Major Histocompatibility Complex Class II Compartments in Human and Mouse B Lymphoblasts Represent Conventional Endocytic Compartments

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© The Rockefeller University Press, 0021-9525/1997//639 $5.00
The Journal of Cell Biology, Volume 139, Number 3, , 1997 639-649

Article

Major Histocompatibility Complex Class II Compartments in Human and Mouse B Lymphoblasts Represent Conventional Endocytic Compartments

Monique J. Kleijmeer^*, Stanislaw Morkowski, Janice M. Griffith^*, Alexander Y. Rudensky^,, and Hans J. Geuze^*

^* Department of Cell Biology, School of Medicine and Institute of Biomembranes, Utrecht University, 3584 CX Utrecht, The Netherlands; and Department of Immunology and Howard Hughes Medical Institute, University of Washington, School of Medicine, Seattle, Washington 98105

In most human and mouse antigen-presenting cells, the majorityof intracellular major histocompatibility complex (MHC) classII molecules resides in late endocytic MHC class II compartments(MIICs), thought to function in antigen processing and peptide loading. However, in mouse A20 B cells, early endocytic classII-containing vesicles (CIIVs) have been reported to containmost of the intracellular MHC class II molecules and have alsobeen implicated in formation of MHC class II–peptide complexes.To address this discrepancy, we have studied in great detailthe endocytic pathways of both a human (6H5.DM) and a mouse(A20.A^b) B cell line. Using quantitative immunoelectron microscopyon cryosections of cells that had been pulse–chased withtransferrin-HRP or BSA-gold as endocytic tracers, we have identifiedup to six endocytic subcompartments including an early MIICtype enriched in invariant chain, suggesting that it servesas an important entrance to the endocytic pathway for newlysynthesized MHC class II/invariant chain complexes. In addition,early MIICs represented the earliest endocytic compartment containingMHC class II– peptide complexes, as shown by using anantibody against an abundant endogenous class II–peptidecomplex. The early MIIC exhibited several though not all of the characteristics reported for the CIIV and was situatedjust downstream of early endosomes. We have not encounteredany special class II-containing endocytic structures besidesthose normally present in nonantigen-presenting cells. Our resultstherefore suggest that B cells use conventional endocytic compartments rather than having developed a unique compartment to accomplishMHC class II presentation.

Abbreviations used in this paper: APC, antigen-presenting cell; CD, cation dependent; CIIV, class II-containing vesicle; EE, early endosome; HLA, human leukocyte antigen; I-chain, invariant chain; IEM, immunoelectron microscopy; LAMPS, lysosome-associated membrane proteins; MPR, mannose 6-phosphate receptor; LE, late endosome; MHC, major histocompatibility complex; MIIC, MHC class II-enriched compartment; Tf, transferrin.

Address all correspondence to Hans J. Geuze, Medical School,Department of Cell Biology, AZU H02.314, Heidelberglaan 100,3584 CX Utrecht, The Netherlands. Tel.: (31) 30-2507652. Fax:(31) 30-2541797. E-mail: h.j.geuze{at}lab.azu.nl

