Caveolin-1 and -2 in the Exocytic Pathway of MDCK Cells

doi:10.1083/jcb.140.4.795

This Article

	Full Text
	Full Text (PDF, 501K)
	PPT slides of all figures
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JCB
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Scheiffele, P.
	Articles by Ikonen, E.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Scheiffele, P.
	Articles by Ikonen, E.


Social Bookmarking

	What's this?

J. Cell Biol., Volume 140, Number 4, February 23, 1998 795-806

Caveolin-1 and -2 in the Exocytic Pathway of MDCK Cells

P. Scheiffele,^* >P. Verkade,^* >A.M. Fra, >H. Virta,^* >K. Simons,^* and >E. Ikonen^*

^* Cell Biology Programme, European Molecular Biology Laboratory, D-69012 Heidelberg, Germany; and Department of Biological and Technical Research-Hospital San Raffaele, 20132 Milan, Italy

Abstract. We have studied the biosynthesis and transport of the endogenous caveolins in MDCK cells. We show that in additionto homooligomers of caveolin-1, heterooligomeric complexes ofcaveolin-1 and -2 are formed in the ER. The oligomers become larger,increasingly detergent insoluble, and phosphorylated on caveolin-2during transport to the cell surface. In the TGN caveolin-1/-2heterooligomers are sorted into basolateral vesicles, whereaslarger caveolin-1 homooligomers are targeted to the apical side.Caveolin-1 is present on both the apical and basolateral plasmamembrane, whereas caveolin-2 is enriched on the basolateral surfacewhere caveolae are present. This suggests that caveolin-1 and-2 heterooligomers are involved in caveolar biogenesis in thebasolateral plasma membrane. Anti-caveolin-1 antibodies inhibitthe apical delivery of influenza virus hemagglutinin without affectingbasolateral transport of vesicular stomatitis virus G protein.Thus, we suggest that caveolin-1 homooligomers play a role inapical transport.

Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Mitsui, K., Hatakeyama, K., Matsushita, M., Kanazawa, H. (2009). Saccharomyces cerevisiae Na+/H+ Antiporter Nha1p Associates with Lipid Rafts and Requires Sphingolipid for Stable Localization to the Plasma Membrane. J Biochem 145: 709-720 [Abstract] [Full Text]
Paladino, S., Lebreton, S., Tivodar, S., Campana, V., Tempre, R., Zurzolo, C. (2008). Different GPI-attachment signals affect the oligomerisation of GPI-anchored proteins and their apical sorting. J. Cell Sci. 121: 4001-4007 [Abstract] [Full Text]
Langlois, S., Cowan, K. N., Shao, Q., Cowan, B. J., Laird, D. W. (2008). Caveolin-1 and -2 Interact with Connexin43 and Regulate Gap Junctional Intercellular Communication in Keratinocytes. Mol. Biol. Cell 19: 912-928 [Abstract] [Full Text]
Boulware, M. I., Kordasiewicz, H., Mermelstein, P. G. (2007). Caveolin Proteins Are Essential for Distinct Effects of Membrane Estrogen Receptors in Neurons. J. Neurosci. 27: 9941-9950 [Abstract] [Full Text]
