Differentiation and Death of Premyelinating Oligodendrocytes in Developing Rodent Brain

doi:10.1083/jcb.137.2.459

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© The Rockefeller University Press, 0021-9525/1997//459 $5.00
The Journal of Cell Biology, Volume 137, Number 2, , 1997 459-468

Article

Differentiation and Death of Premyelinating Oligodendrocytes in Developing Rodent Brain

Bruce D. Trapp, Akiko Nishiyama, David Cheng, and Wendy Macklin

Department of Neurosciences, Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195

Previous studies have indicated that newly formed oligodendrocytesare dynamic cells whose production, survival, and differentiationdepend upon axonal influences. This study has characterizedthe appearance and fate of newly formed oligodendrocytes in developing rat brain. Oligodendrocytes appear in predictablelocations and radially extend DM-20–positive processesthat cover 80-µm domains in the cortex and 40-µmdomains in the corpus callosum. These premyelinating oligodendrocyteshave one of two fates: they myelinate axons or degenerate.Between 7 and 21 d after birth, $~$ 20% of premyelinating oligodendrocytes identified in the cerebral cortex were degenerating. Oligodendrocytesthat ensheathed axons expressed and selectively targeted proteolipidprotein to compact myelin and did not degenerate. These observationssupport the hypothesis that axonal influences affect oligodendrocytesurvival, differentiation, and expression of proteolipid proteingene products.

Abbreviations used in this paper: CNS, central nervous system; MAG, myelin-associated glycoprotein; MBP, myelin basic protein; PLP, proteolipid protein.

Address all correspondence to Dr. Bruce D. Trapp, Departmentof Neurosciences-NC30, The Cleveland Clinic Foundation, 9500Euclid Avenue, Cleveland, OH 44195. Tel: (216) 444-7177. Fax:(216) 444-7927.

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