Peroxisome Biogenesis: Involvement of ARF and Coatomer

doi:10.1083/jcb.141.2.373

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© The Rockefeller University Press, 0021-9525/1998//373 $5.00
The Journal of Cell Biology, Volume 141, Number 2, , 1998 373-383

Articles

Peroxisome Biogenesis: Involvement of ARF and Coatomer

Michael Passreiter^*, Markus Anton^*, Dorothee Lay^*, Rainer Frank, Cordula Harter^*, Felix T. Wieland^*, Karin Gorgas, and Wilhelm W. Just^*

^* Biochemie-Zentrum, Zentrum für Molekülare Biologie Heidelberg, and Institut für Anatomie und Zellbiologie II, Universität Heidelberg, D-69120 Heidelberg, Germany

Peroxisomal membrane protein (Pmp)26p (RnPex11p), a major constituentof induced rat liver peroxisomal membrane, was found to containa COOH-terminal, cytoplasmically exposed consensus dilysinemotif with the potential to bind coatomer. Biochemical as wellas immunocytochemical evidence is presented showing that peroxisomesincubated with preparations of bovine brain or rat liver cytosolrecruit ADP-ribosylation factor (ARF) and coatomer in a strictlyguanosine 5'-O-(3-thiotriphosphate)–dependent manner.Consistent with this observation, ldlF cells expressing a temperature-sensitivemutant version of the ${varepsilon}$ -subunit of coatomer exhibit elongatedtubular peroxisomes possibly due to impaired vesiculation at the nonpermissive temperature. Since overexpression of Pex11pin Chinese hamster ovary wild-type cells causes proliferationof peroxisomes, these data suggest that Pex11p plays an importantrole in peroxisome biogenesis by supporting ARF- and coatomer-dependent vesiculation of the organelles.

Abbreviations used in this paper: ARF, ADP-ribosylation factor; COP, coat protein; GDP-βS, guanosine 5'-O-(2-thiodiphosphate); GTP- ${gamma}$ S, guanosine 5'-O-(3-thiotriphosphate); Pmp, peroxisomal membrane protein; PTS, peroxisomal targeting signal; PVDF, polyvinylidene difluoride; RT-PCR, reverse transcriptase PCR; SLO, streptolysin O; ERGIC, ER Golgi intermediate compartment.

The work was supported by the Deutsche Forschungsgemeinschaft (SFB 352).

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Yamasaki, M., Hashiguchi, N., Fujiwara, C., Imanaka, T., Tsukamoto, T., Osumi, T. (1999). Formation of Peroxisomes from Peroxisomal Ghosts in a Peroxisome-deficient Mammalian Cell Mutant upon Complementation by Protein Microinjection. J. Biol. Chem. 274: 35293-35296 [Abstract] [Full Text]
Kal, A. J., van Zonneveld, A. J., Benes, V., van den Berg, M., Koerkamp, M. G., Albermann, K., Strack, N., Ruijter, J. M., Richter, A., Dujon, B., Ansorge, W., Tabak, H. F. (1999). Dynamics of Gene Expression Revealed by Comparison of Serial Analysis of Gene Expression Transcript Profiles from Yeast Grown on Two Different Carbon Sources. Mol. Biol. Cell 10: 1859-1872 [Abstract] [Full Text]
Hu, T., Kao, C.-Y., Hudson, R. T., Chen, A., Draper, R. K. (1999). Inhibition of Secretion by 1,3-Cyclohexanebis(methylamine), a Dibasic Compound That Interferes with Coatomer Function. Mol. Biol. Cell 10: 921-933 [Abstract] [Full Text]
Sata, M., Moss, J., Vaughan, M. (1999). Structural basis for the inhibitory effect of brefeldin A on guanine nucleotide-exchange proteins for ADP-ribosylation factors. Proc. Natl. Acad. Sci. USA 96: 2752-2757 [Abstract] [Full Text]
Will, G. K., Soukupova, M., Hong, X., Erdmann, K. S., Kiel, J. A.�K.�W., Dodt, G., Kunau, W.-H., Erdmann, R. (1999). Identification and Characterization of the Human Orthologue of Yeast Pex14p. Mol. Cell. Biol. 19: 2265-2277 [Abstract] [Full Text]
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Huang, C.-F., Buu, L.-M., Yu, W.-L., Lee, F.-J. S. (1999). Characterization of a Novel ADP-ribosylation Factor-like Protein (yARL3) in Saccharomyces cerevisiae. J. Biol. Chem. 274: 3819-3827 [Abstract] [Full Text]
South, S. T., Gould, S. J. (1999). Peroxisome Synthesis in the Absence of Preexisting Peroxisomes. JCB 144: 255-266 [Abstract] [Full Text]
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Schrader, M., Reuber, B. E., Morrell, J. C., Jimenez-Sanchez, G., Obie, C., Stroh, T. A., Valle, D., Schroer, T. A., Gould, S. J. (1998). Expression of PEX11beta Mediates Peroxisome Proliferation in the Absence of Extracellular Stimuli. J. Biol. Chem. 273: 29607-29614 [Abstract] [Full Text]
Mullen, R. T., Trelease, R. N. (2000). The Sorting Signals for Peroxisomal Membrane-bound Ascorbate Peroxidase Are within Its C-terminal Tail. J. Biol. Chem. 275: 16337-16344 [Abstract] [Full Text]
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