Storey, S. M., Gibbons, T. F., Williams, C. V., Parr, R. D., Schroeder, F., Ball, J. M. (2007). Full-Length, Glycosylated NSP4 Is Localized to Plasma Membrane Caveolae by a Novel Raft Isolation Technique. J. Virol. 81: 5472-5483 [Abstract] [Full Text]
Shmuel, M., Nodel-Berner, E., Hyman, T., Rouvinski, A., Altschuler, Y. (2007). Caveolin 2 Regulates Endocytosis and Trafficking of the M1 Muscarinic Receptor in MDCK Epithelial Cells. Mol. Biol. Cell 18: 1570-1585 [Abstract] [Full Text]
Dupont, E., Prochiantz, A., Joliot, A. (2007). Identification of a Signal Peptide for Unconventional Secretion. J. Biol. Chem. 282: 8994-9000 [Abstract] [Full Text]
Sun, X.-H., Flynn, D. C., Castranova, V., Millecchia, L. L., Beardsley, A. R., Liu, J. (2007). Identification of a Novel Domain at the N Terminus of Caveolin-1 That Controls Rear Polarization of the Protein and Caveolae Formation. J. Biol. Chem. 282: 7232-7241 [Abstract] [Full Text]
Reversi, A., Rimoldi, V., Brambillasca, S., Chini, B. (2006). Effects of cholesterol manipulation on the signaling of the human oxytocin receptor. Am. J. Physiol. Regul. Integr. Comp. Physiol. 291: R861-R869 [Abstract] [Full Text]
Browman, D. T., Resek, M. E., Zajchowski, L. D., Robbins, S. M. (2006). Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER. J. Cell Sci. 119: 3149-3160 [Abstract] [Full Text]
Rajendran, L., Honsho, M., Zahn, T. R., Keller, P., Geiger, K. D., Verkade, P., Simons, K. (2006). Alzheimer's disease beta-amyloid peptides are released in association with exosomes. Proc. Natl. Acad. Sci. USA 103: 11172-11177 [Abstract] [Full Text]
Murtazina, R., Kovbasnjuk, O., Donowitz, M., Li, X. (2006). Na+/H+ Exchanger NHE3 Activity and Trafficking Are Lipid Raft-dependent. J. Biol. Chem. 281: 17845-17855 [Abstract] [Full Text]
Ullrich, N., Caplanusi, A., Brone, B., Hermans, D., Lariviere, E., Nilius, B., Van Driessche, W., Eggermont, J. (2006). Stimulation by caveolin-1 of the hypotonicity-induced release of taurine and ATP at basolateral, but not apical, membrane of Caco-2 cells. Am. J. Physiol. Cell Physiol. 290: C1287-C1296 [Abstract] [Full Text]
Parton, R. G., Hanzal-Bayer, M., Hancock, J. F. (2006). Biogenesis of caveolae: a structural model for caveolin-induced domain formation.. J. Cell Sci. 119: 787-796 [Abstract] [Full Text]
Mora, R. C., Bonilha, V. L., Shin, B.-C., Hu, J., Cohen-Gould, L., Bok, D., Rodriguez-Boulan, E. (2006). Bipolar assembly of caveolae in retinal pigment epithelium. Am. J. Physiol. Cell Physiol. 290: C832-C843 [Abstract] [Full Text]
Orlichenko, L., Huang, B., Krueger, E., McNiven, M. A. (2006). Epithelial Growth Factor-induced Phosphorylation of Caveolin 1 at Tyrosine 14 Stimulates Caveolae Formation in Epithelial Cells. J. Biol. Chem. 281: 4570-4579 [Abstract] [Full Text]
Hernandez-Deviez, D. J., Martin, S., Laval, S. H., Lo, H. P., Cooper, S. T., North, K. N., Bushby, K., Parton, R. G. (2006). Aberrant dysferlin trafficking in cells lacking caveolin or expressing dystrophy mutants of caveolin-3. Hum Mol Genet 15: 129-142 [Abstract] [Full Text]
Mehta, D., Malik, A. B. (2006). Signaling Mechanisms Regulating Endothelial Permeability. Physiol. Rev. 86: 279-367 [Abstract] [Full Text]
