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© The Rockefeller University Press, 0021-9525/1997//1017 $5.00
The Journal of Cell Biology, Volume 137, Number 5, , 1997 1017-1028

ERS-24, a Mammalian v-SNARE Implicated in Vesicle Traffic between the ER and the Golgi

Inbok Paek^*,, Lelio Orci^||, Mariella Ravazzola^||, Hediye Erdjument-Bromage, Mylene Amherdt^||, Paul Tempst, Thomas H. Söllner^*, and James E. Rothman^*

^* Cellular Biochemistry and Biophysics Program, Molecular Biology Program, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York 10021; and ^|| Institute of Histology and Embryology, Department of Morphology, University of Geneva Medical School, 1211 Geneva 4, Switzerland

We report the identification and characterization of ERS-24 (Endoplasmic Reticulum SNARE of 24 kD), a new mammalian v-SNARE implicated in vesicular transport between the ER and the Golgi. ERS24 is incorporated into 20S docking and fusion particles and disassembles from this complex in an ATP-dependent manner. ERS-24 has significant sequence homology to Sec22p, a v-SNARE in Saccharomyces cerevisiae required for transport between the ER and the Golgi. ERS-24 is localized to the ER and to the Golgi, and it is enriched in transport vesicles associated with these organelles.

Please address all correspondence to James E. Rothman, Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 251, New York 10021. Tel.: (212) 6398598. Fax: (212) 717-3604.

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