Peroxisome Biogenesis: Involvement of ARF and Coatomer

doi:10.1083/jcb.141.2.373

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J. Cell Biol., Volume 141, Number 2, April 20, 1998 373-383

Peroxisome Biogenesis: Involvement of ARF and Coatomer

Michael Passreiter,^* Markus Anton,^* Dorothee Lay,^* Rainer Frank, Cordula Harter,^* Felix T. Wieland,^* Karin Gorgas,^§ and Wilhelm W. Just^*

^* Biochemie-Zentrum, Zentrum für Molekülare Biologie Heidelberg, and ^§ Institut für Anatomie und Zellbiologie II, Universität Heidelberg, D-69120 Heidelberg, Germany

Peroxisomal membrane protein (Pmp)26p (RnPex11p), a major constituent of induced rat liver peroxisomal membrane, was foundto contain a COOH-terminal, cytoplasmically exposed consensusdilysine motif with the potential to bind coatomer. Biochemicalas well as immunocytochemical evidence is presented showing thatperoxisomes incubated with preparations of bovine brain or ratliver cytosol recruit ADP-ribosylation factor (ARF) and coatomerin a strictly guanosine 5'-O-(3-thiotriphosphate)-dependent manner.Consistent with this observation, ldlF cells expressing a temperature-sensitivemutant version of the $epsilon$ -subunit of coatomer exhibit elongatedtubular peroxisomes possibly due to impaired vesiculation at thenonpermissive temperature. Since overexpression of Pex11p in Chinesehamster ovary wild-type cells causes proliferation of peroxisomes,these data suggest that Pex11p plays an important role in peroxisomebiogenesis by supporting ARF- and coatomer-dependent vesiculationof the organelles.

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