Vagin, O., Turdikulova, S., Sachs, G. (2005). Recombinant Addition of N-Glycosylation Sites to the Basolateral Na,K-ATPase beta1 Subunit Results in Its Clustering in Caveolae and Apical Sorting in HGT-1 Cells. J. Biol. Chem. 280: 43159-43167 [Abstract] [Full Text]
Manninen, A., Verkade, P., Le Lay, S., Torkko, J., Kasper, M., Fullekrug, J., Simons, K. (2005). Caveolin-1 Is Not Essential for Biosynthetic Apical Membrane Transport. Mol. Cell. Biol. 25: 10087-10096 [Abstract] [Full Text]
Sleight, S. B., Miranda, P. V., Plaskett, N.-W., Maier, B., Lysiak, J., Scrable, H., Herr, J. C., Visconti, P. E. (2005). Isolation and Proteomic Analysis of Mouse Sperm Detergent-Resistant Membrane Fractions: Evidence for Dissociation of Lipid Rafts During Capacitation. Biol. Reprod. 73: 721-729 [Abstract] [Full Text]
Tagawa, A., Mezzacasa, A., Hayer, A., Longatti, A., Pelkmans, L., Helenius, A. (2005). Assembly and trafficking of caveolar domains in the cell: caveolae as stable, cargo-triggered, vesicular transporters. JCB 170: 769-779 [Abstract] [Full Text]
Vieira, O. V., Verkade, P., Manninen, A., Simons, K. (2005). FAPP2 is involved in the transport of apical cargo in polarized MDCK cells. JCB 170: 521-526 [Abstract] [Full Text]
Papanikolaou, A., Papafotika, A., Murphy, C., Papamarcaki, T., Tsolas, O., Drab, M., Kurzchalia, T. V., Kasper, M., Christoforidis, S. (2005). Cholesterol-dependent Lipid Assemblies Regulate the Activity of the Ecto-nucleotidase CD39. J. Biol. Chem. 280: 26406-26414 [Abstract] [Full Text]
Delacour, D., Gouyer, V., Zanetta, J.-P., Drobecq, H., Leteurtre, E., Grard, G., Moreau-Hannedouche, O., Maes, E., Pons, A., Andre, S., Le Bivic, A., Gabius, H. J., Manninen, A., Simons, K., Huet, G. (2005). Galectin-4 and sulfatides in apical membrane trafficking in enterocyte-like cells. JCB 169: 491-501 [Abstract] [Full Text]
Pol, A., Martin, S., Fernandez, M. A., Ingelmo-Torres, M., Ferguson, C., Enrich, C., Parton, R. G. (2005). Cholesterol and Fatty Acids Regulate Dynamic Caveolin Trafficking through the Golgi Complex and between the Cell Surface and Lipid Bodies. Mol. Biol. Cell 16: 2091-2105 [Abstract] [Full Text]
Paladino, S., Sarnataro, D., Pillich, R., Tivodar, S., Nitsch, L., Zurzolo, C. (2004). Protein oligomerization modulates raft partitioning and apical sorting of GPI-anchored proteins. JCB 167: 699-709 [Abstract] [Full Text]
Pang, S., Urquhart, P., Hooper, N. M. (2004). N-Glycans, not the GPI anchor, mediate the apical targeting of a naturally glycosylated, GPI-anchored protein in polarised epithelial cells. J. Cell Sci. 117: 5079-5086 [Abstract] [Full Text]
Ren, X., Ostermeyer, A. G., Ramcharan, L. T., Zeng, Y., Lublin, D. M., Brown, D. A. (2004). Conformational Defects Slow Golgi Exit, Block Oligomerization, and Reduce Raft Affinity of Caveolin-1 Mutant Proteins. Mol. Biol. Cell 15: 4556-4567 [Abstract] [Full Text]
