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J. Cell Biol.,
Volume 139, Number 3, November 3, 1997 729-734

* Physiologisch-chemisches Institut, Universität Tübingen, 72076 Tübingen, Germany; and A Saccharomyces cerevisiae mutant in cell division cycle gene CDC48 shows typical markers of apoptosis: membrane staining with annexin V, indicating an
exposure of phosphatidylserine at the outer layer of the
cytoplasmic membrane; intense staining, using the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling method, indicating DNA fragmentation; and chromatin condensation and fragmentation.
The coordinate occurrence of these events at different
locations in the cell, which have no obvious connection
except their relation to apoptosis, implies the presence of the molecular machinery performing the basic steps
of apoptosis already in yeast. Saccharomyces cerevisiae
may prove a suitable model to trace the roots of apoptosis.
Anatomisches Institut, Universität
Tübingen, 72072 Tübingen, Germany
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