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Ramachandra, L., Noss, E., Boom, W. H., Harding, C. V. (2001). Processing of Mycobacterium tuberculosis Antigen 85B Involves Intraphagosomal Formation of Peptide-Major Histocompatibility Complex II Complexes and Is Inhibited by Live Bacilli that Decrease Phagosome Maturation. JEM 194: 1421-1432 [Abstract] [Full Text]
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Kujala, P., Ikäheimonen, A., Ehsani, N., Vihinen, H., Auvinen, P., Kääriäinen, L. (2001). Biogenesis of the Semliki Forest Virus RNA Replication Complex. J. Virol. 75: 3873-3884 [Abstract] [Full Text]
Baron, C, Raposo, G, Scholl, S., Bausinger, H, Tenza, D, Bohbot, A, Pouillart, P, Goud, B, Hanau, D, Salamero, J (2001). Modulation of MHC class II transport and lysosome distribution by macrophage-colony stimulating factor in human dendritic cells derived from monocytes. J. Cell Sci. 114: 999-1010 [Abstract]
Forestier, C., Deleuil, F., Lapaque, N., Moreno, E., Gorvel, J.-P. (2000). Brucella abortus Lipopolysaccharide in Murine Peritoneal Macrophages Acts as a Down-Regulator of T Cell Activation. J. Immunol. 165: 5202-5210 [Abstract] [Full Text]
Denzer, K., van Eijk, M., Kleijmeer, M. J., Jakobson, E., de Groot, C., J. Geuze, H. (2000). Follicular Dendritic Cells Carry MHC Class II-Expressing Microvesicles at Their Surface. J. Immunol. 165: 1259-1265 [Abstract] [Full Text]
Chames, P., Hufton, S. E., Coulie, P. G., Uchanska-Ziegler, B., Hoogenboom, H. R. (2000). Direct selection of a human antibody fragment directed against the tumor T-cell epitope HLA-A1-MAGE-A1 from a nonimmunized phage-Fab library. Proc. Natl. Acad. Sci. USA 97: 7969-7974 [Abstract] [Full Text]
DELL’ANGELICA, E. C., MULLINS, C., CAPLAN, S., BONIFACINO, J. S. (2000). Lysosome-related organelles. FASEB J. 14: 1265-1278 [Abstract] [Full Text]
Ramachandra, L., Harding, C. V. (2000). Phagosomes Acquire Nascent and Recycling Class II MHC Molecules but Primarily Use Nascent Molecules in Phagocytic Antigen Processing. J. Immunol. 164: 5103-5112 [Abstract] [Full Text]
Hausmann, G., O'Reilly, L. A., van Driel, R., Beaumont, J. G., Strasser, A., Adams, J. M., Huang, D. C.S. (2000). Pro-Apoptotic Apoptosis Protease-Activating Factor 1 (Apaf-1) Has a Cytoplasmic Localization Distinct from Bcl-2 or Bcl-XL. JCB 149: 623-634 [Abstract] [Full Text]
Turley, S. J., Inaba, K., Garrett, W. S., Ebersold, M., Unternaehrer, J., Steinman, R. M., Mellman, I. (2000). Transport of Peptide-MHC Class II Complexes in Developing Dendritic Cells. Science 288: 522-527 [Abstract] [Full Text]
Hess, M. W., Schwendinger, M. G., Eskelinen, E.-L., Pfaller, K., Pavelka, M., Dierich, M. P., Prodinger, W. M. (2000). Tracing uptake of C3dg-conjugated antigen into B cells via complement receptor type 2 (CR2, CD21). Blood 95: 2617-2623 [Abstract] [Full Text]
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Reaves, B., Row, P., Bright, N., Luzio, J., Davidson, H. (2000). Loss of cation-independent mannose 6-phosphate receptor expression promotes the accumulation of lysobisphosphatidic acid in multilamellar bodies. J. Cell Sci. 113: 4099-4108 [Abstract]
Denzer, K, Kleijmeer, M., Heijnen, H., Stoorvogel, W, Geuze, H. (2000). Exosome: from internal vesicle of the multivesicular body to intercellular signaling device. J. Cell Sci. 113: 3365-3374 [Abstract]