Nomura, R., Kiyota, A., Suzaki, E., Kataoka, K., Ohe, Y., Miyamoto, K., Senda, T., Fujimoto, T. (2004). Human Coronavirus 229E Binds to CD13 in Rafts and Enters the Cell through Caveolae. J. Virol. 78: 8701-8708 [Abstract] [Full Text]
Kogo, H., Aiba, T., Fujimoto, T. (2004). Cell Type-specific Occurrence of Caveolin-1{alpha} and -1{beta} in the Lung Caused by Expression of Distinct mRNAs. J. Biol. Chem. 279: 25574-25581 [Abstract] [Full Text]
Kasahara, K., Nakayama, Y., Ikeda, K., Fukushima, Y., Matsuda, D., Horimoto, S., Yamaguchi, N. (2004). Trafficking of Lyn through the Golgi caveolin involves the charged residues on {alpha}E and {alpha}I helices in the kinase domain. JCB 165: 641-652 [Abstract] [Full Text]
Buk, D. M., Waibel, M., Braig, C., Martens, A. S., Heinrich, P. C., Graeve, L. (2004). Polarity and lipid raft association of the components of the ciliary neurotrophic factor receptor complex in Madin-Darby canine kidney cells. J. Cell Sci. 117: 2063-2075 [Abstract] [Full Text]
Zhang, H., Links, P. H., Ngsee, J. K., Tran, K., Cui, Z., Ko, K. W. S., Yao, Z. (2004). Localization of Low Density Lipoprotein Receptor-related Protein 1 to Caveolae in 3T3-L1 Adipocytes in Response to Insulin Treatment. J. Biol. Chem. 279: 2221-2230 [Abstract] [Full Text]
Delacour, D., Gouyer, V., Leteurtre, E., Ait-Slimane, T., Drobecq, H., Lenoir, C., Moreau-Hannedouche, O., Trugnan, G., Huet, G. (2003). 1-Benzyl-2-acetamido-2-deoxy-{alpha}-D-galactopyranoside Blocks the Apical Biosynthetic Pathway in Polarized HT-29 Cells. J. Biol. Chem. 278: 37799-37809 [Abstract] [Full Text]
Kifor, O., Kifor, I., Moore, F. D. Jr., Butters, R. R. Jr., Cantor, T., Gao, P., Brown, E. M. (2003). Decreased Expression of Caveolin-1 and Altered Regulation of Mitogen-Activated Protein Kinase in Cultured Bovine Parathyroid Cells and Human Parathyroid Adenomas. J. Clin. Endocrinol. Metab. 88: 4455-4464 [Abstract] [Full Text]
Kifor, O., Kifor, I., Moore, F. D. Jr., Butters, R. R. Jr., Brown, E. M. (2003). m-Calpain Colocalizes with the Calcium-sensing Receptor (CaR) in Caveolae in Parathyroid Cells and Participates in Degradation of the CaR. J. Biol. Chem. 278: 31167-31176 [Abstract] [Full Text]
Cho, K. A., Ryu, S. J., Park, J. S., Jang, I. S., Ahn, J. S., Kim, K. T., Park, S. C. (2003). Senescent Phenotype Can Be Reversed by Reduction of Caveolin Status. J. Biol. Chem. 278: 27789-27795 [Abstract] [Full Text]
Spitzenberger, F., Pietropaolo, S., Verkade, P., Habermann, B., Lacas-Gervais, S., Mziaut, H., Pietropaolo, M., Solimena, M. (2003). Islet Cell Autoantigen of 69 kDa Is an Arfaptin-related Protein Associated with the Golgi Complex of Insulinoma INS-1 Cells. J. Biol. Chem. 278: 26166-26173 [Abstract] [Full Text]
TUMA, P. L., HUBBARD, A. L. (2003). Transcytosis: Crossing Cellular Barriers. Physiol. Rev. 83: 871-932 [Abstract] [Full Text]
Wyse, B. D., Prior, I. A., Qian, H., Morrow, I. C., Nixon, S., Muncke, C., Kurzchalia, T. V., Thomas, W. G., Parton, R. G., Hancock, J. F. (2003). Caveolin Interacts with the Angiotensin II Type 1 Receptor during Exocytic Transport but Not at the Plasma Membrane. J. Biol. Chem. 278: 23738-23746 [Abstract] [Full Text]
