by Decorin, a Decidual Product. Biol. Reprod. 67: 681-689 [Abstract] [Full Text]
Kielty, C. M., Sherratt, M. J., Shuttleworth, C. A. (2002). Elastic fibres. J. Cell Sci. 115: 2817-2828 [Abstract] [Full Text]
AMEYE, L., ARIA, D., JEPSEN, K., OLDBERG, A., XU, T., YOUNG, M. F. (2002). Abnormal collagen fibrils in tendons of biglycan/fibromodulin-deficient mice lead to gait impairment, ectopic ossification, and osteoarthritis. FASEB J. 16: 673-680 [Abstract] [Full Text]
Mavroidis, M., Capetanaki, Y. (2002). Extensive Induction of Important Mediators of Fibrosis and Dystrophic Calcification in Desmin-Deficient Cardiomyopathy. Am. J. Pathol. 160: 943-952 [Abstract] [Full Text]
Schaefer, L., Macakova, K., Raslik, I., Micegova, M., Grone, H.-J., Schonherr, E., Robenek, H., Echtermeyer, F. G., Grassel, S., Bruckner, P., Schaefer, R. M., Iozzo, R. V., Kresse, H. (2002). Absence of Decorin Adversely Influences Tubulointerstitial Fibrosis of the Obstructed Kidney by Enhanced Apoptosis and Increased Inflammatory Reaction. Am. J. Pathol. 160: 1181-1191 [Abstract] [Full Text]
Reinboth, B., Hanssen, E., Cleary, E. G., Gibson, M. A. (2002). Molecular Interactions of Biglycan and Decorin with Elastic Fiber Components. BIGLYCAN FORMS A TERNARY COMPLEX WITH TROPOELASTIN AND MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 1. J. Biol. Chem. 277: 3950-3957 [Abstract] [Full Text]
Di Lullo, G. A., Sweeney, S. M., Korkko, J., Ala-Kokko, L., San Antonio, J. D. (2002). Mapping the Ligand-binding Sites and Disease-associated Mutations on the Most Abundant Protein in the Human, Type I Collagen. J. Biol. Chem. 277: 4223-4231 [Abstract] [Full Text]
Xaus, J., Comalada, M., Cardo, M., Valledor, A. F., Celada, A. (2001). Decorin inhibits macrophage colony-stimulating factor proliferation of macrophages and enhances cell survival through induction of p27Kip1 and p21Waf1. Blood 98: 2124-2133 [Abstract] [Full Text]