Ramm, G, Pond, L, Watts, C, Stoorvogel, W (2000). Clathrin-coated lattices and buds on MHC class II compartments do not selectively recruit mature MHC-II. J. Cell Sci. 113: 303-313 [Abstract]
de Wit, H., Lichtenstein, Y., Geuze, H. J., Kelly, R. B., van der Sluijs, P., Klumperman, J. (1999). Synaptic Vesicles Form by Budding from Tubular Extensions of Sorting Endosomes in PC12 Cells. Mol. Biol. Cell 10: 4163-4176 [Abstract] [Full Text]
Driessen, C., Bryant, R. A.R., Lennon-Dumenil, A.-M., Villadangos, J. A., Bryant, P. W., Shi, G.-P., Chapman, H. A., Ploegh, H. L. (1999). Cathepsin S Controls the Trafficking and Maturation of Mhc Class II Molecules in Dendritic Cells. JCB 147: 775-790 [Abstract] [Full Text]
Davidson, H. W. (1999). Direct Transport of Newly Synthesized HLA-DR from the trans-Golgi Network to Major Histocompatibility Complex Class II Containing Compartments (MIICS) Demonstrated Using a Novel Tyrosine-sulfated Chimera. J. Biol. Chem. 274: 27315-27322 [Abstract] [Full Text]
van der Meer, Y., Snijder, E. J., Dobbe, J. C., Schleich, S., Denison, M. R., Spaan, W. J. M., Locker, J. K. (1999). Localization of Mouse Hepatitis Virus Nonstructural Proteins and RNA Synthesis Indicates a Role for Late Endosomes in Viral Replication. J. Virol. 73: 7641-7657 [Abstract] [Full Text]
Simonsen, A., Pedersen, K. W., Nordeng, T. W., von der Lippe, A., Stang, E., Long, E. O., Bakke, O. (1999). Polarized Transport of MHC Class II Molecules in Madin-Darby Canine Kidney Cells Is Directed by a Leucine-Based Signal in the Cytoplasmic Tail of the {beta}-Chain. J. Immunol. 163: 2540-2548 [Abstract] [Full Text]
Brachet, V., Péhau-Arnaudet, G., Desaymard, C., Raposo, G., Amigorena, S. (1999). Early Endosomes Are Required for Major Histocompatiblity Complex Class II Transport to Peptide-loading Compartments. Mol. Biol. Cell 10: 2891-2904 [Abstract] [Full Text]
Advani, R. J., Yang, B., Prekeris, R., Lee, K. C., Klumperman, J., Scheller, R. H. (1999). Vamp-7 Mediates Vesicular Transport from Endosomes to Lysosomes. JCB 146: 765-776 [Abstract] [Full Text]
Mallet, W. G., Maxfield, F. R. (1999). Chimeric Forms of Furin and Tgn38 Are Transported from the Plasma Membrane to the Trans-Golgi Network via Distinct Endosomal Pathways. JCB 146: 345-360 [Abstract] [Full Text]
Barrat, F. J., Le Deist, F., Benkerrou, M., Bousso, P., Feldmann, J., Fischer, A., de Saint Basile, G. (1999). Defective CTLA-4 cycling pathway in Chediak-Higashi syndrome: A possible mechanism for deregulation of T lymphocyte activation. Proc. Natl. Acad. Sci. USA 96: 8645-8650 [Abstract] [Full Text]
van Vugt, M. J., Kleijmeer, M. J., Keler, T., Zeelenberg, I., van Dijk, M. A., Leusen, J. H.W., Geuze, H. J., van de Winkel, J. G.J. (1999). The Fcgamma RIa (CD64) Ligand Binding Chain Triggers Major Histocompatibility Complex Class II Antigen Presentation Independently of Its Associated FcR gamma -Chain. Blood 94: 808-817 [Abstract] [Full Text]
Pond, L., Watts, C. (1999). Functional Early Endosomes Are Required for Maturation of Major Histocompatibility Complex Class II Molecules in Human B Lymphoblastoid Cells. J. Biol. Chem. 274: 18049-18054 [Abstract] [Full Text]
Beatty, W. L., Meresse, S., Gounon, P., Davoust, J., Mounier, J., Sansonetti, P. J., Gorvel, J.-P. (1999). Trafficking of Shigella Lipopolysaccharide in Polarized Intestinal Epithelial Cells. JCB 145: 689-698 [Abstract] [Full Text]