Rybin, V. O., Grabham, P. W., Elouardighi, H., Steinberg, S. F. (2003). Caveolae-associated proteins in cardiomyocytes: caveolin-2 expression and interactions with caveolin-3. Am. J. Physiol. Heart Circ. Physiol. 285: H325-H332 [Abstract] [Full Text]
Liu, S. M., Cogny, A., Kockx, M., Dean, R. T., Gaus, K., Jessup, W., Kritharides, L. (2003). Cyclodextrins differentially mobilize free and esterified cholesterol from primary human foam cell macrophages. J. Lipid Res. 44: 1156-1166 [Abstract] [Full Text]
Sowa, G., Pypaert, M., Fulton, D., Sessa, W. C. (2003). The phosphorylation of caveolin-2 on serines 23 and 36 modulates caveolin-1-dependent caveolae formation. Proc. Natl. Acad. Sci. USA 100: 6511-6516 [Abstract] [Full Text]
Kumar, V., Farell, G., Deganello, S., Lieske, J. C. (2003). Annexin II Is Present on Renal Epithelial Cells and Binds Calcium Oxalate Monohydrate Crystals. J. Am. Soc. Nephrol. 14: 289-297 [Abstract] [Full Text]
Liu, P., Rudick, M., Anderson, R. G. W. (2002). Multiple Functions of Caveolin-1. J. Biol. Chem. 277: 41295-41298 [Full Text]
Brown, G., Rixon, H. W. McL., Sugrue, R. J. (2002). Respiratory syncytial virus assembly occurs in GM1-rich regions of the host-cell membrane and alters the cellular distribution of tyrosine phosphorylated caveolin-1. J. Gen. Virol. 83: 1841-1850 [Abstract] [Full Text]
Sotgia, F., Razani, B., Bonuccelli, G., Schubert, W., Battista, M., Lee, H., Capozza, F., Schubert, A. L., Minetti, C., Buckley, J. T., Lisanti, M. P. (2002). Intracellular Retention of Glycosylphosphatidyl Inositol-Linked Proteins in Caveolin-Deficient Cells. Mol. Cell. Biol. 22: 3905-3926 [Abstract] [Full Text]
Garver, W. S., Krishnan, K., Gallagos, J. R., Michikawa, M., Francis, G. A., Heidenreich, R. A. (2002). Niemann-Pick C1 protein regulates cholesterol transport to the trans-Golgi network and plasma membrane caveolae. J. Lipid Res. 43: 579-589 [Abstract] [Full Text]
Alonso, M. A., Millan, J. (2002). The role of lipid rafts in signalling and membrane trafficking in T lymphocytes. J. Cell Sci. 114: 3957-3965 [Abstract] [Full Text]
Torgersen, M. L., Skretting, G., van Deurs, B., Sandvig, K. (2002). Internalization of cholera toxin by different endocytic mechanisms. J. Cell Sci. 114: 3737-3747 [Abstract] [Full Text]
Breuza, L., Corby, S., Arsanto, J.-P., Delgrossi, M.-H., Scheiffele, P., Le Bivic, A. (2002). The scaffolding domain of caveolin 2 is responsible for its Golgi localization in Caco-2 cells. J. Cell Sci. 115: 4457-4467 [Abstract] [Full Text]
Ramirez, M. I., Pollack, L., Millien, G., Cao, Y. X., Hinds, A., Williams, M. C. (2002). The {alpha}-Isoform of Caveolin-1 Is a Marker of Vasculogenesis in Early Lung Development. J. Histochem. Cytochem. 50: 33-42 [Abstract] [Full Text]
