J. Cell Biol.
© The Rockefeller University Press
0021-9525/97/06/1017/12 $2.00
Volume 137, Number 5, June 2, 1997 1017-1028

ERS-24, a Mammalian v-SNARE Implicated in Vesicle Traffic between the ER and the Golgi

Inbok Paek,^*§ Lelio Orci, Mariella Ravazzola, Hediye Erdjument-Bromage, Mylene Amherdt, Paul Tempst, Thomas H. Söllner,^* and James E. Rothman^*

^* Cellular Biochemistry and Biophysics Program,  Molecular Biology Program, ^§ Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York 10021; and  Institute of Histology and Embryology, Department of Morphology, University of Geneva Medical School, 1211 Geneva 4, Switzerland

We report the identification and characterization of ERS-24 (Endoplasmic Reticulum SNARE of 24 kD), a new mammalian v-SNARE implicated in vesicular transport between the ER and the Golgi. ERS24 is incorporated into 20S docking and fusion particles and disassembles from this complex in an ATP-dependent manner. ERS-24 has significant sequence homology to Sec22p, a v-SNARE in Saccharomyces cerevisiae required for transport between the ER and the Golgi. ERS-24 is localized to the ER and to the Golgi, and it is enriched in transport vesicles associated with these organelles.

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