Brown, B. K., Li, C., Cheng, P. C., Song, W. (1999). Trafficking of the Igalpha /Igbeta Heterodimer with Membrane Ig and Bound Antigen to the Major Histocompatibility Complex Class II Peptide-loading Compartment. J. Biol. Chem. 274: 11439-11446 [Abstract] [Full Text]
Ramachandra, L., Song, R., Harding, C. V. (1999). Phagosomes Are Fully Competent Antigen-Processing Organelles That Mediate the Formation of Peptide:Class II MHC Complexes. J. Immunol. 162: 3263-3272 [Abstract] [Full Text]
Drake, J. R., Lewis, T. A., Condon, K. B., Mitchell, R. N., Webster, P. (1999). Involvement of MIIC-Like Late Endosomes in B Cell Receptor-Mediated Antigen Processing in Murine B Cells. J. Immunol. 162: 1150-1155 [Abstract] [Full Text]
Antoine, J., Lang, T, Prina, E, Courret, N, Hellio, R (1999). H-2M molecules, like MHC class II molecules, are targeted to parasitophorous vacuoles of Leishmania-infected macrophages and internalized by amastigotes of L. amazonensis and L. mexicana. J. Cell Sci. 112: 2559-2570 [Abstract]
Lem, L., Riethof, D. A., Scidmore-Carlson, M., Griffiths, G. M., Hackstadt, T., Brodsky, F. M. (1999). Enhanced Interaction of HLA-DM with HLA-DR in Enlarged Vacuoles of Hereditary and Infectious Lysosomal Diseases. J. Immunol. 162: 523-532 [Abstract] [Full Text]
Hammond, C., Denzin, L. K., Pan, M., Griffith, J. M., Geuze, H. J., Cresswell, P. (1998). The Tetraspan Protein CD82 Is a Resident of MHC Class II Compartments Where It Associates with HLA-DR, -DM, and -DO Molecules. J. Immunol. 161: 3282-3291 [Abstract] [Full Text]
Maurer, D., Fiebiger, E., Reininger, B., Ebner, C., Petzelbauer, P., Shi, G.-P., Chapman, H. A., Stingl, G. (1998). Fc{epsilon} Receptor I on Dendritic Cells Delivers IgE-Bound Multivalent Antigens into a Cathepsin S-Dependent Pathway of MHC Class II Presentation. J. Immunol. 161: 2731-2739 [Abstract] [Full Text]
Thery, C., Brachet, V., Regnault, A., Rescigno, M., Ricciardi-Castagnoli, P., Bonnerot, C., Amigorena, S. (1998). MHC Class II Transport from Lysosomal Compartments to the Cell Surface Is Determined by Stable Peptide Binding, But Not by the Cytosolic Domains of the {alpha}- and {beta}-Chains. J. Immunol. 161: 2106-2113 [Abstract] [Full Text]
Escola, J.-M., Kleijmeer, M. J., Stoorvogel, W., Griffith, J. M., Yoshie, O., Geuze, H. J. (1998). Selective Enrichment of Tetraspan Proteins on the Internal Vesicles of Multivesicular Endosomes and on Exosomes Secreted by Human B-lymphocytes. J. Biol. Chem. 273: 20121-20127 [Abstract] [Full Text]
Faigle, W., Raposo, G., Tenza, D., Pinet, V., Vogt, A. B., Kropshofer, H., Fischer, A., de Saint-Basile, G., Amigorena, S. (1998). Deficient Peptide Loading and MHC Class II Endosomal Sorting in a Human Genetic Immunodeficiency Disease: the Chediak-Higashi Syndrome. JCB 141: 1121-1134 [Abstract] [Full Text]
Guerra, C. B., Busch, R., Doebele, R. C., Liu, W., Sawada, T., Kwok, W. W., Chang, M.-d. Y., Mellins, E. D. (1998). Novel Glycosylation of HLA-DR{alpha} Disrupts Antigen Presentation Without Altering Endosomal Localization. J. Immunol. 160: 4289-4297 [Abstract] [Full Text]
Harsay, E., Schekman, R. (2002). A subset of yeast vacuolar protein sorting mutants is blocked in one branch of the exocytic pathway. JCB 156: 271-286 [Abstract] [Full Text]
Sachse, M., Urbe, S., Oorschot, V., Strous, G. J., Klumperman, J. (2002). Bilayered Clathrin Coats on Endosomal Vacuoles Are Involved in Protein Sorting toward Lysosomes. Mol. Biol. Cell 13: 1313-1328 [Abstract] [Full Text]