Mobius, W., Ohno-Iwashita, Y., van Donselaar, E. G., Oorschot, V. M.J., Shimada, Y., Fujimoto, T., Heijnen, H. F.G., Geuze, H. J., Slot, J. W. (2002). Immunoelectron Microscopic Localization of Cholesterol Using Biotinylated and Non-cytolytic Perfringolysin O. J. Histochem. Cytochem. 50: 43-56 [Abstract] [Full Text]
Li, X., Galli, T., Leu, S., Wade, J. B, Weinman, E. J, Leung, G., Cheong, A., Louvard, D., Donowitz, M. (2001). Na+-H+ exchanger 3 (NHE3) is present in lipid rafts in the rabbit ileal brush border: a role for rafts in trafficking and rapid stimulation of NHE3. J. Physiol. 537: 537-552 [Abstract] [Full Text]
Bagnat, M., Chang, A., Simons, K. (2001). Plasma Membrane Proton ATPase Pma1p Requires Raft Association for Surface Delivery in Yeast. Mol. Biol. Cell 12: 4129-4138 [Abstract] [Full Text]
Sowa, G., Pypaert, M., Sessa, W. C. (2001). Distinction between signaling mechanisms in lipid rafts vs. caveolae. Proc. Natl. Acad. Sci. USA 10.1073/pnas.241409998v1 [Abstract] [Full Text]
Simons, M., Schwarz, K., Kriz, W., Miettinen, A., Reiser, J., Mundel, P., Holthofer, H. (2001). Involvement of Lipid Rafts in Nephrin Phosphorylation and Organization of the Glomerular Slit Diaphragm. Am. J. Pathol. 159: 1069-1077 [Abstract] [Full Text]
Pol, A., Luetterforst, R., Lindsay, M., Heino, S., Ikonen, E., Parton, R. G. (2001). A Caveolin Dominant Negative Mutant Associates with Lipid Bodies and Induces Intracellular Cholesterol Imbalance. JCB 152: 1057-1070 [Abstract] [Full Text]
Fujimoto, T., Kogo, H., Ishiguro, K., Tauchi, K., Nomura, R. (2001). Caveolin-2 Is Targeted to Lipid Droplets, a New "Membrane Domain" in the Cell. JCB 152: 1079-1086 [Abstract] [Full Text]
Li, H., Brodsky, S., Basco, M., Romanov, V., De Angelis, D. A., Goligorsky, M. S. (2001). Nitric Oxide Attenuates Signal Transduction : Possible Role in Dissociating Caveolin-1 Scaffold. Circ. Res. 88: 229-236 [Abstract] [Full Text]
Doyle, D. D., Goings, G., Upshaw-Earley, J., Ambler, S. K., Mondul, A., Palfrey, H. C., Page, E. (2000). Dystrophin Associates With Caveolae of Rat Cardiac Myocytes : Relationship to Dystroglycan. Circ. Res. 87: 480-488 [Abstract] [Full Text]
Plant, P. J., Lafont, F., Lecat, S., Verkade, P., Simons, K., Rotin, D. (2000). Apical Membrane Targeting of Nedd4 Is Mediated by an Association of Its C2 Domain with Annexin XIIIb. JCB 149: 1473-1484 [Abstract] [Full Text]
Park, H., Go, Y.-M., Darji, R., Choi, J.-W., Lisanti, M. P., Maland, M. C., Jo, H. (2000). Caveolin-1 regulates shear stress-dependent activation of extracellular signal-regulated kinase. Am. J. Physiol. Heart Circ. Physiol. 278: H1285-H1293 [Abstract] [Full Text]
Verkade, P., Harder, T., Lafont, F., Simons, K. (2000). Induction of Caveolae in the Apical Plasma Membrane of Madin-Darby Canine Kidney Cells. JCB 148: 727-740 [Abstract] [Full Text]
Machleidt, T., Li, W.-P., Liu, P., Anderson, R. G.W. (2000). Multiple Domains in Caveolin-1 Control its Intracellular Traffic. JCB 148: 17-28 [Abstract] [Full Text]
Fujimoto, T, Kogo, H, Nomura, R, Une, T (2000). Isoforms of caveolin-1 and caveolar structure. J. Cell Sci. 113: 3509-3517 [Abstract]
Nusrat, A, Parkos, C., Verkade, P, Foley, C., Liang, T., Innis-Whitehouse, W, Eastburn, K., Madara, J. (2000). Tight junctions are membrane microdomains. J. Cell Sci. 113: 1771-1781 [Abstract]
Stahlhut, M., van Deurs, B. (2000). Identification of Filamin as a Novel Ligand for Caveolin-1: Evidence for the Organization of Caveolin-1-associated Membrane Domains by the Actin Cytoskeleton. Mol. Biol. Cell 11: 325-337 [Abstract] [Full Text]
Ostermeyer, A. G., Beckrich, B. T., Ivarson, K. A., Grove, K. E., Brown, D. A. (1999). Glycosphingolipids Are Not Essential for Formation of Detergent-resistant Membrane Rafts in Melanoma Cells. METHYL-beta -CYCLODEXTRIN DOES NOT AFFECT CELL SURFACE TRANSPORT OF A GPI-ANCHORED PROTEIN. J. Biol. Chem. 274: 34459-34466 [Abstract] [Full Text]
Smart, E. J., Graf, G. A., McNiven, M. A., Sessa, W. C., Engelman, J. A., Scherer, P. E., Okamoto, T., Lisanti, M. P. (1999). Caveolins, Liquid-Ordered Domains, and Signal Transduction. Mol. Cell. Biol. 19: 7289-7304 [Full Text]
Tugizov, S., Maidji, E., Xiao, J., Pereira, L. (1999). An Acidic Cluster in the Cytosolic Domain of Human Cytomegalovirus Glycoprotein B Is a Signal for Endocytosis from the Plasma Membrane. J. Virol. 73: 8677-8688 [Abstract] [Full Text]
Trouet, D., Nilius, B., Jacobs, A., Remacle, C., Droogmans, G., Eggermont, J. (1999). Caveolin-1 modulates the activity of the volume-regulated chloride channel. J. Physiol. 520: 113-119 [Abstract] [Full Text]
Mora, R., Bonilha, V. L., Marmorstein, A., Scherer, P. E., Brown, D., Lisanti, M. P., Rodriguez-Boulan, E. (1999). Caveolin-2 Localizes to the Golgi Complex but Redistributes to Plasma Membrane, Caveolae, and Rafts when Co-expressed with Caveolin-1. J. Biol. Chem. 274: 25708-25717 [Abstract] [Full Text]
Oliferenko, S., Paiha, K., Harder, T., Gerke, V., Schwarzler, C., Schwarz, H., Beug, H., Gunthert, U., Huber, L. A. (1999). Analysis of CD44-containing Lipid Rafts: Recruitment of Annexin II and Stabilization by the Actin Cytoskeleton. JCB 146: 843-854 [Abstract] [Full Text]
Benting, J. H., Rietveld, A. G., Simons, K. (1999). N-Glycans Mediate the Apical Sorting of a GPI-anchored, Raft-associated Protein in Madin-Darby Canine Kidney Cells. JCB 146: 313-320 [Abstract] [Full Text]
Luetterforst, R., Stang, E., Zorzi, N., Carozzi, A., Way, M., Parton, R. G. (1999). Molecular Characterization of Caveolin Association with the Golgi Complex: Identification of a Cis-Golgi Targeting Domain in the Caveolin Molecule. JCB 145: 1443-1459 [Abstract] [Full Text]
Das, K., Lewis, R. Y., Scherer, P. E., Lisanti, M. P. (1999). The Membrane-spanning Domains of Caveolins-1 and -2 Mediate the Formation of Caveolin Hetero-oligomers. IMPLICATIONS FOR THE ASSEMBLY OF CAVEOLAE MEMBRANES IN VIVO. J. Biol. Chem. 274: 18721-18728 [Abstract] [Full Text]
Cheong, K. H., Zacchetti, D., Schneeberger, E. E., Simons, K. (1999). VIP17/MAL, a lipid raft-associated protein, is involved in apical transport in MDCK cells. Proc. Natl. Acad. Sci. USA 96: 6241-6248 [Abstract] [Full Text]
Lafont, F., Verkade, P., Galli, T., Wimmer, C., Louvard, D., Simons, K. (1999). Raft association of SNAP receptors acting in apical trafficking in Madin-Darby canine kidney cells. Proc. Natl. Acad. Sci. USA 96: 3734-3738 [Abstract] [Full Text]
Scheiffele, P., Rietveld, A., Wilk, T., Simons, K. (1999). Influenza Viruses Select Ordered Lipid Domains during Budding from the Plasma Membrane. J. Biol. Chem. 274: 2038-2044 [Abstract] [Full Text]
YEAMAN, C., GRINDSTAFF, K. K., NELSON, W. J. (1999). New Perspectives on Mechanisms Involved in Generating Epithelial Cell Polarity. Physiol. Rev. 79: 73-98 [Abstract] [Full Text]
Lavie, Y., Fiucci, G., Liscovitch, M. (1998). Up-regulation of Caveolae and Caveolar Constituents in Multidrug-resistant Cancer Cells. J. Biol. Chem. 273: 32380-32383 [Abstract] [Full Text]
Lafont, F., Lecat, S., Verkade, P., Simons, K. (1998). Annexin XIIIb Associates with Lipid Microdomains to Function in Apical Delivery. JCB 142: 1413-1427 [Abstract] [Full Text]
Waugh, M. G., Lawson, D., Tan, S. K., Hsuan, J. J. (1998). Phosphatidylinositol 4-Phosphate Synthesis in Immunoisolated Caveolae-like Vesicles and Low Buoyant Density Non-caveolar Membranes. J. Biol. Chem. 273: 17115-17121 [Abstract] [Full Text]
Peiro, S., Comella, J. X., Enrich, C., Martin-Zanca, D., Rocamora, N. (2000). PC12 Cells Have Caveolae That Contain TrkA. CAVEOLAE-DISRUPTING DRUGS INHIBIT NERVE GROWTH FACTOR-INDUCED, BUT NOT EPIDERMAL GROWTH FACTOR-INDUCED, MAPK PHOSPHORYLATION. J. Biol. Chem. 275: 37846-37852 [Abstract] [Full Text]
Schreiber, S., Fleischer, J., Breer, H., Boekhoff, I. (2000). A Possible Role for Caveolin as a Signaling Organizer in Olfactory Sensory Membranes. J. Biol. Chem. 275: 24115-24123 [Abstract] [Full Text]
Schlegel, A., Arvan, P., Lisanti, M. P. (2001). Caveolin-1 Binding to Endoplasmic Reticulum Membranes and Entry into the Regulated Secretory Pathway Are Regulated by Serine Phosphorylation. PROTEIN SORTING AT THE LEVEL OF THE ENDOPLASMIC RETICULUM. J. Biol. Chem. 276: 4398-4408 [Abstract] [Full Text]
Parat, M.-O., Fox, P. L. (2001). Palmitoylation of Caveolin-1 in Endothelial Cells Is Post-translational but Irreversible. J. Biol. Chem. 276: 15776-15782 [Abstract] [Full Text]
del Carmen de Marco, M., Kremer, L., Albar, J. P., Martinez-Menarguez, J. A., Ballesta, J., Garcia-Lopez, M. A., Marazuela, M., Puertollano, R., Alonso, M. A. (2001). BENE, a Novel Raft-associated Protein of the MAL Proteolipid Family, Interacts with Caveolin-1 in Human Endothelial-like ECV304 Cells. J. Biol. Chem. 276: 23009-23017 [Abstract] [Full Text]
Park, W.-Y., Park, J.-S., Cho, K.-A, Kim, D.-I., Ko, Y.-G., Seo, J.-S., Park, S. C. (2000). Up-regulation of Caveolin Attenuates Epidermal Growth Factor Signaling in Senescent Cells. J. Biol. Chem. 275: 20847-20852 [Abstract] [Full Text]
Sowa, G., Pypaert, M., Sessa, W. C. (2001). Distinction between signaling mechanisms in lipid rafts vs. caveolae. Proc. Natl. Acad. Sci. USA 98: 14072-14077 [Abstract] [Full Text]